EIF4B | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	40 studies	37% ± 14%	Explore
B cell	39 studies	45% ± 16%	Explore
fibroblast	37 studies	37% ± 15%	Explore
natural killer cell	35 studies	35% ± 12%	Explore
macrophage	33 studies	31% ± 10%	Explore
CD8-positive, alpha-beta T cell	33 studies	40% ± 16%	Explore
CD4-positive, alpha-beta T cell	33 studies	46% ± 17%	Explore
T cell	32 studies	37% ± 16%	Explore
conventional dendritic cell	28 studies	47% ± 18%	Explore
pericyte	27 studies	38% ± 15%	Explore
smooth muscle cell	27 studies	39% ± 16%	Explore
regulatory T cell	26 studies	49% ± 14%	Explore
classical monocyte	25 studies	38% ± 16%	Explore
dendritic cell	23 studies	41% ± 23%	Explore
non-classical monocyte	23 studies	38% ± 15%	Explore
basal cell	21 studies	42% ± 16%	Explore
mast cell	20 studies	36% ± 15%	Explore
mature NK T cell	20 studies	36% ± 12%	Explore
memory B cell	20 studies	58% ± 11%	Explore
naive B cell	20 studies	48% ± 11%	Explore
plasmacytoid dendritic cell	20 studies	48% ± 15%	Explore
monocyte	19 studies	32% ± 13%	Explore
gamma-delta T cell	19 studies	46% ± 14%	Explore
plasma cell	18 studies	40% ± 14%	Explore
epithelial cell	18 studies	44% ± 21%	Explore
endothelial cell of lymphatic vessel	17 studies	40% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	59% ± 17%	Explore
connective tissue cell	17 studies	39% ± 12%	Explore
mucosal invariant T cell	15 studies	51% ± 18%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	60% ± 15%	Explore
ciliated cell	15 studies	35% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	14 studies	44% ± 12%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	44% ± 10%	Explore
myofibroblast cell	14 studies	42% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	47% ± 15%	Explore
CD4-positive, alpha-beta memory T cell	12 studies	49% ± 17%	Explore
vein endothelial cell	12 studies	39% ± 11%	Explore
endothelial cell of vascular tree	12 studies	42% ± 14%	Explore
myeloid cell	12 studies	35% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	49% ± 15%	Explore
secretory cell	11 studies	36% ± 15%	Explore
club cell	10 studies	32% ± 16%	Explore
capillary endothelial cell	10 studies	29% ± 13%	Explore
abnormal cell	10 studies	47% ± 17%	Explore
endothelial cell of artery	10 studies	30% ± 8%	Explore
mesothelial cell	10 studies	40% ± 19%	Explore
type II pneumocyte	9 studies	42% ± 18%	Explore
plasmablast	9 studies	51% ± 18%	Explore
leukocyte	9 studies	35% ± 10%	Explore
progenitor cell	9 studies	46% ± 15%	Explore
goblet cell	9 studies	34% ± 15%	Explore
innate lymphoid cell	8 studies	36% ± 11%	Explore
T follicular helper cell	8 studies	54% ± 11%	Explore
alveolar macrophage	7 studies	33% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	39% ± 11%	Explore
neuron	7 studies	38% ± 17%	Explore
microglial cell	7 studies	25% ± 8%	Explore
hematopoietic stem cell	7 studies	74% ± 11%	Explore
precursor B cell	7 studies	45% ± 17%	Explore
astrocyte	7 studies	22% ± 5%	Explore
oligodendrocyte precursor cell	7 studies	29% ± 10%	Explore
type I pneumocyte	6 studies	39% ± 16%	Explore
hematopoietic precursor cell	6 studies	57% ± 25%	Explore
platelet	6 studies	24% ± 5%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	45% ± 11%	Explore
mononuclear phagocyte	6 studies	38% ± 16%	Explore
epithelial cell of proximal tubule	6 studies	34% ± 13%	Explore
renal alpha-intercalated cell	6 studies	47% ± 4%	Explore
