NDUFS8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	34% ± 12%	Explore
CD8-positive, alpha-beta T cell	26 studies	32% ± 14%	Explore
CD4-positive, alpha-beta T cell	25 studies	29% ± 14%	Explore
conventional dendritic cell	24 studies	41% ± 14%	Explore
endothelial cell	24 studies	30% ± 12%	Explore
fibroblast	24 studies	31% ± 14%	Explore
T cell	23 studies	29% ± 10%	Explore
macrophage	23 studies	32% ± 11%	Explore
pericyte	22 studies	28% ± 9%	Explore
smooth muscle cell	22 studies	33% ± 13%	Explore
classical monocyte	20 studies	30% ± 11%	Explore
B cell	19 studies	25% ± 8%	Explore
regulatory T cell	18 studies	30% ± 9%	Explore
non-classical monocyte	17 studies	29% ± 11%	Explore
plasmacytoid dendritic cell	16 studies	28% ± 11%	Explore
epithelial cell	16 studies	42% ± 20%	Explore
monocyte	16 studies	29% ± 10%	Explore
basal cell	15 studies	35% ± 16%	Explore
ciliated cell	15 studies	35% ± 17%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	34% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	34% ± 9%	Explore
mature NK T cell	14 studies	30% ± 8%	Explore
endothelial cell of lymphatic vessel	14 studies	30% ± 11%	Explore
gamma-delta T cell	14 studies	33% ± 14%	Explore
plasma cell	13 studies	43% ± 15%	Explore
myofibroblast cell	13 studies	35% ± 12%	Explore
connective tissue cell	13 studies	36% ± 12%	Explore
mast cell	13 studies	21% ± 8%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	24% ± 5%	Explore
myeloid cell	12 studies	34% ± 15%	Explore
dendritic cell	11 studies	47% ± 22%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	31% ± 8%	Explore
memory B cell	11 studies	22% ± 7%	Explore
plasmablast	10 studies	44% ± 22%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	30% ± 14%	Explore
progenitor cell	10 studies	38% ± 15%	Explore
capillary endothelial cell	10 studies	23% ± 10%	Explore
abnormal cell	9 studies	34% ± 16%	Explore
endothelial cell of artery	9 studies	22% ± 5%	Explore
mucosal invariant T cell	9 studies	26% ± 4%	Explore
type I pneumocyte	8 studies	32% ± 13%	Explore
secretory cell	8 studies	33% ± 15%	Explore
naive B cell	8 studies	19% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	33% ± 9%	Explore
club cell	7 studies	37% ± 6%	Explore
epithelial cell of proximal tubule	7 studies	44% ± 15%	Explore
goblet cell	7 studies	33% ± 12%	Explore
vein endothelial cell	7 studies	24% ± 9%	Explore
T follicular helper cell	7 studies	24% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	41% ± 16%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	31% ± 7%	Explore
kidney loop of Henle epithelial cell	6 studies	45% ± 13%	Explore
renal alpha-intercalated cell	6 studies	62% ± 11%	Explore
neuron	6 studies	47% ± 21%	Explore
mesothelial cell	6 studies	47% ± 17%	Explore
transit amplifying cell	6 studies	38% ± 18%	Explore
innate lymphoid cell	6 studies	28% ± 8%	Explore
type II pneumocyte	6 studies	42% ± 18%	Explore
erythrocyte	6 studies	37% ± 23%	Explore
alveolar macrophage	5 studies	27% ± 8%	Explore
hematopoietic precursor cell	5 studies	42% ± 24%	Explore
exhausted T cell	5 studies	40% ± 9%	Explore
ionocyte	5 studies	38% ± 13%	Explore
respiratory goblet cell	5 studies	40% ± 21%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	54% ± 8%	Explore
enterocyte	5 studies	36% ± 5%	Explore
enteroendocrine cell	5 studies	40% ± 19%	Explore
intestinal crypt stem cell	5 studies	29% ± 14%	Explore
retinal rod cell	5 studies	31% ± 15%	Explore
endothelial cell of vascular tree	5 studies	24% ± 5%	Explore
leukocyte	4 studies	36% ± 11%	Explore
mononuclear phagocyte	4 studies	40% ± 18%	Explore
retinal ganglion cell	4 studies	68% ± 25%	Explore
retinal cone cell	4 studies	58% ± 24%	Explore
erythroblast	4 studies	46% ± 22%	Explore
hematopoietic stem cell	4 studies	35% ± 6%	Explore
pro-B cell	4 studies	27% ± 6%	Explore
brush cell	4 studies	28% ± 9%	Explore
immature B cell	4 studies	33% ± 18%	Explore
amacrine cell	4 studies	36% ± 17%	Explore
astrocyte	4 studies	27% ± 13%	Explore
adventitial cell	4 studies	21% ± 6%	Explore
cardiac muscle cell	4 studies	24% ± 7%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	41% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	38% ± 13%	Explore
hepatocyte	4 studies	35% ± 26%	Explore
T-helper 17 cell	4 studies	32% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	27% ± 6%	Explore
deuterosomal cell	3 studies	31% ± 5%	Explore
duct epithelial cell	3 studies	37% ± 10%	Explore
precursor cell	3 studies	50% ± 6%	Explore
pancreatic A cell	3 studies	49% ± 15%	Explore
type B pancreatic cell	3 studies	42% ± 17%	Explore
neural crest cell	3 studies	42% ± 5%	Explore
IgG plasma cell	3 studies	25% ± 5%	Explore
retinal bipolar neuron	3 studies	43% ± 19%	Explore
