NFKBIA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031663Biological processlipopolysaccharide-mediated signaling pathway
GO_0045638Biological processnegative regulation of myeloid cell differentiation
GO_0035994Biological processresponse to muscle stretch
GO_0070427Biological processnucleotide-binding oligomerization domain containing 1 signaling pathway
GO_0051247Biological processpositive regulation of protein metabolic process
GO_0007219Biological processNotch signaling pathway
GO_0007249Biological processcanonical NF-kappaB signal transduction
GO_0032495Biological processresponse to muramyl dipeptide
GO_0043330Biological processresponse to exogenous dsRNA
GO_0050853Biological processB cell receptor signaling pathway
GO_0070498Biological processinterleukin-1-mediated signaling pathway
GO_0032088Biological processnegative regulation of NF-kappaB transcription factor activity
GO_0070417Biological processcellular response to cold
GO_0010745Biological processnegative regulation of macrophage derived foam cell differentiation
GO_0071356Biological processcellular response to tumor necrosis factor
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_0007253Biological processcytoplasmic sequestering of NF-kappaB
GO_0042127Biological processregulation of cell population proliferation
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_0006606Biological processprotein import into nucleus
GO_0034142Biological processtoll-like receptor 4 signaling pathway
GO_0070431Biological processnucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0050729Biological processpositive regulation of inflammatory response
GO_0038061Biological processnon-canonical NF-kappaB signal transduction
GO_0010888Biological processnegative regulation of lipid storage
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0043124Biological processnegative regulation of canonical NF-kappaB signal transduction
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005886Cellular componentplasma membrane
GO_0033256Cellular componentI-kappaB/NF-kappaB complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0008139Molecular functionnuclear localization sequence binding
GO_0140416Molecular functiontranscription regulator inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0140311Molecular functionprotein sequestering activity
GO_0140313Molecular functionmolecular sequestering activity
GO_0005515Molecular functionprotein binding
GO_0051059Molecular functionNF-kappaB binding

IV. Literature review

[source]
Gene nameNFKBIA
Protein nameNFKB inhibitor alpha
NF-kappa-B inhibitor alpha (I-kappa-B-alpha) (IkB-alpha) (IkappaBalpha) (Major histocompatibility complex enhancer-binding protein MAD3)
NF-kappa-B inhibitor alpha (I-kappa-B-alpha)
SynonymsMAD3
NFKBI
IKBA
DescriptionFUNCTION: Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals . On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription . .

AccessionsG3V286
P25963
G3V3I4
ENST00000553342.2
ENST00000697962.1
ENST00000557389.1
A0A8V8TLC3
G3V3K1
A0A8V8TLE7
G3V2A2
ENST00000216797.10
ENST00000697961.1
ENST00000554001.5
ENST00000557140.5