TNRC6B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	50 studies	40% ± 19%	Explore
B cell	40 studies	39% ± 17%	Explore
fibroblast	40 studies	34% ± 14%	Explore
natural killer cell	37 studies	32% ± 14%	Explore
pericyte	33 studies	31% ± 14%	Explore
T cell	29 studies	36% ± 15%	Explore
CD8-positive, alpha-beta T cell	29 studies	31% ± 12%	Explore
CD4-positive, alpha-beta T cell	28 studies	34% ± 14%	Explore
smooth muscle cell	27 studies	34% ± 12%	Explore
macrophage	23 studies	37% ± 20%	Explore
astrocyte	21 studies	62% ± 17%	Explore
regulatory T cell	21 studies	32% ± 12%	Explore
mast cell	20 studies	33% ± 15%	Explore
ciliated cell	19 studies	45% ± 16%	Explore
naive B cell	19 studies	34% ± 7%	Explore
mature NK T cell	19 studies	30% ± 12%	Explore
endothelial cell of lymphatic vessel	18 studies	37% ± 16%	Explore
memory B cell	18 studies	35% ± 8%	Explore
plasmacytoid dendritic cell	18 studies	32% ± 12%	Explore
microglial cell	18 studies	56% ± 18%	Explore
gamma-delta T cell	17 studies	33% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	16 studies	30% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	37% ± 15%	Explore
oligodendrocyte precursor cell	16 studies	57% ± 20%	Explore
basal cell	15 studies	40% ± 20%	Explore
oligodendrocyte	15 studies	60% ± 15%	Explore
capillary endothelial cell	15 studies	27% ± 11%	Explore
myofibroblast cell	15 studies	30% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	32% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	34% ± 15%	Explore
mucosal invariant T cell	14 studies	32% ± 14%	Explore
classical monocyte	13 studies	25% ± 10%	Explore
plasma cell	12 studies	33% ± 19%	Explore
glutamatergic neuron	12 studies	75% ± 20%	Explore
epithelial cell	12 studies	47% ± 24%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	27% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	32% ± 8%	Explore
leukocyte	11 studies	45% ± 26%	Explore
non-classical monocyte	11 studies	25% ± 12%	Explore
GABAergic neuron	11 studies	70% ± 19%	Explore
conventional dendritic cell	11 studies	26% ± 13%	Explore
connective tissue cell	11 studies	31% ± 11%	Explore
monocyte	11 studies	40% ± 16%	Explore
endothelial cell of artery	11 studies	30% ± 10%	Explore
endothelial cell of vascular tree	11 studies	31% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	41% ± 17%	Explore
vein endothelial cell	10 studies	31% ± 15%	Explore
type I pneumocyte	9 studies	38% ± 12%	Explore
neuron	9 studies	61% ± 20%	Explore
retinal rod cell	9 studies	57% ± 23%	Explore
myeloid cell	9 studies	38% ± 12%	Explore
adipocyte	9 studies	48% ± 14%	Explore
innate lymphoid cell	9 studies	40% ± 17%	Explore
T follicular helper cell	8 studies	35% ± 11%	Explore
amacrine cell	8 studies	63% ± 14%	Explore
retinal cone cell	8 studies	68% ± 13%	Explore
dendritic cell	8 studies	51% ± 14%	Explore
type II pneumocyte	7 studies	42% ± 14%	Explore
progenitor cell	7 studies	32% ± 15%	Explore
abnormal cell	7 studies	33% ± 18%	Explore
mesothelial cell	7 studies	43% ± 16%	Explore
retinal ganglion cell	7 studies	69% ± 15%	Explore
club cell	7 studies	45% ± 14%	Explore
respiratory goblet cell	6 studies	40% ± 17%	Explore
goblet cell	6 studies	35% ± 24%	Explore
glial cell	6 studies	42% ± 16%	Explore
interneuron	6 studies	81% ± 13%	Explore
retina horizontal cell	6 studies	70% ± 11%	Explore
Mueller cell	6 studies	60% ± 15%	Explore
ionocyte	5 studies	31% ± 13%	Explore
secretory cell	5 studies	36% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	36% ± 18%	Explore
retinal bipolar neuron	5 studies	60% ± 10%	Explore
kidney loop of Henle epithelial cell	5 studies	36% ± 20%	Explore
precursor B cell	5 studies	35% ± 8%	Explore
brush cell	5 studies	34% ± 18%	Explore
cardiac muscle cell	5 studies	67% ± 12%	Explore
lymphocyte	5 studies	57% ± 19%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	39% ± 14%	Explore
erythrocyte	5 studies	46% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	33% ± 19%	Explore
hematopoietic precursor cell	4 studies	34% ± 17%	Explore
plasmablast	4 studies	33% ± 17%	Explore
pancreatic A cell	4 studies	38% ± 23%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	22% ± 6%	Explore
renal alpha-intercalated cell	4 studies	42% ± 21%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	49% ± 18%	Explore
granule cell	4 studies	70% ± 9%	Explore
pro-B cell	4 studies	26% ± 2%	Explore
immature B cell	4 studies	31% ± 8%	Explore
retinal pigment epithelial cell	4 studies	61% ± 22%	Explore
mononuclear phagocyte	4 studies	34% ± 10%	Explore
OFF-bipolar cell	4 studies	57% ± 9%	Explore
ON-bipolar cell	4 studies	61% ± 8%	Explore
chondrocyte	4 studies	39% ± 17%	Explore
CD4-positive helper T cell	4 studies	30% ± 9%	Explore
hepatocyte	4 studies	67% ± 15%	Explore
muscle cell	4 studies	44% ± 22%	Explore
neutrophil	4 studies	21% ± 7%	Explore
enteroendocrine cell	4 studies	37% ± 12%	Explore