common myeloid progenitor	3 studies	36% ± 19%	Explore
lymphocyte	3 studies	38% ± 14%	Explore
megakaryocyte	3 studies	25% ± 6%	Explore
neuroendocrine cell	3 studies	51% ± 19%	Explore
precursor B cell	3 studies	35% ± 10%	Explore
retina horizontal cell	3 studies	41% ± 15%	Explore
microglial cell	3 studies	26% ± 9%	Explore
serous secreting cell	3 studies	46% ± 6%	Explore
intraepithelial lymphocyte	3 studies	36% ± 11%	Explore
Mueller cell	3 studies	31% ± 9%	Explore
germinal center B cell	3 studies	24% ± 2%	Explore
intermediate monocyte	3 studies	44% ± 14%	Explore
glutamatergic neuron	3 studies	39% ± 14%	Explore
oligodendrocyte precursor cell	3 studies	34% ± 6%	Explore
granulocyte monocyte progenitor cell	3 studies	41% ± 27%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	45% ± 27%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 17%	Explore
keratinocyte	3 studies	21% ± 1%	Explore
T-helper 1 cell	3 studies	33% ± 13%	Explore
double negative thymocyte	3 studies	44% ± 18%	Explore
progenitor cell of mammary luminal epithelium	3 studies	21% ± 2%	Explore
IgA plasma cell	3 studies	22% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	33% ± 12%	Explore
peripheral blood	15 studies	30% ± 8%	Explore
intestine	12 studies	28% ± 13%	Explore
kidney	9 studies	33% ± 8%	Explore
eye	6 studies	34% ± 15%	Explore
liver	6 studies	32% ± 22%	Explore
lymph node	5 studies	32% ± 14%	Explore
brain	5 studies	28% ± 7%	Explore
bone marrow	4 studies	23% ± 4%	Explore
uterus	4 studies	35% ± 16%	Explore
pancreas	3 studies	41% ± 19%	Explore
adrenal gland	3 studies	30% ± 2%	Explore
breast	3 studies	26% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	9423.45	258 / 258	100%	78.63	230 / 230
esophagus	100%	3898.79	1445 / 1445	100%	66.04	183 / 183
liver	100%	2608.08	226 / 226	100%	58.62	406 / 406
ovary	100%	2125.12	180 / 180	100%	147.49	430 / 430
thymus	100%	3685.11	653 / 653	100%	75.74	605 / 605
uterus	100%	2766.42	170 / 170	100%	77.11	459 / 459
brain	100%	3715.65	2638 / 2642	100%	59.79	705 / 705
pancreas	100%	1718.97	328 / 328	99%	50.39	177 / 178
intestine	100%	3840.52	966 / 966	99%	67.06	524 / 527
prostate	100%	4107.79	245 / 245	99%	83.43	498 / 502
stomach	100%	3407.53	359 / 359	99%	68.66	283 / 286
kidney	100%	5266.82	89 / 89	99%	58.41	890 / 901
skin	100%	2844.85	1806 / 1809	99%	69.28	467 / 472
breast	100%	2897.73	459 / 459	98%	59.29	1101 / 1118
bladder	100%	3068.33	21 / 21	98%	72.32	496 / 504
lung	99%	2562.51	573 / 578	99%	57.06	1138 / 1155
adipose	100%	2872.01	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	93.92	80 / 80
lymph node	0%	0	0 / 0	100%	81.49	29 / 29
muscle	100%	6415.64	803 / 803	0%	0	0 / 0
spleen	100%	2599.30	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	66.33	45 / 45
ureter	0%	0	0 / 0	100%	95.01	1 / 1
blood vessel	100%	2850.23	1329 / 1335	0%	0	0 / 0
heart	99%	7763.36	855 / 861	0%	0	0 / 0
peripheral blood	87%	1620.81	805 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0009060	Biological process	aerobic respiration
GO_0006979	Biological process	response to oxidative stress
GO_0006120	Biological process	mitochondrial electron transport, NADH to ubiquinone
GO_0042776	Biological process	proton motive force-driven mitochondrial ATP synthesis
GO_0055085	Biological process	transmembrane transport
GO_0032981	Biological process	mitochondrial respiratory chain complex I assembly
GO_0045271	Cellular component	respiratory chain complex I
GO_0005759	Cellular component	mitochondrial matrix
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005739	Cellular component	mitochondrion
GO_0051539	Molecular function	4 iron, 4 sulfur cluster binding
GO_0008137	Molecular function	NADH dehydrogenase (ubiquinone) activity
GO_0003954	Molecular function	NADH dehydrogenase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

IV. Literature review

[source]

Gene name	NDUFS8
Protein name	NADH:ubiquinone oxidoreductase core subunit S8 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 7.1.1.2) (Complex I-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit) NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial (EC 7.1.1.2) (Complex I-23kD) (CI-23kD) (NADH-ubiquinone oxidoreductase 23 kDa subunit) (TYKY subunit)
Synonyms
Description	FUNCTION: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor . Essential for the catalytic activity and assembly of complex I . .
Accessions	O00217 ENST00000524810.5 E9PN51 ENST00000525419.5 H0YDT4 H0YCB2 ENST00000525628.1 ENST00000529645.1 E9PJY7 ENST00000526339.5 F8W9K7 ENST00000453471.6 ENST00000313468.10 Q08E91 ENST00000528492.1 E9PKH6 ENST00000526446.5 E9PPW7

NDUFS8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review