SRSF10 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	35 studies	31% ± 9%	Explore
B cell	33 studies	38% ± 12%	Explore
fibroblast	33 studies	32% ± 11%	Explore
natural killer cell	31 studies	35% ± 16%	Explore
smooth muscle cell	29 studies	30% ± 10%	Explore
CD4-positive, alpha-beta T cell	29 studies	32% ± 14%	Explore
CD8-positive, alpha-beta T cell	29 studies	31% ± 14%	Explore
pericyte	28 studies	32% ± 11%	Explore
T cell	25 studies	33% ± 11%	Explore
mast cell	20 studies	27% ± 12%	Explore
macrophage	19 studies	22% ± 7%	Explore
memory B cell	19 studies	39% ± 11%	Explore
naive B cell	19 studies	36% ± 11%	Explore
regulatory T cell	19 studies	35% ± 10%	Explore
endothelial cell of lymphatic vessel	17 studies	28% ± 7%	Explore
mature NK T cell	17 studies	30% ± 10%	Explore
conventional dendritic cell	16 studies	31% ± 18%	Explore
ciliated cell	16 studies	38% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	33% ± 12%	Explore
plasmacytoid dendritic cell	15 studies	38% ± 15%	Explore
classical monocyte	15 studies	27% ± 12%	Explore
non-classical monocyte	15 studies	27% ± 13%	Explore
gamma-delta T cell	15 studies	36% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	32% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	35% ± 12%	Explore
mucosal invariant T cell	13 studies	31% ± 11%	Explore
basal cell	13 studies	33% ± 13%	Explore
capillary endothelial cell	13 studies	26% ± 7%	Explore
myofibroblast cell	13 studies	35% ± 11%	Explore
connective tissue cell	13 studies	34% ± 15%	Explore
epithelial cell	13 studies	38% ± 20%	Explore
monocyte	12 studies	23% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	32% ± 13%	Explore
vein endothelial cell	12 studies	30% ± 10%	Explore
endothelial cell of vascular tree	12 studies	27% ± 7%	Explore
type I pneumocyte	11 studies	31% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	35% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	36% ± 9%	Explore
dendritic cell	10 studies	39% ± 24%	Explore
type II pneumocyte	10 studies	28% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	38% ± 10%	Explore
endothelial cell of artery	10 studies	28% ± 5%	Explore
plasma cell	9 studies	33% ± 15%	Explore
plasmablast	9 studies	54% ± 28%	Explore
astrocyte	9 studies	30% ± 10%	Explore
club cell	8 studies	31% ± 11%	Explore
mesothelial cell	8 studies	43% ± 12%	Explore
myeloid cell	8 studies	25% ± 11%	Explore
innate lymphoid cell	7 studies	32% ± 8%	Explore
secretory cell	7 studies	33% ± 15%	Explore
progenitor cell	7 studies	38% ± 14%	Explore
abnormal cell	7 studies	38% ± 11%	Explore
retinal rod cell	7 studies	36% ± 8%	Explore
precursor B cell	7 studies	50% ± 8%	Explore
neuron	7 studies	37% ± 12%	Explore
adipocyte	7 studies	33% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	6 studies	27% ± 9%	Explore
leukocyte	6 studies	29% ± 7%	Explore
goblet cell	6 studies	28% ± 16%	Explore
glutamatergic neuron	6 studies	37% ± 25%	Explore
hematopoietic stem cell	6 studies	43% ± 11%	Explore
lymphocyte	6 studies	37% ± 14%	Explore
microglial cell	6 studies	25% ± 4%	Explore
T follicular helper cell	6 studies	32% ± 9%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	41% ± 14%	Explore
oligodendrocyte	6 studies	27% ± 9%	Explore
oligodendrocyte precursor cell	6 studies	35% ± 10%	Explore
hematopoietic precursor cell	5 studies	52% ± 17%	Explore
respiratory goblet cell	5 studies	30% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	32% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	34% ± 16%	Explore
kidney loop of Henle epithelial cell	5 studies	21% ± 5%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	32% ± 13%	Explore
transit amplifying cell	5 studies	35% ± 22%	Explore
pro-B cell	5 studies	57% ± 6%	Explore
immature B cell	5 studies	44% ± 8%	Explore
retinal cone cell	5 studies	37% ± 14%	Explore
cardiac muscle cell	5 studies	28% ± 6%	Explore
GABAergic neuron	5 studies	38% ± 15%	Explore
erythrocyte	5 studies	36% ± 18%	Explore
interneuron	5 studies	38% ± 18%	Explore
CD4-positive helper T cell	4 studies	29% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	27% ± 7%	Explore
deuterosomal cell	4 studies	29% ± 10%	Explore
enteroendocrine cell	4 studies	26% ± 6%	Explore
amacrine cell	4 studies	41% ± 7%	Explore
retinal bipolar neuron	4 studies	33% ± 11%	Explore
erythroblast	4 studies	38% ± 9%	Explore
brush cell	4 studies	32% ± 8%	Explore
retina horizontal cell	4 studies	27% ± 9%	Explore
Mueller cell	4 studies	32% ± 7%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	30% ± 6%	Explore
myoepithelial cell	4 studies	36% ± 8%	Explore
ionocyte	3 studies	27% ± 8%	Explore
precursor cell	3 studies	48% ± 18%	Explore
platelet	3 studies	18% ± 2%	Explore
mononuclear phagocyte	3 studies	20% ± 2%	Explore
glomerular endothelial cell	3 studies	27% ± 4%	Explore
podocyte	3 studies	42% ± 19%	Explore
