NDUFAB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006120Biological processmitochondrial electron transport, NADH to ubiquinone
GO_0042776Biological processproton motive force-driven mitochondrial ATP synthesis
GO_0006633Biological processfatty acid biosynthetic process
GO_0016226Biological processiron-sulfur cluster assembly
GO_0009249Biological processprotein lipoylation
GO_0044571Biological process[2Fe-2S] cluster assembly
GO_0032981Biological processmitochondrial respiratory chain complex I assembly
GO_0009060Biological processaerobic respiration
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0005654Cellular componentnucleoplasm
GO_0005743Cellular componentmitochondrial inner membrane
GO_1990229Cellular componentiron-sulfur cluster assembly complex
GO_0005759Cellular componentmitochondrial matrix
GO_0045271Cellular componentrespiratory chain complex I
GO_0140978Molecular functionmitochondrial large ribosomal subunit binding
GO_0000036Molecular functionacyl carrier activity
GO_0000035Molecular functionacyl binding
GO_0005504Molecular functionfatty acid binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameNDUFAB1
Protein nameNADH:ubiquinone oxidoreductase subunit AB1
Acyl carrier protein
Acyl carrier protein, mitochondrial (ACP) (CI-SDAP) (NADH-ubiquinone oxidoreductase 9.6 kDa subunit)
Synonyms
DescriptionFUNCTION: Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) . Accessory and non-catalytic subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), which functions in the transfer of electrons from NADH to the respiratory chain . Accessory protein, of the core iron-sulfur cluster (ISC) assembly complex, that regulates, in association with LYRM4, the stability and the cysteine desulfurase activity of NFS1 and participates in the [2Fe-2S] clusters assembly on the scaffolding protein ISCU . The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). .

FUNCTION: Carrier of the growing fatty acid chain in fatty acid biosynthesis. .

FUNCTION: Carrier of the growing fatty acid chain in fatty acid biosynthesis. .

AccessionsH3BNE8
ENST00000562133.5
ENST00000484769.1
ENST00000567761.1
O14561
ENST00000007516.8
ENST00000570319.5
H3BNK3
I3L505