SPCS2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	39 studies	40% ± 14%	Explore
endothelial cell	38 studies	40% ± 16%	Explore
fibroblast	38 studies	46% ± 17%	Explore
natural killer cell	36 studies	41% ± 10%	Explore
CD8-positive, alpha-beta T cell	32 studies	37% ± 12%	Explore
macrophage	31 studies	35% ± 12%	Explore
CD4-positive, alpha-beta T cell	31 studies	33% ± 11%	Explore
pericyte	30 studies	42% ± 16%	Explore
T cell	28 studies	36% ± 11%	Explore
plasma cell	28 studies	72% ± 21%	Explore
smooth muscle cell	24 studies	41% ± 12%	Explore
conventional dendritic cell	23 studies	36% ± 13%	Explore
plasmacytoid dendritic cell	22 studies	51% ± 15%	Explore
epithelial cell	22 studies	44% ± 21%	Explore
mast cell	21 studies	36% ± 14%	Explore
classical monocyte	21 studies	29% ± 13%	Explore
regulatory T cell	21 studies	35% ± 7%	Explore
memory B cell	19 studies	33% ± 9%	Explore
basal cell	19 studies	46% ± 18%	Explore
naive B cell	19 studies	31% ± 8%	Explore
non-classical monocyte	19 studies	33% ± 14%	Explore
mature NK T cell	19 studies	36% ± 10%	Explore
connective tissue cell	18 studies	47% ± 16%	Explore
endothelial cell of lymphatic vessel	17 studies	48% ± 12%	Explore
gamma-delta T cell	17 studies	39% ± 11%	Explore
monocyte	16 studies	29% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	38% ± 8%	Explore
dendritic cell	14 studies	36% ± 25%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	30% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	33% ± 10%	Explore
myofibroblast cell	14 studies	45% ± 14%	Explore
ciliated cell	13 studies	44% ± 17%	Explore
mucosal invariant T cell	13 studies	35% ± 8%	Explore
plasmablast	12 studies	76% ± 19%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	35% ± 10%	Explore
astrocyte	12 studies	30% ± 13%	Explore
capillary endothelial cell	12 studies	38% ± 9%	Explore
endothelial cell of vascular tree	12 studies	36% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	33% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	35% ± 10%	Explore
vein endothelial cell	11 studies	38% ± 9%	Explore
secretory cell	10 studies	49% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	36% ± 12%	Explore
endothelial cell of artery	10 studies	39% ± 9%	Explore
goblet cell	10 studies	38% ± 16%	Explore
mesothelial cell	10 studies	47% ± 17%	Explore
myeloid cell	10 studies	37% ± 14%	Explore
type I pneumocyte	9 studies	37% ± 14%	Explore
type II pneumocyte	9 studies	40% ± 20%	Explore
club cell	9 studies	40% ± 18%	Explore
leukocyte	9 studies	36% ± 12%	Explore
progenitor cell	9 studies	39% ± 15%	Explore
abnormal cell	9 studies	45% ± 14%	Explore
IgG plasma cell	9 studies	71% ± 18%	Explore
microglial cell	9 studies	24% ± 10%	Explore
oligodendrocyte precursor cell	9 studies	33% ± 13%	Explore
neuron	8 studies	44% ± 19%	Explore
IgA plasma cell	8 studies	75% ± 15%	Explore
T follicular helper cell	8 studies	37% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	46% ± 15%	Explore
epithelial cell of proximal tubule	7 studies	34% ± 16%	Explore
oligodendrocyte	7 studies	30% ± 11%	Explore
alveolar macrophage	6 studies	34% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	39% ± 12%	Explore
mononuclear phagocyte	6 studies	41% ± 15%	Explore
kidney loop of Henle epithelial cell	6 studies	38% ± 10%	Explore
renal alpha-intercalated cell	6 studies	60% ± 7%	Explore
transit amplifying cell	6 studies	29% ± 6%	Explore
precursor B cell	6 studies	37% ± 13%	Explore
innate lymphoid cell	6 studies	40% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	39% ± 12%	Explore
GABAergic neuron	6 studies	36% ± 15%	Explore
hematopoietic precursor cell	5 studies	42% ± 22%	Explore
ionocyte	5 studies	37% ± 8%	Explore
respiratory goblet cell	5 studies	39% ± 24%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	59% ± 13%	Explore
enterocyte	5 studies	24% ± 5%	Explore
enteroendocrine cell	5 studies	41% ± 20%	Explore
intestinal crypt stem cell	5 studies	28% ± 11%	Explore
glutamatergic neuron	5 studies	45% ± 18%	Explore
pro-B cell	5 studies	40% ± 7%	Explore
mucus secreting cell	5 studies	37% ± 16%	Explore
granulocyte	5 studies	34% ± 12%	Explore
erythrocyte	5 studies	31% ± 18%	Explore
interneuron	5 studies	35% ± 18%	Explore
pancreatic A cell	4 studies	55% ± 18%	Explore
type B pancreatic cell	4 studies	64% ± 20%	Explore
exhausted T cell	4 studies	44% ± 8%	Explore
glomerular endothelial cell	4 studies	34% ± 9%	Explore
retinal ganglion cell	4 studies	56% ± 24%	Explore
lymphocyte	4 studies	40% ± 17%	Explore
immature B cell	4 studies	33% ± 8%	Explore
amacrine cell	4 studies	42% ± 16%	Explore
retina horizontal cell	4 studies	39% ± 15%	Explore
adventitial cell	4 studies	49% ± 12%	Explore
cardiac muscle cell	4 studies	18% ± 2%	Explore
CD4-positive helper T cell	4 studies	36% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	61% ± 3%	Explore
luminal cell of prostate epithelium	4 studies	40% ± 12%	Explore
