VMP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	45 studies	41% ± 16%	Explore
macrophage	43 studies	45% ± 18%	Explore
endothelial cell	43 studies	34% ± 13%	Explore
pericyte	30 studies	38% ± 16%	Explore
mast cell	26 studies	43% ± 13%	Explore
smooth muscle cell	26 studies	35% ± 15%	Explore
classical monocyte	26 studies	47% ± 16%	Explore
monocyte	24 studies	47% ± 19%	Explore
conventional dendritic cell	24 studies	34% ± 15%	Explore
non-classical monocyte	24 studies	50% ± 15%	Explore
T cell	23 studies	26% ± 10%	Explore
basal cell	23 studies	47% ± 18%	Explore
CD8-positive, alpha-beta T cell	22 studies	20% ± 3%	Explore
epithelial cell	22 studies	45% ± 20%	Explore
CD4-positive, alpha-beta T cell	21 studies	23% ± 6%	Explore
natural killer cell	20 studies	21% ± 6%	Explore
regulatory T cell	20 studies	28% ± 8%	Explore
dendritic cell	19 studies	40% ± 19%	Explore
ciliated cell	19 studies	46% ± 20%	Explore
B cell	16 studies	20% ± 6%	Explore
endothelial cell of lymphatic vessel	16 studies	30% ± 10%	Explore
connective tissue cell	15 studies	31% ± 9%	Explore
oligodendrocyte	15 studies	36% ± 13%	Explore
microglial cell	15 studies	40% ± 16%	Explore
myofibroblast cell	14 studies	32% ± 14%	Explore
myeloid cell	14 studies	47% ± 16%	Explore
endothelial cell of vascular tree	13 studies	42% ± 15%	Explore
plasma cell	11 studies	27% ± 12%	Explore
type II pneumocyte	11 studies	39% ± 13%	Explore
club cell	11 studies	49% ± 20%	Explore
neutrophil	11 studies	44% ± 15%	Explore
secretory cell	11 studies	49% ± 16%	Explore
leukocyte	11 studies	36% ± 13%	Explore
goblet cell	11 studies	42% ± 21%	Explore
capillary endothelial cell	11 studies	23% ± 15%	Explore
vein endothelial cell	11 studies	32% ± 21%	Explore
type I pneumocyte	10 studies	38% ± 10%	Explore
GABAergic neuron	10 studies	40% ± 21%	Explore
astrocyte	10 studies	30% ± 12%	Explore
oligodendrocyte precursor cell	10 studies	26% ± 10%	Explore
adipocyte	10 studies	46% ± 15%	Explore
mature NK T cell	9 studies	25% ± 10%	Explore
progenitor cell	9 studies	26% ± 11%	Explore
endothelial cell of artery	9 studies	26% ± 11%	Explore
gamma-delta T cell	9 studies	22% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	25% ± 7%	Explore
respiratory goblet cell	8 studies	49% ± 22%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	22% ± 7%	Explore
glutamatergic neuron	8 studies	46% ± 25%	Explore
CD8-positive, alpha-beta memory T cell	8 studies	23% ± 3%	Explore
alveolar macrophage	7 studies	45% ± 25%	Explore
mononuclear phagocyte	7 studies	52% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	7 studies	21% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	24% ± 3%	Explore
abnormal cell	7 studies	43% ± 17%	Explore
neuron	7 studies	38% ± 19%	Explore
enterocyte	7 studies	38% ± 15%	Explore
T follicular helper cell	7 studies	34% ± 10%	Explore
epithelial cell of proximal tubule	6 studies	31% ± 8%	Explore
glial cell	6 studies	39% ± 17%	Explore
mesothelial cell	6 studies	32% ± 10%	Explore
mucosal invariant T cell	6 studies	19% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	24% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	5 studies	20% ± 3%	Explore
hepatocyte	5 studies	58% ± 21%	Explore
CD16-negative, CD56-bright natural killer cell, human	5 studies	19% ± 4%	Explore
transit amplifying cell	5 studies	36% ± 20%	Explore
retinal ganglion cell	5 studies	30% ± 13%	Explore
kidney loop of Henle epithelial cell	5 studies	34% ± 11%	Explore
adventitial cell	5 studies	40% ± 16%	Explore
cardiac muscle cell	5 studies	36% ± 5%	Explore
lymphocyte	5 studies	41% ± 11%	Explore
intermediate monocyte	5 studies	49% ± 19%	Explore
interneuron	5 studies	44% ± 22%	Explore
