SELENOK | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	37 studies	36% ± 15%	Explore
natural killer cell	35 studies	41% ± 12%	Explore
fibroblast	34 studies	41% ± 16%	Explore
CD8-positive, alpha-beta T cell	32 studies	38% ± 13%	Explore
CD4-positive, alpha-beta T cell	30 studies	37% ± 12%	Explore
T cell	29 studies	38% ± 15%	Explore
endothelial cell	29 studies	40% ± 14%	Explore
macrophage	28 studies	38% ± 13%	Explore
pericyte	28 studies	46% ± 18%	Explore
plasma cell	27 studies	61% ± 21%	Explore
smooth muscle cell	24 studies	44% ± 14%	Explore
conventional dendritic cell	23 studies	40% ± 15%	Explore
non-classical monocyte	22 studies	38% ± 14%	Explore
mast cell	21 studies	58% ± 21%	Explore
classical monocyte	21 studies	35% ± 12%	Explore
regulatory T cell	20 studies	40% ± 10%	Explore
monocyte	19 studies	38% ± 15%	Explore
plasmacytoid dendritic cell	18 studies	37% ± 15%	Explore
basal cell	17 studies	42% ± 17%	Explore
naive B cell	17 studies	30% ± 10%	Explore
epithelial cell	17 studies	49% ± 21%	Explore
mature NK T cell	16 studies	41% ± 13%	Explore
dendritic cell	15 studies	36% ± 18%	Explore
gamma-delta T cell	15 studies	43% ± 15%	Explore
memory B cell	15 studies	32% ± 11%	Explore
endothelial cell of lymphatic vessel	14 studies	34% ± 10%	Explore
ciliated cell	14 studies	35% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	31% ± 13%	Explore
connective tissue cell	14 studies	42% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	41% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	36% ± 12%	Explore
mucosal invariant T cell	13 studies	44% ± 13%	Explore
plasmablast	12 studies	56% ± 20%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	33% ± 12%	Explore
myofibroblast cell	12 studies	38% ± 16%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	41% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	45% ± 17%	Explore
secretory cell	11 studies	46% ± 21%	Explore
capillary endothelial cell	11 studies	29% ± 4%	Explore
goblet cell	11 studies	50% ± 17%	Explore
endothelial cell of vascular tree	11 studies	43% ± 11%	Explore
vein endothelial cell	10 studies	30% ± 6%	Explore
myeloid cell	10 studies	40% ± 15%	Explore
endothelial cell of artery	9 studies	34% ± 6%	Explore
neutrophil	8 studies	30% ± 15%	Explore
leukocyte	8 studies	52% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	45% ± 20%	Explore
abnormal cell	8 studies	30% ± 12%	Explore
type I pneumocyte	7 studies	31% ± 12%	Explore
club cell	7 studies	37% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	43% ± 13%	Explore
IgG plasma cell	7 studies	51% ± 20%	Explore
retinal rod cell	7 studies	51% ± 26%	Explore
erythrocyte	7 studies	31% ± 19%	Explore
type II pneumocyte	6 studies	37% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	43% ± 13%	Explore
epithelial cell of proximal tubule	6 studies	35% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	29% ± 5%	Explore
neuron	6 studies	32% ± 16%	Explore
enterocyte	6 studies	29% ± 8%	Explore
IgA plasma cell	6 studies	55% ± 23%	Explore
astrocyte	6 studies	33% ± 19%	Explore
retinal cone cell	6 studies	59% ± 30%	Explore
mesothelial cell	6 studies	37% ± 20%	Explore
T follicular helper cell	6 studies	38% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	45% ± 20%	Explore
ionocyte	5 studies	35% ± 8%	Explore
respiratory goblet cell	5 studies	31% ± 17%	Explore
mononuclear phagocyte	5 studies	58% ± 17%	Explore
enteroendocrine cell	5 studies	48% ± 18%	Explore
innate lymphoid cell	5 studies	43% ± 10%	Explore
granulocyte	5 studies	56% ± 20%	Explore
alveolar macrophage	4 studies	30% ± 8%	Explore
exhausted T cell	4 studies	37% ± 4%	Explore
