DHX36 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_2000767Biological processpositive regulation of cytoplasmic translation
GO_0007283Biological processspermatogenesis
GO_0045995Biological processregulation of embryonic development
GO_1903843Biological processcellular response to arsenite ion
GO_0043488Biological processregulation of mRNA stability
GO_0034605Biological processcellular response to heat
GO_0061003Biological processpositive regulation of dendritic spine morphogenesis
GO_0034644Biological processcellular response to UV
GO_0045087Biological processinnate immune response
GO_0002735Biological processpositive regulation of myeloid dendritic cell cytokine production
GO_0031442Biological processpositive regulation of mRNA 3'-end processing
GO_0043330Biological processresponse to exogenous dsRNA
GO_0051607Biological processdefense response to virus
GO_0010628Biological processpositive regulation of gene expression
GO_0051891Biological processpositive regulation of cardioblast differentiation
GO_0032727Biological processpositive regulation of interferon-alpha production
GO_0061158Biological process3'-UTR-mediated mRNA destabilization
GO_1901534Biological processpositive regulation of hematopoietic progenitor cell differentiation
GO_1900153Biological processpositive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO_0060261Biological processpositive regulation of transcription initiation by RNA polymerase II
GO_1904582Biological processpositive regulation of intracellular mRNA localization
GO_0044806Biological processG-quadruplex DNA unwinding
GO_0030154Biological processcell differentiation
GO_0032206Biological processpositive regulation of telomere maintenance
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_1904358Biological processpositive regulation of telomere maintenance via telomere lengthening
GO_0001503Biological processossification
GO_0006359Biological processregulation of transcription by RNA polymerase III
GO_0090669Biological processtelomerase RNA stabilization
GO_0010501Biological processRNA secondary structure unwinding
GO_0017148Biological processnegative regulation of translation
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005622Cellular componentintracellular anatomical structure
GO_0005739Cellular componentmitochondrion
GO_0016607Cellular componentnuclear speck
GO_0043204Cellular componentperikaryon
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0000781Cellular componentchromosome, telomeric region
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0048027Molecular functionmRNA 5'-UTR binding
GO_0003724Molecular functionRNA helicase activity
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0070883Molecular functionpre-miRNA binding
GO_0000287Molecular functionmagnesium ion binding
GO_0051880Molecular functionG-quadruplex DNA binding
GO_0003678Molecular functionDNA helicase activity
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0003725Molecular functiondouble-stranded RNA binding
GO_0070034Molecular functiontelomerase RNA binding
GO_0008094Molecular functionATP-dependent activity, acting on DNA
GO_0002151Molecular functionG-quadruplex RNA binding
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameDHX36
Protein nameATP-dependent DNA/RNA helicase DHX36 (EC 3.6.4.12) (EC 3.6.4.13) (DEAD/H box polypeptide 36) (DEAH-box protein 36) (G4-resolvase-1) (G4R1) (MLE-like protein 1) (RNA helicase associated with AU-rich element protein)
ATP-dependent DNA/RNA helicase DHX36
RNA helicase (EC 3.6.4.13)
SynonymsRHAU
DDX36
MLEL1
KIAA1488
DescriptionFUNCTION: Multifunctional ATP-dependent helicase that unwinds G-quadruplex (G4) structures . Plays a role in many biological processes such as genomic integrity, gene expression regulations and as a sensor to initiate antiviral responses . G4 structures correspond to helical structures containing guanine tetrads (By similarity). Binds with high affinity to and unwinds G4 structures that are formed in nucleic acids (G4-ADN and G4-RNA) . Plays a role in genomic integrity . Converts the G4-RNA structure present in telomerase RNA template component (TREC) into a double-stranded RNA to promote P1 helix formation that acts as a template boundary ensuring accurate reverse transcription . Plays a role in transcriptional regulation . Resolves G4-DNA structures in promoters of genes, such as YY1, KIT/c-kit and ALPL and positively regulates their expression . Plays a role in post-transcriptional regulation . Unwinds a G4-RNA structure located in the 3'-UTR polyadenylation site of the pre-mRNA TP53 and stimulates TP53 pre-mRNA 3'-end processing in response to ultraviolet (UV)-induced DNA damage . Binds to the precursor-microRNA-134 (pre-miR-134) terminal loop and regulates its transport into the synapto-dendritic compartment (By similarity). Involved in the pre-miR-134-dependent inhibition of target gene expression and the control of dendritic spine size (By similarity). Plays a role in the regulation of cytoplasmic mRNA translation and mRNA stability . Binds to both G4-RNA structures and alternative non-quadruplex-forming sequence within the 3'-UTR of the PITX1 mRNA regulating negatively PITX1 protein expression . Binds to both G4-RNA structure in the 5'-UTR and AU-rich elements (AREs) localized in the 3'-UTR of NKX2-5 mRNA to either stimulate protein translation or induce mRNA decay in an ELAVL1-dependent manner, respectively . Binds also to ARE sequences present in several mRNAs mediating exosome-mediated 3'-5' mRNA degradation . Involved in cytoplasmic urokinase-type plasminogen activator (uPA) mRNA decay . Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of pro-inflammatory cytokines via the adapter molecule TICAM1 (By similarity). Required for early embryonic development and hematopoiesis. Involved in the regulation of cardioblast differentiation and proliferation during heart development. Involved in spermatogonia differentiation. May play a role in ossification (By similarity). .

AccessionsENST00000627269.2
H7C514
ENST00000329463.9 [Q9H2U1-2]
ENST00000308361.10 [Q9H2U1-3]
A0A0G2JRP3
ENST00000479934.5
ENST00000629736.2
ENST00000481941.5
H7C5F5
A0A0G2JQU7
ENST00000469977.1
E7EWK3
ENST00000626678.1
Q9H2U1
ENST00000496811.6 [Q9H2U1-1]
ENST00000630672.2