TCP1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	30 studies	25% ± 8%	Explore
endothelial cell	29 studies	33% ± 14%	Explore
natural killer cell	28 studies	28% ± 11%	Explore
fibroblast	28 studies	30% ± 12%	Explore
CD8-positive, alpha-beta T cell	27 studies	26% ± 12%	Explore
CD4-positive, alpha-beta T cell	26 studies	27% ± 14%	Explore
macrophage	23 studies	25% ± 10%	Explore
T cell	22 studies	28% ± 11%	Explore
smooth muscle cell	22 studies	29% ± 9%	Explore
pericyte	21 studies	29% ± 10%	Explore
conventional dendritic cell	19 studies	30% ± 14%	Explore
epithelial cell	18 studies	32% ± 19%	Explore
memory B cell	17 studies	23% ± 9%	Explore
regulatory T cell	17 studies	25% ± 12%	Explore
gamma-delta T cell	15 studies	26% ± 17%	Explore
basal cell	15 studies	34% ± 12%	Explore
ciliated cell	14 studies	37% ± 13%	Explore
connective tissue cell	14 studies	36% ± 12%	Explore
non-classical monocyte	13 studies	25% ± 11%	Explore
endothelial cell of lymphatic vessel	12 studies	28% ± 9%	Explore
naive B cell	12 studies	21% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	21% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	21% ± 5%	Explore
mast cell	11 studies	23% ± 3%	Explore
monocyte	11 studies	29% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	23% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	25% ± 7%	Explore
capillary endothelial cell	11 studies	23% ± 9%	Explore
myofibroblast cell	11 studies	34% ± 13%	Explore
endothelial cell of vascular tree	11 studies	33% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	24% ± 7%	Explore
mature NK T cell	10 studies	22% ± 5%	Explore
classical monocyte	9 studies	22% ± 11%	Explore
mucosal invariant T cell	9 studies	21% ± 3%	Explore
secretory cell	9 studies	27% ± 8%	Explore
plasma cell	8 studies	33% ± 17%	Explore
plasmablast	8 studies	40% ± 20%	Explore
leukocyte	8 studies	30% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	19% ± 3%	Explore
abnormal cell	8 studies	30% ± 10%	Explore
neuron	8 studies	37% ± 22%	Explore
endothelial cell of artery	8 studies	23% ± 6%	Explore
vein endothelial cell	8 studies	27% ± 9%	Explore
plasmacytoid dendritic cell	8 studies	22% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	23% ± 3%	Explore
epithelial cell of proximal tubule	7 studies	21% ± 6%	Explore
progenitor cell	7 studies	36% ± 16%	Explore
precursor B cell	7 studies	36% ± 15%	Explore
kidney loop of Henle epithelial cell	6 studies	18% ± 2%	Explore
innate lymphoid cell	6 studies	29% ± 10%	Explore
myeloid cell	6 studies	26% ± 11%	Explore
dendritic cell	5 studies	41% ± 23%	Explore
hematopoietic precursor cell	5 studies	47% ± 21%	Explore
mesothelial cell	5 studies	37% ± 18%	Explore
erythroblast	5 studies	47% ± 22%	Explore
hematopoietic stem cell	5 studies	36% ± 6%	Explore
pro-B cell	5 studies	37% ± 7%	Explore
erythrocyte	5 studies	38% ± 25%	Explore
T follicular helper cell	5 studies	22% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	27% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	33% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	25% ± 5%	Explore
type I pneumocyte	4 studies	25% ± 9%	Explore
deuterosomal cell	4 studies	27% ± 3%	Explore
pancreatic A cell	4 studies	39% ± 14%	Explore
mononuclear phagocyte	4 studies	27% ± 14%	Explore
exhausted T cell	4 studies	24% ± 5%	Explore
retinal ganglion cell	4 studies	52% ± 27%	Explore
immature B cell	4 studies	29% ± 9%	Explore
astrocyte	4 studies	22% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	23% ± 5%	Explore
GABAergic neuron	4 studies	30% ± 6%	Explore
glutamatergic neuron	4 studies	40% ± 8%	Explore
oligodendrocyte precursor cell	4 studies	28% ± 7%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	47% ± 24%	Explore
goblet cell	4 studies	27% ± 8%	Explore
transit amplifying cell	4 studies	20% ± 3%	Explore
precursor cell	3 studies	44% ± 12%	Explore
type B pancreatic cell	3 studies	50% ± 11%	Explore
glomerular endothelial cell	3 studies	32% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	40% ± 16%	Explore
renal alpha-intercalated cell	3 studies	35% ± 15%	Explore
neural crest cell	3 studies	37% ± 10%	Explore
extravillous trophoblast	3 studies	29% ± 13%	Explore
placental villous trophoblast	3 studies	26% ± 9%	Explore
lymphocyte	3 studies	37% ± 9%	Explore
club cell	3 studies	25% ± 6%	Explore
type II pneumocyte	3 studies	24% ± 11%	Explore
retina horizontal cell	3 studies	32% ± 14%	Explore
retinal rod cell	3 studies	21% ± 7%	Explore
serous secreting cell	3 studies	18% ± 2%	Explore
Mueller cell	3 studies	18% ± 2%	Explore
acinar cell	3 studies	37% ± 19%	Explore
germinal center B cell	3 studies	26% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	20% ± 5%	Explore
pancreatic ductal cell	3 studies	61% ± 16%	Explore
enteroendocrine cell	3 studies	35% ± 11%	Explore
