PCM1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	42 studies	36% ± 15%	Explore
B cell	37 studies	27% ± 10%	Explore
macrophage	30 studies	33% ± 16%	Explore
natural killer cell	30 studies	28% ± 8%	Explore
fibroblast	30 studies	33% ± 12%	Explore
CD8-positive, alpha-beta T cell	29 studies	26% ± 8%	Explore
pericyte	28 studies	32% ± 13%	Explore
smooth muscle cell	27 studies	30% ± 10%	Explore
CD4-positive, alpha-beta T cell	27 studies	25% ± 8%	Explore
T cell	25 studies	28% ± 9%	Explore
mast cell	22 studies	29% ± 11%	Explore
astrocyte	21 studies	44% ± 18%	Explore
ciliated cell	20 studies	68% ± 15%	Explore
regulatory T cell	20 studies	24% ± 6%	Explore
memory B cell	18 studies	25% ± 5%	Explore
classical monocyte	17 studies	21% ± 8%	Explore
naive B cell	17 studies	23% ± 6%	Explore
plasmacytoid dendritic cell	16 studies	32% ± 12%	Explore
oligodendrocyte precursor cell	16 studies	43% ± 17%	Explore
microglial cell	16 studies	46% ± 16%	Explore
gamma-delta T cell	16 studies	30% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	25% ± 6%	Explore
oligodendrocyte	15 studies	46% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	30% ± 9%	Explore
endothelial cell of lymphatic vessel	14 studies	34% ± 13%	Explore
epithelial cell	14 studies	39% ± 19%	Explore
mature NK T cell	14 studies	26% ± 8%	Explore
capillary endothelial cell	14 studies	24% ± 7%	Explore
basal cell	13 studies	32% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	27% ± 9%	Explore
glutamatergic neuron	13 studies	54% ± 24%	Explore
myofibroblast cell	13 studies	29% ± 9%	Explore
mucosal invariant T cell	13 studies	26% ± 5%	Explore
monocyte	12 studies	31% ± 11%	Explore
endothelial cell of artery	12 studies	22% ± 4%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	30% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	27% ± 10%	Explore
GABAergic neuron	11 studies	56% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	31% ± 10%	Explore
connective tissue cell	11 studies	27% ± 8%	Explore
vein endothelial cell	11 studies	25% ± 11%	Explore
type I pneumocyte	10 studies	32% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	25% ± 6%	Explore
neuron	10 studies	52% ± 19%	Explore
conventional dendritic cell	9 studies	27% ± 14%	Explore
myeloid cell	9 studies	38% ± 12%	Explore
adipocyte	9 studies	38% ± 15%	Explore
dendritic cell	8 studies	34% ± 13%	Explore
type II pneumocyte	8 studies	35% ± 7%	Explore
respiratory goblet cell	8 studies	31% ± 13%	Explore
leukocyte	8 studies	39% ± 11%	Explore
abnormal cell	8 studies	37% ± 18%	Explore
mesothelial cell	8 studies	31% ± 14%	Explore
amacrine cell	8 studies	48% ± 10%	Explore
retinal rod cell	8 studies	41% ± 11%	Explore
endothelial cell of vascular tree	8 studies	29% ± 15%	Explore
non-classical monocyte	7 studies	26% ± 10%	Explore
progenitor cell	7 studies	32% ± 10%	Explore
retinal ganglion cell	7 studies	46% ± 17%	Explore
club cell	7 studies	35% ± 9%	Explore
retinal cone cell	7 studies	54% ± 15%	Explore
T follicular helper cell	7 studies	24% ± 6%	Explore
alveolar macrophage	6 studies	33% ± 14%	Explore
secretory cell	6 studies	35% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	21% ± 6%	Explore
interneuron	6 studies	68% ± 15%	Explore
hematopoietic stem cell	6 studies	34% ± 10%	Explore
lymphocyte	6 studies	38% ± 14%	Explore
retina horizontal cell	6 studies	48% ± 12%	Explore
Mueller cell	6 studies	46% ± 11%	Explore
hematopoietic precursor cell	5 studies	37% ± 13%	Explore
ionocyte	5 studies	33% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	25% ± 7%	Explore
retinal bipolar neuron	5 studies	50% ± 8%	Explore
