SEPTIN2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	42 studies	39% ± 14%	Explore
endothelial cell	40 studies	41% ± 16%	Explore
pericyte	35 studies	41% ± 16%	Explore
macrophage	33 studies	31% ± 11%	Explore
smooth muscle cell	31 studies	37% ± 15%	Explore
natural killer cell	28 studies	26% ± 8%	Explore
T cell	26 studies	24% ± 6%	Explore
mast cell	26 studies	42% ± 13%	Explore
B cell	24 studies	25% ± 7%	Explore
CD4-positive, alpha-beta T cell	23 studies	22% ± 7%	Explore
endothelial cell of lymphatic vessel	22 studies	42% ± 16%	Explore
conventional dendritic cell	22 studies	30% ± 14%	Explore
CD8-positive, alpha-beta T cell	21 studies	23% ± 5%	Explore
epithelial cell	19 studies	37% ± 21%	Explore
classical monocyte	18 studies	27% ± 10%	Explore
connective tissue cell	18 studies	40% ± 17%	Explore
regulatory T cell	18 studies	25% ± 5%	Explore
astrocyte	17 studies	35% ± 15%	Explore
basal cell	16 studies	37% ± 17%	Explore
ciliated cell	16 studies	35% ± 14%	Explore
dendritic cell	15 studies	39% ± 20%	Explore
monocyte	15 studies	28% ± 9%	Explore
memory B cell	15 studies	22% ± 4%	Explore
plasmacytoid dendritic cell	15 studies	36% ± 12%	Explore
non-classical monocyte	15 studies	25% ± 11%	Explore
myofibroblast cell	15 studies	46% ± 16%	Explore
plasma cell	13 studies	31% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	29% ± 9%	Explore
naive B cell	13 studies	24% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	29% ± 8%	Explore
capillary endothelial cell	13 studies	37% ± 15%	Explore
endothelial cell of artery	13 studies	37% ± 16%	Explore
vein endothelial cell	13 studies	39% ± 16%	Explore
gamma-delta T cell	13 studies	29% ± 11%	Explore
endothelial cell of vascular tree	13 studies	30% ± 10%	Explore
type I pneumocyte	12 studies	36% ± 12%	Explore
oligodendrocyte	12 studies	34% ± 12%	Explore
myeloid cell	12 studies	31% ± 11%	Explore
microglial cell	12 studies	33% ± 14%	Explore
type II pneumocyte	11 studies	30% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	25% ± 4%	Explore
club cell	11 studies	32% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	25% ± 6%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	10 studies	23% ± 5%	Explore
oligodendrocyte precursor cell	10 studies	38% ± 17%	Explore
mesothelial cell	10 studies	39% ± 17%	Explore
adipocyte	10 studies	35% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	9 studies	26% ± 5%	Explore
alveolar macrophage	8 studies	26% ± 8%	Explore
secretory cell	8 studies	31% ± 12%	Explore
platelet	8 studies	23% ± 7%	Explore
leukocyte	8 studies	28% ± 6%	Explore
GABAergic neuron	8 studies	37% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	23% ± 6%	Explore
neuron	8 studies	48% ± 18%	Explore
glutamatergic neuron	8 studies	38% ± 21%	Explore
mucosal invariant T cell	8 studies	24% ± 5%	Explore
mononuclear phagocyte	7 studies	30% ± 14%	Explore
mature NK T cell	7 studies	26% ± 5%	Explore
progenitor cell	7 studies	32% ± 15%	Explore
abnormal cell	7 studies	34% ± 15%	Explore
plasmablast	6 studies	35% ± 18%	Explore
respiratory goblet cell	6 studies	36% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	23% ± 3%	Explore
lymphocyte	6 studies	36% ± 12%	Explore
retina horizontal cell	6 studies	28% ± 8%	Explore
cardiac muscle cell	6 studies	33% ± 6%	Explore
goblet cell	6 studies	36% ± 21%	Explore
hematopoietic precursor cell	5 studies	38% ± 15%	Explore
transit amplifying cell	5 studies	33% ± 22%	Explore
hematopoietic stem cell	5 studies	27% ± 6%	Explore
precursor B cell	5 studies	32% ± 9%	Explore
pro-B cell	5 studies	29% ± 6%	Explore
brush cell	5 studies	45% ± 9%	Explore
amacrine cell	5 studies	28% ± 8%	Explore