glomerular endothelial cell	4 studies	35% ± 9%	Explore
progenitor cell	4 studies	34% ± 3%	Explore
renal alpha-intercalated cell	4 studies	38% ± 7%	Explore
transit amplifying cell	4 studies	23% ± 5%	Explore
OFF-bipolar cell	4 studies	27% ± 10%	Explore
microglial cell	4 studies	34% ± 17%	Explore
precursor B cell	4 studies	31% ± 9%	Explore
brush cell	4 studies	30% ± 9%	Explore
immature B cell	4 studies	22% ± 5%	Explore
retina horizontal cell	4 studies	35% ± 17%	Explore
Mueller cell	4 studies	42% ± 17%	Explore
intermediate monocyte	4 studies	46% ± 22%	Explore
CD4-positive helper T cell	4 studies	53% ± 16%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	62% ± 6%	Explore
IgM plasma cell	4 studies	41% ± 18%	Explore
duct epithelial cell	3 studies	31% ± 1%	Explore
pancreatic A cell	3 studies	77% ± 9%	Explore
type B pancreatic cell	3 studies	75% ± 14%	Explore
monocyte-derived dendritic cell	3 studies	50% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	39% ± 6%	Explore
neural crest cell	3 studies	29% ± 8%	Explore
retinal bipolar neuron	3 studies	68% ± 20%	Explore
retinal ganglion cell	3 studies	54% ± 23%	Explore
ON-bipolar cell	3 studies	30% ± 9%	Explore
renal principal cell	3 studies	42% ± 8%	Explore
extravillous trophoblast	3 studies	34% ± 3%	Explore
hematopoietic stem cell	3 studies	18% ± 2%	Explore
lymphocyte	3 studies	40% ± 18%	Explore
megakaryocyte	3 studies	24% ± 8%	Explore
pro-B cell	3 studies	20% ± 3%	Explore
amacrine cell	3 studies	50% ± 16%	Explore
retinal pigment epithelial cell	3 studies	52% ± 25%	Explore
adventitial cell	3 studies	35% ± 12%	Explore
mucus secreting cell	3 studies	33% ± 7%	Explore
intraepithelial lymphocyte	3 studies	36% ± 10%	Explore
rod bipolar cell	3 studies	50% ± 15%	Explore
acinar cell	3 studies	26% ± 10%	Explore
endothelial cell of sinusoid	3 studies	23% ± 6%	Explore
germinal center B cell	3 studies	25% ± 6%	Explore
myoepithelial cell	3 studies	44% ± 10%	Explore
luminal cell of prostate epithelium	3 studies	67% ± 7%	Explore
GABAergic neuron	3 studies	25% ± 4%	Explore
glutamatergic neuron	3 studies	29% ± 10%	Explore
oligodendrocyte precursor cell	3 studies	35% ± 8%	Explore
glial cell	3 studies	37% ± 18%	Explore
group 3 innate lymphoid cell	3 studies	53% ± 17%	Explore
keratinocyte	3 studies	45% ± 23%	Explore
T-helper 17 cell	3 studies	44% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	33% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	29% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	31% ± 8%	Explore
double negative thymocyte	3 studies	47% ± 10%	Explore
progenitor cell of mammary luminal epithelium	3 studies	46% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	38% ± 13%	Explore
peripheral blood	17 studies	33% ± 12%	Explore
intestine	10 studies	35% ± 12%	Explore
eye	9 studies	46% ± 22%	Explore
kidney	8 studies	37% ± 6%	Explore
brain	7 studies	27% ± 8%	Explore
bone marrow	5 studies	23% ± 6%	Explore
uterus	5 studies	49% ± 13%	Explore
liver	5 studies	44% ± 19%	Explore
pancreas	4 studies	55% ± 27%	Explore
placenta	4 studies	29% ± 6%	Explore
prostate	4 studies	53% ± 13%	Explore
lymph node	4 studies	25% ± 6%	Explore
breast	4 studies	50% ± 5%	Explore
adrenal gland	3 studies	38% ± 12%	Explore
esophagus	3 studies	40% ± 16%	Explore
skin	3 studies	46% ± 14%	Explore
thymus	3 studies	35% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	3297.78	258 / 258	100%	109.76	230 / 230
esophagus	100%	2240.30	1445 / 1445	100%	49.41	183 / 183
kidney	100%	2516.91	89 / 89	100%	58.58	901 / 901
liver	100%	2601.62	226 / 226	100%	55.87	406 / 406
lung	100%	2659.35	578 / 578	100%	59.33	1155 / 1155
