SNRNP70 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	38 studies	31% ± 12%	Explore
fibroblast	37 studies	29% ± 11%	Explore
B cell	31 studies	27% ± 9%	Explore
natural killer cell	27 studies	26% ± 7%	Explore
CD4-positive, alpha-beta T cell	27 studies	27% ± 8%	Explore
pericyte	26 studies	29% ± 9%	Explore
smooth muscle cell	26 studies	27% ± 8%	Explore
CD8-positive, alpha-beta T cell	26 studies	27% ± 8%	Explore
T cell	24 studies	26% ± 9%	Explore
macrophage	24 studies	27% ± 10%	Explore
regulatory T cell	19 studies	26% ± 5%	Explore
epithelial cell	18 studies	33% ± 21%	Explore
memory B cell	17 studies	23% ± 5%	Explore
basal cell	17 studies	31% ± 15%	Explore
astrocyte	17 studies	41% ± 16%	Explore
naive B cell	16 studies	24% ± 7%	Explore
endothelial cell of lymphatic vessel	15 studies	28% ± 8%	Explore
ciliated cell	15 studies	33% ± 15%	Explore
oligodendrocyte precursor cell	15 studies	38% ± 15%	Explore
oligodendrocyte	14 studies	38% ± 14%	Explore
mast cell	13 studies	21% ± 6%	Explore
plasma cell	13 studies	30% ± 12%	Explore
monocyte	13 studies	24% ± 8%	Explore
conventional dendritic cell	13 studies	28% ± 16%	Explore
mature NK T cell	13 studies	24% ± 6%	Explore
capillary endothelial cell	13 studies	23% ± 9%	Explore
myofibroblast cell	13 studies	35% ± 10%	Explore
connective tissue cell	13 studies	33% ± 16%	Explore
classical monocyte	12 studies	25% ± 13%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	23% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	25% ± 7%	Explore
gamma-delta T cell	12 studies	29% ± 15%	Explore
microglial cell	12 studies	31% ± 9%	Explore
plasmacytoid dendritic cell	11 studies	30% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	25% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	25% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	24% ± 6%	Explore
glutamatergic neuron	11 studies	40% ± 21%	Explore
endothelial cell of vascular tree	11 studies	22% ± 5%	Explore
type I pneumocyte	10 studies	32% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	25% ± 6%	Explore
GABAergic neuron	10 studies	39% ± 20%	Explore
vein endothelial cell	10 studies	26% ± 8%	Explore
mucosal invariant T cell	10 studies	23% ± 5%	Explore
dendritic cell	10 studies	30% ± 19%	Explore
club cell	9 studies	26% ± 9%	Explore
abnormal cell	9 studies	29% ± 11%	Explore
neuron	9 studies	45% ± 17%	Explore
myeloid cell	9 studies	23% ± 10%	Explore
adipocyte	9 studies	33% ± 8%	Explore
non-classical monocyte	8 studies	27% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	27% ± 7%	Explore
progenitor cell	8 studies	38% ± 11%	Explore
endothelial cell of artery	8 studies	22% ± 4%	Explore
mesothelial cell	8 studies	36% ± 14%	Explore
type II pneumocyte	8 studies	30% ± 12%	Explore
plasmablast	7 studies	45% ± 22%	Explore
leukocyte	7 studies	28% ± 7%	Explore
goblet cell	7 studies	30% ± 12%	Explore
interneuron	7 studies	41% ± 20%	Explore
innate lymphoid cell	7 studies	24% ± 4%	Explore
respiratory goblet cell	6 studies	29% ± 8%	Explore
secretory cell	6 studies	28% ± 8%	Explore
amacrine cell	6 studies	33% ± 9%	Explore
lymphocyte	6 studies	31% ± 8%	Explore
precursor B cell	6 studies	36% ± 15%	Explore
T follicular helper cell	6 studies	26% ± 6%	Explore
hematopoietic precursor cell	5 studies	41% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	26% ± 10%	Explore
kidney loop of Henle epithelial cell	5 studies	19% ± 3%	Explore
enteroendocrine cell	5 studies	32% ± 12%	Explore
transit amplifying cell	5 studies	29% ± 14%	Explore
retinal ganglion cell	5 studies	41% ± 22%	Explore
pro-B cell	5 studies	42% ± 13%	Explore
retina horizontal cell	5 studies	27% ± 10%	Explore
retinal rod cell	5 studies	18% ± 2%	Explore
cardiac muscle cell	5 studies	27% ± 1%	Explore
Mueller cell	5 studies	26% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	28% ± 8%	Explore
deuterosomal cell	4 studies	22% ± 8%	Explore
exhausted T cell	4 studies	29% ± 7%	Explore
renal alpha-intercalated cell	4 studies	29% ± 12%	Explore
retinal bipolar neuron	4 studies	25% ± 7%	Explore
glial cell	4 studies	35% ± 19%	Explore
granule cell	4 studies	30% ± 6%	Explore
immature B cell	4 studies	33% ± 10%	Explore
retinal cone cell	4 studies	25% ± 6%	Explore
retinal pigment epithelial cell	4 studies	37% ± 22%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	30% ± 3%	Explore
hepatocyte	4 studies	65% ± 16%	Explore
muscle cell	4 studies	36% ± 18%	Explore
brush cell	4 studies	27% ± 4%	Explore
alveolar macrophage	4 studies	23% ± 6%	Explore
ionocyte	3 studies	28% ± 2%	Explore
precursor cell	3 studies	40% ± 18%	Explore
pancreatic A cell	3 studies	32% ± 20%	Explore
glomerular endothelial cell	3 studies	20% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	45% ± 14%	Explore
