ELOC report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0140958Biological processtarget-directed miRNA degradation
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0006367Biological processtranscription initiation at RNA polymerase II promoter
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0031466Cellular componentCul5-RING ubiquitin ligase complex
GO_0070449Cellular componentelongin complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0031462Cellular componentCul2-RING ubiquitin ligase complex
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0001222Molecular functiontranscription corepressor binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameELOC
Protein nameElongin-C
Elongin-C (EloC) (Elongin 15 kDa subunit) (RNA polymerase II transcription factor SIII subunit C) (SIII p15) (Transcription elongation factor B polypeptide 1)
Elongin C
SynonymsTCEB1
DescriptionFUNCTION: SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) . In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity). .; FUNCTION: Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins . This includes the von Hippel-Lindau ubiquitination complex CBC(VHL) . By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes . As part of a multisubunit ubiquitin ligase complex composed of elongin BC complex (ELOB and ELOC), elongin A/ELOA, RBX1 and CUL5; polyubiquitinates monoubiquitinated POLR2A . A number of ECS complexes (containing either KLHDC2, KLHDC3, KLHDC10, APPBP2, FEM1A, FEM1B or FEM1C as substrate-recognition component) are part of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation . ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase (By similarity). .

AccessionsA0A8I5KYG1
ENST00000518127.5 [Q15369-1]
ENST00000522337.5 [Q15369-1]
Q15369
R4GMY8
ENST00000602840.5
ENST00000523815.5 [Q15369-1]
ENST00000622804.2 [Q15369-1]
ENST00000687224.1 [Q15369-1]
ENST00000520210.1 [Q15369-2]
ENST00000284811.12 [Q15369-1]
ENST00000688584.1 [Q15369-2]
ENST00000685938.1
A0A8J9AD82
ENST00000519487.6
E5RHG8
ENST00000519082.5
ENST00000520242.6 [Q15369-1]