ROMO1 report

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	33 studies	34% ± 15%	Explore
natural killer cell	31 studies	29% ± 10%	Explore
macrophage	29 studies	33% ± 13%	Explore
B cell	27 studies	30% ± 12%	Explore
T cell	27 studies	30% ± 12%	Explore
conventional dendritic cell	27 studies	34% ± 13%	Explore
CD4-positive, alpha-beta T cell	27 studies	29% ± 11%	Explore
CD8-positive, alpha-beta T cell	27 studies	33% ± 13%	Explore
endothelial cell	26 studies	37% ± 15%	Explore
pericyte	26 studies	35% ± 13%	Explore
smooth muscle cell	24 studies	35% ± 12%	Explore
classical monocyte	23 studies	38% ± 12%	Explore
non-classical monocyte	21 studies	37% ± 12%	Explore
regulatory T cell	21 studies	35% ± 9%	Explore
epithelial cell	20 studies	50% ± 20%	Explore
monocyte	18 studies	37% ± 14%	Explore
plasma cell	18 studies	46% ± 15%	Explore
plasmacytoid dendritic cell	18 studies	40% ± 15%	Explore
basal cell	18 studies	40% ± 21%	Explore
mast cell	17 studies	31% ± 11%	Explore
endothelial cell of lymphatic vessel	16 studies	48% ± 16%	Explore
memory B cell	16 studies	28% ± 8%	Explore
ciliated cell	16 studies	65% ± 18%	Explore
connective tissue cell	16 studies	36% ± 13%	Explore
gamma-delta T cell	16 studies	32% ± 14%	Explore
naive B cell	15 studies	25% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	28% ± 9%	Explore
mature NK T cell	14 studies	29% ± 10%	Explore
dendritic cell	13 studies	40% ± 23%	Explore
myofibroblast cell	13 studies	39% ± 14%	Explore
myeloid cell	13 studies	39% ± 20%	Explore
secretory cell	12 studies	42% ± 18%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	23% ± 6%	Explore
capillary endothelial cell	12 studies	30% ± 14%	Explore
plasmablast	11 studies	53% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	33% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	31% ± 7%	Explore
endothelial cell of artery	11 studies	34% ± 15%	Explore
vein endothelial cell	11 studies	33% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	30% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	31% ± 6%	Explore
progenitor cell	10 studies	48% ± 17%	Explore
abnormal cell	10 studies	41% ± 15%	Explore
mucosal invariant T cell	10 studies	28% ± 7%	Explore
endothelial cell of vascular tree	10 studies	28% ± 9%	Explore
mesothelial cell	9 studies	45% ± 15%	Explore
type II pneumocyte	8 studies	43% ± 24%	Explore
goblet cell	8 studies	43% ± 19%	Explore
T follicular helper cell	8 studies	34% ± 12%	Explore
type I pneumocyte	7 studies	38% ± 19%	Explore
club cell	7 studies	55% ± 10%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	32% ± 7%	Explore
epithelial cell of proximal tubule	7 studies	50% ± 14%	Explore
innate lymphoid cell	7 studies	26% ± 5%	Explore
hematopoietic precursor cell	6 studies	36% ± 7%	Explore
respiratory goblet cell	6 studies	50% ± 16%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	41% ± 12%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 10%	Explore
renal alpha-intercalated cell	6 studies	58% ± 11%	Explore
enterocyte	6 studies	50% ± 12%	Explore
neuron	6 studies	40% ± 20%	Explore
alveolar macrophage	5 studies	34% ± 9%	Explore
exhausted T cell	5 studies	39% ± 7%	Explore
ionocyte	5 studies	47% ± 15%	Explore
leukocyte	5 studies	31% ± 8%	Explore
mononuclear phagocyte	5 studies	31% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	56% ± 12%	Explore
enteroendocrine cell	5 studies	49% ± 20%	Explore
IgG plasma cell	5 studies	29% ± 11%	Explore
transit amplifying cell	5 studies	38% ± 18%	Explore
erythroblast	5 studies	42% ± 24%	Explore
hematopoietic stem cell	5 studies	34% ± 10%	Explore
precursor B cell	5 studies	43% ± 13%	Explore
pro-B cell	5 studies	35% ± 11%	Explore
brush cell	5 studies	36% ± 18%	Explore
erythrocyte	5 studies	40% ± 17%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	31% ± 8%	Explore
deuterosomal cell	4 studies	56% ± 20%	Explore
pancreatic A cell	4 studies	64% ± 7%	Explore
type B pancreatic cell	4 studies	54% ± 11%	Explore
IgA plasma cell	4 studies	31% ± 10%	Explore
adventitial cell	4 studies	30% ± 7%	Explore
neutrophil	4 studies	22% ± 7%	Explore
intermediate monocyte	4 studies	51% ± 8%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	36% ± 8%	Explore
T-helper 17 cell	4 studies	28% ± 4%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	28% ± 7%	Explore
duct epithelial cell	3 studies	51% ± 14%	Explore
precursor cell	3 studies	53% ± 14%	Explore
squamous epithelial cell	3 studies	48% ± 23%	Explore
pancreatic D cell	3 studies	55% ± 15%	Explore
glomerular endothelial cell	3 studies	26% ± 5%	Explore
intestinal crypt stem cell	3 studies	41% ± 8%	Explore
neural crest cell	3 studies	35% ± 4%	Explore
extravillous trophoblast	3 studies	40% ± 6%	Explore
placental villous trophoblast	3 studies	57% ± 7%	Explore
common myeloid progenitor	3 studies	43% ± 19%	Explore
lymphocyte	3 studies	49% ± 7%	Explore
neuroendocrine cell	3 studies	69% ± 20%	Explore
immature B cell	3 studies	37% ± 11%	Explore
