SYF2 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
B cell	36 studies	38% ± 13%	Explore
natural killer cell	34 studies	37% ± 10%	Explore
fibroblast	29 studies	32% ± 11%	Explore
CD8-positive, alpha-beta T cell	29 studies	30% ± 11%	Explore
endothelial cell	28 studies	36% ± 13%	Explore
CD4-positive, alpha-beta T cell	28 studies	33% ± 12%	Explore
T cell	26 studies	32% ± 10%	Explore
pericyte	25 studies	34% ± 11%	Explore
conventional dendritic cell	24 studies	35% ± 15%	Explore
macrophage	23 studies	26% ± 9%	Explore
classical monocyte	23 studies	38% ± 14%	Explore
regulatory T cell	23 studies	37% ± 8%	Explore
smooth muscle cell	22 studies	33% ± 10%	Explore
non-classical monocyte	22 studies	39% ± 17%	Explore
memory B cell	20 studies	35% ± 9%	Explore
naive B cell	19 studies	36% ± 10%	Explore
plasmacytoid dendritic cell	18 studies	34% ± 13%	Explore
mast cell	17 studies	32% ± 10%	Explore
gamma-delta T cell	17 studies	36% ± 14%	Explore
monocyte	16 studies	34% ± 10%	Explore
basal cell	16 studies	31% ± 14%	Explore
ciliated cell	16 studies	34% ± 17%	Explore
mature NK T cell	16 studies	34% ± 9%	Explore
dendritic cell	15 studies	35% ± 24%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	37% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	37% ± 11%	Explore
endothelial cell of lymphatic vessel	14 studies	30% ± 10%	Explore
epithelial cell	14 studies	39% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	39% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	34% ± 11%	Explore
myofibroblast cell	13 studies	31% ± 10%	Explore
connective tissue cell	13 studies	35% ± 10%	Explore
capillary endothelial cell	12 studies	25% ± 7%	Explore
mucosal invariant T cell	12 studies	29% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	31% ± 9%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	36% ± 11%	Explore
vein endothelial cell	11 studies	26% ± 6%	Explore
endothelial cell of artery	10 studies	27% ± 7%	Explore
endothelial cell of vascular tree	10 studies	32% ± 6%	Explore
secretory cell	9 studies	29% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	38% ± 14%	Explore
leukocyte	8 studies	33% ± 12%	Explore
abnormal cell	8 studies	27% ± 5%	Explore
T follicular helper cell	8 studies	36% ± 6%	Explore
myeloid cell	8 studies	31% ± 15%	Explore
plasma cell	8 studies	29% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	30% ± 11%	Explore
progenitor cell	7 studies	26% ± 10%	Explore
goblet cell	7 studies	25% ± 10%	Explore
hematopoietic stem cell	7 studies	37% ± 11%	Explore
precursor B cell	7 studies	49% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	33% ± 6%	Explore
epithelial cell of proximal tubule	6 studies	26% ± 9%	Explore
enterocyte	6 studies	24% ± 7%	Explore
mesothelial cell	6 studies	38% ± 16%	Explore
innate lymphoid cell	6 studies	36% ± 6%	Explore
immature B cell	6 studies	47% ± 10%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	37% ± 16%	Explore
alveolar macrophage	5 studies	22% ± 4%	Explore
type I pneumocyte	5 studies	28% ± 7%	Explore
ionocyte	5 studies	29% ± 12%	Explore
plasmablast	5 studies	41% ± 25%	Explore
mononuclear phagocyte	5 studies	35% ± 15%	Explore
kidney loop of Henle epithelial cell	5 studies	30% ± 4%	Explore
intestinal crypt stem cell	5 studies	26% ± 7%	Explore
pro-B cell	5 studies	44% ± 6%	Explore
brush cell	5 studies	28% ± 16%	Explore
club cell	5 studies	28% ± 11%	Explore
hematopoietic precursor cell	4 studies	48% ± 23%	Explore
deuterosomal cell	4 studies	20% ± 1%	Explore
platelet	4 studies	21% ± 5%	Explore
pancreatic A cell	4 studies	26% ± 4%	Explore
exhausted T cell	4 studies	38% ± 15%	Explore
