PPIG report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
endothelial cell	43 studies	34% ± 11%	Explore
fibroblast	41 studies	31% ± 11%	Explore
B cell	38 studies	33% ± 10%	Explore
macrophage	36 studies	28% ± 10%	Explore
natural killer cell	35 studies	29% ± 8%	Explore
T cell	33 studies	28% ± 8%	Explore
pericyte	32 studies	31% ± 9%	Explore
CD8-positive, alpha-beta T cell	31 studies	29% ± 8%	Explore
CD4-positive, alpha-beta T cell	30 studies	32% ± 9%	Explore
smooth muscle cell	29 studies	31% ± 10%	Explore
conventional dendritic cell	25 studies	29% ± 12%	Explore
classical monocyte	22 studies	27% ± 10%	Explore
regulatory T cell	22 studies	32% ± 6%	Explore
mast cell	20 studies	30% ± 9%	Explore
monocyte	20 studies	29% ± 9%	Explore
endothelial cell of lymphatic vessel	20 studies	31% ± 9%	Explore
memory B cell	20 studies	34% ± 7%	Explore
basal cell	20 studies	32% ± 15%	Explore
non-classical monocyte	20 studies	29% ± 11%	Explore
naive B cell	19 studies	32% ± 7%	Explore
mature NK T cell	19 studies	28% ± 6%	Explore
epithelial cell	18 studies	38% ± 20%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	32% ± 8%	Explore
gamma-delta T cell	17 studies	33% ± 13%	Explore
plasmacytoid dendritic cell	17 studies	30% ± 9%	Explore
ciliated cell	16 studies	35% ± 14%	Explore
connective tissue cell	16 studies	35% ± 11%	Explore
myofibroblast cell	15 studies	33% ± 9%	Explore
dendritic cell	15 studies	30% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	28% ± 6%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	27% ± 7%	Explore
capillary endothelial cell	14 studies	26% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	34% ± 7%	Explore
astrocyte	13 studies	31% ± 12%	Explore
endothelial cell of vascular tree	13 studies	29% ± 8%	Explore
myeloid cell	13 studies	30% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	33% ± 8%	Explore
vein endothelial cell	12 studies	28% ± 6%	Explore
microglial cell	12 studies	28% ± 8%	Explore
mucosal invariant T cell	12 studies	27% ± 3%	Explore
type II pneumocyte	11 studies	27% ± 11%	Explore
plasma cell	11 studies	28% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	31% ± 9%	Explore
club cell	11 studies	25% ± 10%	Explore
glutamatergic neuron	11 studies	42% ± 25%	Explore
progenitor cell	11 studies	34% ± 13%	Explore
oligodendrocyte	11 studies	27% ± 10%	Explore
type I pneumocyte	10 studies	30% ± 9%	Explore
secretory cell	10 studies	29% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	33% ± 11%	Explore
abnormal cell	10 studies	33% ± 11%	Explore
neuron	10 studies	40% ± 17%	Explore
endothelial cell of artery	10 studies	28% ± 6%	Explore
oligodendrocyte precursor cell	10 studies	29% ± 10%	Explore
leukocyte	9 studies	33% ± 8%	Explore
mesothelial cell	9 studies	32% ± 13%	Explore
GABAergic neuron	9 studies	41% ± 22%	Explore
alveolar macrophage	8 studies	27% ± 7%	Explore
plasmablast	8 studies	35% ± 20%	Explore
goblet cell	8 studies	32% ± 13%	Explore
adipocyte	8 studies	23% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	31% ± 5%	Explore
precursor B cell	7 studies	36% ± 14%	Explore
retinal rod cell	7 studies	29% ± 10%	Explore
T follicular helper cell	7 studies	31% ± 5%	Explore
hematopoietic precursor cell	6 studies	43% ± 19%	Explore
ionocyte	6 studies	28% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	30% ± 6%	Explore
mononuclear phagocyte	6 studies	32% ± 15%	Explore
transit amplifying cell	6 studies	30% ± 16%	Explore
amacrine cell	6 studies	42% ± 19%	Explore
interneuron	6 studies	42% ± 24%	Explore
lymphocyte	6 studies	35% ± 12%	Explore
innate lymphoid cell	6 studies	30% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	36% ± 14%	Explore
respiratory goblet cell	5 studies	28% ± 12%	Explore
kidney loop of Henle epithelial cell	5 studies	21% ± 4%	Explore
enteroendocrine cell	5 studies	35% ± 11%	Explore
retinal bipolar neuron	5 studies	43% ± 21%	Explore
glial cell	5 studies	29% ± 17%	Explore
OFF-bipolar cell	5 studies	32% ± 12%	Explore
ON-bipolar cell	5 studies	31% ± 11%	Explore
retinal ganglion cell	5 studies	46% ± 24%	Explore
hematopoietic stem cell	5 studies	36% ± 9%	Explore
pro-B cell	5 studies	39% ± 6%	Explore
brush cell	5 studies	25% ± 11%	Explore
retina horizontal cell	5 studies	41% ± 16%	Explore
retinal cone cell	5 studies	38% ± 15%	Explore
mucus secreting cell	5 studies	23% ± 3%	Explore