IgM plasma cell	4 studies	64% ± 14%	Explore
hematopoietic stem cell	4 studies	31% ± 8%	Explore
glial cell	4 studies	41% ± 22%	Explore
hepatocyte	4 studies	44% ± 26%	Explore
group 3 innate lymphoid cell	4 studies	46% ± 14%	Explore
T-helper 17 cell	4 studies	45% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	38% ± 9%	Explore
duct epithelial cell	3 studies	49% ± 9%	Explore
pancreatic D cell	3 studies	63% ± 19%	Explore
podocyte	3 studies	65% ± 13%	Explore
neural crest cell	3 studies	44% ± 8%	Explore
retinal bipolar neuron	3 studies	41% ± 13%	Explore
renal principal cell	3 studies	54% ± 1%	Explore
extravillous trophoblast	3 studies	70% ± 5%	Explore
placental villous trophoblast	3 studies	70% ± 10%	Explore
brush cell	3 studies	39% ± 16%	Explore
neuroendocrine cell	3 studies	40% ± 25%	Explore
retinal cone cell	3 studies	54% ± 7%	Explore
retinal rod cell	3 studies	30% ± 10%	Explore
serous secreting cell	3 studies	54% ± 21%	Explore
tissue-resident macrophage	3 studies	30% ± 10%	Explore
intraepithelial lymphocyte	3 studies	44% ± 12%	Explore
Mueller cell	3 studies	48% ± 7%	Explore
ON-bipolar cell	3 studies	30% ± 9%	Explore
rod bipolar cell	3 studies	38% ± 11%	Explore
erythroblast	3 studies	45% ± 28%	Explore
germinal center B cell	3 studies	40% ± 2%	Explore
intermediate monocyte	3 studies	42% ± 21%	Explore
myoepithelial cell	3 studies	44% ± 13%	Explore
acinar cell	3 studies	38% ± 19%	Explore
pancreatic ductal cell	3 studies	58% ± 4%	Explore
melanocyte	3 studies	38% ± 6%	Explore
keratinocyte	3 studies	32% ± 7%	Explore
T-helper 1 cell	3 studies	42% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	32% ± 9%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	33% ± 11%	Explore
double negative thymocyte	3 studies	51% ± 15%	Explore
progenitor cell of mammary luminal epithelium	3 studies	40% ± 3%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	42% ± 16%	Explore
peripheral blood	17 studies	35% ± 11%	Explore
brain	12 studies	33% ± 14%	Explore
intestine	11 studies	39% ± 18%	Explore
kidney	9 studies	37% ± 12%	Explore
eye	9 studies	30% ± 12%	Explore
bone marrow	6 studies	25% ± 7%	Explore
liver	6 studies	41% ± 21%	Explore
lymph node	5 studies	40% ± 11%	Explore
pancreas	4 studies	58% ± 19%	Explore
uterus	4 studies	59% ± 10%	Explore
prostate	4 studies	36% ± 11%	Explore
breast	4 studies	44% ± 4%	Explore
placenta	3 studies	67% ± 4%	Explore
heart	3 studies	23% ± 8%	Explore
adrenal gland	3 studies	33% ± 13%	Explore
skin	3 studies	31% ± 10%	Explore
thymus	3 studies	50% ± 23%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1883.18	1445 / 1445	100%	56.53	183 / 183
liver	100%	2155.85	226 / 226	100%	43.59	406 / 406
lung	100%	2417.95	578 / 578	100%	54.32	1155 / 1155
ovary	100%	2115.40	180 / 180	100%	73.64	430 / 430
pancreas	100%	2320.73	328 / 328	100%	43.34	178 / 178
stomach	100%	2004.75	359 / 359	100%	53.86	286 / 286
uterus	100%	2550.96	170 / 170	100%	49.91	459 / 459
brain	100%	2223.39	2641 / 2642	100%	66.56	705 / 705
skin	100%	1934.29	1808 / 1809	100%	43.78	471 / 472
thymus	100%	2980.75	653 / 653	100%	55.63	603 / 605
bladder	100%	2173.57	21 / 21	100%	47.70	502 / 504
prostate	100%	2382.70	245 / 245	100%	71.68	500 / 502
adrenal gland	100%	2908.33	258 / 258	100%	41.55	229 / 230
kidney	100%	2018.28	89 / 89	100%	41.53	897 / 901
intestine	100%	2209.33	966 / 966	99%	47.65	524 / 527
breast	100%	2319.06	459 / 459	99%	63.38	1109 / 1118
adipose	100%	2238.13	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	45.12	29 / 29
spleen	100%	2713.79	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	36.26	45 / 45
ureter	0%	0	0 / 0	100%	31.10	1 / 1
blood vessel	100%	2306.91	1334 / 1335	0%	0	0 / 0
muscle	99%	1172.51	798 / 803	0%	0	0 / 0
heart	99%	1558.22	852 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	32.41	77 / 80
peripheral blood	96%	1697.31	890 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	SPCS2
Protein name	Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit) Signal peptidase complex subunit 2
Synonyms	SPC25 KIAA0102
Description	FUNCTION: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum . Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). . FUNCTION: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site. . FUNCTION: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site. . FUNCTION: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site. . FUNCTION: Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site. .
Accessions	ENST00000263672.11 Q15005 ENST00000526361.1 E9PRB9 ENST00000526883.1 E9PL01 E9PI68 ENST00000530257.5 ENST00000532972.5 H0YE04

GO_0006465	Biological process	signal peptide processing
GO_0045047	Biological process	protein targeting to ER
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005787	Cellular component	signal peptidase complex
GO_0005515	Molecular function	protein binding

SPCS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review