SF3B2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	37 studies	36% ± 12%	Explore
natural killer cell	37 studies	40% ± 17%	Explore
fibroblast	34 studies	30% ± 13%	Explore
CD8-positive, alpha-beta T cell	32 studies	39% ± 18%	Explore
endothelial cell	30 studies	30% ± 11%	Explore
CD4-positive, alpha-beta T cell	29 studies	40% ± 16%	Explore
T cell	26 studies	38% ± 13%	Explore
macrophage	25 studies	27% ± 10%	Explore
conventional dendritic cell	25 studies	34% ± 17%	Explore
regulatory T cell	25 studies	41% ± 13%	Explore
pericyte	24 studies	32% ± 10%	Explore
classical monocyte	22 studies	35% ± 14%	Explore
smooth muscle cell	21 studies	30% ± 9%	Explore
memory B cell	20 studies	39% ± 12%	Explore
naive B cell	20 studies	35% ± 11%	Explore
non-classical monocyte	20 studies	40% ± 15%	Explore
plasmacytoid dendritic cell	19 studies	42% ± 15%	Explore
gamma-delta T cell	18 studies	42% ± 17%	Explore
monocyte	17 studies	29% ± 11%	Explore
mature NK T cell	17 studies	40% ± 12%	Explore
ciliated cell	17 studies	52% ± 17%	Explore
epithelial cell	17 studies	34% ± 19%	Explore
mast cell	16 studies	25% ± 7%	Explore
basal cell	16 studies	32% ± 14%	Explore
mucosal invariant T cell	15 studies	41% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	36% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	49% ± 14%	Explore
connective tissue cell	15 studies	35% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	45% ± 14%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	40% ± 11%	Explore
dendritic cell	13 studies	41% ± 21%	Explore
plasma cell	12 studies	44% ± 16%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	45% ± 12%	Explore
capillary endothelial cell	12 studies	27% ± 11%	Explore
myofibroblast cell	12 studies	35% ± 11%	Explore
endothelial cell of lymphatic vessel	11 studies	30% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	42% ± 11%	Explore
vein endothelial cell	11 studies	26% ± 11%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	43% ± 14%	Explore
plasmablast	10 studies	58% ± 24%	Explore
endothelial cell of artery	10 studies	25% ± 5%	Explore
endothelial cell of vascular tree	10 studies	26% ± 6%	Explore
myeloid cell	10 studies	32% ± 12%	Explore
secretory cell	9 studies	31% ± 13%	Explore
abnormal cell	9 studies	38% ± 13%	Explore
type I pneumocyte	8 studies	27% ± 10%	Explore
innate lymphoid cell	8 studies	33% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	47% ± 21%	Explore
club cell	7 studies	28% ± 9%	Explore
neuron	7 studies	41% ± 20%	Explore
precursor B cell	7 studies	46% ± 9%	Explore
astrocyte	7 studies	26% ± 11%	Explore
T follicular helper cell	7 studies	37% ± 10%	Explore
hematopoietic precursor cell	6 studies	44% ± 20%	Explore
respiratory goblet cell	6 studies	30% ± 13%	Explore
leukocyte	6 studies	29% ± 10%	Explore
progenitor cell	6 studies	42% ± 12%	Explore
mesothelial cell	6 studies	42% ± 16%	Explore
hematopoietic stem cell	6 studies	48% ± 14%	Explore
immature B cell	6 studies	45% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	45% ± 15%	Explore
goblet cell	6 studies	27% ± 8%	Explore
oligodendrocyte	6 studies	24% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	42% ± 14%	Explore
exhausted T cell	5 studies	51% ± 6%	Explore
ionocyte	5 studies	32% ± 10%	Explore
mononuclear phagocyte	5 studies	27% ± 13%	Explore
enteroendocrine cell	5 studies	33% ± 14%	Explore
transit amplifying cell	5 studies	22% ± 5%	Explore
microglial cell	5 studies	25% ± 10%	Explore
pro-B cell	5 studies	48% ± 10%	Explore
type II pneumocyte	5 studies	29% ± 14%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	48% ± 18%	Explore
glutamatergic neuron	5 studies	33% ± 17%	Explore
CD4-positive helper T cell	4 studies	30% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	38% ± 17%	Explore
deuterosomal cell	4 studies	36% ± 7%	Explore
pancreatic A cell	4 studies	57% ± 5%	Explore
kidney loop of Henle epithelial cell	4 studies	23% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	34% ± 11%	Explore
enterocyte	4 studies	19% ± 1%	Explore
retinal ganglion cell	4 studies	50% ± 28%	Explore
erythroblast	4 studies	40% ± 17%	Explore
brush cell	4 studies	28% ± 10%	Explore
amacrine cell	4 studies	40% ± 18%	Explore
retina horizontal cell	4 studies	40% ± 16%	Explore
retinal rod cell	4 studies	28% ± 13%	Explore
intermediate monocyte	4 studies	50% ± 20%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	29% ± 9%	Explore
GABAergic neuron	4 studies	29% ± 13%	Explore
oligodendrocyte precursor cell	4 studies	34% ± 6%	Explore
erythrocyte	4 studies	44% ± 15%	Explore
T-helper 17 cell	4 studies	39% ± 23%	Explore
double negative thymocyte	4 studies	57% ± 17%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	42% ± 13%	Explore
precursor cell	3 studies	64% ± 11%	Explore
