COPS9 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	34 studies	36% ± 10%	Explore
CD8-positive, alpha-beta T cell	33 studies	33% ± 10%	Explore
fibroblast	32 studies	35% ± 15%	Explore
endothelial cell	30 studies	39% ± 16%	Explore
B cell	28 studies	27% ± 9%	Explore
macrophage	28 studies	35% ± 14%	Explore
CD4-positive, alpha-beta T cell	28 studies	32% ± 8%	Explore
T cell	27 studies	33% ± 11%	Explore
conventional dendritic cell	25 studies	37% ± 14%	Explore
classical monocyte	23 studies	39% ± 13%	Explore
smooth muscle cell	22 studies	37% ± 12%	Explore
non-classical monocyte	21 studies	36% ± 14%	Explore
regulatory T cell	21 studies	32% ± 7%	Explore
epithelial cell	19 studies	40% ± 21%	Explore
pericyte	19 studies	37% ± 12%	Explore
monocyte	17 studies	38% ± 11%	Explore
basal cell	17 studies	36% ± 18%	Explore
plasmacytoid dendritic cell	17 studies	30% ± 11%	Explore
mature NK T cell	17 studies	35% ± 8%	Explore
dendritic cell	16 studies	37% ± 24%	Explore
plasma cell	16 studies	36% ± 14%	Explore
mast cell	15 studies	27% ± 13%	Explore
endothelial cell of lymphatic vessel	15 studies	45% ± 13%	Explore
ciliated cell	15 studies	48% ± 18%	Explore
connective tissue cell	15 studies	40% ± 14%	Explore
gamma-delta T cell	15 studies	37% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	29% ± 8%	Explore
naive B cell	13 studies	22% ± 6%	Explore
memory B cell	13 studies	24% ± 5%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	36% ± 10%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	12 studies	34% ± 10%	Explore
myofibroblast cell	12 studies	38% ± 15%	Explore
mucosal invariant T cell	12 studies	29% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	34% ± 8%	Explore
capillary endothelial cell	11 studies	29% ± 9%	Explore
plasmablast	10 studies	43% ± 20%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	36% ± 11%	Explore
secretory cell	10 studies	31% ± 14%	Explore
vein endothelial cell	10 studies	35% ± 13%	Explore
endothelial cell of vascular tree	10 studies	29% ± 7%	Explore
myeloid cell	10 studies	35% ± 16%	Explore
progenitor cell	9 studies	40% ± 16%	Explore
abnormal cell	9 studies	34% ± 15%	Explore
endothelial cell of artery	9 studies	33% ± 14%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	31% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	35% ± 12%	Explore
goblet cell	8 studies	34% ± 17%	Explore
type I pneumocyte	7 studies	31% ± 14%	Explore
club cell	7 studies	38% ± 10%	Explore
epithelial cell of proximal tubule	7 studies	39% ± 14%	Explore
enterocyte	7 studies	23% ± 7%	Explore
T follicular helper cell	7 studies	34% ± 11%	Explore
astrocyte	7 studies	33% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	43% ± 9%	Explore
leukocyte	6 studies	39% ± 12%	Explore
kidney loop of Henle epithelial cell	6 studies	42% ± 7%	Explore
renal alpha-intercalated cell	6 studies	51% ± 10%	Explore
mesothelial cell	6 studies	46% ± 19%	Explore
neuron	6 studies	44% ± 18%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	34% ± 14%	Explore
hematopoietic precursor cell	5 studies	38% ± 18%	Explore
ionocyte	5 studies	29% ± 10%	Explore
respiratory goblet cell	5 studies	30% ± 17%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	34% ± 11%	Explore
mononuclear phagocyte	5 studies	42% ± 15%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	53% ± 7%	Explore
transit amplifying cell	5 studies	30% ± 14%	Explore
innate lymphoid cell	5 studies	31% ± 1%	Explore
type II pneumocyte	5 studies	41% ± 18%	Explore
erythrocyte	5 studies	30% ± 16%	Explore
intermediate monocyte	5 studies	51% ± 17%	Explore
alveolar macrophage	4 studies	34% ± 5%	Explore
deuterosomal cell	4 studies	35% ± 10%	Explore
exhausted T cell	4 studies	46% ± 13%	Explore
enteroendocrine cell	4 studies	53% ± 13%	Explore
IgG plasma cell	4 studies	22% ± 3%	Explore
retinal ganglion cell	4 studies	65% ± 26%	Explore
retinal cone cell	4 studies	60% ± 30%	Explore
erythroblast	4 studies	37% ± 22%	Explore
pro-B cell	4 studies	27% ± 4%	Explore
precursor B cell	4 studies	33% ± 15%	Explore
amacrine cell	4 studies	48% ± 22%	Explore
retina horizontal cell	4 studies	42% ± 21%	Explore
microglial cell	4 studies	31% ± 13%	Explore
CD4-positive helper T cell	4 studies	27% ± 6%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	56% ± 12%	Explore
neutrophil	4 studies	19% ± 4%	Explore
duct epithelial cell	3 studies	28% ± 1%	Explore
pancreatic A cell	3 studies	58% ± 5%	Explore
type B pancreatic cell	3 studies	57% ± 11%	Explore
glomerular endothelial cell	3 studies	27% ± 6%	Explore
podocyte	3 studies	47% ± 8%	Explore