epithelial cell of proximal tubule	3 studies	31% ± 8%	Explore
enterocyte	3 studies	17% ± 1%	Explore
intestinal crypt stem cell	3 studies	21% ± 5%	Explore
neural crest cell	3 studies	42% ± 1%	Explore
GABAergic interneuron	3 studies	30% ± 5%	Explore
hematopoietic stem cell	3 studies	27% ± 4%	Explore
mononuclear phagocyte	3 studies	31% ± 18%	Explore
rod bipolar cell	3 studies	24% ± 6%	Explore
germinal center B cell	3 studies	28% ± 9%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	37% ± 22%	Explore
adventitial cell	3 studies	23% ± 3%	Explore
chondrocyte	3 studies	30% ± 9%	Explore
erythrocyte	3 studies	42% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	46% ± 10%	Explore
Schwann cell	3 studies	28% ± 9%	Explore
melanocyte	3 studies	35% ± 6%	Explore
T-helper 1 cell	3 studies	31% ± 2%	Explore
T-helper 17 cell	3 studies	27% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	21% ± 4%	Explore
myoepithelial cell	3 studies	24% ± 2%	Explore
mucus secreting cell	3 studies	23% ± 5%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	18 studies	37% ± 17%	Explore
lung	17 studies	27% ± 10%	Explore
peripheral blood	13 studies	26% ± 11%	Explore
eye	10 studies	25% ± 10%	Explore
kidney	8 studies	25% ± 7%	Explore
intestine	8 studies	27% ± 14%	Explore
lymph node	5 studies	25% ± 3%	Explore
breast	5 studies	22% ± 3%	Explore
bone marrow	4 studies	19% ± 2%	Explore
heart	4 studies	24% ± 1%	Explore
uterus	4 studies	28% ± 17%	Explore
liver	4 studies	45% ± 16%	Explore
adipose	4 studies	33% ± 16%	Explore
pancreas	3 studies	32% ± 18%	Explore
skin	3 studies	19% ± 2%	Explore
prostate	3 studies	23% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	23523.18	1445 / 1445	100%	92.21	183 / 183
liver	100%	19843.24	226 / 226	100%	93.95	406 / 406
pancreas	100%	22206.13	328 / 328	100%	140.49	178 / 178
prostate	100%	40744.93	245 / 245	100%	185.66	502 / 502
skin	100%	21726.36	1809 / 1809	100%	154.08	472 / 472
uterus	100%	39208.91	170 / 170	100%	178.42	459 / 459
bladder	100%	25968.81	21 / 21	100%	159.10	503 / 504
ovary	100%	42511.48	180 / 180	100%	90.32	429 / 430
thymus	100%	40588.84	653 / 653	100%	166.52	603 / 605
intestine	100%	28416.85	966 / 966	100%	117.99	525 / 527
adrenal gland	100%	27881.17	258 / 258	100%	123.66	229 / 230
stomach	100%	23283.72	359 / 359	99%	104.67	284 / 286
breast	100%	27238.41	459 / 459	99%	128.31	1110 / 1118
lung	100%	20113.90	576 / 578	99%	112.53	1147 / 1155
kidney	100%	23497.72	89 / 89	99%	96.25	889 / 901
brain	98%	23726.99	2599 / 2642	100%	177.41	703 / 705
adipose	100%	20125.13	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	137.18	80 / 80
lymph node	0%	0	0 / 0	100%	237.27	29 / 29
spleen	100%	32950.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	144.06	45 / 45
ureter	0%	0	0 / 0	100%	152.19	1 / 1
blood vessel	100%	21223.54	1333 / 1335	0%	0	0 / 0
muscle	100%	15454.09	801 / 803	0%	0	0 / 0
heart	98%	13431.55	840 / 861	0%	0	0 / 0
peripheral blood	95%	12099.98	878 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0043484	Biological process	regulation of RNA splicing
GO_0043462	Biological process	regulation of ATP-dependent activity
GO_0048026	Biological process	positive regulation of mRNA splicing, via spliceosome
GO_0061084	Biological process	negative regulation of protein refolding
GO_1904715	Biological process	negative regulation of chaperone-mediated autophagy
GO_0016607	Cellular component	nuclear speck
GO_0071004	Cellular component	U2-type prespliceosome
GO_0005654	Cellular component	nucleoplasm
GO_0005685	Cellular component	U1 snRNP
GO_0005681	Cellular component	spliceosomal complex
GO_0005634	Cellular component	nucleus
GO_0030619	Molecular function	U1 snRNA binding
GO_0005515	Molecular function	protein binding
GO_0003729	Molecular function	mRNA binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	SNRNP70
Protein name	Small nuclear ribonucleoprotein U1 subunit 70 SNRNP70 protein U1 small nuclear ribonucleoprotein 70 kDa (U1 snRNP 70 kDa) (U1-70K) (snRNP70)
Synonyms	DKFZp434N041 U1AP1 RNPU1Z RPU1 SNRP70
Description	FUNCTION: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome . SNRNP70 binds to the loop I region of U1-snRNA . .; FUNCTION: [Isoform 3]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. .; FUNCTION: [Isoform 4]: Truncated isoforms that lack the RRM domain cannot bind U1-snRNA. .
Accessions	Q9UFS1 ENST00000221448.9 [P08621-2] M0QX04 P08621 ENST00000598984.5 ENST00000595231.5 [P08621-3] ENST00000601411.1 ENST00000601065.5 [P08621-3] ENST00000401730.5 [P08621-3] ENST00000598441.6 [P08621-1] M0QYR1

SNRNP70 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review