squamous epithelial cell	3 studies	41% ± 23%	Explore
platelet	3 studies	21% ± 3%	Explore
pancreatic D cell	3 studies	48% ± 13%	Explore
type B pancreatic cell	3 studies	53% ± 9%	Explore
glomerular endothelial cell	3 studies	23% ± 5%	Explore
neural crest cell	3 studies	42% ± 4%	Explore
retinal bipolar neuron	3 studies	40% ± 15%	Explore
extravillous trophoblast	3 studies	26% ± 1%	Explore
placental villous trophoblast	3 studies	33% ± 12%	Explore
lymphocyte	3 studies	41% ± 13%	Explore
megakaryocyte	3 studies	24% ± 4%	Explore
retinal cone cell	3 studies	38% ± 15%	Explore
serous secreting cell	3 studies	19% ± 1%	Explore
Mueller cell	3 studies	31% ± 7%	Explore
germinal center B cell	3 studies	37% ± 10%	Explore
myoepithelial cell	3 studies	33% ± 5%	Explore
muscle cell	3 studies	29% ± 15%	Explore
pancreatic ductal cell	3 studies	56% ± 11%	Explore
granulocyte	3 studies	26% ± 4%	Explore
alveolar macrophage	3 studies	21% ± 4%	Explore
group 3 innate lymphoid cell	3 studies	46% ± 11%	Explore
interneuron	3 studies	28% ± 13%	Explore
T-helper 1 cell	3 studies	52% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	46% ± 16%	Explore
IgA plasma cell	3 studies	30% ± 16%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	43% ± 12%	Explore
lung	16 studies	33% ± 12%	Explore
intestine	9 studies	26% ± 11%	Explore
eye	8 studies	27% ± 12%	Explore
brain	7 studies	29% ± 9%	Explore
kidney	6 studies	30% ± 12%	Explore
lymph node	5 studies	39% ± 4%	Explore
pancreas	4 studies	48% ± 14%	Explore
placenta	4 studies	26% ± 8%	Explore
bone marrow	4 studies	30% ± 9%	Explore
uterus	4 studies	34% ± 14%	Explore
breast	4 studies	23% ± 5%	Explore
liver	4 studies	34% ± 17%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	10890.50	1445 / 1445	100%	66.20	183 / 183
lung	100%	12738.19	578 / 578	100%	82.72	1155 / 1155
ovary	100%	15008.50	180 / 180	100%	67.76	430 / 430
pancreas	100%	7636.30	328 / 328	100%	77.47	178 / 178
prostate	100%	11428.76	245 / 245	100%	82.38	502 / 502
uterus	100%	14923.96	170 / 170	100%	94.59	459 / 459
brain	100%	10288.80	2640 / 2642	100%	123.55	705 / 705
thymus	100%	14370.28	653 / 653	100%	109.84	604 / 605
intestine	100%	11133.10	966 / 966	100%	74.14	526 / 527
skin	100%	13697.10	1809 / 1809	100%	109.52	471 / 472
stomach	100%	8972.84	359 / 359	100%	66.47	285 / 286
breast	100%	13157.98	459 / 459	100%	97.66	1114 / 1118
liver	100%	5901.06	226 / 226	100%	50.27	404 / 406
bladder	100%	12740.57	21 / 21	99%	86.49	501 / 504
kidney	100%	9771.12	89 / 89	99%	59.80	894 / 901
adrenal gland	100%	9985.16	258 / 258	96%	66.12	221 / 230
adipose	100%	13008.48	1204 / 1204	0%	0	0 / 0
blood vessel	100%	14684.17	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	98.65	80 / 80
lymph node	0%	0	0 / 0	100%	109.50	29 / 29
spleen	100%	12824.08	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	92.64	45 / 45
ureter	0%	0	0 / 0	100%	67.95	1 / 1
muscle	100%	7537.72	800 / 803	0%	0	0 / 0
peripheral blood	98%	11311.90	915 / 929	0%	0	0 / 0
heart	98%	6373.49	847 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0008380	Biological process	RNA splicing
GO_0006397	Biological process	mRNA processing
GO_1903241	Biological process	U2-type prespliceosome assembly
GO_0005686	Cellular component	U2 snRNP
GO_0016607	Cellular component	nuclear speck
GO_0071011	Cellular component	precatalytic spliceosome
GO_0005654	Cellular component	nucleoplasm
GO_0071013	Cellular component	catalytic step 2 spliceosome
GO_0005681	Cellular component	spliceosomal complex
GO_0071005	Cellular component	U2-type precatalytic spliceosome
GO_0005689	Cellular component	U12-type spliceosomal complex
GO_0005684	Cellular component	U2-type spliceosomal complex
GO_0005634	Cellular component	nucleus
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SF3B2
Protein name	Splicing factor 3b subunit 2 Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145)
Synonyms	SAP145
Description	FUNCTION: Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs . The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing . Within the 17S U2 SnRNP complex, SF3B2 is part of the SF3B subcomplex, which is required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence in pre-mRNA . Sequence independent binding of SF3A and SF3B subcomplexes upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA . May also be involved in the assembly of the 'E' complex . Also acts as a component of the minor spliceosome, which is involved in the splicing of U12-type introns in pre-mRNAs . .
Accessions	ENST00000524627.5 ENST00000322535.11 ENST00000530322.5 H0YEX5 H0YCG1 E9PJT3 E9PPJ0 Q13435 ENST00000524475.1 E9PJ04 ENST00000533595.5 ENST00000530981.1 ENST00000528302.5 E9PIL8

SF3B2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review