LDHB | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	39 studies	42% ± 15%	Explore
T cell	37 studies	56% ± 24%	Explore
CD8-positive, alpha-beta T cell	37 studies	57% ± 25%	Explore
natural killer cell	35 studies	43% ± 18%	Explore
fibroblast	35 studies	52% ± 20%	Explore
CD4-positive, alpha-beta T cell	35 studies	70% ± 23%	Explore
pericyte	31 studies	54% ± 21%	Explore
endothelial cell	31 studies	42% ± 18%	Explore
regulatory T cell	28 studies	71% ± 18%	Explore
conventional dendritic cell	27 studies	47% ± 17%	Explore
macrophage	25 studies	35% ± 15%	Explore
smooth muscle cell	25 studies	60% ± 21%	Explore
plasmacytoid dendritic cell	25 studies	62% ± 18%	Explore
mast cell	23 studies	51% ± 20%	Explore
epithelial cell	21 studies	58% ± 25%	Explore
dendritic cell	20 studies	48% ± 23%	Explore
basal cell	20 studies	60% ± 20%	Explore
monocyte	19 studies	31% ± 12%	Explore
plasma cell	19 studies	46% ± 19%	Explore
connective tissue cell	19 studies	57% ± 23%	Explore
gamma-delta T cell	18 studies	48% ± 18%	Explore
memory B cell	18 studies	48% ± 10%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	18 studies	75% ± 19%	Explore
classical monocyte	18 studies	30% ± 11%	Explore
mature NK T cell	17 studies	44% ± 17%	Explore
ciliated cell	17 studies	58% ± 17%	Explore
naive B cell	16 studies	32% ± 9%	Explore
mucosal invariant T cell	15 studies	50% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	71% ± 23%	Explore
astrocyte	15 studies	41% ± 19%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	42% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	40% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	62% ± 26%	Explore
myofibroblast cell	13 studies	63% ± 23%	Explore
innate lymphoid cell	12 studies	44% ± 16%	Explore
plasmablast	12 studies	60% ± 24%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	54% ± 24%	Explore
endothelial cell of vascular tree	11 studies	35% ± 9%	Explore
myeloid cell	11 studies	41% ± 17%	Explore
type II pneumocyte	10 studies	63% ± 26%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	46% ± 19%	Explore
secretory cell	10 studies	55% ± 19%	Explore
mesothelial cell	10 studies	67% ± 24%	Explore
vein endothelial cell	10 studies	36% ± 22%	Explore
club cell	9 studies	49% ± 21%	Explore
effector CD8-positive, alpha-beta T cell	9 studies	52% ± 24%	Explore
non-classical monocyte	9 studies	28% ± 13%	Explore
abnormal cell	9 studies	50% ± 23%	Explore
T follicular helper cell	9 studies	66% ± 14%	Explore
leukocyte	8 studies	49% ± 16%	Explore
glutamatergic neuron	8 studies	35% ± 19%	Explore
progenitor cell	8 studies	81% ± 17%	Explore
neuron	8 studies	63% ± 24%	Explore
goblet cell	8 studies	32% ± 11%	Explore
hematopoietic stem cell	8 studies	67% ± 33%	Explore
oligodendrocyte precursor cell	8 studies	45% ± 28%	Explore
ionocyte	7 studies	73% ± 16%	Explore
respiratory goblet cell	7 studies	42% ± 21%	Explore
epithelial cell of proximal tubule	7 studies	85% ± 8%	Explore
capillary endothelial cell	7 studies	40% ± 20%	Explore
transit amplifying cell	7 studies	34% ± 13%	Explore
hematopoietic precursor cell	6 studies	56% ± 32%	Explore
platelet	6 studies	28% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	65% ± 29%	Explore
kidney loop of Henle epithelial cell	6 studies	90% ± 7%	Explore
renal alpha-intercalated cell	6 studies	89% ± 6%	Explore
megakaryocyte	6 studies	59% ± 24%	Explore
erythroblast	6 studies	48% ± 24%	Explore
intestinal crypt stem cell	6 studies	41% ± 11%	Explore
IgG plasma cell	6 studies	28% ± 14%	Explore
retinal ganglion cell	6 studies	69% ± 31%	Explore
retinal cone cell	6 studies	44% ± 22%	Explore
