TUBA1A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	38 studies	46% ± 19%	Explore
fibroblast	38 studies	52% ± 20%	Explore
CD8-positive, alpha-beta T cell	34 studies	37% ± 13%	Explore
B cell	33 studies	37% ± 14%	Explore
macrophage	32 studies	30% ± 12%	Explore
natural killer cell	32 studies	30% ± 10%	Explore
pericyte	32 studies	59% ± 22%	Explore
conventional dendritic cell	30 studies	49% ± 17%	Explore
T cell	29 studies	35% ± 15%	Explore
smooth muscle cell	27 studies	61% ± 24%	Explore
CD4-positive, alpha-beta T cell	27 studies	41% ± 15%	Explore
dendritic cell	25 studies	47% ± 22%	Explore
classical monocyte	24 studies	42% ± 16%	Explore
non-classical monocyte	24 studies	59% ± 19%	Explore
mast cell	23 studies	47% ± 17%	Explore
endothelial cell of lymphatic vessel	23 studies	60% ± 20%	Explore
regulatory T cell	23 studies	38% ± 14%	Explore
monocyte	22 studies	36% ± 16%	Explore
ciliated cell	19 studies	76% ± 20%	Explore
naive B cell	19 studies	37% ± 14%	Explore
connective tissue cell	19 studies	59% ± 22%	Explore
memory B cell	18 studies	37% ± 15%	Explore
mature NK T cell	17 studies	36% ± 11%	Explore
astrocyte	17 studies	44% ± 21%	Explore
oligodendrocyte	16 studies	55% ± 19%	Explore
gamma-delta T cell	15 studies	42% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	31% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	37% ± 15%	Explore
capillary endothelial cell	14 studies	41% ± 21%	Explore
myofibroblast cell	14 studies	70% ± 19%	Explore
plasmacytoid dendritic cell	13 studies	27% ± 8%	Explore
oligodendrocyte precursor cell	13 studies	41% ± 22%	Explore
mucosal invariant T cell	12 studies	35% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	42% ± 17%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	35% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	37% ± 19%	Explore
endothelial cell of artery	12 studies	43% ± 22%	Explore
microglial cell	12 studies	35% ± 17%	Explore
endothelial cell of vascular tree	12 studies	36% ± 13%	Explore
basal cell	12 studies	34% ± 17%	Explore
glutamatergic neuron	11 studies	47% ± 24%	Explore
vein endothelial cell	11 studies	37% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	41% ± 18%	Explore
GABAergic neuron	10 studies	46% ± 24%	Explore
neuron	10 studies	67% ± 29%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	43% ± 14%	Explore
leukocyte	9 studies	34% ± 8%	Explore
myeloid cell	9 studies	42% ± 18%	Explore
type I pneumocyte	8 studies	44% ± 14%	Explore
innate lymphoid cell	8 studies	35% ± 10%	Explore
epithelial cell	8 studies	46% ± 20%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	33% ± 9%	Explore
progenitor cell	8 studies	41% ± 23%	Explore
abnormal cell	8 studies	55% ± 26%	Explore
retinal ganglion cell	8 studies	77% ± 27%	Explore
retinal rod cell	8 studies	39% ± 20%	Explore
neutrophil	7 studies	27% ± 8%	Explore
mesothelial cell	7 studies	64% ± 25%	Explore
glial cell	7 studies	57% ± 26%	Explore
interneuron	7 studies	51% ± 23%	Explore
hematopoietic stem cell	7 studies	55% ± 16%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	39% ± 9%	Explore
enteroendocrine cell	6 studies	63% ± 14%	Explore
amacrine cell	6 studies	58% ± 18%	Explore
precursor B cell	6 studies	44% ± 12%	Explore
T follicular helper cell	6 studies	42% ± 23%	Explore
alveolar macrophage	5 studies	20% ± 1%	Explore
CD4-positive helper T cell	5 studies	40% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	35% ± 6%	Explore
hematopoietic precursor cell	5 studies	56% ± 24%	Explore
monocyte-derived dendritic cell	5 studies	51% ± 21%	Explore
mononuclear phagocyte	5 studies	36% ± 7%	Explore
OFF-bipolar cell	5 studies	52% ± 29%	Explore
retinal cone cell	5 studies	36% ± 23%	Explore
pro-B cell	5 studies	35% ± 11%	Explore
brush cell	5 studies	57% ± 16%	Explore
immature B cell	5 studies	52% ± 9%	Explore
retina horizontal cell	5 studies	66% ± 19%	Explore