double negative thymocyte	4 studies	38% ± 12%	Explore
pancreatic D cell	3 studies	38% ± 25%	Explore
type B pancreatic cell	3 studies	48% ± 21%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	27% ± 8%	Explore
cholangiocyte	3 studies	52% ± 25%	Explore
exhausted T cell	3 studies	27% ± 12%	Explore
glomerular endothelial cell	3 studies	31% ± 6%	Explore
epithelial cell of proximal tubule	3 studies	39% ± 16%	Explore
podocyte	3 studies	33% ± 10%	Explore
renal beta-intercalated cell	3 studies	45% ± 17%	Explore
interstitial cell of Cajal	3 studies	37% ± 8%	Explore
neural crest cell	3 studies	25% ± 3%	Explore
GABAergic interneuron	3 studies	78% ± 4%	Explore
endocardial cell	3 studies	42% ± 8%	Explore
GABAergic amacrine cell	3 studies	71% ± 8%	Explore
glycinergic amacrine cell	3 studies	63% ± 3%	Explore
rod bipolar cell	3 studies	68% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	23% ± 4%	Explore
ependymal cell	3 studies	77% ± 8%	Explore
granulocyte	3 studies	32% ± 15%	Explore
hematopoietic stem cell	3 studies	27% ± 12%	Explore
adventitial cell	3 studies	39% ± 7%	Explore
alveolar macrophage	3 studies	52% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	41% ± 12%	Explore
Schwann cell	3 studies	53% ± 13%	Explore
melanocyte	3 studies	49% ± 13%	Explore
T-helper 17 cell	3 studies	36% ± 3%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	34% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	29% ± 10%	Explore
renal principal cell	3 studies	39% ± 16%	Explore
mural cell	3 studies	62% ± 8%	Explore
mucus secreting cell	3 studies	51% ± 10%	Explore
myoepithelial cell	3 studies	45% ± 23%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	63% ± 22%	Explore
lung	16 studies	35% ± 13%	Explore
peripheral blood	15 studies	33% ± 12%	Explore
eye	11 studies	54% ± 22%	Explore
intestine	9 studies	25% ± 9%	Explore
kidney	7 studies	35% ± 17%	Explore
liver	6 studies	42% ± 17%	Explore
heart	5 studies	50% ± 12%	Explore
bone marrow	4 studies	28% ± 11%	Explore
uterus	4 studies	31% ± 12%	Explore
skin	4 studies	25% ± 13%	Explore
adipose	4 studies	48% ± 18%	Explore
pancreas	3 studies	43% ± 20%	Explore
breast	3 studies	29% ± 6%	Explore
lymph node	3 studies	29% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3011.65	1445 / 1445	100%	14.38	183 / 183
prostate	100%	3104.68	245 / 245	100%	8.88	500 / 502
ovary	100%	3112.84	180 / 180	100%	8.35	428 / 430
thymus	100%	3611.01	653 / 653	99%	8.36	596 / 605
breast	100%	3038.27	459 / 459	98%	8.09	1100 / 1118
brain	100%	3060.53	2634 / 2642	99%	10.38	695 / 705
lung	100%	3470.74	578 / 578	98%	9.07	1132 / 1155
skin	100%	3453.36	1809 / 1809	97%	8.86	460 / 472
stomach	100%	2332.28	359 / 359	97%	9.55	278 / 286
kidney	100%	2212.62	89 / 89	97%	7.31	871 / 901
intestine	100%	3523.98	966 / 966	97%	6.55	509 / 527
pancreas	99%	1708.37	326 / 328	97%	6.39	173 / 178
uterus	100%	3574.05	170 / 170	95%	5.86	436 / 459
bladder	100%	2847.71	21 / 21	94%	5.63	473 / 504
adrenal gland	100%	2795.92	258 / 258	90%	4.77	208 / 230
liver	100%	1912.83	226 / 226	80%	3.59	324 / 406
adipose	100%	2888.93	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	5.93	29 / 29
spleen	100%	4243.49	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	2.09	1 / 1
muscle	100%	2664.24	802 / 803	0%	0	0 / 0
blood vessel	100%	2750.68	1332 / 1335	0%	0	0 / 0
heart	98%	2346.84	848 / 861	0%	0	0 / 0
peripheral blood	98%	2839.94	912 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	8.30	44 / 45
eye	0%	0	0 / 0	89%	4.65	71 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0035195	Biological process	miRNA-mediated post-transcriptional gene silencing
GO_1900153	Biological process	positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0031047	Biological process	regulatory ncRNA-mediated gene silencing
GO_0035278	Biological process	miRNA-mediated gene silencing by inhibition of translation
GO_0060213	Biological process	positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO_0000932	Cellular component	P-body
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	TNRC6B
Protein name	Trinucleotide repeat-containing gene 6B protein Alternative protein TNRC6B Trinucleotide repeat containing adaptor 6B
Synonyms	KIAA1093
Description	FUNCTION: Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs) . Required for miRNA-dependent translational repression and siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins . As scaffolding protein associates with argonaute proteins bound to partially complementary mRNAs and simultaneously can recruit CCR4-NOT and PAN deadenylase complexes . .
Accessions	ENST00000446273.1 ENST00000301923.13 [Q9UPQ9-2] B0QYM5 ENST00000335727.13 [Q9UPQ9-1] ENST00000402203.5 [Q9UPQ9-2] Q9UPQ9 L8E721 ENST00000454349.7 [Q9UPQ9-3] H0Y720 ENST00000441751.5

TNRC6B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review