RAB7A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0061724Biological processlipophagy
GO_0046907Biological processintracellular transport
GO_0006897Biological processendocytosis
GO_0006622Biological processprotein targeting to lysosome
GO_0090382Biological processphagosome maturation
GO_0000045Biological processautophagosome assembly
GO_0090383Biological processphagosome acidification
GO_0009617Biological processresponse to bacterium
GO_0099638Biological processendosome to plasma membrane protein transport
GO_1903543Biological processpositive regulation of exosomal secretion
GO_0016042Biological processlipid catabolic process
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0090385Biological processphagosome-lysosome fusion
GO_0007174Biological processepidermal growth factor catabolic process
GO_0008333Biological processendosome to lysosome transport
GO_1903542Biological processnegative regulation of exosomal secretion
GO_0022615Biological processprotein to membrane docking
GO_0019076Biological processviral release from host cell
GO_0045453Biological processbone resorption
GO_1905366Biological processnegative regulation of intralumenal vesicle formation
GO_0015031Biological processprotein transport
GO_0045022Biological processearly endosome to late endosome transport
GO_0048524Biological processpositive regulation of viral process
GO_0051650Biological processestablishment of vesicle localization
GO_0030667Cellular componentsecretory granule membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0005811Cellular componentlipid droplet
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0034045Cellular componentphagophore assembly site membrane
GO_0005764Cellular componentlysosome
GO_0000421Cellular componentautophagosome membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0005794Cellular componentGolgi apparatus
GO_0030904Cellular componentretromer complex
GO_0097208Cellular componentalveolar lamellar body
GO_0033162Cellular componentmelanosome membrane
GO_0005829Cellular componentcytosol
GO_0045335Cellular componentphagocytic vesicle
GO_0005770Cellular componentlate endosome
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0019003Molecular functionGDP binding
GO_1905394Molecular functionretromer complex binding
GO_0003925Molecular functionG protein activity
GO_0031267Molecular functionsmall GTPase binding
GO_0005525Molecular functionGTP binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameRAB7A
Protein nameRAB7A, member RAS oncogene family
Ras-related protein Rab-7a (EC 3.6.5.2)
Ras-related protein Rab-7a
SynonymsRAB7
hCG_1780455
DescriptionFUNCTION: Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins playing a key role in the regulation of endo-lysosomal trafficking. Governs early-to-late endosomal maturation, microtubule minus-end as well as plus-end directed endosomal migration and positioning, and endosome-lysosome transport through different protein-protein interaction cascades. Plays a central role, not only in endosomal traffic, but also in many other cellular and physiological events, such as growth-factor-mediated cell signaling, nutrient-transportor mediated nutrient uptake, neurotrophin transport in the axons of neurons and lipid metabolism. Also involved in regulation of some specialized endosomal membrane trafficking, such as maturation of melanosomes, pathogen-induced phagosomes (or vacuoles) and autophagosomes. Plays a role in the maturation and acidification of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Plays important roles in microbial pathogen infection and survival, as well as in participating in the life cycle of viruses. Microbial pathogens possess survival strategies governed by RAB7A, sometimes by employing RAB7A function (e.g. Salmonella) and sometimes by excluding RAB7A function (e.g. Mycobacterium). In concert with RAC1, plays a role in regulating the formation of RBs (ruffled borders) in osteoclasts. Controls the endosomal trafficking and neurite outgrowth signaling of NTRK1/TRKA . Regulates the endocytic trafficking of the EGF-EGFR complex by regulating its lysosomal degradation. Involved in the ADRB2-stimulated lipolysis through lipophagy, a cytosolic lipase-independent autophagic pathway (By similarity). Required for the exosomal release of SDCBP, CD63 and syndecan . Required for vesicular trafficking and cell surface expression of ACE2 . May play a role in PRPH neuronal intermediate filament assembly (By similarity). .

AccessionsP51149
A0A6Q8PGE6
ENST00000482525.5
A0A6Q8PF79
C9J592
ENST00000490093.6
ENST00000676214.1
ENST00000676147.1
ENST00000674748.1
ENST00000493186.6
ENST00000265062.8
ENST00000675864.1
C9J8S3
C9IZZ0
ENST00000485280.1
ENST00000675497.1
A0A6Q8PG52
C9J4V0
ENST00000483906.5
ENST00000676425.1
A0A158RFU6
A0A6Q8PH84
C9J4S4
ENST00000464496.5
ENST00000674589.1
C9J7D1
ENST00000675342.1