glomerular endothelial cell	4 studies	37% ± 12%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	43% ± 11%	Explore
transit amplifying cell	4 studies	17% ± 1%	Explore
CD4-positive helper T cell	4 studies	29% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	30% ± 6%	Explore
neuron	4 studies	33% ± 18%	Explore
granulocyte	4 studies	34% ± 12%	Explore
neutrophil	4 studies	22% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	29% ± 7%	Explore
double negative thymocyte	4 studies	51% ± 15%	Explore
erythrocyte	4 studies	29% ± 17%	Explore
squamous epithelial cell	3 studies	39% ± 27%	Explore
type B pancreatic cell	3 studies	31% ± 8%	Explore
neural crest cell	3 studies	32% ± 2%	Explore
retinal bipolar neuron	3 studies	34% ± 12%	Explore
placental villous trophoblast	3 studies	31% ± 12%	Explore
lymphocyte	3 studies	38% ± 14%	Explore
amacrine cell	3 studies	37% ± 12%	Explore
retina horizontal cell	3 studies	32% ± 14%	Explore
microglial cell	3 studies	22% ± 6%	Explore
intraepithelial lymphocyte	3 studies	37% ± 15%	Explore
Mueller cell	3 studies	29% ± 6%	Explore
germinal center B cell	3 studies	40% ± 5%	Explore
intermediate monocyte	3 studies	56% ± 21%	Explore
glutamatergic neuron	3 studies	32% ± 6%	Explore
pancreatic ductal cell	3 studies	45% ± 3%	Explore
enteroendocrine cell	3 studies	36% ± 13%	Explore
glial cell	3 studies	33% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 16%	Explore
keratinocyte	3 studies	25% ± 2%	Explore
T-helper 17 cell	3 studies	31% ± 10%	Explore
T-helper 1 cell	3 studies	32% ± 12%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	37% ± 2%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	30% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	23% ± 5%	Explore
oligodendrocyte precursor cell	3 studies	30% ± 8%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	41% ± 15%	Explore
lung	15 studies	32% ± 11%	Explore
intestine	11 studies	27% ± 11%	Explore
kidney	7 studies	31% ± 5%	Explore
brain	6 studies	23% ± 3%	Explore
eye	5 studies	29% ± 10%	Explore
lymph node	5 studies	33% ± 6%	Explore
pancreas	4 studies	29% ± 2%	Explore
placenta	4 studies	26% ± 6%	Explore
bone marrow	4 studies	27% ± 8%	Explore
uterus	4 studies	43% ± 14%	Explore
breast	4 studies	27% ± 5%	Explore
liver	4 studies	36% ± 14%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3183.90	1445 / 1445	100%	38.07	183 / 183
kidney	100%	3120.99	89 / 89	100%	46.37	901 / 901
ovary	100%	5071.13	180 / 180	100%	44.66	430 / 430
prostate	100%	3087.76	245 / 245	100%	51.45	502 / 502
thymus	100%	3631.69	653 / 653	100%	88.50	605 / 605
uterus	100%	3906.69	170 / 170	100%	54.87	459 / 459
brain	100%	1894.89	2638 / 2642	100%	40.99	705 / 705
lung	100%	2830.35	577 / 578	100%	41.95	1154 / 1155
breast	100%	4094.48	459 / 459	100%	51.13	1115 / 1118
bladder	100%	3679.33	21 / 21	100%	47.92	502 / 504
stomach	100%	2849.78	359 / 359	99%	41.07	284 / 286
intestine	100%	3786.31	966 / 966	99%	44.40	523 / 527
adrenal gland	100%	3196.79	258 / 258	99%	36.18	228 / 230
liver	99%	1227.92	224 / 226	100%	28.69	406 / 406
pancreas	99%	1960.93	324 / 328	100%	49.05	178 / 178
skin	100%	3299.19	1809 / 1809	99%	46.96	466 / 472
adipose	100%	3985.14	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4543.09	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	63.47	29 / 29
muscle	100%	3042.91	803 / 803	0%	0	0 / 0
spleen	100%	3207.97	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	45.07	45 / 45
ureter	0%	0	0 / 0	100%	29.77	1 / 1
eye	0%	0	0 / 0	99%	38.86	79 / 80
heart	98%	1888.24	847 / 861	0%	0	0 / 0
peripheral blood	96%	2484.70	895 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0