ovary	100%	3209.21	180 / 180	100%	55.93	430 / 430
pancreas	100%	1910.68	328 / 328	100%	56.34	178 / 178
stomach	100%	2090.16	359 / 359	100%	54.95	286 / 286
uterus	100%	2035.35	170 / 170	100%	68.94	459 / 459
brain	100%	2890.77	2641 / 2642	100%	123.93	705 / 705
thymus	100%	3158.56	653 / 653	100%	95.05	604 / 605
skin	100%	1512.44	1803 / 1809	100%	67.42	472 / 472
intestine	100%	2359.05	966 / 966	100%	56.10	525 / 527
bladder	100%	2344.05	21 / 21	99%	62.09	501 / 504
prostate	100%	2387.98	244 / 245	100%	80.04	500 / 502
breast	100%	2398.40	459 / 459	99%	61.39	1107 / 1118
blood vessel	100%	3309.38	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	66.78	29 / 29
muscle	100%	3573.50	803 / 803	0%	0	0 / 0
spleen	100%	2109.85	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	61.68	45 / 45
ureter	0%	0	0 / 0	100%	40.57	1 / 1
adipose	100%	2474.30	1203 / 1204	0%	0	0 / 0
heart	100%	3737.68	859 / 861	0%	0	0 / 0
peripheral blood	98%	1632.56	911 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	91%	29.24	73 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_1990266	Biological process	neutrophil migration
GO_0042102	Biological process	positive regulation of T cell proliferation
GO_0070059	Biological process	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0010742	Biological process	macrophage derived foam cell differentiation
GO_0042098	Biological process	T cell proliferation
GO_0045728	Biological process	respiratory burst after phagocytosis
GO_0051223	Biological process	regulation of protein transport
GO_0051649	Biological process	establishment of localization in cell
GO_1902624	Biological process	positive regulation of neutrophil migration
GO_0050848	Biological process	regulation of calcium-mediated signaling
GO_0071639	Biological process	positive regulation of monocyte chemotactic protein-1 production
GO_0018345	Biological process	protein palmitoylation
GO_2000406	Biological process	positive regulation of T cell migration
GO_0072678	Biological process	T cell migration
GO_0006979	Biological process	response to oxidative stress
GO_0002230	Biological process	positive regulation of defense response to virus by host
GO_0006816	Biological process	calcium ion transport
GO_0032469	Biological process	endoplasmic reticulum calcium ion homeostasis
GO_0032760	Biological process	positive regulation of tumor necrosis factor production
GO_0032755	Biological process	positive regulation of interleukin-6 production
GO_0005886	Cellular component	plasma membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005794	Cellular component	Golgi apparatus
GO_0005783	Cellular component	endoplasmic reticulum
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	SELENOK
Protein name	Selenoprotein K (SelK) Selenoprotein K
Synonyms	HSPC297 HSPC030 SELK hCG_1641209
Description	FUNCTION: Required for Ca(2+) flux in immune cells and plays a role in T-cell proliferation and in T-cell and neutrophil migration (By similarity). Involved in endoplasmic reticulum-associated degradation (ERAD) of soluble glycosylated proteins . Required for palmitoylation and cell surface expression of CD36 and involved in macrophage uptake of low-density lipoprotein and in foam cell formation (By similarity). Together with ZDHHC6, required for palmitoylation of ITPR1 in immune cells, leading to regulate ITPR1 stability and function . Plays a role in protection of cells from ER stress-induced apoptosis . Protects cells from oxidative stress when overexpressed in cardiomyocytes . .
Accessions	ENST00000495461.6 F8WAX7 A8K0M9 Q9Y6D0 ENST00000488746.1

SELENOK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review