deuterosomal cell	4 studies	26% ± 0%	Explore
duct epithelial cell	4 studies	38% ± 14%	Explore
squamous epithelial cell	4 studies	54% ± 20%	Explore
cholangiocyte	4 studies	57% ± 23%	Explore
exhausted T cell	4 studies	31% ± 12%	Explore
hematopoietic precursor cell	4 studies	35% ± 15%	Explore
parietal epithelial cell	4 studies	47% ± 6%	Explore
intestinal crypt stem cell	4 studies	26% ± 9%	Explore
memory B cell	4 studies	18% ± 2%	Explore
innate lymphoid cell	4 studies	26% ± 5%	Explore
retinal cone cell	4 studies	23% ± 7%	Explore
retinal rod cell	4 studies	18% ± 2%	Explore
acinar cell	4 studies	45% ± 24%	Explore
chondrocyte	4 studies	22% ± 3%	Explore
CD4-positive helper T cell	4 studies	26% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	28% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	80% ± 5%	Explore
luminal cell of prostate epithelium	4 studies	76% ± 8%	Explore
muscle cell	4 studies	42% ± 7%	Explore
enteroendocrine cell	4 studies	31% ± 13%	Explore
mucus secreting cell	4 studies	41% ± 9%	Explore
melanocyte	4 studies	50% ± 17%	Explore
T-helper 17 cell	4 studies	27% ± 7%	Explore
hillock cell	3 studies	35% ± 17%	Explore
pancreatic A cell	3 studies	37% ± 12%	Explore
type B pancreatic cell	3 studies	41% ± 6%	Explore
naive B cell	3 studies	19% ± 4%	Explore
hepatic stellate cell	3 studies	52% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	21% ± 6%	Explore
renal alpha-intercalated cell	3 studies	18% ± 2%	Explore
GABAergic interneuron	3 studies	22% ± 4%	Explore
renal principal cell	3 studies	42% ± 18%	Explore
retinal pigment epithelial cell	3 studies	39% ± 15%	Explore
tissue-resident macrophage	3 studies	56% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	28% ± 6%	Explore
granulocyte	3 studies	44% ± 7%	Explore
pancreatic ductal cell	3 studies	76% ± 11%	Explore
ependymal cell	3 studies	28% ± 15%	Explore
Schwann cell	3 studies	49% ± 11%	Explore
keratinocyte	3 studies	28% ± 8%	Explore
plasmacytoid dendritic cell	3 studies	25% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	23% ± 5%	Explore
myoepithelial cell	3 studies	30% ± 3%	Explore
progenitor cell of mammary luminal epithelium	3 studies	40% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	40% ± 17%	Explore
brain	19 studies	33% ± 18%	Explore
peripheral blood	13 studies	27% ± 9%	Explore
intestine	11 studies	25% ± 8%	Explore
kidney	9 studies	27% ± 7%	Explore
liver	7 studies	35% ± 15%	Explore
eye	6 studies	30% ± 14%	Explore
heart	5 studies	33% ± 7%	Explore
uterus	5 studies	39% ± 18%	Explore
prostate	5 studies	56% ± 10%	Explore
breast	5 studies	45% ± 10%	Explore
pancreas	4 studies	43% ± 12%	Explore
placenta	4 studies	26% ± 14%	Explore
esophagus	4 studies	36% ± 12%	Explore
adipose	4 studies	43% ± 29%	Explore
lymph node	3 studies	27% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	7778.44	459 / 459	100%	134.76	1116 / 1118
uterus	100%	4572.45	170 / 170	100%	121.86	458 / 459
esophagus	100%	5900.85	1440 / 1445	100%	108.38	183 / 183
lung	100%	11037.45	576 / 578	100%	120.37	1155 / 1155
stomach	100%	5367.92	359 / 359	100%	92.14	285 / 286
prostate	100%	11135.56	245 / 245	100%	106.33	500 / 502
bladder	100%	8107.05	21 / 21	99%	119.97	501 / 504
intestine	100%	5998.92	966 / 966	99%	90.35	521 / 527
ovary	100%	4731.81	180 / 180	99%	72.31	425 / 430
thymus	100%	5618.04	652 / 653	98%	75.85	595 / 605
skin	99%	4633.53	1799 / 1809	97%	80.91	457 / 472
kidney	100%	6651.11	89 / 89	95%	104.33	856 / 901
liver	96%	4013.81	217 / 226	99%	70.00	401 / 406
pancreas	95%	3375.89	312 / 328	99%	150.88	177 / 178
adrenal gland	100%	6120.28	258 / 258	88%	36.89	203 / 230
brain	85%	1981.94	2242 / 2642	97%	46.59	683 / 705