hepatocyte	5 studies	43% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	24% ± 6%	Explore
duct epithelial cell	4 studies	20% ± 3%	Explore
pancreatic A cell	4 studies	59% ± 12%	Explore
type B pancreatic cell	4 studies	53% ± 22%	Explore
exhausted T cell	4 studies	38% ± 11%	Explore
epithelial cell of proximal tubule	4 studies	20% ± 7%	Explore
enterocyte	4 studies	27% ± 7%	Explore
intestinal crypt stem cell	4 studies	28% ± 8%	Explore
glycinergic amacrine cell	4 studies	26% ± 11%	Explore
erythroblast	4 studies	45% ± 25%	Explore
immature B cell	4 studies	32% ± 7%	Explore
Mueller cell	4 studies	36% ± 5%	Explore
CD4-positive helper T cell	4 studies	30% ± 11%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	39% ± 6%	Explore
granulocyte	4 studies	30% ± 8%	Explore
neutrophil	4 studies	19% ± 2%	Explore
erythrocyte	4 studies	35% ± 19%	Explore
keratinocyte	4 studies	22% ± 3%	Explore
T-helper 17 cell	4 studies	29% ± 2%	Explore
double negative thymocyte	4 studies	42% ± 16%	Explore
pancreatic D cell	3 studies	58% ± 20%	Explore
glomerular endothelial cell	3 studies	27% ± 4%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	34% ± 8%	Explore
renal alpha-intercalated cell	3 studies	32% ± 5%	Explore
neural crest cell	3 studies	41% ± 8%	Explore
GABAergic interneuron	3 studies	26% ± 1%	Explore
extravillous trophoblast	3 studies	25% ± 4%	Explore
placental villous trophoblast	3 studies	36% ± 4%	Explore
megakaryocyte	3 studies	24% ± 9%	Explore
serous secreting cell	3 studies	23% ± 3%	Explore
cardiac muscle cell	3 studies	19% ± 2%	Explore
tissue-resident macrophage	3 studies	26% ± 4%	Explore
rod bipolar cell	3 studies	62% ± 8%	Explore
germinal center B cell	3 studies	24% ± 2%	Explore
intermediate monocyte	3 studies	42% ± 23%	Explore
muscle cell	3 studies	38% ± 13%	Explore
pancreatic ductal cell	3 studies	51% ± 13%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	48% ± 24%	Explore
adventitial cell	3 studies	24% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 14%	Explore
melanocyte	3 studies	30% ± 8%	Explore
granule cell	3 studies	28% ± 4%	Explore
T-helper 1 cell	3 studies	29% ± 6%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	32% ± 3%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	29% ± 5%	Explore
myoepithelial cell	3 studies	29% ± 8%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
lung	19 studies	31% ± 11%	Explore
brain	18 studies	33% ± 18%	Explore
peripheral blood	16 studies	32% ± 9%	Explore
eye	11 studies	32% ± 12%	Explore
kidney	9 studies	25% ± 8%	Explore
intestine	9 studies	31% ± 14%	Explore
liver	6 studies	39% ± 20%	Explore
lymph node	5 studies	33% ± 8%	Explore
breast	5 studies	27% ± 6%	Explore
pancreas	4 studies	51% ± 18%	Explore
bone marrow	4 studies	30% ± 9%	Explore
uterus	4 studies	40% ± 13%	Explore
adipose	4 studies	26% ± 4%	Explore
placenta	3 studies	32% ± 2%	Explore
heart	3 studies	21% ± 2%	Explore
prostate	3 studies	22% ± 7%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	4214.18	1445 / 1445	100%	32.98	183 / 183
lung	100%	4334.81	578 / 578	100%	24.72	1155 / 1155
ovary	100%	4970.27	180 / 180	100%	22.14	430 / 430
prostate	100%	4336.20	245 / 245	100%	23.28	502 / 502
uterus	100%	5174.31	170 / 170	100%	24.27	459 / 459
brain	100%	3271.05	2640 / 2642	100%	21.69	705 / 705
breast	100%	4882.28	459 / 459	100%	30.51	1117 / 1118
thymus	100%	4844.17	653 / 653	100%	27.41	602 / 605
pancreas	100%	2151.33	328 / 328	99%	19.81	177 / 178
bladder	100%	4652.95	21 / 21	99%	20.26	499 / 504
adrenal gland	100%	3822.16	258 / 258	98%	17.48	226 / 230
stomach	100%	3347.31	359 / 359	98%	23.56	281 / 286
liver	100%	2821.97	226 / 226	98%	13.10	398 / 406
intestine	100%	4842.30	966 / 966	98%	22.80	515 / 527
kidney	100%	2983.18	89 / 89	97%	17.25	872 / 901
skin	100%	4389.56	1809 / 1809	92%	18.84	432 / 472
blood vessel	100%	4762.25	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	19.06	29 / 29
muscle	100%	3431.04	803 / 803	0%	0	0 / 0
spleen	100%	4398.71	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	20.53	45 / 45
ureter	0%	0	0 / 0	100%	9.16	1 / 1
adipose	100%	4643.49	1203 / 1204	0%	0	0 / 0
heart	99%	2605.51	849 / 861	0%	0	0 / 0
peripheral blood	74%	2546.84	692 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	55%	6.12	44 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0