precursor B cell	5 studies	27% ± 9%	Explore
pro-B cell	5 studies	30% ± 3%	Explore
brush cell	5 studies	34% ± 10%	Explore
cardiac muscle cell	5 studies	41% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	30% ± 9%	Explore
innate lymphoid cell	5 studies	24% ± 5%	Explore
goblet cell	5 studies	33% ± 23%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	25% ± 5%	Explore
deuterosomal cell	4 studies	83% ± 3%	Explore
pancreatic A cell	4 studies	40% ± 18%	Explore
plasmablast	4 studies	35% ± 20%	Explore
podocyte	4 studies	34% ± 7%	Explore
renal alpha-intercalated cell	4 studies	23% ± 6%	Explore
differentiation-committed oligodendrocyte precursor	4 studies	45% ± 14%	Explore
glial cell	4 studies	37% ± 12%	Explore
granule cell	4 studies	50% ± 3%	Explore
erythroblast	4 studies	38% ± 9%	Explore
immature B cell	4 studies	21% ± 4%	Explore
retinal pigment epithelial cell	4 studies	47% ± 20%	Explore
OFF-bipolar cell	4 studies	47% ± 18%	Explore
ON-bipolar cell	4 studies	46% ± 18%	Explore
muscle cell	4 studies	35% ± 23%	Explore
enteroendocrine cell	4 studies	27% ± 9%	Explore
erythrocyte	4 studies	39% ± 17%	Explore
kidney loop of Henle epithelial cell	4 studies	28% ± 9%	Explore
renal principal cell	4 studies	35% ± 7%	Explore
pancreatic D cell	3 studies	40% ± 27%	Explore
type B pancreatic cell	3 studies	50% ± 24%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	27% ± 7%	Explore
exhausted T cell	3 studies	31% ± 12%	Explore
glomerular endothelial cell	3 studies	31% ± 4%	Explore
epithelial cell of proximal tubule	3 studies	20% ± 5%	Explore
neural crest cell	3 studies	31% ± 3%	Explore
GABAergic interneuron	3 studies	60% ± 9%	Explore
plasma cell	3 studies	31% ± 10%	Explore
mononuclear phagocyte	3 studies	34% ± 10%	Explore
GABAergic amacrine cell	3 studies	55% ± 9%	Explore
glycinergic amacrine cell	3 studies	49% ± 5%	Explore
rod bipolar cell	3 studies	54% ± 11%	Explore
CD4-positive helper T cell	3 studies	28% ± 5%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	26% ± 3%	Explore
hepatocyte	3 studies	53% ± 22%	Explore
pancreatic ductal cell	3 studies	41% ± 19%	Explore
ependymal cell	3 studies	64% ± 14%	Explore
granulocyte	3 studies	25% ± 4%	Explore
adventitial cell	3 studies	28% ± 5%	Explore
chondrocyte	3 studies	34% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 11%	Explore
Schwann cell	3 studies	33% ± 19%	Explore
transit amplifying cell	3 studies	42% ± 29%	Explore
T-helper 17 cell	3 studies	24% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	23% ± 2%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	25% ± 3%	Explore
double negative thymocyte	3 studies	40% ± 15%	Explore
mural cell	3 studies	46% ± 5%	Explore
mucus secreting cell	3 studies	31% ± 4%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	20 studies	48% ± 21%	Explore
lung	17 studies	30% ± 10%	Explore
peripheral blood	16 studies	26% ± 11%	Explore
eye	9 studies	48% ± 13%	Explore
kidney	8 studies	26% ± 7%	Explore
intestine	7 studies	22% ± 8%	Explore
heart	5 studies	32% ± 8%	Explore
liver	5 studies	39% ± 17%	Explore
bone marrow	4 studies	25% ± 9%	Explore
lymph node	4 studies	26% ± 9%	Explore
breast	4 studies	20% ± 5%	Explore
adipose	4 studies	33% ± 10%	Explore
pancreas	3 studies	44% ± 19%	Explore
uterus	3 studies	42% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6985.79	1445 / 1445	100%	31.03	183 / 183
thymus	100%	9409.82	653 / 653	100%	45.00	604 / 605
prostate	100%	7291.78	245 / 245	100%	27.98	501 / 502
breast	100%	7429.52	459 / 459	100%	54.23	1114 / 1118
brain	100%	7341.02	2640 / 2642	100%	35.94	703 / 705