spleen	100%	8463.67	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	71.78	45 / 45
ureter	0%	0	0 / 0	100%	80.44	1 / 1
adipose	100%	6942.94	1203 / 1204	0%	0	0 / 0
peripheral blood	100%	18067.01	927 / 929	0%	0	0 / 0
blood vessel	99%	6992.24	1322 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	66.74	28 / 29
eye	0%	0	0 / 0	90%	49.82	72 / 80
heart	87%	3501.94	750 / 861	0%	0	0 / 0
muscle	68%	1564.25	549 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0140056	Biological process	organelle localization by membrane tethering
GO_0000045	Biological process	autophagosome assembly
GO_0016240	Biological process	autophagosome membrane docking
GO_0007030	Biological process	Golgi organization
GO_1901896	Biological process	positive regulation of ATPase-coupled calcium transmembrane transporter activity
GO_0034329	Biological process	cell junction assembly
GO_0017121	Biological process	plasma membrane phospholipid scrambling
GO_0042953	Biological process	lipoprotein transport
GO_0006914	Biological process	autophagy
GO_0098609	Biological process	cell-cell adhesion
GO_0007566	Biological process	embryo implantation
GO_1990456	Biological process	mitochondrion-endoplasmic reticulum membrane tethering
GO_0005730	Cellular component	nucleolus
GO_0005886	Cellular component	plasma membrane
GO_0012505	Cellular component	endomembrane system
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0000421	Cellular component	autophagosome membrane
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0000407	Cellular component	phagophore assembly site
GO_0017128	Molecular function	phospholipid scramblase activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	VMP1
Protein name	Vacuole membrane protein 1 Vacuole membrane protein 1 (Transmembrane protein 49)
Synonyms	TMEM49 TDC1 hCG_32729 HSPC292
Description	FUNCTION: Phospholipid scramblase involved in lipid homeostasis and membrane dynamics processes . Has phospholipid scramblase activity toward cholesterol and phosphatidylserine, as well as phosphatidylethanolamine and phosphatidylcholine . Required for autophagosome formation: participates in early stages of autophagosome biogenesis at the endoplasmic reticulum (ER) membrane by reequilibrating the leaflets of the ER as lipids are extracted by ATG2 (ATG2A or ATG2B) to mediate autophagosome assembly . Regulates ATP2A2 activity to control ER-isolation membrane contacts for autophagosome formation . In addition to autophagy, involved in other processes in which phospholipid scramblase activity is required . Modulates ER contacts with lipid droplets, mitochondria and endosomes . Plays an essential role in formation of cell junctions . Upon stress such as bacterial and viral infection, promotes formation of cytoplasmic vacuoles followed by cell death (By similarity). Involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis (By similarity). .; FUNCTION: (Microbial infection) Host factor required for infection by all flaviviruses tested such as Zika virus and Yellow fever virus . Probably required post-entry of the virus to facilitate the ER membrane remodeling necessary to form replication organelles . .
Accessions	K7EMN6 ENST00000591315.6 [Q96GC9-1] ENST00000592619.5 A0AA34QVJ7 ENST00000593168.6 ENST00000591877.2 K7ENU2 ENST00000585847.6 K7EK01 A0AA34QVW5 ENST00000589823.7 K7ELS2 ENST00000587945.1 ENST00000262291.9 [Q96GC9-1] K7EPE7 K7EL93 K7EM96 K7EL46 ENST00000586245.6 ENST00000592106.5 ENST00000590850.2 ENST00000587259.6 [Q96GC9-1] K7EL74 Q96GC9 ENST00000710770.1 K7EMI0 ENST00000591315.5 ENST00000587259.5

VMP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review