HM13 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	35 studies	26% ± 11%	Explore
macrophage	31 studies	33% ± 13%	Explore
endothelial cell	26 studies	27% ± 9%	Explore
plasma cell	25 studies	52% ± 23%	Explore
classical monocyte	24 studies	35% ± 13%	Explore
natural killer cell	22 studies	24% ± 7%	Explore
conventional dendritic cell	21 studies	31% ± 16%	Explore
non-classical monocyte	21 studies	40% ± 14%	Explore
monocyte	20 studies	28% ± 7%	Explore
plasmacytoid dendritic cell	19 studies	41% ± 15%	Explore
CD4-positive, alpha-beta T cell	19 studies	23% ± 7%	Explore
CD8-positive, alpha-beta T cell	18 studies	25% ± 7%	Explore
regulatory T cell	17 studies	27% ± 9%	Explore
pericyte	15 studies	26% ± 7%	Explore
myeloid cell	14 studies	33% ± 14%	Explore
epithelial cell	14 studies	39% ± 21%	Explore
T cell	13 studies	21% ± 4%	Explore
connective tissue cell	13 studies	27% ± 9%	Explore
plasmablast	12 studies	61% ± 23%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	23% ± 5%	Explore
smooth muscle cell	12 studies	20% ± 4%	Explore
B cell	12 studies	21% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	26% ± 5%	Explore
dendritic cell	11 studies	34% ± 17%	Explore
gamma-delta T cell	11 studies	27% ± 10%	Explore
endothelial cell of lymphatic vessel	10 studies	25% ± 9%	Explore
basal cell	10 studies	32% ± 14%	Explore
mature NK T cell	10 studies	24% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	21% ± 6%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	26% ± 7%	Explore
club cell	9 studies	25% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	9 studies	19% ± 3%	Explore
microglial cell	9 studies	28% ± 9%	Explore
mucosal invariant T cell	9 studies	30% ± 4%	Explore
type II pneumocyte	9 studies	26% ± 14%	Explore
abnormal cell	8 studies	35% ± 18%	Explore
myofibroblast cell	8 studies	29% ± 3%	Explore
ciliated cell	8 studies	29% ± 13%	Explore
goblet cell	8 studies	30% ± 12%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	30% ± 10%	Explore
respiratory goblet cell	7 studies	30% ± 16%	Explore
secretory cell	7 studies	29% ± 12%	Explore
IgA plasma cell	7 studies	45% ± 19%	Explore
IgG plasma cell	7 studies	40% ± 15%	Explore
glutamatergic neuron	7 studies	38% ± 25%	Explore
mesothelial cell	7 studies	27% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	25% ± 4%	Explore
vein endothelial cell	6 studies	22% ± 6%	Explore
innate lymphoid cell	6 studies	26% ± 7%	Explore
type I pneumocyte	6 studies	24% ± 9%	Explore
adipocyte	6 studies	22% ± 5%	Explore
endothelial cell of vascular tree	6 studies	23% ± 4%	Explore
T follicular helper cell	6 studies	20% ± 3%	Explore
neuron	6 studies	32% ± 15%	Explore
GABAergic neuron	6 studies	37% ± 22%	Explore
oligodendrocyte precursor cell	6 studies	29% ± 9%	Explore
alveolar macrophage	5 studies	22% ± 5%	Explore
hematopoietic precursor cell	5 studies	32% ± 7%	Explore
mononuclear phagocyte	5 studies	28% ± 10%	Explore
progenitor cell	5 studies	22% ± 7%	Explore
endothelial cell of artery	5 studies	18% ± 2%	Explore
astrocyte	5 studies	27% ± 8%	Explore
oligodendrocyte	5 studies	22% ± 5%	Explore
naive B cell	5 studies	17% ± 3%	Explore
squamous epithelial cell	4 studies	45% ± 21%	Explore
exhausted T cell	4 studies	29% ± 6%	Explore
leukocyte	4 studies	23% ± 2%	Explore
lymphocyte	4 studies	25% ± 7%	Explore
capillary endothelial cell	4 studies	25% ± 8%	Explore
adventitial cell	4 studies	34% ± 6%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	41% ± 8%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	33% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	35% ± 10%	Explore
hematopoietic stem cell	4 studies	27% ± 6%	Explore
enteroendocrine cell	4 studies	26% ± 9%	Explore
interneuron	4 studies	37% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	21% ± 6%	Explore
memory B cell	4 studies	19% ± 3%	Explore
pancreatic A cell	3 studies	41% ± 1%	Explore
type B pancreatic cell	3 studies	49% ± 7%	Explore
extravillous trophoblast	3 studies	20% ± 2%	Explore
common myeloid progenitor	3 studies	31% ± 16%	Explore
megakaryocyte	3 studies	19% ± 3%	Explore
retinal cone cell	3 studies	30% ± 11%	Explore
mucus secreting cell	3 studies	27% ± 6%	Explore
serous secreting cell	3 studies	25% ± 3%	Explore
tissue-resident macrophage	3 studies	25% ± 5%	Explore
chondrocyte	3 studies	25% ± 3%	Explore
mast cell	3 studies	21% ± 3%	Explore
intermediate monocyte	3 studies	48% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	25% ± 6%	Explore
IgM plasma cell	3 studies	43% ± 12%	Explore
muscle cell	3 studies	28% ± 9%	Explore