precursor B cell	6 studies	50% ± 18%	Explore
brush cell	6 studies	62% ± 36%	Explore
adipocyte	6 studies	23% ± 5%	Explore
cardiac muscle cell	6 studies	42% ± 17%	Explore
erythrocyte	6 studies	55% ± 23%	Explore
oligodendrocyte	6 studies	28% ± 7%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	79% ± 23%	Explore
alveolar macrophage	5 studies	49% ± 14%	Explore
CD4-positive helper T cell	5 studies	51% ± 15%	Explore
exhausted T cell	5 studies	67% ± 15%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	93% ± 6%	Explore
endothelial cell of artery	5 studies	32% ± 20%	Explore
retinal rod cell	5 studies	37% ± 17%	Explore
pro-B cell	5 studies	56% ± 23%	Explore
T-helper 17 cell	5 studies	70% ± 24%	Explore
group 3 innate lymphoid cell	5 studies	70% ± 17%	Explore
amacrine cell	5 studies	51% ± 18%	Explore
microglial cell	5 studies	33% ± 14%	Explore
double negative thymocyte	5 studies	69% ± 29%	Explore
granulocyte	5 studies	59% ± 13%	Explore
GABAergic neuron	5 studies	39% ± 14%	Explore
interneuron	5 studies	47% ± 22%	Explore
type I pneumocyte	4 studies	52% ± 27%	Explore
CD4-positive, alpha-beta cytotoxic T cell	4 studies	60% ± 25%	Explore
central memory CD8-positive, alpha-beta T cell	4 studies	57% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	40% ± 13%	Explore
deuterosomal cell	4 studies	26% ± 3%	Explore
mononuclear phagocyte	4 studies	38% ± 11%	Explore
kidney connecting tubule epithelial cell	4 studies	87% ± 7%	Explore
endothelial cell of lymphatic vessel	4 studies	25% ± 7%	Explore
enteroendocrine cell	4 studies	48% ± 24%	Explore
IgA plasma cell	4 studies	28% ± 15%	Explore
OFF-bipolar cell	4 studies	54% ± 28%	Explore
ON-bipolar cell	4 studies	53% ± 29%	Explore
immature B cell	4 studies	63% ± 23%	Explore
retina horizontal cell	4 studies	47% ± 11%	Explore
adventitial cell	4 studies	39% ± 3%	Explore
germinal center B cell	4 studies	58% ± 16%	Explore
intermediate monocyte	4 studies	37% ± 23%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	53% ± 10%	Explore
T-helper 1 cell	4 studies	77% ± 16%	Explore
duct epithelial cell	3 studies	24% ± 6%	Explore
precursor cell	3 studies	89% ± 9%	Explore
monocyte-derived dendritic cell	3 studies	44% ± 18%	Explore
renal beta-intercalated cell	3 studies	93% ± 6%	Explore
enterocyte	3 studies	46% ± 14%	Explore
neural crest cell	3 studies	88% ± 12%	Explore
retinal bipolar neuron	3 studies	55% ± 24%	Explore
GABAergic amacrine cell	3 studies	39% ± 11%	Explore
glycinergic amacrine cell	3 studies	42% ± 11%	Explore
renal principal cell	3 studies	79% ± 11%	Explore
thymocyte	3 studies	65% ± 25%	Explore
extravillous trophoblast	3 studies	48% ± 15%	Explore
placental villous trophoblast	3 studies	89% ± 11%	Explore
common myeloid progenitor	3 studies	64% ± 29%	Explore
neuroendocrine cell	3 studies	48% ± 10%	Explore
retinal pigment epithelial cell	3 studies	61% ± 26%	Explore
serous secreting cell	3 studies	32% ± 23%	Explore
intraepithelial lymphocyte	3 studies	51% ± 27%	Explore
Mueller cell	3 studies	36% ± 7%	Explore
rod bipolar cell	3 studies	48% ± 15%	Explore
muscle cell	3 studies	55% ± 15%	Explore
myoepithelial cell	3 studies	58% ± 18%	Explore
acinar cell	3 studies	63% ± 25%	Explore
granulocyte monocyte progenitor cell	3 studies	75% ± 16%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	82% ± 19%	Explore
glial cell	3 studies	50% ± 27%	Explore
hepatocyte	3 studies	34% ± 9%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	71% ± 28%	Explore
double-positive, alpha-beta thymocyte	3 studies	67% ± 28%	Explore
progenitor cell of mammary luminal epithelium	3 studies	61% ± 13%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	20 studies	51% ± 13%	Explore