adventitial cell	5 studies	28% ± 5%	Explore
Mueller cell	5 studies	32% ± 10%	Explore
muscle cell	5 studies	34% ± 18%	Explore
interneuron	5 studies	48% ± 20%	Explore
deuterosomal cell	4 studies	24% ± 9%	Explore
ionocyte	4 studies	31% ± 10%	Explore
exhausted T cell	4 studies	31% ± 5%	Explore
epithelial cell of proximal tubule	4 studies	22% ± 6%	Explore
kidney loop of Henle epithelial cell	4 studies	26% ± 6%	Explore
retinal ganglion cell	4 studies	26% ± 8%	Explore
erythroblast	4 studies	46% ± 24%	Explore
megakaryocyte	4 studies	31% ± 8%	Explore
innate lymphoid cell	4 studies	26% ± 4%	Explore
Schwann cell	4 studies	42% ± 19%	Explore
retinal cone cell	4 studies	27% ± 8%	Explore
retinal rod cell	4 studies	18% ± 2%	Explore
glial cell	4 studies	39% ± 24%	Explore
T follicular helper cell	4 studies	24% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	24% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	29% ± 3%	Explore
myoepithelial cell	4 studies	33% ± 12%	Explore
granulocyte	4 studies	34% ± 16%	Explore
enteroendocrine cell	4 studies	41% ± 16%	Explore
T-helper 17 cell	4 studies	20% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	21% ± 3%	Explore
precursor cell	3 studies	45% ± 19%	Explore
pancreatic A cell	3 studies	36% ± 11%	Explore
glomerular endothelial cell	3 studies	45% ± 3%	Explore
neural crest cell	3 studies	47% ± 2%	Explore
extravillous trophoblast	3 studies	31% ± 1%	Explore
placental villous trophoblast	3 studies	29% ± 5%	Explore
immature B cell	3 studies	26% ± 8%	Explore
retinal pigment epithelial cell	3 studies	49% ± 18%	Explore
serous secreting cell	3 studies	24% ± 10%	Explore
tissue-resident macrophage	3 studies	27% ± 1%	Explore
GABAergic amacrine cell	3 studies	22% ± 5%	Explore
glycinergic amacrine cell	3 studies	22% ± 4%	Explore
rod bipolar cell	3 studies	25% ± 1%	Explore
germinal center B cell	3 studies	29% ± 6%	Explore
intermediate monocyte	3 studies	38% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	27% ± 12%	Explore
intestinal crypt stem cell	3 studies	26% ± 8%	Explore
chondrocyte	3 studies	38% ± 5%	Explore
erythrocyte	3 studies	34% ± 18%	Explore
group 3 innate lymphoid cell	3 studies	51% ± 7%	Explore
melanocyte	3 studies	33% ± 10%	Explore
hepatocyte	3 studies	52% ± 8%	Explore
double negative thymocyte	3 studies	39% ± 13%	Explore
mucus secreting cell	3 studies	27% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	20 studies	33% ± 14%	Explore
brain	15 studies	32% ± 16%	Explore
peripheral blood	13 studies	27% ± 9%	Explore
eye	10 studies	26% ± 13%	Explore
intestine	7 studies	36% ± 16%	Explore
kidney	7 studies	30% ± 7%	Explore
heart	6 studies	28% ± 4%	Explore
lymph node	5 studies	24% ± 5%	Explore
bone marrow	4 studies	30% ± 10%	Explore
uterus	4 studies	43% ± 12%	Explore
skin	4 studies	24% ± 5%	Explore
breast	4 studies	25% ± 4%	Explore
liver	4 studies	42% ± 23%	Explore
pancreas	3 studies	34% ± 16%	Explore
placenta	3 studies	34% ± 9%	Explore
adipose	3 studies	34% ± 9%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	17325.95	1445 / 1445	100%	152.11	183 / 183
pancreas	100%	14822.35	328 / 328	100%	169.19	178 / 178
brain	100%	17969.34	2641 / 2642	100%	353.21	705 / 705
lung	100%	19794.63	578 / 578	100%	171.78	1154 / 1155
breast	100%	21799.70	459 / 459	100%	206.28	1117 / 1118
intestine	100%	18672.56	966 / 966	100%	164.08	526 / 527
prostate	100%	17346.11	245 / 245	100%	164.57	501 / 502
ovary	100%	20083.97	180 / 180	100%	156.43	429 / 430
stomach	100%	14370.68	359 / 359	100%	154.56	285 / 286
thymus	100%	21833.57	653 / 653	100%	200.26	602 / 605
bladder	100%	18328.43	21 / 21	99%	141.69	500 / 504