pancreatic ductal cell	3 studies	39% ± 16%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	35% ± 25%	Explore
intestinal crypt stem cell	3 studies	19% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 9%	Explore
transit amplifying cell	3 studies	29% ± 13%	Explore
T-helper 1 cell	3 studies	31% ± 14%	Explore
double negative thymocyte	3 studies	34% ± 14%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	15 studies	26% ± 7%	Explore
lung	13 studies	28% ± 12%	Explore
brain	10 studies	32% ± 15%	Explore
intestine	7 studies	22% ± 7%	Explore
kidney	5 studies	22% ± 8%	Explore
bone marrow	4 studies	21% ± 6%	Explore
adipose	4 studies	27% ± 13%	Explore
pancreas	3 studies	46% ± 2%	Explore
placenta	3 studies	28% ± 4%	Explore
uterus	3 studies	33% ± 15%	Explore
liver	3 studies	34% ± 15%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	100%	7771.33	226 / 226	100%	71.38	406 / 406
ovary	100%	5204.08	180 / 180	100%	78.13	430 / 430
pancreas	100%	11330.95	328 / 328	100%	67.81	178 / 178
prostate	100%	7414.69	245 / 245	100%	103.49	502 / 502
stomach	100%	6037.99	359 / 359	100%	89.22	286 / 286
skin	100%	6879.07	1808 / 1809	100%	101.33	472 / 472
esophagus	100%	6581.98	1444 / 1445	100%	58.22	183 / 183
lung	100%	7653.84	578 / 578	100%	77.74	1154 / 1155
thymus	100%	7324.50	653 / 653	100%	62.48	604 / 605
bladder	100%	6039.33	21 / 21	100%	87.56	503 / 504
uterus	100%	6365.45	170 / 170	100%	91.03	458 / 459
adrenal gland	100%	9088.84	258 / 258	100%	56.82	229 / 230
breast	100%	5813.56	459 / 459	100%	81.43	1113 / 1118
intestine	100%	4717.91	966 / 966	99%	89.35	524 / 527
kidney	100%	5777.27	89 / 89	99%	57.11	894 / 901
brain	98%	3014.61	2583 / 2642	100%	53.23	705 / 705
adipose	100%	6343.14	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	97.04	80 / 80
lymph node	0%	0	0 / 0	100%	57.31	29 / 29
spleen	100%	6593.06	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	65.67	45 / 45
ureter	0%	0	0 / 0	100%	38.68	1 / 1
blood vessel	100%	5720.62	1331 / 1335	0%	0	0 / 0
peripheral blood	99%	6452.86	922 / 929	0%	0	0 / 0
muscle	96%	2515.73	770 / 803	0%	0	0 / 0
heart	95%	3244.14	818 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006465	Biological process	signal peptide processing
GO_0031293	Biological process	membrane protein intracellular domain proteolysis
GO_0001701	Biological process	in utero embryonic development
GO_0033619	Biological process	membrane protein proteolysis
GO_0034599	Biological process	cellular response to oxidative stress
GO_1904211	Biological process	membrane protein proteolysis involved in retrograde protein transport, ER to cytosol
GO_0006509	Biological process	membrane protein ectodomain proteolysis
GO_0005886	Cellular component	plasma membrane
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0098554	Cellular component	cytoplasmic side of endoplasmic reticulum membrane
GO_0009986	Cellular component	cell surface
GO_0005783	Cellular component	endoplasmic reticulum
GO_0098553	Cellular component	lumenal side of endoplasmic reticulum membrane
GO_0036513	Cellular component	Derlin-1 retrotranslocation complex
GO_0005791	Cellular component	rough endoplasmic reticulum
GO_0042803	Molecular function	protein homodimerization activity
GO_0008233	Molecular function	peptidase activity
GO_0042500	Molecular function	aspartic endopeptidase activity, intramembrane cleaving
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	HM13
Protein name	Histocompatibility 13 isoform 1 Minor histocompatibility antigen H13 (EC 3.4.23.-) (Intramembrane protease 1) (IMP-1) (IMPAS-1) (hIMP1) (Presenilin-like protein 3) (Signal peptide peptidase) Histocompatibility 13 isoform 2 (Histocompatibility minor 13) Histocompatibility minor 13
Synonyms	SPP PSL3 H13 MSTP086 IMP1
Description	FUNCTION: Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides . May be necessary for the removal of the signal peptide that remains attached to the hepatitis C virus core protein after the initial proteolytic processing of the polyprotein . Involved in the intramembrane cleavage of the integral membrane protein PSEN1 . Cleaves the integral membrane protein XBP1 isoform 1 in a DERL1/RNF139-dependent manner . May play a role in graft rejection (By similarity). .
Accessions	ENST00000398174.9 [Q8TCT9-2] ENST00000649374.1 ENST00000619859.1 ENST00000340852.9 [Q8TCT9-1] A0A0C4DGU3 ENST00000498035.5 ENST00000649820.1 A0A3B3IT72 Q8TCT9 ENST00000650367.1 ENST00000466766.2 A0A3B3IUB5 ENST00000674240.1 [Q8TCT9-4] A0A0S2Z5V7 ENST00000344042.5 A0A087WVH6 A0A0S2Z6F0 A0A075B6F6

HM13 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review