KPNB1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0040001Biological processestablishment of mitotic spindle localization
GO_0090307Biological processmitotic spindle assembly
GO_0006606Biological processprotein import into nucleus
GO_0007079Biological processmitotic chromosome movement towards spindle pole
GO_0030953Biological processastral microtubule organization
GO_0006610Biological processribosomal protein import into nucleus
GO_0007080Biological processmitotic metaphase chromosome alignment
GO_0006404Biological processRNA import into nucleus
GO_0006607Biological processNLS-bearing protein import into nucleus
GO_0005643Cellular componentnuclear pore
GO_0005576Cellular componentextracellular region
GO_0035580Cellular componentspecific granule lumen
GO_0016020Cellular componentmembrane
GO_0071782Cellular componentendoplasmic reticulum tubular network
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005635Cellular componentnuclear envelope
GO_1904813Cellular componentficolin-1-rich granule lumen
GO_0042564Cellular componentNLS-dependent protein nuclear import complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0031965Cellular componentnuclear membrane
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0019899Molecular functionenzyme binding
GO_0019904Molecular functionprotein domain specific binding
GO_0061676Molecular functionimportin-alpha family protein binding
GO_0051879Molecular functionHsp90 protein binding
GO_0008139Molecular functionnuclear localization sequence binding
GO_0031267Molecular functionsmall GTPase binding
GO_0008270Molecular functionzinc ion binding
GO_0061608Molecular functionnuclear import signal receptor activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameKPNB1
Protein nameImportin subunit beta-1
Importin subunit beta-1 (Importin-90) (Karyopherin subunit beta-1) (Nuclear factor p97) (Pore targeting complex 97 kDa subunit) (PTAC97)
Karyopherin subunit beta 1
SynonymsNTF97
DescriptionFUNCTION: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 . In association with IPO7, mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus. .

AccessionsENST00000540627.5 [Q14974-2]
ENST00000582126.1
J3QR48
ENST00000583648.6 [Q14974-1]
J3KS06
J3QKQ5
ENST00000582097.5
J3KTM9
J3QRG4
ENST00000577875.5
ENST00000290158.9 [Q14974-1]
ENST00000535458.6 [Q14974-2]
ENST00000583648
Q14974
ENST00000583013.1