intestinal crypt stem cell	3 studies	32% ± 10%	Explore
neural crest cell	3 studies	46% ± 8%	Explore
retinal bipolar neuron	3 studies	48% ± 23%	Explore
ON-bipolar cell	3 studies	45% ± 28%	Explore
lymphocyte	3 studies	47% ± 12%	Explore
brush cell	3 studies	33% ± 17%	Explore
neuroendocrine cell	3 studies	58% ± 20%	Explore
immature B cell	3 studies	22% ± 4%	Explore
retinal pigment epithelial cell	3 studies	49% ± 28%	Explore
retinal rod cell	3 studies	45% ± 13%	Explore
adventitial cell	3 studies	25% ± 6%	Explore
intraepithelial lymphocyte	3 studies	38% ± 11%	Explore
Mueller cell	3 studies	42% ± 11%	Explore
acinar cell	3 studies	31% ± 12%	Explore
oligodendrocyte	3 studies	34% ± 7%	Explore
germinal center B cell	3 studies	33% ± 4%	Explore
myoepithelial cell	3 studies	31% ± 7%	Explore
luminal cell of prostate epithelium	3 studies	34% ± 9%	Explore
oligodendrocyte precursor cell	3 studies	40% ± 10%	Explore
granulocyte	3 studies	27% ± 8%	Explore
granulocyte monocyte progenitor cell	3 studies	36% ± 16%	Explore
hematopoietic stem cell	3 studies	27% ± 7%	Explore
glial cell	3 studies	42% ± 24%	Explore
hepatocyte	3 studies	47% ± 26%	Explore
group 3 innate lymphoid cell	3 studies	38% ± 17%	Explore
keratinocyte	3 studies	38% ± 4%	Explore
T-helper 17 cell	3 studies	34% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	31% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	30% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	28% ± 10%	Explore
double negative thymocyte	3 studies	50% ± 19%	Explore
progenitor cell of mammary luminal epithelium	3 studies	29% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	35% ± 13%	Explore
lung	17 studies	38% ± 14%	Explore
intestine	9 studies	34% ± 15%	Explore
kidney	9 studies	35% ± 9%	Explore
eye	8 studies	35% ± 16%	Explore
brain	6 studies	34% ± 6%	Explore
liver	6 studies	38% ± 19%	Explore
pancreas	4 studies	45% ± 19%	Explore
bone marrow	4 studies	26% ± 6%	Explore
uterus	4 studies	46% ± 16%	Explore
lymph node	4 studies	34% ± 10%	Explore
breast	4 studies	35% ± 8%	Explore
placenta	3 studies	28% ± 10%	Explore
adrenal gland	3 studies	33% ± 9%	Explore
prostate	3 studies	23% ± 1%	Explore
skin	3 studies	28% ± 9%	Explore
thymus	3 studies	45% ± 16%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	3702.85	2642 / 2642	100%	93.18	705 / 705
esophagus	100%	1711.65	1445 / 1445	100%	39.87	183 / 183
ovary	100%	1211.21	180 / 180	100%	68.09	430 / 430
stomach	100%	1384.11	359 / 359	100%	51.36	286 / 286
uterus	100%	1241.39	170 / 170	100%	74.32	459 / 459
skin	100%	1688.24	1806 / 1809	100%	57.70	472 / 472
intestine	100%	1572.80	966 / 966	100%	60.34	525 / 527
adrenal gland	100%	1493.97	258 / 258	100%	67.98	229 / 230
kidney	100%	1832.44	89 / 89	100%	40.70	897 / 901
thymus	100%	1538.82	651 / 653	100%	68.22	604 / 605
bladder	100%	1428.14	21 / 21	99%	63.17	501 / 504
pancreas	99%	980.06	326 / 328	100%	56.99	178 / 178
breast	100%	1680.93	459 / 459	99%	81.83	1107 / 1118
prostate	100%	1596.44	244 / 245	99%	73.12	498 / 502
lung	99%	1139.36	571 / 578	100%	51.37	1153 / 1155
liver	91%	576.48	205 / 226	100%	40.61	404 / 406
eye	0%	0	0 / 0	100%	70.12	80 / 80
lymph node	0%	0	0 / 0	100%	103.65	29 / 29
spleen	100%	1348.91	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	54.71	45 / 45
ureter	0%	0	0 / 0	100%	83.96	1 / 1
adipose	100%	1530.57	1202 / 1204	0%	0	0 / 0
blood vessel	100%	1674.23	1329 / 1335	0%	0	0 / 0
muscle	99%	1677.22	796 / 803	0%	0	0 / 0
heart	98%	1758.10	847 / 861	0%	0	0 / 0
peripheral blood	69%	601.95	637 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	COPS9
Protein name	COP9 signalosome complex subunit 9 (CSN acidic protein) (CSNAP) (Myeloma-overexpressed gene 2 protein) COP9 signalosome subunit 9
Synonyms	MYEOV2
Description	FUNCTION: [Isoform 1]: Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Plays a role in cell proliferation. .; FUNCTION: [Isoform 2]: Negatively regulates neddylation of proteins, including ribosoaml protein RPL11. .
Accessions	ENST00000607357.2 [Q8WXC6-2] Q8WXC6 ENST00000307266.7 [Q8WXC6-1] J3QT29 ENST00000403160.4

GO_0008284	Biological process	positive regulation of cell population proliferation
GO_0034644	Biological process	cellular response to UV
GO_2000435	Biological process	negative regulation of protein neddylation
GO_0005654	Cellular component	nucleoplasm
GO_0000785	Cellular component	chromatin
GO_0008180	Cellular component	COP9 signalosome
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0005515	Molecular function	protein binding

COPS9 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review