UBE2D2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	43 studies	47% ± 15%	Explore
endothelial cell	42 studies	37% ± 13%	Explore
natural killer cell	40 studies	42% ± 14%	Explore
fibroblast	37 studies	31% ± 10%	Explore
T cell	36 studies	41% ± 15%	Explore
CD8-positive, alpha-beta T cell	36 studies	46% ± 19%	Explore
macrophage	35 studies	30% ± 9%	Explore
CD4-positive, alpha-beta T cell	34 studies	50% ± 18%	Explore
pericyte	30 studies	34% ± 11%	Explore
smooth muscle cell	29 studies	33% ± 10%	Explore
conventional dendritic cell	28 studies	40% ± 16%	Explore
regulatory T cell	27 studies	54% ± 17%	Explore
classical monocyte	23 studies	35% ± 14%	Explore
dendritic cell	22 studies	40% ± 22%	Explore
mast cell	22 studies	33% ± 13%	Explore
plasmacytoid dendritic cell	22 studies	56% ± 15%	Explore
epithelial cell	22 studies	41% ± 23%	Explore
endothelial cell of lymphatic vessel	21 studies	36% ± 12%	Explore
non-classical monocyte	21 studies	38% ± 17%	Explore
monocyte	20 studies	34% ± 10%	Explore
mature NK T cell	20 studies	41% ± 12%	Explore
memory B cell	20 studies	51% ± 8%	Explore
naive B cell	20 studies	45% ± 11%	Explore
plasma cell	19 studies	43% ± 16%	Explore
basal cell	19 studies	38% ± 19%	Explore
gamma-delta T cell	18 studies	45% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	45% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	16 studies	42% ± 13%	Explore
mucosal invariant T cell	16 studies	40% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	46% ± 13%	Explore
connective tissue cell	16 studies	37% ± 12%	Explore
myofibroblast cell	15 studies	36% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	53% ± 12%	Explore
ciliated cell	14 studies	39% ± 21%	Explore
capillary endothelial cell	14 studies	29% ± 12%	Explore
microglial cell	14 studies	32% ± 12%	Explore
myeloid cell	14 studies	37% ± 12%	Explore
astrocyte	14 studies	31% ± 12%	Explore
type I pneumocyte	12 studies	29% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	41% ± 17%	Explore
plasmablast	12 studies	56% ± 23%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	51% ± 14%	Explore
vein endothelial cell	12 studies	33% ± 12%	Explore
endothelial cell of vascular tree	12 studies	31% ± 7%	Explore
type II pneumocyte	11 studies	33% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	52% ± 15%	Explore
club cell	11 studies	25% ± 8%	Explore
endothelial cell of artery	11 studies	37% ± 13%	Explore
oligodendrocyte precursor cell	11 studies	29% ± 12%	Explore
oligodendrocyte	11 studies	29% ± 11%	Explore
secretory cell	10 studies	35% ± 16%	Explore
leukocyte	10 studies	36% ± 10%	Explore
abnormal cell	10 studies	47% ± 19%	Explore
progenitor cell	9 studies	34% ± 12%	Explore
neuron	9 studies	50% ± 20%	Explore
mesothelial cell	9 studies	36% ± 15%	Explore
glutamatergic neuron	9 studies	42% ± 25%	Explore
adipocyte	9 studies	26% ± 7%	Explore
innate lymphoid cell	8 studies	38% ± 10%	Explore
goblet cell	8 studies	30% ± 19%	Explore
T follicular helper cell	8 studies	49% ± 7%	Explore
GABAergic neuron	8 studies	39% ± 21%	Explore
alveolar macrophage	7 studies	25% ± 7%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	47% ± 14%	Explore
mononuclear phagocyte	7 studies	32% ± 14%	Explore
epithelial cell of proximal tubule	7 studies	24% ± 10%	Explore
retinal ganglion cell	7 studies	54% ± 27%	Explore
hematopoietic stem cell	7 studies	44% ± 16%	Explore
precursor B cell	7 studies	53% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	32% ± 9%	Explore
platelet	6 studies	21% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	54% ± 20%	Explore
kidney loop of Henle epithelial cell	6 studies	22% ± 4%	Explore
IgA plasma cell	6 studies	30% ± 12%	Explore
transit amplifying cell	6 studies	32% ± 21%	Explore
interneuron	6 studies	37% ± 21%	Explore
lymphocyte	6 studies	47% ± 11%	Explore
