PSME1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	41 studies	67% ± 20%	Explore
B cell	40 studies	58% ± 17%	Explore
CD8-positive, alpha-beta T cell	37 studies	66% ± 19%	Explore
T cell	35 studies	57% ± 19%	Explore
fibroblast	35 studies	40% ± 16%	Explore
macrophage	33 studies	49% ± 17%	Explore
endothelial cell	33 studies	47% ± 19%	Explore
CD4-positive, alpha-beta T cell	33 studies	65% ± 18%	Explore
conventional dendritic cell	30 studies	67% ± 18%	Explore
pericyte	29 studies	44% ± 15%	Explore
dendritic cell	26 studies	61% ± 25%	Explore
regulatory T cell	26 studies	67% ± 18%	Explore
smooth muscle cell	25 studies	39% ± 15%	Explore
classical monocyte	24 studies	60% ± 15%	Explore
non-classical monocyte	24 studies	74% ± 19%	Explore
plasmacytoid dendritic cell	24 studies	70% ± 15%	Explore
plasma cell	23 studies	58% ± 23%	Explore
mature NK T cell	22 studies	64% ± 20%	Explore
monocyte	21 studies	53% ± 18%	Explore
memory B cell	20 studies	64% ± 13%	Explore
naive B cell	20 studies	57% ± 14%	Explore
basal cell	20 studies	49% ± 19%	Explore
epithelial cell	20 studies	54% ± 21%	Explore
mast cell	19 studies	40% ± 14%	Explore
gamma-delta T cell	19 studies	67% ± 16%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	56% ± 18%	Explore
endothelial cell of lymphatic vessel	17 studies	52% ± 10%	Explore
connective tissue cell	17 studies	40% ± 15%	Explore
mucosal invariant T cell	16 studies	66% ± 18%	Explore
ciliated cell	16 studies	46% ± 15%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	70% ± 20%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	76% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	70% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	61% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	64% ± 22%	Explore
myofibroblast cell	13 studies	46% ± 15%	Explore
myeloid cell	13 studies	50% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	62% ± 24%	Explore
plasmablast	12 studies	71% ± 18%	Explore
secretory cell	12 studies	53% ± 14%	Explore
capillary endothelial cell	12 studies	52% ± 13%	Explore
endothelial cell of artery	11 studies	49% ± 11%	Explore
vein endothelial cell	11 studies	47% ± 13%	Explore
endothelial cell of vascular tree	11 studies	51% ± 13%	Explore
progenitor cell	10 studies	50% ± 20%	Explore
goblet cell	10 studies	47% ± 20%	Explore
mesothelial cell	10 studies	50% ± 21%	Explore
innate lymphoid cell	9 studies	55% ± 18%	Explore
T follicular helper cell	9 studies	57% ± 12%	Explore
type I pneumocyte	8 studies	49% ± 16%	Explore
type II pneumocyte	8 studies	44% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	8 studies	68% ± 26%	Explore
leukocyte	8 studies	52% ± 13%	Explore
enterocyte	8 studies	47% ± 18%	Explore
IgG plasma cell	8 studies	37% ± 20%	Explore
abnormal cell	8 studies	50% ± 17%	Explore
hematopoietic stem cell	8 studies	64% ± 25%	Explore
club cell	7 studies	58% ± 7%	Explore
neutrophil	7 studies	34% ± 8%	Explore
platelet	7 studies	31% ± 11%	Explore
epithelial cell of proximal tubule	7 studies	41% ± 13%	Explore
precursor B cell	7 studies	66% ± 19%	Explore
erythrocyte	7 studies	47% ± 20%	Explore
ionocyte	6 studies	46% ± 13%	Explore
respiratory goblet cell	6 studies	50% ± 19%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	75% ± 25%	Explore
kidney loop of Henle epithelial cell	6 studies	36% ± 9%	Explore