astrocyte	3 studies	39% ± 11%	Explore
retinal cone cell	3 studies	65% ± 16%	Explore
retinal rod cell	3 studies	30% ± 12%	Explore
mucus secreting cell	3 studies	44% ± 15%	Explore
serous secreting cell	3 studies	62% ± 12%	Explore
Mueller cell	3 studies	34% ± 9%	Explore
acinar cell	3 studies	30% ± 4%	Explore
endothelial cell of sinusoid	3 studies	23% ± 4%	Explore
muscle cell	3 studies	39% ± 21%	Explore
germinal center B cell	3 studies	58% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	44% ± 8%	Explore
myoepithelial cell	3 studies	27% ± 4%	Explore
luminal cell of prostate epithelium	3 studies	31% ± 8%	Explore
pancreatic ductal cell	3 studies	55% ± 10%	Explore
granulocyte monocyte progenitor cell	3 studies	39% ± 10%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	44% ± 26%	Explore
glial cell	3 studies	38% ± 20%	Explore
hepatocyte	3 studies	61% ± 31%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 16%	Explore
keratinocyte	3 studies	24% ± 1%	Explore
T-helper 1 cell	3 studies	35% ± 4%	Explore
double negative thymocyte	3 studies	44% ± 18%	Explore
progenitor cell of mammary luminal epithelium	3 studies	24% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	42% ± 20%	Explore
peripheral blood	17 studies	32% ± 9%	Explore
intestine	10 studies	36% ± 17%	Explore
kidney	9 studies	37% ± 8%	Explore
liver	7 studies	34% ± 22%	Explore
eye	6 studies	31% ± 13%	Explore
pancreas	5 studies	48% ± 15%	Explore
bone marrow	5 studies	28% ± 8%	Explore
uterus	5 studies	39% ± 19%	Explore
brain	5 studies	28% ± 10%	Explore
lymph node	5 studies	37% ± 7%	Explore
placenta	4 studies	40% ± 12%	Explore
breast	4 studies	29% ± 3%	Explore
adrenal gland	3 studies	38% ± 2%	Explore
esophagus	3 studies	45% ± 23%	Explore
prostate	3 studies	25% ± 5%	Explore
skin	3 studies	27% ± 4%	Explore
thymus	3 studies	40% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	2197.37	258 / 258	100%	261.30	230 / 230
esophagus	100%	1654.86	1445 / 1445	100%	209.17	183 / 183
ovary	100%	1286.95	180 / 180	100%	404.26	430 / 430
thymus	100%	1622.27	653 / 653	100%	304.10	605 / 605
uterus	100%	1330.04	170 / 170	100%	410.40	458 / 459
liver	100%	1330.93	225 / 226	100%	299.03	406 / 406
brain	100%	1128.34	2630 / 2642	100%	255.41	705 / 705
intestine	100%	1482.09	966 / 966	99%	384.39	524 / 527
skin	100%	1645.13	1809 / 1809	99%	261.08	469 / 472
stomach	100%	1211.99	359 / 359	99%	363.32	284 / 286
prostate	100%	1593.58	244 / 245	99%	298.52	498 / 502
kidney	100%	2041.58	89 / 89	99%	208.98	890 / 901
pancreas	100%	909.36	327 / 328	99%	253.92	176 / 178
bladder	100%	1365.76	21 / 21	98%	418.83	495 / 504
lung	100%	1256.57	576 / 578	98%	258.69	1137 / 1155
breast	100%	1534.54	459 / 459	98%	227.11	1095 / 1118
adipose	100%	1493.19	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	242.12	80 / 80
lymph node	0%	0	0 / 0	100%	586.44	29 / 29
spleen	100%	1264.77	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	307.84	45 / 45
ureter	0%	0	0 / 0	100%	390.56	1 / 1
blood vessel	100%	1660.46	1332 / 1335	0%	0	0 / 0
muscle	100%	1702.82	801 / 803	0%	0	0 / 0
heart	99%	1794.05	853 / 861	0%	0	0 / 0
peripheral blood	88%	912.73	817 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0034614	Biological process	cellular response to reactive oxygen species
GO_0050829	Biological process	defense response to Gram-negative bacterium
GO_0030150	Biological process	protein import into mitochondrial matrix
GO_0006886	Biological process	intracellular protein transport
GO_0090399	Biological process	replicative senescence
GO_0051838	Biological process	cytolysis by host of symbiont cells
GO_0031640	Biological process	killing of cells of another organism
GO_0050830	Biological process	defense response to Gram-positive bacterium
GO_2000379	Biological process	positive regulation of reactive oxygen species metabolic process
GO_0098655	Biological process	monoatomic cation transmembrane transport
GO_0042742	Biological process	defense response to bacterium
GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0061844	Biological process	antimicrobial humoral immune response mediated by antimicrobial peptide
GO_0045039	Biological process	protein insertion into mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005744	Cellular component	TIM23 mitochondrial import inner membrane translocase complex
GO_0008324	Molecular function	monoatomic cation transmembrane transporter activity
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

Gene name	ROMO1
Protein name	Reactive oxygen species modulator 1 (ROS modulator 1) (Epididymis tissue protein Li 175) (Glyrichin) (Mitochondrial targeting GxxxG motif protein) (MTGM) (Protein MGR2 homolog)
Synonyms	C20orf52
Description	FUNCTION: Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.; FUNCTION: Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.
Accessions	ENST00000374072.5 [P60602-2] P60602 ENST00000397416.1 [P60602-1] ENST00000374077.8 [P60602-1] ENST00000374078.5 [P60602-1] ENST00000336695.4 [P60602-1]