immature B cell	6 studies	44% ± 13%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	55% ± 17%	Explore
interneuron	6 studies	27% ± 16%	Explore
oligodendrocyte	6 studies	21% ± 5%	Explore
CD4-positive helper T cell	5 studies	36% ± 12%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	56% ± 14%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	42% ± 12%	Explore
respiratory goblet cell	5 studies	29% ± 17%	Explore
kidney loop of Henle epithelial cell	5 studies	30% ± 4%	Explore
enteroendocrine cell	5 studies	40% ± 13%	Explore
intestinal crypt stem cell	5 studies	41% ± 12%	Explore
IgA plasma cell	5 studies	27% ± 5%	Explore
IgG plasma cell	5 studies	24% ± 5%	Explore
transit amplifying cell	5 studies	35% ± 9%	Explore
lymphocyte	5 studies	36% ± 12%	Explore
pro-B cell	5 studies	43% ± 21%	Explore
hepatocyte	5 studies	42% ± 26%	Explore
granulocyte	5 studies	39% ± 9%	Explore
GABAergic neuron	5 studies	32% ± 14%	Explore
glutamatergic neuron	5 studies	39% ± 17%	Explore
duct epithelial cell	4 studies	29% ± 6%	Explore
pancreatic A cell	4 studies	57% ± 21%	Explore
type B pancreatic cell	4 studies	58% ± 24%	Explore
exhausted T cell	4 studies	47% ± 9%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	50% ± 11%	Explore
enterocyte	4 studies	29% ± 5%	Explore
retinal ganglion cell	4 studies	64% ± 26%	Explore
erythroblast	4 studies	58% ± 27%	Explore
brush cell	4 studies	33% ± 25%	Explore
amacrine cell	4 studies	30% ± 9%	Explore
retina horizontal cell	4 studies	25% ± 8%	Explore
retinal rod cell	4 studies	23% ± 7%	Explore
adventitial cell	4 studies	22% ± 5%	Explore
Mueller cell	4 studies	23% ± 5%	Explore
acinar cell	4 studies	60% ± 30%	Explore
intermediate monocyte	4 studies	47% ± 26%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	54% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	65% ± 27%	Explore
erythrocyte	4 studies	56% ± 19%	Explore
T-helper 17 cell	4 studies	41% ± 9%	Explore
double negative thymocyte	4 studies	59% ± 5%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	37% ± 9%	Explore
hillock cell	3 studies	24% ± 6%	Explore
ionocyte	3 studies	35% ± 8%	Explore
precursor cell	3 studies	51% ± 8%	Explore
pancreatic D cell	3 studies	54% ± 28%	Explore
monocyte-derived dendritic cell	3 studies	39% ± 21%	Explore
glomerular endothelial cell	3 studies	25% ± 3%	Explore
neural crest cell	3 studies	52% ± 5%	Explore
retinal bipolar neuron	3 studies	33% ± 9%	Explore
thymocyte	3 studies	33% ± 14%	Explore
extravillous trophoblast	3 studies	54% ± 11%	Explore
placental villous trophoblast	3 studies	39% ± 8%	Explore
common myeloid progenitor	3 studies	49% ± 27%	Explore
megakaryocyte	3 studies	27% ± 5%	Explore
neuroendocrine cell	3 studies	43% ± 19%	Explore
retinal cone cell	3 studies	36% ± 6%	Explore
retinal pigment epithelial cell	3 studies	48% ± 22%	Explore
mucus secreting cell	3 studies	45% ± 12%	Explore
serous secreting cell	3 studies	47% ± 0%	Explore
adipocyte	3 studies	21% ± 4%	Explore
tissue-resident macrophage	3 studies	29% ± 14%	Explore
germinal center B cell	3 studies	58% ± 7%	Explore
myoepithelial cell	3 studies	44% ± 5%	Explore
luminal cell of prostate epithelium	3 studies	30% ± 8%	Explore
muscle cell	3 studies	36% ± 8%	Explore
pancreatic ductal cell	3 studies	61% ± 23%	Explore
granulocyte monocyte progenitor cell	3 studies	39% ± 12%	Explore
neutrophil	3 studies	19% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	57% ± 12%	Explore
