PSMD8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	36 studies	36% ± 12%	Explore
B cell	32 studies	30% ± 9%	Explore
fibroblast	32 studies	38% ± 13%	Explore
endothelial cell	31 studies	36% ± 14%	Explore
CD8-positive, alpha-beta T cell	29 studies	37% ± 19%	Explore
CD4-positive, alpha-beta T cell	28 studies	35% ± 19%	Explore
macrophage	27 studies	32% ± 12%	Explore
T cell	26 studies	34% ± 13%	Explore
pericyte	26 studies	44% ± 12%	Explore
conventional dendritic cell	25 studies	36% ± 16%	Explore
smooth muscle cell	24 studies	39% ± 12%	Explore
non-classical monocyte	22 studies	38% ± 17%	Explore
classical monocyte	21 studies	32% ± 14%	Explore
regulatory T cell	21 studies	42% ± 12%	Explore
basal cell	19 studies	39% ± 17%	Explore
dendritic cell	18 studies	37% ± 23%	Explore
epithelial cell	18 studies	42% ± 20%	Explore
memory B cell	17 studies	26% ± 10%	Explore
plasmacytoid dendritic cell	17 studies	34% ± 12%	Explore
mast cell	16 studies	27% ± 8%	Explore
monocyte	16 studies	29% ± 8%	Explore
ciliated cell	16 studies	42% ± 19%	Explore
naive B cell	16 studies	25% ± 7%	Explore
mature NK T cell	16 studies	33% ± 10%	Explore
connective tissue cell	16 studies	42% ± 14%	Explore
gamma-delta T cell	16 studies	35% ± 14%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	36% ± 13%	Explore
endothelial cell of lymphatic vessel	13 studies	39% ± 11%	Explore
plasma cell	13 studies	51% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	26% ± 7%	Explore
plasmablast	12 studies	52% ± 24%	Explore
CD16-negative, CD56-bright natural killer cell, human	12 studies	38% ± 11%	Explore
capillary endothelial cell	12 studies	31% ± 11%	Explore
myofibroblast cell	12 studies	44% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	35% ± 16%	Explore
secretory cell	11 studies	34% ± 17%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	32% ± 11%	Explore
vein endothelial cell	11 studies	28% ± 9%	Explore
endothelial cell of vascular tree	11 studies	31% ± 8%	Explore
abnormal cell	10 studies	42% ± 17%	Explore
endothelial cell of artery	10 studies	30% ± 7%	Explore
mucosal invariant T cell	10 studies	31% ± 5%	Explore
myeloid cell	10 studies	36% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	36% ± 15%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	36% ± 13%	Explore
progenitor cell	9 studies	34% ± 13%	Explore
type I pneumocyte	8 studies	32% ± 12%	Explore
goblet cell	8 studies	27% ± 14%	Explore
type II pneumocyte	7 studies	34% ± 16%	Explore
club cell	7 studies	31% ± 11%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	47% ± 21%	Explore
leukocyte	7 studies	32% ± 10%	Explore
neuron	7 studies	47% ± 24%	Explore
mesothelial cell	7 studies	43% ± 17%	Explore
respiratory goblet cell	6 studies	30% ± 21%	Explore
epithelial cell of proximal tubule	6 studies	35% ± 9%	Explore
enterocyte	6 studies	29% ± 6%	Explore
precursor B cell	6 studies	40% ± 12%	Explore
innate lymphoid cell	6 studies	32% ± 4%	Explore
erythrocyte	6 studies	37% ± 22%	Explore
T follicular helper cell	6 studies	31% ± 5%	Explore
alveolar macrophage	5 studies	32% ± 5%	Explore
ionocyte	5 studies	33% ± 11%	Explore
mononuclear phagocyte	5 studies	34% ± 14%	Explore
kidney loop of Henle epithelial cell	5 studies	31% ± 7%	Explore
renal alpha-intercalated cell	5 studies	46% ± 7%	Explore
enteroendocrine cell	5 studies	41% ± 17%	Explore
transit amplifying cell	5 studies	20% ± 3%	Explore
retinal ganglion cell	5 studies	58% ± 27%	Explore
erythroblast	5 studies	38% ± 23%	Explore
pro-B cell	5 studies	35% ± 9%	Explore
immature B cell	5 studies	36% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	52% ± 20%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	46% ± 18%	Explore
hematopoietic precursor cell	4 studies	51% ± 26%	Explore
deuterosomal cell	4 studies	26% ± 5%	Explore
pancreatic A cell	4 studies	65% ± 17%	Explore
type B pancreatic cell	4 studies	52% ± 16%	Explore
exhausted T cell	4 studies	54% ± 13%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	45% ± 13%	Explore
hematopoietic stem cell	4 studies	35% ± 10%	Explore
amacrine cell	4 studies	38% ± 18%	Explore
astrocyte	4 studies	29% ± 13%	Explore
retina horizontal cell	4 studies	35% ± 18%	Explore
adventitial cell	4 studies	31% ± 6%	Explore
cardiac muscle cell	4 studies	19% ± 3%	Explore
CD4-positive helper T cell	4 studies	27% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	45% ± 10%	Explore
hepatocyte	4 studies	31% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	31% ± 9%	Explore
duct epithelial cell	3 studies	28% ± 6%	Explore
precursor cell	3 studies	61% ± 10%	Explore
squamous epithelial cell	3 studies	39% ± 25%	Explore
glomerular endothelial cell	3 studies	26% ± 4%	Explore
intestinal crypt stem cell	3 studies	25% ± 10%	Explore