uterus	100%	20526.88	170 / 170	99%	146.01	454 / 459
kidney	100%	15380.15	89 / 89	98%	154.48	884 / 901
adrenal gland	100%	17057.76	258 / 258	97%	115.53	222 / 230
skin	100%	19066.20	1807 / 1809	96%	164.86	455 / 472
liver	100%	5923.27	225 / 226	77%	60.42	314 / 406
adipose	100%	23740.85	1204 / 1204	0%	0	0 / 0
blood vessel	100%	25136.67	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	114.19	29 / 29
spleen	100%	15224.98	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	133.07	45 / 45
ureter	0%	0	0 / 0	100%	78.85	1 / 1
muscle	99%	8909.55	797 / 803	0%	0	0 / 0
heart	97%	11163.78	838 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	81%	84.46	65 / 80
peripheral blood	80%	8285.23	741 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060271	Biological process	cilium assembly
GO_0007224	Biological process	smoothened signaling pathway
GO_0007283	Biological process	spermatogenesis
GO_0061640	Biological process	cytoskeleton-dependent cytokinesis
GO_0017157	Biological process	regulation of exocytosis
GO_0030154	Biological process	cell differentiation
GO_0008104	Biological process	protein localization
GO_0030496	Cellular component	midbody
GO_0032391	Cellular component	photoreceptor connecting cilium
GO_0032153	Cellular component	cell division site
GO_0005886	Cellular component	plasma membrane
GO_0097227	Cellular component	sperm annulus
GO_0000776	Cellular component	kinetochore
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0045171	Cellular component	intercellular bridge
GO_0060170	Cellular component	ciliary membrane
GO_0005930	Cellular component	axoneme
GO_0015629	Cellular component	actin cytoskeleton
GO_0097730	Cellular component	non-motile cilium
GO_0008021	Cellular component	synaptic vesicle
GO_0005938	Cellular component	cell cortex
GO_0015630	Cellular component	microtubule cytoskeleton
GO_0031105	Cellular component	septin complex
GO_0005737	Cellular component	cytoplasm
GO_0005940	Cellular component	septin ring
GO_0032154	Cellular component	cleavage furrow
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0060090	Molecular function	molecular adaptor activity
GO_0045296	Molecular function	cadherin binding
GO_0005525	Molecular function	GTP binding
GO_0005515	Molecular function	protein binding
GO_0003924	Molecular function	GTPase activity

IV. Literature review

[source]

Gene name	SEPTIN2
Protein name	Septin 2 Septin-2 (Neural precursor cell expressed developmentally down-regulated protein 5) (NEDD-5) Septin-2
Synonyms	KIAA0158 SEPT2 NEDD5 DIFF6
Description	FUNCTION: Filament-forming cytoskeletal GTPase. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation . Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes: probably acts by regulating the assembly of the tectonic-like complex (also named B9 complex) by localizing TMEM231 protein. May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. .
Accessions	C9J938 H7C1T1 ENST00000443492.5 ENST00000436795.5 C9JFT1 ENST00000407017.5 ENST00000441533.5 ENST00000434955.5 ENST00000437066.5 ENST00000391973.6 [Q15019-1] ENST00000425899.5 A0A1B0GXJ2 F8WCX3 ENST00000407971.5 C9JB25 ENST00000402092.6 [Q15019-1] C9JQJ4 ENST00000445030.5 ENST00000428282.5 ENST00000428524.5 ENST00000451310.1 ENST00000457335.5 ENST00000421717.1 C9IY94 C9J2Q4 C9JZI2 F8WB65 ENST00000429791.5 C9IZU3 B5MCX3 ENST00000411484.5 Q15019 ENST00000616972.4 [Q15019-2] ENST00000391971.7 [Q15019-1] ENST00000401990.5 [Q15019-3] ENST00000457874.1 C9JG93 H7C310 ENST00000360051.7 [Q15019-1] C9JT15 H7C2Y0 ENST00000449239.5 C9JSE7 B5MD47 ENST00000420786.5

SEPTIN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review