keratinocyte	3 studies	41% ± 7%	Explore
T-helper 1 cell	3 studies	52% ± 16%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	66% ± 4%	Explore
double-positive, alpha-beta thymocyte	3 studies	68% ± 9%	Explore
progenitor cell of mammary luminal epithelium	3 studies	59% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	49% ± 13%	Explore
lung	17 studies	38% ± 13%	Explore
intestine	11 studies	35% ± 15%	Explore
brain	10 studies	29% ± 10%	Explore
kidney	8 studies	36% ± 9%	Explore
eye	8 studies	29% ± 10%	Explore
liver	7 studies	35% ± 16%	Explore
lymph node	6 studies	46% ± 14%	Explore
uterus	5 studies	44% ± 20%	Explore
pancreas	4 studies	58% ± 21%	Explore
placenta	4 studies	34% ± 11%	Explore
bone marrow	4 studies	47% ± 20%	Explore
breast	4 studies	44% ± 6%	Explore
prostate	3 studies	30% ± 7%	Explore
adipose	3 studies	27% ± 12%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	24211.24	459 / 459	100%	208.55	1118 / 1118
intestine	100%	19796.17	966 / 966	100%	182.81	527 / 527
ovary	100%	42716.91	180 / 180	100%	162.42	430 / 430
pancreas	100%	20144.20	328 / 328	100%	152.04	178 / 178
prostate	100%	16898.75	245 / 245	100%	247.51	502 / 502
esophagus	100%	17116.57	1444 / 1445	100%	138.33	183 / 183
skin	100%	26270.12	1809 / 1809	100%	215.19	471 / 472
thymus	100%	18750.62	653 / 653	100%	238.92	603 / 605
lung	100%	15842.44	576 / 578	100%	155.09	1155 / 1155
stomach	100%	17184.62	359 / 359	100%	158.43	285 / 286
kidney	100%	15227.26	89 / 89	99%	214.41	894 / 901
bladder	100%	20680.57	21 / 21	99%	138.64	500 / 504
uterus	100%	26166.68	170 / 170	99%	138.11	454 / 459
adrenal gland	100%	19661.58	258 / 258	98%	137.48	226 / 230
brain	98%	9514.35	2588 / 2642	100%	153.51	705 / 705
liver	96%	6636.72	218 / 226	98%	109.06	397 / 406
adipose	100%	23195.45	1204 / 1204	0%	0	0 / 0
blood vessel	100%	19373.18	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	370.52	80 / 80
lymph node	0%	0	0 / 0	100%	228.43	29 / 29
muscle	100%	31301.28	803 / 803	0%	0	0 / 0
spleen	100%	15805.92	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	142.55	45 / 45
ureter	0%	0	0 / 0	100%	56.90	1 / 1
peripheral blood	95%	16358.71	879 / 929	0%	0	0 / 0
heart	92%	10527.70	792 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	EIF4B
Protein name	Eukaryotic translation initiation factor 4B (eIF-4B) Alternative protein EIF4B eIF4B protein Eukaryotic translation initiation factor 4B
Synonyms
Description	FUNCTION: Required for the binding of mRNA to ribosomes. Functions in close association with EIF4-F and EIF4-A. Binds near the 5'-terminal cap of mRNA in presence of EIF-4F and ATP. Promotes the ATPase activity and the ATP-dependent RNA unwinding activity of both EIF4-A and EIF4-F.
Accessions	F8VRU1 ENST00000552490.5 ENST00000420463.7 ENST00000549481.5 ENST00000416762.7 [P23588-2] ENST00000549077.5 F8VYE9 F8VX11 E7EX17 ENST00000262056.14 [P23588-1] P23588 F8VSC7 F8W0K0 Q7Z5Y0 ENST00000551002.5 L8EC87 ENST00000550704.5 F8VP89 ENST00000550390.1

GO_0006446	Biological process	regulation of translational initiation
GO_0006413	Biological process	translational initiation
GO_0005829	Cellular component	cytosol
GO_0016281	Cellular component	eukaryotic translation initiation factor 4F complex
GO_0003743	Molecular function	translation initiation factor activity
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

EIF4B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review