POLR1D | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	33 studies	32% ± 11%	Explore
natural killer cell	32 studies	30% ± 9%	Explore
CD4-positive, alpha-beta T cell	30 studies	35% ± 11%	Explore
CD8-positive, alpha-beta T cell	30 studies	32% ± 12%	Explore
endothelial cell	28 studies	28% ± 11%	Explore
fibroblast	27 studies	29% ± 10%	Explore
T cell	26 studies	31% ± 7%	Explore
conventional dendritic cell	26 studies	35% ± 15%	Explore
regulatory T cell	25 studies	35% ± 10%	Explore
macrophage	24 studies	25% ± 8%	Explore
classical monocyte	22 studies	35% ± 14%	Explore
non-classical monocyte	21 studies	37% ± 16%	Explore
basal cell	21 studies	45% ± 17%	Explore
pericyte	20 studies	28% ± 10%	Explore
smooth muscle cell	19 studies	31% ± 10%	Explore
memory B cell	19 studies	29% ± 6%	Explore
plasmacytoid dendritic cell	19 studies	31% ± 12%	Explore
naive B cell	19 studies	27% ± 6%	Explore
epithelial cell	18 studies	44% ± 18%	Explore
monocyte	17 studies	31% ± 9%	Explore
gamma-delta T cell	17 studies	32% ± 15%	Explore
dendritic cell	16 studies	37% ± 23%	Explore
mature NK T cell	16 studies	29% ± 8%	Explore
endothelial cell of lymphatic vessel	15 studies	31% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	33% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	35% ± 11%	Explore
ciliated cell	14 studies	31% ± 16%	Explore
connective tissue cell	14 studies	30% ± 11%	Explore
mast cell	12 studies	29% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	30% ± 7%	Explore
plasma cell	11 studies	31% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	35% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	30% ± 8%	Explore
mucosal invariant T cell	11 studies	30% ± 6%	Explore
endothelial cell of vascular tree	11 studies	25% ± 6%	Explore
type I pneumocyte	10 studies	31% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	35% ± 11%	Explore
secretory cell	10 studies	31% ± 14%	Explore
myofibroblast cell	10 studies	33% ± 11%	Explore
abnormal cell	10 studies	29% ± 5%	Explore
vein endothelial cell	10 studies	25% ± 9%	Explore
type II pneumocyte	9 studies	40% ± 16%	Explore
plasmablast	9 studies	35% ± 23%	Explore
club cell	9 studies	27% ± 15%	Explore
myeloid cell	9 studies	30% ± 13%	Explore
leukocyte	8 studies	31% ± 8%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	35% ± 13%	Explore
T follicular helper cell	8 studies	36% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	33% ± 8%	Explore
progenitor cell	7 studies	40% ± 9%	Explore
endothelial cell of artery	7 studies	23% ± 5%	Explore
goblet cell	7 studies	32% ± 13%	Explore
mesothelial cell	7 studies	39% ± 15%	Explore
erythrocyte	7 studies	35% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	41% ± 13%	Explore
capillary endothelial cell	6 studies	27% ± 8%	Explore
enterocyte	6 studies	25% ± 8%	Explore
hematopoietic stem cell	6 studies	44% ± 6%	Explore
precursor B cell	6 studies	39% ± 14%	Explore
innate lymphoid cell	6 studies	28% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	40% ± 14%	Explore
hematopoietic precursor cell	5 studies	51% ± 22%	Explore
ionocyte	5 studies	36% ± 16%	Explore
enteroendocrine cell	5 studies	39% ± 16%	Explore
erythroblast	5 studies	40% ± 15%	Explore
intestinal crypt stem cell	5 studies	36% ± 8%	Explore
transit amplifying cell	5 studies	30% ± 14%	Explore
pro-B cell	5 studies	37% ± 9%	Explore
immature B cell	5 studies	38% ± 14%	Explore
neuron	5 studies	41% ± 16%	Explore
alveolar macrophage	5 studies	24% ± 5%	Explore
CD4-positive helper T cell	4 studies	26% ± 8%	Explore
respiratory goblet cell	4 studies	24% ± 12%	Explore
mononuclear phagocyte	4 studies	39% ± 14%	Explore
exhausted T cell	4 studies	47% ± 15%	Explore
epithelial cell of proximal tubule	4 studies	23% ± 4%	Explore
brush cell	4 studies	32% ± 25%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	31% ± 3%	Explore
astrocyte	4 studies	26% ± 10%	Explore
glutamatergic neuron	4 studies	41% ± 15%	Explore
granulocyte	4 studies	33% ± 11%	Explore
T-helper 17 cell	4 studies	35% ± 12%	Explore
oligodendrocyte	4 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	26% ± 6%	Explore
double negative thymocyte	4 studies	45% ± 19%	Explore
oligodendrocyte precursor cell	4 studies	25% ± 9%	Explore
precursor cell	3 studies	50% ± 7%	Explore
pancreatic A cell	3 studies	40% ± 3%	Explore
type B pancreatic cell	3 studies	37% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	29% ± 9%	Explore
neural crest cell	3 studies	35% ± 4%	Explore
OFF-bipolar cell	3 studies	25% ± 12%	Explore
extravillous trophoblast	3 studies	48% ± 10%	Explore