lung	100%	7460.33	577 / 578	99%	27.39	1147 / 1155
pancreas	99%	5225.27	326 / 328	99%	25.13	177 / 178
uterus	100%	9504.27	170 / 170	99%	27.76	453 / 459
bladder	100%	7802.38	21 / 21	97%	21.48	490 / 504
kidney	100%	5364.12	89 / 89	96%	25.42	868 / 901
intestine	100%	8147.59	966 / 966	96%	22.23	507 / 527
stomach	100%	5606.55	359 / 359	96%	25.25	275 / 286
adrenal gland	100%	6651.97	258 / 258	96%	24.83	220 / 230
skin	100%	6384.12	1808 / 1809	93%	33.10	438 / 472
ovary	100%	10944.26	180 / 180	92%	14.77	397 / 430
liver	100%	3946.25	226 / 226	87%	15.81	352 / 406
blood vessel	100%	8265.26	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	23.26	29 / 29
muscle	100%	14664.23	803 / 803	0%	0	0 / 0
spleen	100%	7132.70	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	32.33	45 / 45
adipose	100%	7353.50	1203 / 1204	0%	0	0 / 0
heart	97%	5953.30	832 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	76%	13.87	61 / 80
peripheral blood	75%	4678.18	700 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_1905515	Biological process	non-motile cilium assembly
GO_0060271	Biological process	cilium assembly
GO_0097150	Biological process	neuronal stem cell population maintenance
GO_0031122	Biological process	cytoplasmic microtubule organization
GO_0022027	Biological process	interkinetic nuclear migration
GO_0061635	Biological process	regulation of protein complex stability
GO_0071539	Biological process	protein localization to centrosome
GO_0001764	Biological process	neuron migration
GO_0034453	Biological process	microtubule anchoring
GO_0007098	Biological process	centrosome cycle
GO_0140706	Biological process	protein-containing complex localization to centriolar satellite
GO_0035735	Biological process	intraciliary transport involved in cilium assembly
GO_0034454	Biological process	microtubule anchoring at centrosome
GO_0035176	Biological process	social behavior
GO_0090316	Biological process	positive regulation of intracellular protein transport
GO_0050768	Biological process	negative regulation of neurogenesis
GO_0034451	Cellular component	centriolar satellite
GO_0016020	Cellular component	membrane
GO_0005813	Cellular component	centrosome
GO_0032991	Cellular component	protein-containing complex
GO_0005654	Cellular component	nucleoplasm
GO_0005814	Cellular component	centriole
GO_0097730	Cellular component	non-motile cilium
GO_0005829	Cellular component	cytosol
GO_0035869	Cellular component	ciliary transition zone
GO_0005737	Cellular component	cytoplasm
GO_0036064	Cellular component	ciliary basal body
GO_0000242	Cellular component	pericentriolar material
GO_0031965	Cellular component	nuclear membrane
GO_0045177	Cellular component	apical part of cell
GO_0060090	Molecular function	molecular adaptor activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	PCM1
Protein name	Pericentriolar material 1 protein (PCM-1) (hPCM-1) Pericentriolar material 1 PCM1 protein
Synonyms
Description	FUNCTION: Required for centrosome assembly and function . Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 . Required to anchor microtubules to the centrosome . Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites . Recruits the tubulin polyglutamylase complex (TPGC) to centriolar satellites . .
Accessions	ENST00000517730.5 A2RUU9 ENST00000522275.6 Q15154 E7EV93 E9PGW9 E5RGQ4 ENST00000523055.5 ENST00000519253.5 [Q15154-5] A0A4W8VX11 H0YBA1 ENST00000325083.13 [Q15154-1] ENST00000524226.5 B9EIS5 ENST00000518537.5 A0A5H1ZRS1 ENST00000524226.5 [Q15154-4] ENST00000518537.5 [Q15154-3] ENST00000519253.5

PCM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review