EIF5A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045901Biological processpositive regulation of translational elongation
GO_1902255Biological processpositive regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO_0045905Biological processpositive regulation of translational termination
GO_0006414Biological processtranslational elongation
GO_0098586Biological processcellular response to virus
GO_0033209Biological processtumor necrosis factor-mediated signaling pathway
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005643Cellular componentnuclear pore
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005642Cellular componentannulate lamellae
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0043022Molecular functionribosome binding
GO_0017070Molecular functionU6 snRNA binding
GO_0003723Molecular functionRNA binding
GO_0003746Molecular functiontranslation elongation factor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameEIF5A
Protein nameUORF
Eukaryotic translation initiation factor 5A-1 (Eukaryotic initiation factor 5A isoform 1) (eIF-4D)
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (eIF-5A1) (Eukaryotic initiation factor 5A isoform 1) (eIF-5A) (Rev-binding factor) (eIF-4D)
Eukaryotic translation initiation factor 5A (eIF-5A)
SynonymsEIF5A1
DescriptionFUNCTION: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts . Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome (By similarity). Acts as a ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step (By similarity). Also involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity . With syntenin SDCBP, functions as a regulator of p53/TP53 and p53/TP53-dependent apoptosis . Regulates also TNF-alpha-mediated apoptosis . Mediates effects of polyamines on neuronal process extension and survival . Is required for autophagy by assisting the ribosome in translating the ATG3 protein at a specific amino acid sequence, the 'ASP-ASP-Gly' motif, leading to the increase of the efficiency of ATG3 translation and facilitation of LC3B lipidation and autophagosome formation . .; FUNCTION: (Microbial infection) Cellular cofactor of human T-cell leukemia virus type I (HTLV-1) Rex protein and of human immunodeficiency virus type 1 (HIV-1) Rev protein, essential for mRNA export of retroviral transcripts. .

FUNCTION: Translation factor that promotes translation elongation and termination, particularly upon ribosome stalling at specific amino acid sequence contexts. Binds between the exit (E) and peptidyl (P) site of the ribosome and promotes rescue of stalled ribosome: specifically required for efficient translation of polyproline-containing peptides as well as other motifs that stall the ribosome. Acts as ribosome quality control (RQC) cofactor by joining the RQC complex to facilitate peptidyl transfer during CAT tailing step. .

AccessionsENST00000673210.1 [P63241-1]
ENST00000673304.1 [P63241-1]
ENST00000672765.1 [P63241-2]
I3L504
ENST00000419711.6 [P63241-1]
ENST00000672755.1 [P63241-1]
P63241
ENST00000573542.5 [P63241-1]
ENST00000416016.2 [P63241-1]
I3L397
ENST00000672250.1 [P63241-1]
ENST00000572815.5
ENST00000673099.1 [P63241-1]
ENST00000673259.1 [P63241-1]
ENST00000571955.5 [P63241-1]
ENST00000336452.11 [P63241-2]
ENST00000336458.13 [P63241-1]
Q8WXQ9
ENST00000576930.5 [P63241-1]
ENST00000573714.5