placental villous trophoblast	3 studies	26% ± 7%	Explore
lymphocyte	3 studies	39% ± 9%	Explore
retina horizontal cell	3 studies	28% ± 8%	Explore
retinal cone cell	3 studies	35% ± 9%	Explore
retinal rod cell	3 studies	22% ± 7%	Explore
serous secreting cell	3 studies	34% ± 8%	Explore
acinar cell	3 studies	46% ± 22%	Explore
muscle cell	3 studies	26% ± 11%	Explore
germinal center B cell	3 studies	42% ± 7%	Explore
myoepithelial cell	3 studies	34% ± 2%	Explore
GABAergic neuron	3 studies	35% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	55% ± 30%	Explore
hepatocyte	3 studies	43% ± 19%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 15%	Explore
keratinocyte	3 studies	46% ± 9%	Explore
interneuron	3 studies	32% ± 13%	Explore
T-helper 1 cell	3 studies	39% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	33% ± 5%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	26% ± 8%	Explore
progenitor cell of mammary luminal epithelium	3 studies	36% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	36% ± 13%	Explore
lung	16 studies	35% ± 15%	Explore
intestine	11 studies	28% ± 14%	Explore
kidney	7 studies	25% ± 6%	Explore
brain	7 studies	27% ± 10%	Explore
liver	6 studies	31% ± 16%	Explore
eye	5 studies	24% ± 5%	Explore
lymph node	5 studies	31% ± 3%	Explore
bone marrow	4 studies	28% ± 7%	Explore
uterus	4 studies	36% ± 18%	Explore
breast	4 studies	30% ± 3%	Explore
pancreas	3 studies	45% ± 1%	Explore
placenta	3 studies	30% ± 7%	Explore
adrenal gland	3 studies	31% ± 9%	Explore
prostate	3 studies	32% ± 11%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	5024.95	21 / 21	100%	36.36	504 / 504
esophagus	100%	5436.33	1445 / 1445	100%	26.97	183 / 183
intestine	100%	5087.53	966 / 966	100%	41.96	527 / 527
kidney	100%	3983.27	89 / 89	100%	21.25	901 / 901
lung	100%	4315.92	578 / 578	100%	25.92	1155 / 1155
ovary	100%	5302.29	180 / 180	100%	25.38	430 / 430
pancreas	100%	6936.40	328 / 328	100%	25.31	178 / 178
prostate	100%	4904.54	245 / 245	100%	31.30	502 / 502
skin	100%	6110.77	1809 / 1809	100%	29.05	472 / 472
stomach	100%	5208.09	359 / 359	100%	38.63	286 / 286
uterus	100%	4049.28	170 / 170	100%	32.49	459 / 459
breast	100%	4345.73	459 / 459	100%	26.10	1115 / 1118
thymus	100%	3803.94	653 / 653	100%	21.87	603 / 605
liver	100%	2413.15	226 / 226	99%	14.89	400 / 406
adrenal gland	100%	5946.38	258 / 258	98%	16.97	225 / 230
brain	98%	2912.44	2595 / 2642	97%	10.75	686 / 705
adipose	100%	4253.27	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4052.25	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	26.45	80 / 80
lymph node	0%	0	0 / 0	100%	33.89	29 / 29
muscle	100%	3864.94	803 / 803	0%	0	0 / 0
spleen	100%	4098.41	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.93	45 / 45
ureter	0%	0	0 / 0	100%	24.27	1 / 1
peripheral blood	100%	4735.28	928 / 929	0%	0	0 / 0
heart	97%	2431.75	838 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006362	Biological process	transcription elongation by RNA polymerase I
GO_0006383	Biological process	transcription by RNA polymerase III
GO_0005736	Cellular component	RNA polymerase I complex
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005666	Cellular component	RNA polymerase III complex
GO_0003677	Molecular function	DNA binding
GO_0001056	Molecular function	RNA polymerase III activity
GO_0046983	Molecular function	protein dimerization activity
GO_0001054	Molecular function	RNA polymerase I activity
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	POLR1D
Protein name	DNA-directed RNA polymerases I and III subunit RPAC2 (RNA polymerases I and III subunit AC2) (AC19) (DNA-directed RNA polymerase I subunit D) (RNA polymerase I 16 kDa subunit) (RPA16) (RPC16) (hRPA19) POLR1D protein (RNA polymerase I and III subunit D) RNA polymerase I and III subunit D DNA-directed RNA polymerases I and III subunit RPAC2 (DNA-directed RNA polymerase I subunit D) HCG2020048, isoform CRA_c (RNA polymerase I and III subunit D) Protein POLR1D, isoform 2
Synonyms	hCG_2020048
Description	FUNCTION: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and short non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs, respectively. .
Accessions	ENST00000637071.1 ENST00000489647.4 ENST00000693488.1 ENST00000636952.2 ENST00000630983.1 A0A8I5KX40 A0A1B0GUZ5 A0A0R4J2F3 ENST00000692944.1 ENST00000685267.1 ENST00000399696.3 A0A087WTY1 A0A087X0U2 ENST00000637180.1 ENST00000302979.5 [P0DPB6-1] P0DPB6 Q7Z776 ENST00000636817.1 ENST00000465887.2 ENST00000621089.2 P0DPB5 A0A8I5QL02 ENST00000399697.7 [P0DPB5-1]

POLR1D report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review