UFC1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	35 studies	33% ± 11%	Explore
natural killer cell	35 studies	36% ± 10%	Explore
CD4-positive, alpha-beta T cell	30 studies	34% ± 10%	Explore
CD8-positive, alpha-beta T cell	30 studies	35% ± 13%	Explore
T cell	29 studies	31% ± 10%	Explore
fibroblast	29 studies	29% ± 12%	Explore
endothelial cell	28 studies	32% ± 13%	Explore
macrophage	26 studies	30% ± 9%	Explore
conventional dendritic cell	26 studies	40% ± 15%	Explore
regulatory T cell	24 studies	37% ± 10%	Explore
classical monocyte	22 studies	32% ± 13%	Explore
smooth muscle cell	21 studies	27% ± 8%	Explore
memory B cell	20 studies	33% ± 7%	Explore
non-classical monocyte	20 studies	32% ± 14%	Explore
plasmacytoid dendritic cell	20 studies	43% ± 13%	Explore
epithelial cell	19 studies	44% ± 21%	Explore
pericyte	19 studies	27% ± 8%	Explore
mast cell	18 studies	33% ± 12%	Explore
ciliated cell	18 studies	77% ± 17%	Explore
mature NK T cell	18 studies	35% ± 10%	Explore
naive B cell	18 studies	29% ± 7%	Explore
basal cell	17 studies	35% ± 17%	Explore
gamma-delta T cell	17 studies	37% ± 13%	Explore
dendritic cell	16 studies	42% ± 21%	Explore
monocyte	15 studies	30% ± 9%	Explore
endothelial cell of lymphatic vessel	15 studies	37% ± 11%	Explore
plasma cell	15 studies	44% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	40% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	37% ± 12%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	39% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	34% ± 9%	Explore
connective tissue cell	14 studies	31% ± 9%	Explore
mucosal invariant T cell	12 studies	37% ± 11%	Explore
plasmablast	12 studies	45% ± 24%	Explore
capillary endothelial cell	12 studies	24% ± 9%	Explore
myofibroblast cell	12 studies	31% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	33% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	37% ± 14%	Explore
secretory cell	11 studies	33% ± 16%	Explore
vein endothelial cell	11 studies	29% ± 10%	Explore
abnormal cell	10 studies	39% ± 19%	Explore
endothelial cell of artery	10 studies	26% ± 7%	Explore
endothelial cell of vascular tree	10 studies	31% ± 7%	Explore
myeloid cell	10 studies	33% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	39% ± 15%	Explore
goblet cell	9 studies	36% ± 14%	Explore
leukocyte	8 studies	30% ± 11%	Explore
progenitor cell	8 studies	42% ± 10%	Explore
hematopoietic stem cell	8 studies	48% ± 18%	Explore
club cell	7 studies	30% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	41% ± 16%	Explore
T follicular helper cell	7 studies	30% ± 6%	Explore
type I pneumocyte	6 studies	30% ± 16%	Explore
respiratory goblet cell	6 studies	27% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	44% ± 16%	Explore
epithelial cell of proximal tubule	6 studies	29% ± 6%	Explore
kidney loop of Henle epithelial cell	6 studies	28% ± 6%	Explore
renal alpha-intercalated cell	6 studies	37% ± 6%	Explore
mesothelial cell	6 studies	55% ± 15%	Explore
precursor B cell	6 studies	36% ± 11%	Explore
innate lymphoid cell	6 studies	35% ± 7%	Explore
type II pneumocyte	6 studies	34% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	43% ± 14%	Explore
alveolar macrophage	5 studies	26% ± 3%	Explore
CD4-positive helper T cell	5 studies	26% ± 8%	Explore
hematopoietic precursor cell	5 studies	55% ± 24%	Explore
mononuclear phagocyte	5 studies	36% ± 16%	Explore
enterocyte	5 studies	28% ± 3%	Explore
enteroendocrine cell	5 studies	43% ± 17%	Explore
intestinal crypt stem cell	5 studies	30% ± 8%	Explore
IgA plasma cell	5 studies	27% ± 10%	Explore
erythroblast	5 studies	34% ± 17%	Explore
pro-B cell	5 studies	37% ± 7%	Explore
immature B cell	5 studies	39% ± 16%	Explore
neuron	5 studies	44% ± 18%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	29% ± 12%	Explore
deuterosomal cell	4 studies	51% ± 11%	Explore
pancreatic A cell	4 studies	51% ± 13%	Explore
type B pancreatic cell	4 studies	49% ± 19%	Explore
exhausted T cell	4 studies	48% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	35% ± 5%	Explore
IgG plasma cell	4 studies	27% ± 10%	Explore
transit amplifying cell	4 studies	21% ± 3%	Explore
brush cell	4 studies	27% ± 15%	Explore
acinar cell	4 studies	37% ± 17%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	48% ± 7%	Explore
granulocyte	4 studies	36% ± 10%	Explore
erythrocyte	4 studies	33% ± 18%	Explore
T-helper 17 cell	4 studies	35% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	35% ± 10%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	36% ± 15%	Explore