intestinal crypt stem cell	3 studies	22% ± 6%	Explore
neural crest cell	3 studies	51% ± 9%	Explore
glial cell	3 studies	27% ± 7%	Explore
rod bipolar cell	3 studies	29% ± 4%	Explore
germinal center B cell	3 studies	42% ± 6%	Explore
muscle cell	3 studies	40% ± 9%	Explore
pancreatic A cell	3 studies	43% ± 9%	Explore
pancreatic ductal cell	3 studies	45% ± 13%	Explore
group 3 innate lymphoid cell	3 studies	48% ± 12%	Explore
T-helper 17 cell	3 studies	26% ± 3%	Explore
T-helper 1 cell	3 studies	40% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	33% ± 11%	Explore
IgA plasma cell	3 studies	22% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	33% ± 15%	Explore
lung	15 studies	31% ± 11%	Explore
brain	9 studies	34% ± 17%	Explore
intestine	8 studies	27% ± 11%	Explore
eye	8 studies	34% ± 10%	Explore
kidney	5 studies	27% ± 9%	Explore
bone marrow	5 studies	27% ± 8%	Explore
heart	5 studies	23% ± 5%	Explore
uterus	4 studies	35% ± 14%	Explore
breast	4 studies	26% ± 7%	Explore
adipose	4 studies	36% ± 18%	Explore
placenta	3 studies	19% ± 1%	Explore
pancreas	3 studies	37% ± 15%	Explore
liver	3 studies	37% ± 8%	Explore
lymph node	3 studies	43% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	7109.10	459 / 459	100%	33.97	1118 / 1118
esophagus	100%	5410.08	1445 / 1445	100%	31.85	183 / 183
intestine	100%	6615.85	966 / 966	100%	29.52	527 / 527
lung	100%	7053.27	578 / 578	100%	29.34	1155 / 1155
ovary	100%	8355.08	180 / 180	100%	23.37	430 / 430
stomach	100%	5147.25	359 / 359	100%	28.96	286 / 286
uterus	100%	8392.48	170 / 170	100%	35.23	459 / 459
bladder	100%	5928.24	21 / 21	100%	29.17	502 / 504
prostate	100%	6775.71	245 / 245	100%	24.19	500 / 502
pancreas	100%	3903.34	328 / 328	99%	23.21	177 / 178
thymus	100%	9358.27	653 / 653	99%	30.27	601 / 605
brain	99%	3690.27	2620 / 2642	100%	23.66	705 / 705
adrenal gland	100%	6917.83	258 / 258	98%	17.74	226 / 230
kidney	100%	4860.27	89 / 89	98%	18.20	879 / 901
skin	100%	5887.41	1808 / 1809	96%	26.25	453 / 472
liver	100%	3309.98	226 / 226	96%	12.49	389 / 406
adipose	100%	7030.29	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	33.51	29 / 29
spleen	100%	6286.35	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	31.40	45 / 45
ureter	0%	0	0 / 0	100%	13.99	1 / 1
blood vessel	100%	6572.43	1334 / 1335	0%	0	0 / 0
muscle	100%	3068.13	799 / 803	0%	0	0 / 0
heart	98%	3339.80	845 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	84%	12.18	67 / 80
peripheral blood	65%	3933.17	600 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006376	Biological process	mRNA splice site recognition
GO_0000244	Biological process	spliceosomal tri-snRNP complex assembly
GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0048024	Biological process	regulation of mRNA splicing, via spliceosome
GO_0016482	Biological process	cytosolic transport
GO_0006355	Biological process	regulation of DNA-templated transcription
GO_0048025	Biological process	negative regulation of mRNA splicing, via spliceosome
GO_0000375	Biological process	RNA splicing, via transesterification reactions
GO_0016607	Cellular component	nuclear speck
GO_0043679	Cellular component	axon terminus
GO_0005654	Cellular component	nucleoplasm
GO_0043025	Cellular component	neuronal cell body
GO_0030425	Cellular component	dendrite
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0050733	Molecular function	RS domain binding
GO_0051082	Molecular function	unfolded protein binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SRSF10
Protein name	FUSIP1 protein (Serine and arginine rich splicing factor 10) Serine and arginine rich splicing factor 10 (Serine/arginine-rich splicing factor 10 isoform 2) Serine/arginine-rich splicing factor 10 (40 kDa SR-repressor protein) (SRrp40) (FUS-interacting serine-arginine-rich protein 1) (Splicing factor SRp38) (Splicing factor, arginine/serine-rich 13A) (TLS-associated protein with Ser-Arg repeats) (TASR) (TLS-associated protein with SR repeats) (TLS-associated serine-arginine protein) (TLS-associated SR protein) Serine and arginine rich splicing factor 10 Serine/arginine-rich splicing factor 10 isoform 1
Synonyms	FUSIP1 FUSIP2 TASR SFRS13A
Description	FUNCTION: Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing . Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 . Required for splicing repression in M-phase cells and after heat shock . Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing . Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator . .
Accessions	ENST00000495785.1 Q6IQ42 ENST00000374453.7 ENST00000473858.5 Q5JRI1 A0A0S2Z504 ENST00000343255.9 [O75494-2] ENST00000453840.7 [O75494-6] R4GMP8 O75494 ENST00000374452.9 [O75494-4] ENST00000344989.10 [O75494-3] ENST00000484146.6 [O75494-5] ENST00000492112.3 [O75494-1]

SRSF10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review