Mueller cell	5 studies	57% ± 22%	Explore
intermediate monocyte	5 studies	54% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	49% ± 17%	Explore
granulocyte	5 studies	50% ± 15%	Explore
secretory cell	5 studies	26% ± 6%	Explore
deuterosomal cell	4 studies	47% ± 13%	Explore
ionocyte	4 studies	26% ± 11%	Explore
plasmablast	4 studies	37% ± 29%	Explore
platelet	4 studies	24% ± 8%	Explore
pancreatic A cell	4 studies	76% ± 15%	Explore
type B pancreatic cell	4 studies	75% ± 15%	Explore
exhausted T cell	4 studies	31% ± 9%	Explore
retinal bipolar neuron	4 studies	44% ± 18%	Explore
granule cell	4 studies	29% ± 7%	Explore
ON-bipolar cell	4 studies	55% ± 28%	Explore
GABAergic amacrine cell	4 studies	48% ± 11%	Explore
glycinergic amacrine cell	4 studies	40% ± 14%	Explore
type II pneumocyte	4 studies	37% ± 13%	Explore
retinal pigment epithelial cell	4 studies	43% ± 22%	Explore
adventitial cell	4 studies	59% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	33% ± 10%	Explore
T-helper 17 cell	4 studies	36% ± 18%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	31% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	41% ± 1%	Explore
pancreatic D cell	3 studies	81% ± 14%	Explore
glomerular endothelial cell	3 studies	24% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	55% ± 16%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	49% ± 18%	Explore
neural crest cell	3 studies	81% ± 25%	Explore
lymphocyte	3 studies	50% ± 16%	Explore
Schwann cell	3 studies	66% ± 32%	Explore
club cell	3 studies	35% ± 7%	Explore
precursor cell	3 studies	68% ± 21%	Explore
intraepithelial lymphocyte	3 studies	39% ± 19%	Explore
rod bipolar cell	3 studies	37% ± 17%	Explore
muscle cell	3 studies	43% ± 26%	Explore
myoepithelial cell	3 studies	73% ± 8%	Explore
pancreatic ductal cell	3 studies	72% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	44% ± 16%	Explore
melanocyte	3 studies	46% ± 14%	Explore
T-helper 1 cell	3 studies	52% ± 19%	Explore
double negative thymocyte	3 studies	57% ± 18%	Explore
double-positive, alpha-beta thymocyte	3 studies	66% ± 18%	Explore
progenitor cell of mammary luminal epithelium	3 studies	57% ± 6%	Explore
erythrocyte	3 studies	37% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	37% ± 17%	Explore
brain	19 studies	42% ± 16%	Explore
peripheral blood	18 studies	41% ± 16%	Explore
eye	10 studies	50% ± 17%	Explore
intestine	9 studies	37% ± 15%	Explore
kidney	6 studies	38% ± 15%	Explore
uterus	6 studies	44% ± 17%	Explore
pancreas	5 studies	57% ± 28%	Explore
lymph node	5 studies	44% ± 25%	Explore
bone marrow	4 studies	30% ± 11%	Explore
skin	4 studies	28% ± 7%	Explore
breast	4 studies	46% ± 7%	Explore
ovary	3 studies	42% ± 16%	Explore
adrenal gland	3 studies	43% ± 19%	Explore
prostate	3 studies	23% ± 3%	Explore
liver	3 studies	30% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	44630.29	2641 / 2642	100%	1958.88	705 / 705
breast	91%	7243.93	416 / 459	95%	262.73	1066 / 1118
skin	89%	8900.90	1601 / 1809	96%	261.99	451 / 472
ovary	94%	9731.28	169 / 180	86%	218.68	371 / 430
adrenal gland	79%	5828.05	203 / 258	96%	321.80	221 / 230
lung	89%	9067.21	515 / 578	76%	133.92	881 / 1155
prostate	78%	8124.47	190 / 245	76%	93.79	383 / 502
uterus	97%	20171.59	165 / 170	55%	185.85	254 / 459
bladder	81%	14391.95	17 / 21	60%	117.72	303 / 504
intestine	84%	20794.08	813 / 966	49%	64.24	260 / 527
esophagus	76%	19511.69	1105 / 1445	51%	72.42	93 / 183
kidney	40%	2503.30	36 / 89	86%	157.89	779 / 901
thymus	26%	1344.31	169 / 653	75%	103.91	453 / 605
pancreas	12%	735.61	40 / 328	88%	168.96	157 / 178
stomach	43%	7302.63	156 / 359	52%	80.05	148 / 286
blood vessel	94%	10371.62	1257 / 1335	0%	0	0 / 0
adipose	87%	7598.37	1044 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	86%	92.43	25 / 29
heart	79%	6146.25	682 / 861	0%	0	0 / 0
spleen	78%	5341.20	188 / 241	0%	0	0 / 0
