SNX5 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006886Biological processintracellular protein transport
GO_0006907Biological processpinocytosis
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0045776Biological processnegative regulation of blood pressure
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0007174Biological processepidermal growth factor catabolic process
GO_0046628Biological processpositive regulation of insulin receptor signaling pathway
GO_0016241Biological processregulation of macroautophagy
GO_0001726Cellular componentruffle
GO_0005903Cellular componentbrush border
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0097422Cellular componenttubular endosome
GO_0098559Cellular componentcytoplasmic side of early endosome membrane
GO_0030904Cellular componentretromer complex
GO_0005829Cellular componentcytosol
GO_0070685Cellular componentmacropinocytic cup
GO_0001891Cellular componentphagocytic cup
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030905Cellular componentretromer, tubulation complex
GO_0005768Cellular componentendosome
GO_0031748Molecular functionD1 dopamine receptor binding
GO_0070273Molecular functionphosphatidylinositol-4-phosphate binding
GO_0034452Molecular functiondynactin binding
GO_0045296Molecular functioncadherin binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0005515Molecular functionprotein binding
GO_0010314Molecular functionphosphatidylinositol-5-phosphate binding

IV. Literature review

[source]
Gene nameSNX5
Protein nameSorting nexin 5
Sorting nexin 5 isoform 1
Sorting nexin-5
SNX5 protein
Synonyms
DescriptionFUNCTION: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) . Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Does not have in vitro vesicle-to-membrane remodeling activity . Involved in retrograde transport of lysosomal enzyme receptor IGF2R . May function as link between endosomal transport vesicles and dynactin (Probable). Plays a role in the internalization of EGFR after EGF stimulation (Probable). Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer-independent . Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable). Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation . Plays a role in macropinocytosis . .

AccessionsA0A087WUY5
Q9Y5X3
ENST00000463050.5
ENST00000606602.1
ENST00000606557.1 [Q9Y5X3-2]
U3KQL0
Q5QPE4
ENST00000486039.1
U3KQP5
ENST00000431277.5
Q5QPE5
ENST00000481323.1
A0A0S2Z5F1
ENST00000377768.7 [Q9Y5X3-1]
ENST00000377759.9 [Q9Y5X3-1]
ENST00000419004.2
Q6P5V6