immature B cell	6 studies	56% ± 15%	Explore
amacrine cell	6 studies	35% ± 16%	Explore
retina horizontal cell	6 studies	28% ± 14%	Explore
retinal rod cell	6 studies	24% ± 7%	Explore
Mueller cell	6 studies	51% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	59% ± 19%	Explore
CD4-positive helper T cell	5 studies	37% ± 13%	Explore
hematopoietic precursor cell	5 studies	61% ± 17%	Explore
exhausted T cell	5 studies	59% ± 11%	Explore
enteroendocrine cell	5 studies	37% ± 16%	Explore
intestinal crypt stem cell	5 studies	23% ± 6%	Explore
IgG plasma cell	5 studies	29% ± 11%	Explore
glial cell	5 studies	30% ± 19%	Explore
pro-B cell	5 studies	55% ± 9%	Explore
brush cell	5 studies	30% ± 13%	Explore
T-helper 17 cell	5 studies	58% ± 19%	Explore
retinal cone cell	5 studies	33% ± 17%	Explore
mucus secreting cell	5 studies	22% ± 4%	Explore
cardiac muscle cell	5 studies	35% ± 5%	Explore
granulocyte	5 studies	38% ± 9%	Explore
erythrocyte	5 studies	41% ± 16%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	35% ± 4%	Explore
duct epithelial cell	4 studies	21% ± 5%	Explore
precursor cell	4 studies	48% ± 15%	Explore
respiratory goblet cell	4 studies	29% ± 11%	Explore
squamous epithelial cell	4 studies	32% ± 22%	Explore
pancreatic A cell	4 studies	59% ± 9%	Explore
type B pancreatic cell	4 studies	50% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	29% ± 12%	Explore
renal alpha-intercalated cell	4 studies	28% ± 8%	Explore
enterocyte	4 studies	21% ± 4%	Explore
erythroblast	4 studies	46% ± 20%	Explore
germinal center B cell	4 studies	50% ± 21%	Explore
intermediate monocyte	4 studies	52% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	39% ± 6%	Explore
myoepithelial cell	4 studies	33% ± 6%	Explore
hepatocyte	4 studies	46% ± 28%	Explore
muscle cell	4 studies	39% ± 18%	Explore
neutrophil	4 studies	21% ± 5%	Explore
keratinocyte	4 studies	27% ± 5%	Explore
double negative thymocyte	4 studies	52% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	51% ± 23%	Explore
ionocyte	3 studies	32% ± 12%	Explore
pancreatic D cell	3 studies	56% ± 11%	Explore
glomerular endothelial cell	3 studies	28% ± 4%	Explore
neural crest cell	3 studies	41% ± 12%	Explore
retinal bipolar neuron	3 studies	33% ± 11%	Explore
GABAergic interneuron	3 studies	20% ± 5%	Explore
granule cell	3 studies	24% ± 8%	Explore
extravillous trophoblast	3 studies	31% ± 4%	Explore
placental villous trophoblast	3 studies	39% ± 8%	Explore
megakaryocyte	3 studies	30% ± 15%	Explore
neuroendocrine cell	3 studies	40% ± 15%	Explore
Schwann cell	3 studies	44% ± 11%	Explore
retinal pigment epithelial cell	3 studies	43% ± 16%	Explore
serous secreting cell	3 studies	28% ± 2%	Explore
intraepithelial lymphocyte	3 studies	45% ± 15%	Explore
GABAergic amacrine cell	3 studies	29% ± 10%	Explore
OFF-bipolar cell	3 studies	38% ± 27%	Explore
ON-bipolar cell	3 studies	39% ± 28%	Explore
rod bipolar cell	3 studies	25% ± 6%	Explore
pancreatic ductal cell	3 studies	57% ± 8%	Explore
ependymal cell	3 studies	30% ± 11%	Explore
group 3 innate lymphoid cell	3 studies	58% ± 11%	Explore
melanocyte	3 studies	28% ± 6%	Explore
T-helper 1 cell	3 studies	66% ± 13%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	44% ± 14%	Explore
double-positive, alpha-beta thymocyte	3 studies	59% ± 16%	Explore
progenitor cell of mammary luminal epithelium	3 studies	35% ± 6%	Explore
mural cell	3 studies	29% ± 11%	Explore
luminal cell of prostate epithelium	3 studies	25% ± 9%	Explore
renal principal cell	3 studies	24% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	35% ± 13%	Explore
peripheral blood	18 studies	48% ± 13%	Explore
brain	18 studies	31% ± 17%	Explore
intestine	11 studies	30% ± 13%	Explore
eye	11 studies	29% ± 11%	Explore
kidney	9 studies	33% ± 11%	Explore
liver	7 studies	37% ± 21%	Explore
heart	5 studies	27% ± 4%	Explore