renal alpha-intercalated cell	6 studies	48% ± 14%	Explore
IgA plasma cell	6 studies	43% ± 20%	Explore
transit amplifying cell	6 studies	41% ± 24%	Explore
immature B cell	6 studies	68% ± 24%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	71% ± 20%	Explore
alveolar macrophage	5 studies	52% ± 11%	Explore
CD4-positive helper T cell	5 studies	49% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	69% ± 14%	Explore
exhausted T cell	5 studies	84% ± 7%	Explore
mononuclear phagocyte	5 studies	60% ± 21%	Explore
intestinal crypt stem cell	5 studies	47% ± 19%	Explore
pro-B cell	5 studies	72% ± 12%	Explore
T-helper 17 cell	5 studies	70% ± 20%	Explore
group 3 innate lymphoid cell	5 studies	75% ± 9%	Explore
double negative thymocyte	5 studies	78% ± 11%	Explore
intermediate monocyte	5 studies	76% ± 15%	Explore
granulocyte	5 studies	44% ± 16%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	61% ± 28%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	66% ± 15%	Explore
hematopoietic precursor cell	4 studies	80% ± 16%	Explore
deuterosomal cell	4 studies	29% ± 10%	Explore
duct epithelial cell	4 studies	56% ± 10%	Explore
pancreatic A cell	4 studies	53% ± 16%	Explore
glomerular endothelial cell	4 studies	56% ± 16%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	40% ± 12%	Explore
enteroendocrine cell	4 studies	50% ± 11%	Explore
erythroblast	4 studies	60% ± 12%	Explore
brush cell	4 studies	40% ± 15%	Explore
adventitial cell	4 studies	33% ± 6%	Explore
mucus secreting cell	4 studies	45% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	49% ± 10%	Explore
T-helper 1 cell	4 studies	78% ± 11%	Explore
squamous epithelial cell	3 studies	43% ± 22%	Explore
type B pancreatic cell	3 studies	43% ± 5%	Explore
monocyte-derived dendritic cell	3 studies	63% ± 33%	Explore
neural crest cell	3 studies	28% ± 12%	Explore
thymocyte	3 studies	51% ± 31%	Explore
extravillous trophoblast	3 studies	40% ± 12%	Explore
placental villous trophoblast	3 studies	57% ± 27%	Explore
lymphocyte	3 studies	66% ± 16%	Explore
neuroendocrine cell	3 studies	46% ± 11%	Explore
retina horizontal cell	3 studies	21% ± 6%	Explore
retinal cone cell	3 studies	24% ± 6%	Explore
microglial cell	3 studies	37% ± 13%	Explore
serous secreting cell	3 studies	43% ± 2%	Explore
intraepithelial lymphocyte	3 studies	69% ± 6%	Explore
Mueller cell	3 studies	24% ± 4%	Explore
acinar cell	3 studies	32% ± 13%	Explore
muscle cell	3 studies	40% ± 21%	Explore
germinal center B cell	3 studies	58% ± 4%	Explore
myoepithelial cell	3 studies	40% ± 8%	Explore
neuron	3 studies	27% ± 13%	Explore
inflammatory macrophage	3 studies	36% ± 9%	Explore
luminal cell of prostate epithelium	3 studies	28% ± 6%	Explore
IgM plasma cell	3 studies	53% ± 17%	Explore
pancreatic ductal cell	3 studies	62% ± 9%	Explore
glial cell	3 studies	43% ± 13%	Explore
hepatocyte	3 studies	45% ± 24%	Explore
keratinocyte	3 studies	32% ± 11%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	75% ± 12%	Explore
double-positive, alpha-beta thymocyte	3 studies	81% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	45% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	68% ± 13%	Explore
lung	18 studies	53% ± 13%	Explore
intestine	13 studies	41% ± 16%	Explore
kidney	8 studies	49% ± 18%	Explore
bone marrow	7 studies	37% ± 19%	Explore