intestinal crypt stem cell	3 studies	22% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	42% ± 16%	Explore
keratinocyte	3 studies	23% ± 6%	Explore
interneuron	3 studies	28% ± 8%	Explore
double negative thymocyte	3 studies	41% ± 27%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	21% ± 4%	Explore
progenitor cell of mammary luminal epithelium	3 studies	31% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	14 studies	22% ± 10%	Explore
lung	12 studies	31% ± 9%	Explore
kidney	7 studies	26% ± 8%	Explore
intestine	7 studies	30% ± 13%	Explore
brain	7 studies	25% ± 8%	Explore
eye	6 studies	23% ± 8%	Explore
liver	6 studies	29% ± 20%	Explore
bone marrow	5 studies	20% ± 4%	Explore
uterus	5 studies	31% ± 14%	Explore
pancreas	4 studies	41% ± 16%	Explore
lymph node	4 studies	29% ± 12%	Explore
breast	4 studies	28% ± 4%	Explore
placenta	3 studies	23% ± 8%	Explore
esophagus	3 studies	35% ± 22%	Explore
skin	3 studies	22% ± 4%	Explore
thymus	3 studies	48% ± 23%	Explore
prostate	3 studies	37% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	8165.49	1445 / 1445	100%	122.56	183 / 183
lung	100%	8334.09	578 / 578	100%	113.38	1155 / 1155
stomach	100%	6990.19	359 / 359	100%	125.20	286 / 286
breast	100%	9720.11	459 / 459	100%	132.85	1117 / 1118
prostate	100%	6731.13	245 / 245	100%	123.89	501 / 502
brain	100%	7021.60	2636 / 2642	100%	104.60	705 / 705
ovary	100%	10093.79	180 / 180	100%	82.81	429 / 430
bladder	100%	8447.62	21 / 21	99%	124.11	501 / 504
skin	100%	10983.04	1809 / 1809	99%	109.17	469 / 472
intestine	100%	8721.23	966 / 966	99%	139.06	523 / 527
pancreas	100%	5242.32	327 / 328	99%	78.81	177 / 178
thymus	100%	6731.67	653 / 653	99%	82.70	599 / 605
uterus	100%	8734.66	170 / 170	99%	129.41	454 / 459
kidney	100%	7716.03	89 / 89	97%	78.63	874 / 901
liver	99%	4723.38	224 / 226	97%	63.71	395 / 406
adrenal gland	100%	8192.69	258 / 258	96%	80.75	221 / 230
adipose	100%	10450.85	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8708.57	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	132.84	29 / 29
muscle	100%	9360.55	803 / 803	0%	0	0 / 0
spleen	100%	7188.82	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	128.24	45 / 45
ureter	0%	0	0 / 0	100%	23.31	1 / 1
eye	0%	0	0 / 0	99%	85.00	79 / 80
heart	96%	6491.29	826 / 861	0%	0	0 / 0
peripheral blood	95%	7286.75	878 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007339	Biological process	binding of sperm to zona pellucida
GO_1904871	Biological process	positive regulation of protein localization to Cajal body
GO_0061077	Biological process	chaperone-mediated protein folding
GO_1904874	Biological process	positive regulation of telomerase RNA localization to Cajal body
GO_0007021	Biological process	tubulin complex assembly
GO_1904851	Biological process	positive regulation of establishment of protein localization to telomere
GO_0006457	Biological process	protein folding
GO_0050821	Biological process	protein stabilization
GO_0090666	Biological process	scaRNA localization to Cajal body
GO_0051973	Biological process	positive regulation of telomerase activity
GO_0032212	Biological process	positive regulation of telomere maintenance via telomerase
GO_0001669	Cellular component	acrosomal vesicle
GO_0005874	Cellular component	microtubule
GO_0005832	Cellular component	chaperonin-containing T-complex
GO_0002199	Cellular component	zona pellucida receptor complex
GO_0000792	Cellular component	heterochromatin
GO_0005813	Cellular component	centrosome
GO_0070062	Cellular component	extracellular exosome
GO_0005794	Cellular component	Golgi apparatus
GO_0005829	Cellular component	cytosol
GO_0044297	Cellular component	cell body
GO_0000242	Cellular component	pericentriolar material
GO_0044183	Molecular function	protein folding chaperone
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0051082	Molecular function	unfolded protein binding
GO_0140662	Molecular function	ATP-dependent protein folding chaperone
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	TCP1
Protein name	T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha) T-complex 1 T-complex protein 1 subunit alpha (CCT-alpha)
Synonyms	CCTA CCT1
Description	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis . The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance . As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia . The TRiC complex plays a role in the folding of actin and tubulin (Probable). .
Accessions	ENST00000543517.5 ENST00000537390.5 ENST00000539756.1 F5H676 ENST00000536394.1 F5H136 ENST00000392168.6 ENST00000544255.5 ENST00000538128.5 ENST00000420894.6 E7ERF2 E7EQR6 F5H7Y1 ENST00000539948.5 F5H726 F5GYL4 F5GZI8 P17987 F5GZ03 ENST00000538530.5 ENST00000321394.12 F5H282

TCP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review