peripheral blood	60%	12142.10	560 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	45%	56.07	36 / 80
tonsil	0%	0	0 / 0	44%	49.61	20 / 45
liver	0%	73.38	1 / 226	12%	19.16	47 / 406
muscle	2%	129.18	19 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0007224	Biological process	smoothened signaling pathway
GO_0000278	Biological process	mitotic cell cycle
GO_0061744	Biological process	motor behavior
GO_0007017	Biological process	microtubule-based process
GO_0010001	Biological process	glial cell differentiation
GO_0008344	Biological process	adult locomotory behavior
GO_0072384	Biological process	organelle transport along microtubule
GO_0021542	Biological process	dentate gyrus development
GO_0006886	Biological process	intracellular protein transport
GO_0051301	Biological process	cell division
GO_0001764	Biological process	neuron migration
GO_0034612	Biological process	response to tumor necrosis factor
GO_0008542	Biological process	visual learning
GO_0048873	Biological process	homeostasis of number of cells within a tissue
GO_0007098	Biological process	centrosome cycle
GO_0071277	Biological process	cellular response to calcium ion
GO_0051402	Biological process	neuron apoptotic process
GO_0050807	Biological process	regulation of synapse organization
GO_0021859	Biological process	pyramidal neuron differentiation
GO_0021696	Biological process	cerebellar cortex morphogenesis
GO_0046785	Biological process	microtubule polymerization
GO_0140058	Biological process	neuron projection arborization
GO_0000226	Biological process	microtubule cytoskeleton organization
GO_0007613	Biological process	memory
GO_0001964	Biological process	startle response
GO_0010467	Biological process	gene expression
GO_0009612	Biological process	response to mechanical stimulus
GO_0021987	Biological process	cerebral cortex development
GO_0050808	Biological process	synapse organization
GO_0035641	Biological process	locomotory exploration behavior
GO_1902065	Biological process	response to L-glutamate
GO_0048853	Biological process	forebrain morphogenesis
GO_0030705	Biological process	cytoskeleton-dependent intracellular transport
GO_0005886	Cellular component	plasma membrane
GO_0005874	Cellular component	microtubule
GO_0031594	Cellular component	neuromuscular junction
GO_0055037	Cellular component	recycling endosome
GO_0036464	Cellular component	cytoplasmic ribonucleoprotein granule
GO_0070062	Cellular component	extracellular exosome
GO_0005879	Cellular component	axonemal microtubule
GO_0005829	Cellular component	cytosol
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0005737	Cellular component	cytoplasm
GO_0000793	Cellular component	condensed chromosome
GO_0005634	Cellular component	nucleus
GO_0044877	Molecular function	protein-containing complex binding
GO_0005200	Molecular function	structural constituent of cytoskeleton
GO_0016787	Molecular function	hydrolase activity
GO_0042802	Molecular function	identical protein binding
GO_0005198	Molecular function	structural molecule activity
GO_0005525	Molecular function	GTP binding
GO_0046872	Molecular function	metal ion binding
GO_0046982	Molecular function	protein heterodimerization activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	TUBA1A
Protein name	Tubulin alpha-1C chain Tubulin alpha chain Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain] Tubulin alpha 1a
Synonyms	TUBA3
Description	FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. FUNCTION: Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. .
Accessions	ENST00000546918.1 ENST00000547939 F8VQQ4 ENST00000301071.12 [Q71U36-1] A0A7P0Z4A1 ENST00000295766.9 [Q71U36-1] Q71U36 ENST00000547939.6 [Q71U36-2] ENST00000550767.6 [Q71U36-2] ENST00000552924 F8W0F6 F8VRZ4 ENST00000679733.1 ENST00000552924.2 [Q71U36-2]

TUBA1A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review