lymph node	6 studies	54% ± 12%	Explore
pancreas	5 studies	42% ± 15%	Explore
placenta	5 studies	37% ± 19%	Explore
liver	5 studies	55% ± 15%	Explore
eye	4 studies	26% ± 9%	Explore
uterus	4 studies	64% ± 11%	Explore
prostate	4 studies	32% ± 9%	Explore
breast	4 studies	46% ± 9%	Explore
brain	4 studies	31% ± 10%	Explore
adrenal gland	3 studies	54% ± 16%	Explore
esophagus	3 studies	46% ± 25%	Explore
thymus	3 studies	68% ± 28%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6583.86	1445 / 1445	100%	240.65	183 / 183
kidney	100%	9053.87	89 / 89	100%	332.66	901 / 901
liver	100%	5114.97	226 / 226	100%	314.98	406 / 406
ovary	100%	6664.86	180 / 180	100%	373.20	430 / 430
prostate	100%	7023.93	245 / 245	100%	368.48	502 / 502
uterus	100%	7138.84	170 / 170	100%	434.56	459 / 459
thymus	100%	7331.62	653 / 653	100%	393.04	604 / 605
intestine	100%	8152.04	966 / 966	100%	388.16	526 / 527
lung	100%	8552.68	578 / 578	100%	334.02	1150 / 1155
skin	100%	5963.64	1808 / 1809	100%	307.69	470 / 472
stomach	100%	5654.90	359 / 359	99%	310.46	284 / 286
bladder	100%	6088.43	21 / 21	99%	414.08	500 / 504
breast	100%	7170.02	459 / 459	99%	414.82	1104 / 1118
adrenal gland	100%	9871.29	258 / 258	99%	265.72	227 / 230
pancreas	99%	3336.33	325 / 328	99%	350.23	177 / 178
brain	97%	2233.08	2554 / 2642	99%	177.67	701 / 705
adipose	100%	7095.02	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	770.13	29 / 29
spleen	100%	12428.27	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	481.81	45 / 45
ureter	0%	0	0 / 0	100%	119.95	1 / 1
blood vessel	100%	5818.15	1334 / 1335	0%	0	0 / 0
peripheral blood	100%	13360.25	928 / 929	0%	0	0 / 0
heart	99%	3714.92	852 / 861	0%	0	0 / 0
muscle	99%	3610.19	793 / 803	0%	0	0 / 0
eye	0%	0	0 / 0	99%	223.64	79 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_2000045	Biological process	regulation of G1/S transition of mitotic cell cycle
GO_0010950	Biological process	positive regulation of endopeptidase activity
GO_0061136	Biological process	regulation of proteasomal protein catabolic process
GO_0019884	Biological process	antigen processing and presentation of exogenous antigen
GO_0000502	Cellular component	proteasome complex
GO_0070062	Cellular component	extracellular exosome
GO_0008537	Cellular component	proteasome activator complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0061133	Molecular function	endopeptidase activator activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PSME1
Protein name	Proteasome activator complex subunit 1 (Proteasome activator 28 subunit alpha) Proteasome activator complex subunit 1 (11S regulator complex subunit alpha) (REG-alpha) (Activator of multicatalytic protease subunit 1) (Interferon gamma up-regulated I-5111 protein) (IGUP I-5111) (Proteasome activator 28 subunit alpha) (PA28a) (PA28alpha) Proteasome activator subunit 1
Synonyms	IFI5111
Description	FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. FUNCTION: Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome. .
Accessions	ENST00000645537.2 [Q06323-1] ENST00000561435.5 [Q06323-3] H0YKK6 ENST00000382708.7 [Q06323-2] ENST00000646132.1 [Q06323-2] Q06323 ENST00000558112.1 ENST00000206451.11 [Q06323-1] Q6FHU3 ENST00000559123.5 H0YLU2 ENST00000643169.1 [Q06323-3]

PSME1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review