Biological process

EGF breakdown, EGF catabolism, epidermal growth factor breakdown, epidermal growth factor catabolism

The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor.

EGF receptor ligand processing, epidermal growth factor ligand processing, intracellular EGF processing, receptor-mediated EGF processing

This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'.