duct epithelial cell	3 studies	24% ± 1%	Explore
ionocyte	3 studies	32% ± 9%	Explore
squamous epithelial cell	3 studies	43% ± 24%	Explore
neural crest cell	3 studies	36% ± 7%	Explore
extravillous trophoblast	3 studies	50% ± 20%	Explore
placental villous trophoblast	3 studies	45% ± 17%	Explore
common myeloid progenitor	3 studies	48% ± 29%	Explore
lymphocyte	3 studies	42% ± 10%	Explore
megakaryocyte	3 studies	18% ± 2%	Explore
neuroendocrine cell	3 studies	51% ± 12%	Explore
astrocyte	3 studies	33% ± 13%	Explore
retinal cone cell	3 studies	45% ± 15%	Explore
retinal rod cell	3 studies	28% ± 9%	Explore
microglial cell	3 studies	28% ± 10%	Explore
serous secreting cell	3 studies	40% ± 13%	Explore
intraepithelial lymphocyte	3 studies	35% ± 11%	Explore
Mueller cell	3 studies	29% ± 7%	Explore
germinal center B cell	3 studies	28% ± 3%	Explore
intermediate monocyte	3 studies	49% ± 21%	Explore
myoepithelial cell	3 studies	35% ± 12%	Explore
luminal cell of prostate epithelium	3 studies	24% ± 8%	Explore
pancreatic ductal cell	3 studies	51% ± 5%	Explore
oligodendrocyte precursor cell	3 studies	30% ± 10%	Explore
granulocyte monocyte progenitor cell	3 studies	40% ± 21%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	47% ± 32%	Explore
group 3 innate lymphoid cell	3 studies	45% ± 13%	Explore
keratinocyte	3 studies	21% ± 3%	Explore
T-helper 1 cell	3 studies	43% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	38% ± 11%	Explore
double negative thymocyte	3 studies	54% ± 13%	Explore
progenitor cell of mammary luminal epithelium	3 studies	40% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	37% ± 13%	Explore
lung	16 studies	37% ± 13%	Explore
intestine	11 studies	29% ± 11%	Explore
kidney	8 studies	30% ± 7%	Explore
eye	6 studies	27% ± 11%	Explore
bone marrow	5 studies	23% ± 8%	Explore
lymph node	5 studies	36% ± 9%	Explore
brain	5 studies	24% ± 5%	Explore
liver	5 studies	32% ± 19%	Explore
pancreas	4 studies	51% ± 16%	Explore
uterus	4 studies	41% ± 14%	Explore
breast	4 studies	34% ± 5%	Explore
placenta	3 studies	42% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	100%	3837.86	578 / 578	100%	126.50	1155 / 1155
ovary	100%	4757.19	180 / 180	100%	126.70	430 / 430
pancreas	100%	4135.33	328 / 328	100%	143.16	178 / 178
prostate	100%	4660.81	245 / 245	100%	167.28	502 / 502
skin	100%	4256.24	1809 / 1809	100%	148.71	472 / 472
stomach	100%	3844.65	359 / 359	100%	116.05	286 / 286
thymus	100%	3762.03	653 / 653	100%	147.70	605 / 605
uterus	100%	3822.82	170 / 170	100%	138.64	459 / 459
brain	100%	3978.07	2641 / 2642	100%	136.91	705 / 705
intestine	100%	3913.90	966 / 966	100%	135.79	526 / 527
breast	100%	3877.93	459 / 459	100%	216.40	1114 / 1118
liver	100%	1731.27	225 / 226	100%	118.25	406 / 406
bladder	100%	4071.14	21 / 21	99%	166.43	501 / 504
esophagus	100%	3669.28	1445 / 1445	99%	70.29	181 / 183
kidney	100%	4378.92	89 / 89	98%	113.61	887 / 901
adrenal gland	100%	4291.04	258 / 258	98%	122.24	226 / 230
adipose	100%	3602.50	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4296.39	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	159.56	80 / 80
lymph node	0%	0	0 / 0	100%	157.62	29 / 29
spleen	100%	3564.55	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	87.18	45 / 45
ureter	0%	0	0 / 0	100%	94.51	1 / 1
muscle	100%	2791.10	800 / 803	0%	0	0 / 0
peripheral blood	98%	2702.98	913 / 929	0%	0	0 / 0
heart	98%	2821.10	840 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0007420	Biological process	brain development
GO_0061709	Biological process	reticulophagy
GO_1990592	Biological process	protein K69-linked ufmylation
GO_0032649	Biological process	regulation of type II interferon production
GO_0034976	Biological process	response to endoplasmic reticulum stress
GO_0071569	Biological process	protein ufmylation
GO_0070062	Cellular component	extracellular exosome
GO_0071568	Molecular function	UFM1 transferase activity
GO_0061657	Molecular function	UFM1 conjugating enzyme activity
GO_0005515	Molecular function	protein binding

Gene name	UFC1
Protein name	Ubiquitin-fold modifier-conjugating enzyme 1 (Ufm1-conjugating enzyme 1)
Synonyms	HSPC155 CGI-126
Description	FUNCTION: E1-like enzyme which specifically catalyzes the second step in ufmylation . Accepts the ubiquitin-like modifier UFM1 from the E1 enzyme UBA5 and forms an intermediate with UFM1 via a thioester linkage . Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress . .
Accessions	ENST00000368003.6 Q9Y3C8

UFC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review