VPS29 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0006886Biological processintracellular protein transport
GO_0010506Biological processregulation of autophagy
GO_0032456Biological processendocytic recycling
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030904Cellular componentretromer complex
GO_0010008Cellular componentendosome membrane
GO_0030906Cellular componentretromer, cargo-selective complex
GO_0005768Cellular componentendosome
GO_0005829Cellular componentcytosol
GO_0005770Cellular componentlate endosome
GO_0005769Cellular componentearly endosome
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameVPS29
Protein nameVPS29 protein
Vacuolar protein sorting-associated protein 29 (hVPS29) (PEP11 homolog) (Vesicle protein sorting 29)
Vacuolar protein sorting-associated protein 29 (Vesicle protein sorting 29)
SynonymsDC7
MDS007
DC15
DescriptionFUNCTION: Acts as a component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) . Acts also as component of the retriever complex. The retriever complex is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) . In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling . The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes . Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 . .; FUNCTION: (Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus. .

FUNCTION: Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. .

AccessionsENST00000546588.1
F8VXU5
ENST00000549970.5
ENST00000552130.6
Q9UBQ0
ENST00000621131.4
ENST00000360579.11 [Q9UBQ0-2]
Q8N0S8
ENST00000447578.6
ENST00000549578.6 [Q9UBQ0-1]
Q05DG7