lymph node	5 studies	51% ± 8%	Explore
pancreas	4 studies	53% ± 14%	Explore
placenta	4 studies	33% ± 6%	Explore
bone marrow	4 studies	40% ± 13%	Explore
uterus	4 studies	43% ± 15%	Explore
breast	4 studies	35% ± 3%	Explore
prostate	4 studies	23% ± 8%	Explore
adipose	4 studies	30% ± 7%	Explore
esophagus	3 studies	41% ± 27%	Explore
skin	3 studies	24% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	4726.56	2642 / 2642	100%	103.46	705 / 705
breast	100%	4479.08	459 / 459	100%	96.02	1118 / 1118
esophagus	100%	4806.12	1445 / 1445	100%	69.22	183 / 183
liver	100%	1968.89	226 / 226	100%	49.33	406 / 406
ovary	100%	3992.76	180 / 180	100%	121.20	430 / 430
pancreas	100%	2333.83	328 / 328	100%	73.37	178 / 178
stomach	100%	3349.50	359 / 359	100%	77.74	286 / 286
uterus	100%	4612.05	170 / 170	100%	102.67	459 / 459
thymus	100%	4379.81	653 / 653	100%	95.40	604 / 605
bladder	100%	4606.81	21 / 21	100%	83.25	503 / 504
skin	100%	4529.99	1809 / 1809	100%	72.02	471 / 472
lung	100%	4407.53	577 / 578	100%	76.69	1153 / 1155
intestine	100%	4755.02	966 / 966	100%	86.49	525 / 527
prostate	100%	3907.25	245 / 245	100%	74.23	500 / 502
kidney	100%	4084.38	89 / 89	100%	82.83	897 / 901
adrenal gland	100%	3530.32	258 / 258	98%	70.62	226 / 230
adipose	100%	4577.90	1204 / 1204	0%	0	0 / 0
blood vessel	100%	5197.05	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	133.86	29 / 29
muscle	100%	5932.66	803 / 803	0%	0	0 / 0
spleen	100%	4533.12	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	100.71	45 / 45
ureter	0%	0	0 / 0	100%	32.58	1 / 1
peripheral blood	99%	4208.01	921 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	99%	63.75	79 / 80
heart	98%	3476.10	848 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0051865	Biological process	protein autoubiquitination
GO_0016567	Biological process	protein ubiquitination
GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_0000209	Biological process	protein polyubiquitination
GO_0036211	Biological process	protein modification process
GO_0000151	Cellular component	ubiquitin ligase complex
GO_0070062	Cellular component	extracellular exosome
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005634	Cellular component	nucleus
GO_0061630	Molecular function	ubiquitin protein ligase activity
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0061631	Molecular function	ubiquitin conjugating enzyme activity
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0005515	Molecular function	protein binding
GO_0005524	Molecular function	ATP binding

IV. Literature review

[source]

Gene name	UBE2D2
Protein name	Ubiquitin-conjugating enzyme E2 D2 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme D2) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme D2) (Ubiquitin carrier protein D2) (Ubiquitin-conjugating enzyme E2(17)KB 2) (Ubiquitin-conjugating enzyme E2-17 kDa 2) (Ubiquitin-protein ligase D2) (p53-regulated ubiquitin-conjugating enzyme 1) E2 ubiquitin-conjugating enzyme (EC 2.3.2.23)
Synonyms	UBC5B UBC4 UBCH5B UBCH4 PUBC1
Description	FUNCTION: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins . Catalyzes 'Lys-48'-linked polyubiquitination . Mediates the selective degradation of short-lived and abnormal proteins . Functions in the E6/E6-AP-induced ubiquitination of p53/TP53 . Mediates ubiquitination of PEX5 and SQSTM1 and autoubiquitination of STUB1 and TRAF6 . Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by RIGI in response to viral infection . Essential for viral activation of IRF3 . .
Accessions	ENST00000398733.8 [P62837-1] ENST00000505548.5 [P62837-2] ENST00000398734.8 [P62837-1] P62837 ENST00000698322.1 [P62837-2] D6RFM0 ENST00000505007.5 ENST00000698321.1 [P62837-2] ENST00000511725.5 [P62837-2]

UBE2D2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review