NFKBIZ report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032980Biological processkeratinocyte activation
GO_0019221Biological processcytokine-mediated signaling pathway
GO_0002224Biological processtoll-like receptor signaling pathway
GO_0090594Biological processinflammatory response to wounding
GO_0010468Biological processregulation of gene expression
GO_0002544Biological processchronic inflammatory response
GO_0030216Biological processkeratinocyte differentiation
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0070897Biological processtranscription preinitiation complex assembly
GO_0045063Biological processT-helper 1 cell differentiation
GO_0140459Biological processresponse to Gram-positive bacterium
GO_0072539Biological processT-helper 17 cell differentiation
GO_0097398Biological processcellular response to interleukin-17
GO_0061436Biological processestablishment of skin barrier
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_2000321Biological processpositive regulation of T-helper 17 cell differentiation
GO_0072718Biological processresponse to cisplatin
GO_0050852Biological processT cell receptor signaling pathway
GO_0006338Biological processchromatin remodeling
GO_0048873Biological processhomeostasis of number of cells within a tissue
GO_0048536Biological processspleen development
GO_1990117Biological processB cell receptor apoptotic signaling pathway
GO_0051593Biological processresponse to folic acid
GO_1904019Biological processepithelial cell apoptotic process
GO_0042789Biological processmRNA transcription by RNA polymerase II
GO_0002317Biological processplasma cell differentiation
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0097194Biological processexecution phase of apoptosis
GO_0042100Biological processB cell proliferation
GO_0045190Biological processisotype switching
GO_0050729Biological processpositive regulation of inflammatory response
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0002456Biological processT cell mediated immunity
GO_0043616Biological processkeratinocyte proliferation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0016607Cellular componentnuclear speck
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003712Molecular functiontranscription coregulator activity
GO_0005515Molecular functionprotein binding
GO_0070974Molecular functionPOU domain binding

IV. Literature review

[source]
Gene nameNFKBIZ
Protein nameNFKB inhibitor zeta
NF-kappa-B inhibitor zeta (I-kappa-B-zeta) (IkB-zeta) (IkappaBzeta) (IL-1 inducible nuclear ankyrin-repeat protein) (INAP) (Molecule possessing ankyrin repeats induced by lipopolysaccharide) (MAIL)
SynonymsIKBZ
MAIL
INAP
DescriptionFUNCTION: Involved in regulation of NF-kappa-B transcription factor complexes . Inhibits NF-kappa-B activity without affecting its nuclear translocation upon stimulation . Inhibits DNA-binding of RELA and NFKB1/p50, and of the NF-kappa-B p65-p50 heterodimer and the NF-kappa-B p50-p50 homodimer . Seems also to activate NF-kappa-B-mediated transcription . In vitro, upon association with NFKB1/p50 has transcriptional activation activity and, together with NFKB1/p50 and RELA, is recruited to LCN2 promoters . Promotes transcription of LCN2 and DEFB4 . Is recruited to IL-6 promoters and activates IL-6 but decreases TNF-alpha production in response to LPS (By similarity). Seems to be involved in the induction of inflammatory genes activated through TLR/IL-1 receptor signaling (By similarity). Involved in the induction of T helper 17 cells (Th17) differentiation upon recognition of antigen by T cell antigen receptor (TCR) (By similarity). .

AccessionsENST00000461724.5
C9JZ23
C9J5G8
ENST00000326172.9 [Q9BYH8-1]
Q9BYH8
ENST00000483180.5
ENST00000477601.1
ENST00000491281.1
H7C5S1
ENST00000326151.9 [Q9BYH8-3]
ENST00000394054.6 [Q9BYH8-2]
C9J5I7