neural crest cell	3 studies	44% ± 2%	Explore
retinal bipolar neuron	3 studies	37% ± 13%	Explore
extravillous trophoblast	3 studies	51% ± 7%	Explore
placental villous trophoblast	3 studies	71% ± 9%	Explore
lymphocyte	3 studies	45% ± 8%	Explore
brush cell	3 studies	33% ± 14%	Explore
neuroendocrine cell	3 studies	46% ± 18%	Explore
retinal cone cell	3 studies	44% ± 15%	Explore
retinal rod cell	3 studies	33% ± 11%	Explore
microglial cell	3 studies	28% ± 13%	Explore
mucus secreting cell	3 studies	33% ± 9%	Explore
serous secreting cell	3 studies	32% ± 4%	Explore
intraepithelial lymphocyte	3 studies	40% ± 13%	Explore
Mueller cell	3 studies	30% ± 6%	Explore
muscle cell	3 studies	33% ± 21%	Explore
germinal center B cell	3 studies	35% ± 7%	Explore
intermediate monocyte	3 studies	51% ± 19%	Explore
IgA plasma cell	3 studies	31% ± 14%	Explore
IgG plasma cell	3 studies	29% ± 15%	Explore
myoepithelial cell	3 studies	46% ± 5%	Explore
granulocyte	3 studies	30% ± 8%	Explore
luminal cell of prostate epithelium	3 studies	29% ± 5%	Explore
GABAergic neuron	3 studies	27% ± 7%	Explore
glutamatergic neuron	3 studies	39% ± 10%	Explore
pancreatic ductal cell	3 studies	57% ± 8%	Explore
oligodendrocyte precursor cell	3 studies	34% ± 6%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	52% ± 22%	Explore
glial cell	3 studies	37% ± 22%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 16%	Explore
keratinocyte	3 studies	38% ± 3%	Explore
T-helper 17 cell	3 studies	50% ± 26%	Explore
T-helper 1 cell	3 studies	46% ± 21%	Explore
double negative thymocyte	3 studies	50% ± 16%	Explore
progenitor cell of mammary luminal epithelium	3 studies	29% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	39% ± 15%	Explore
peripheral blood	16 studies	35% ± 13%	Explore
intestine	11 studies	28% ± 14%	Explore
kidney	7 studies	37% ± 7%	Explore
eye	7 studies	31% ± 12%	Explore
liver	7 studies	31% ± 21%	Explore
brain	6 studies	27% ± 7%	Explore
bone marrow	5 studies	24% ± 9%	Explore
lymph node	5 studies	38% ± 15%	Explore
pancreas	4 studies	55% ± 18%	Explore
uterus	4 studies	46% ± 15%	Explore
prostate	4 studies	28% ± 9%	Explore
breast	4 studies	35% ± 4%	Explore
placenta	3 studies	56% ± 13%	Explore
adrenal gland	3 studies	33% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	100%	3957.13	180 / 180	100%	230.49	430 / 430
prostate	100%	5981.16	245 / 245	100%	197.39	502 / 502
skin	100%	9774.94	1809 / 1809	100%	214.19	472 / 472
uterus	100%	5231.05	170 / 170	100%	205.28	459 / 459
esophagus	100%	6270.81	1444 / 1445	100%	136.30	183 / 183
breast	100%	9239.54	459 / 459	100%	188.64	1115 / 1118
kidney	100%	5720.76	89 / 89	100%	121.70	898 / 901
stomach	100%	4697.95	359 / 359	100%	163.14	285 / 286
intestine	100%	5490.15	966 / 966	100%	171.58	525 / 527
thymus	100%	5108.49	651 / 653	100%	147.98	604 / 605
liver	99%	3970.35	224 / 226	100%	116.65	406 / 406
bladder	100%	5417.00	21 / 21	99%	190.07	499 / 504
lung	99%	5964.33	575 / 578	99%	182.56	1148 / 1155
pancreas	98%	3261.29	323 / 328	100%	152.37	178 / 178
brain	98%	4789.54	2600 / 2642	100%	143.85	705 / 705
adrenal gland	100%	6506.80	258 / 258	98%	135.44	226 / 230
adipose	100%	10751.31	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	164.94	80 / 80
lymph node	0%	0	0 / 0	100%	173.42	29 / 29
muscle	100%	21141.01	803 / 803	0%	0	0 / 0
spleen	100%	5045.64	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	180.20	45 / 45
ureter	0%	0	0 / 0	100%	76.73	1 / 1
blood vessel	100%	6453.78	1331 / 1335	0%	0	0 / 0
heart	97%	10921.95	839 / 861	0%	0	0 / 0
peripheral blood	96%	4859.46	890 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	PSMD8
Protein name	26S proteasome non-ATPase regulatory subunit 8 26S proteasome non-ATPase regulatory subunit 8 (26S proteasome regulatory subunit RPN12) (26S proteasome regulatory subunit S14) (p31) Proteasome 26S subunit, non-ATPase 8
Synonyms
Description	FUNCTION: Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. .
Accessions	ENST00000215071.9 K7EJR3 ENST00000700294.1 A0A8V8TR48 ENST00000590331.1 K7ERW6 ENST00000592035.5 ENST00000585598.1 ENST00000700293.1 A0A8V8TPK1 ENST00000591250.1 ENST00000602911.5 R4GMR5 ENST00000700295.1 A0A8V8TQ44 ENST00000592561.5 K7EJC1 P48556 K7ENY6 K7EK21

GO_0043161	Biological process	proteasome-mediated ubiquitin-dependent protein catabolic process
GO_0000502	Cellular component	proteasome complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005838	Cellular component	proteasome regulatory particle
GO_0008541	Cellular component	proteasome regulatory particle, lid subcomplex
GO_0022624	Cellular component	proteasome accessory complex
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

PSMD8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review