lung	18 studies	50% ± 16%	Explore
intestine	14 studies	38% ± 21%	Explore
brain	12 studies	35% ± 13%	Explore
kidney	9 studies	66% ± 13%	Explore
eye	8 studies	46% ± 14%	Explore
bone marrow	7 studies	36% ± 16%	Explore
lymph node	7 studies	60% ± 8%	Explore
uterus	6 studies	47% ± 23%	Explore
liver	6 studies	38% ± 15%	Explore
heart	5 studies	30% ± 14%	Explore
placenta	4 studies	52% ± 21%	Explore
pancreas	4 studies	25% ± 9%	Explore
prostate	4 studies	39% ± 11%	Explore
breast	4 studies	44% ± 9%	Explore
ovary	3 studies	45% ± 15%	Explore
adrenal gland	3 studies	51% ± 11%	Explore
esophagus	3 studies	41% ± 20%	Explore
skin	3 studies	25% ± 7%	Explore
thymus	3 studies	75% ± 27%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	29592.34	2641 / 2642	100%	27.59	704 / 705
adrenal gland	100%	24445.17	258 / 258	98%	14.66	226 / 230
kidney	100%	49515.37	89 / 89	98%	21.92	885 / 901
ovary	100%	20939.92	180 / 180	98%	25.10	422 / 430
bladder	100%	19628.33	21 / 21	95%	20.53	480 / 504
thymus	100%	14704.94	651 / 653	94%	13.34	569 / 605
lung	99%	13605.65	572 / 578	91%	15.51	1047 / 1155
uterus	100%	14495.06	170 / 170	87%	16.62	399 / 459
intestine	95%	14864.34	922 / 966	86%	17.01	451 / 527
esophagus	96%	15176.88	1384 / 1445	85%	16.66	155 / 183
stomach	100%	20746.60	359 / 359	80%	14.90	230 / 286
pancreas	99%	12485.79	324 / 328	67%	6.32	120 / 178
skin	62%	12656.08	1128 / 1809	98%	18.81	461 / 472
prostate	100%	12237.67	244 / 245	58%	5.43	292 / 502
breast	100%	18849.05	458 / 459	44%	5.85	492 / 1118
adipose	100%	24903.61	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	24.69	80 / 80
lymph node	0%	0	0 / 0	100%	32.76	29 / 29
spleen	100%	10632.43	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	16.73	1 / 1
blood vessel	100%	15033.19	1331 / 1335	0%	0	0 / 0
heart	98%	54787.38	840 / 861	0%	0	0 / 0
muscle	84%	9461.23	675 / 803	0%	0	0 / 0
tonsil	0%	0	0 / 0	82%	10.72	37 / 45
peripheral blood	64%	16252.03	593 / 929	0%	0	0 / 0
liver	1%	89.30	2 / 226	10%	1.14	39 / 406
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006089	Biological process	lactate metabolic process
GO_0019674	Biological process	NAD metabolic process
GO_0006090	Biological process	pyruvate metabolic process
GO_1990204	Cellular component	oxidoreductase complex
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0045121	Cellular component	membrane raft
GO_0016020	Cellular component	membrane
GO_0005737	Cellular component	cytoplasm
GO_0005739	Cellular component	mitochondrion
GO_0019900	Molecular function	kinase binding
GO_0051287	Molecular function	NAD binding
GO_0004459	Molecular function	L-lactate dehydrogenase activity
GO_0042802	Molecular function	identical protein binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	LDHB
Protein name	L-lactate dehydrogenase B chain L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) L-lactate dehydrogenase (EC 1.1.1.27)
Synonyms	hCG_24788 HEL-S-281
Description	FUNCTION: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). . FUNCTION: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). . FUNCTION: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). . FUNCTION: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). . FUNCTION: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). . FUNCTION: Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). .
Accessions	Q5U077 F5H793 P07195 A0A5F9ZHM4 ENST00000673047.2 ENST00000350669.5 ENST00000396076.5 ENST00000396075.5 ENST00000539782.1 C9J7H8 ENST00000450584.5 A8MW50

LDHB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review