ISCU report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1904439Biological processnegative regulation of iron ion import across plasma membrane
GO_0044572Biological process[4Fe-4S] cluster assembly
GO_0016226Biological processiron-sulfur cluster assembly
GO_0006879Biological processintracellular iron ion homeostasis
GO_0044571Biological process[2Fe-2S] cluster assembly
GO_1902958Biological processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
GO_1904234Biological processpositive regulation of aconitate hydratase activity
GO_0099128Cellular componentmitochondrial [2Fe-2S] assembly complex
GO_0005739Cellular componentmitochondrion
GO_1990229Cellular componentiron-sulfur cluster assembly complex
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0060090Molecular functionmolecular adaptor activity
GO_0008198Molecular functionferrous iron binding
GO_0005506Molecular functioniron ion binding
GO_0008270Molecular functionzinc ion binding
GO_0051537Molecular function2 iron, 2 sulfur cluster binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameISCU
Protein nameIron-sulfur cluster assembly enzyme ISCU (NifU-like N-terminal domain-containing protein) (NifU-like protein)
Iron-sulfur cluster assembly enzyme (cDNA FLJ32689 fis, clone TESTI2000207, highly similar to NifU-like N-terminal domain-containing protein, mitochondrial)
Iron-sulfur cluster assembly enzyme (cDNA FLJ51257, highly similar to NifU-like N-terminal domain-containing protein, mitochondrial)
Iron-sulfur cluster assembly enzyme
ICSU (ISCU)
SynonymsNIFUN
DescriptionFUNCTION: [Isoform 1]: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled . The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (Probable). Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form . May modulate NFS1 desulfurase activity in a zinc-dependent manner . Modulates the interaction between FXN and the cysteine desulfurase complex . .; FUNCTION: [Isoform 2]: Cytoplasmic scaffold protein, of the cytoplasmic core iron-sulfur cluster (ISC) assembly complex that provides the structural architecture on which the Fe-S clusters are assembled and may be involved in the cytoplasmic iron-sulfur protein biogenesis. .

FUNCTION: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. .

FUNCTION: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. .

FUNCTION: Mitochondrial scaffold protein, of the core iron-sulfur cluster (ISC) assembly complex, that provides the structural architecture on which the [2Fe-2S] clusters are assembled. The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis. This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner. Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly. Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5. Exists as two slow interchanging conformational states, a structured (S) and disordered (D) form. May modulate NFS1 desulfurase activity in a zinc-dependent manner. Modulates the interaction between FXN and the cysteine desulfurase complex. .

AccessionsQ9H1K1
B3KQ30
ENST00000535729.5
ENST00000539593.1
B4DNC9
ENST00000311893.14 [Q9H1K1-1]
F5H5N2
ENST00000431221.6
F5H672
ENST00000392807.8 [Q9H1K1-2]
ENST00000547005.5
ENST00000539580.5
B1P7G3