CLTA | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	42 studies	51% ± 17%	Explore
endothelial cell	41 studies	46% ± 17%	Explore
fibroblast	39 studies	44% ± 17%	Explore
natural killer cell	32 studies	28% ± 10%	Explore
pericyte	30 studies	45% ± 16%	Explore
B cell	27 studies	27% ± 10%	Explore
T cell	26 studies	30% ± 15%	Explore
smooth muscle cell	26 studies	43% ± 16%	Explore
conventional dendritic cell	26 studies	45% ± 14%	Explore
classical monocyte	25 studies	45% ± 14%	Explore
CD4-positive, alpha-beta T cell	24 studies	30% ± 18%	Explore
endothelial cell of lymphatic vessel	23 studies	50% ± 20%	Explore
non-classical monocyte	23 studies	46% ± 13%	Explore
dendritic cell	22 studies	42% ± 20%	Explore
epithelial cell	22 studies	54% ± 21%	Explore
CD8-positive, alpha-beta T cell	22 studies	33% ± 18%	Explore
monocyte	20 studies	45% ± 13%	Explore
basal cell	20 studies	54% ± 18%	Explore
regulatory T cell	20 studies	35% ± 13%	Explore
plasmacytoid dendritic cell	18 studies	32% ± 11%	Explore
ciliated cell	18 studies	63% ± 20%	Explore
connective tissue cell	18 studies	51% ± 21%	Explore
mast cell	17 studies	27% ± 16%	Explore
myeloid cell	17 studies	44% ± 22%	Explore
memory B cell	15 studies	23% ± 8%	Explore
naive B cell	14 studies	23% ± 6%	Explore
myofibroblast cell	14 studies	51% ± 18%	Explore
gamma-delta T cell	14 studies	26% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	27% ± 9%	Explore
capillary endothelial cell	13 studies	41% ± 16%	Explore
endothelial cell of vascular tree	13 studies	41% ± 12%	Explore
secretory cell	12 studies	52% ± 14%	Explore
mature NK T cell	12 studies	25% ± 7%	Explore
goblet cell	12 studies	40% ± 18%	Explore
vein endothelial cell	12 studies	46% ± 18%	Explore
plasma cell	11 studies	33% ± 14%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	11 studies	21% ± 4%	Explore
endothelial cell of artery	11 studies	46% ± 16%	Explore
type I pneumocyte	10 studies	40% ± 16%	Explore
club cell	10 studies	42% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	25% ± 9%	Explore
progenitor cell	10 studies	57% ± 21%	Explore
abnormal cell	10 studies	47% ± 19%	Explore
mesothelial cell	10 studies	47% ± 28%	Explore
oligodendrocyte	10 studies	31% ± 13%	Explore
type II pneumocyte	9 studies	45% ± 18%	Explore
plasmablast	9 studies	38% ± 23%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	31% ± 13%	Explore
leukocyte	9 studies	37% ± 18%	Explore
glutamatergic neuron	9 studies	35% ± 19%	Explore
mucosal invariant T cell	9 studies	20% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	32% ± 16%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	27% ± 8%	Explore
microglial cell	8 studies	29% ± 12%	Explore
astrocyte	8 studies	33% ± 11%	Explore
oligodendrocyte precursor cell	8 studies	34% ± 16%	Explore
alveolar macrophage	7 studies	50% ± 16%	Explore
GABAergic neuron	7 studies	33% ± 16%	Explore
hematopoietic precursor cell	6 studies	50% ± 22%	Explore
ionocyte	6 studies	40% ± 12%	Explore
respiratory goblet cell	6 studies	50% ± 19%	Explore
platelet	6 studies	21% ± 5%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	38% ± 19%	Explore
mononuclear phagocyte	6 studies	47% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	6 studies	26% ± 7%	Explore
epithelial cell of proximal tubule	6 studies	51% ± 15%	Explore
kidney loop of Henle epithelial cell	6 studies	41% ± 13%	Explore
renal alpha-intercalated cell	6 studies	63% ± 7%	Explore
enterocyte	6 studies	44% ± 15%	Explore
intestinal crypt stem cell	6 studies	41% ± 21%	Explore
transit amplifying cell	6 studies	45% ± 19%	Explore
hematopoietic stem cell	6 studies	38% ± 18%	Explore
precursor B cell	6 studies	37% ± 15%	Explore
innate lymphoid cell	6 studies	24% ± 7%	Explore
neuron	6 studies	65% ± 18%	Explore
T follicular helper cell	6 studies	25% ± 7%	Explore
interneuron	6 studies	33% ± 18%	Explore
enteroendocrine cell	5 studies	56% ± 21%	Explore
retinal ganglion cell	5 studies	68% ± 31%	Explore
erythroblast	5 studies	39% ± 21%	Explore
lymphocyte	5 studies	41% ± 19%	Explore
mucus secreting cell	5 studies	36% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	36% ± 19%	Explore
deuterosomal cell	4 studies	43% ± 10%	Explore
duct epithelial cell	4 studies	44% ± 9%	Explore
squamous epithelial cell	4 studies	49% ± 24%	Explore
pancreatic A cell	4 studies	59% ± 14%	Explore
type B pancreatic cell	4 studies	61% ± 14%	Explore
exhausted T cell	4 studies	46% ± 12%	Explore
glomerular endothelial cell	4 studies	39% ± 8%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	67% ± 20%	Explore
megakaryocyte	4 studies	41% ± 12%	Explore
pro-B cell	4 studies	36% ± 11%	Explore
brush cell	4 studies	36% ± 23%	Explore
immature B cell	4 studies	36% ± 17%	Explore
amacrine cell	4 studies	53% ± 15%	Explore
retina horizontal cell	4 studies	50% ± 17%	Explore
retinal cone cell	4 studies	42% ± 19%	Explore
retinal pigment epithelial cell	4 studies	46% ± 24%	Explore
retinal rod cell	4 studies	34% ± 11%	Explore
adventitial cell	4 studies	37% ± 7%	Explore
adipocyte	4 studies	20% ± 5%	Explore
glial cell	4 studies	41% ± 25%	Explore
erythrocyte	4 studies	44% ± 22%	Explore
muscle cell	4 studies	34% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	45% ± 17%	Explore
intermediate monocyte	4 studies	58% ± 15%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	48% ± 7%	Explore
luminal cell of prostate epithelium	4 studies	29% ± 10%	Explore
granulocyte	4 studies	35% ± 16%	Explore
hepatocyte	4 studies	45% ± 25%	Explore
T-helper 17 cell	4 studies	34% ± 25%	Explore
hillock cell	3 studies	46% ± 22%	Explore
precursor cell	3 studies	68% ± 15%	Explore
pancreatic D cell	3 studies	62% ± 16%	Explore
podocyte	3 studies	67% ± 16%	Explore
neural crest cell	3 studies	63% ± 9%	Explore
retinal bipolar neuron	3 studies	47% ± 15%	Explore
OFF-bipolar cell	3 studies	51% ± 32%	Explore
GABAergic amacrine cell	3 studies	32% ± 14%	Explore
glycinergic amacrine cell	3 studies	26% ± 12%	Explore
extravillous trophoblast	3 studies	73% ± 6%	Explore
placental villous trophoblast	3 studies	94% ± 3%	Explore
neuroendocrine cell	3 studies	58% ± 24%	Explore
Schwann cell	3 studies	47% ± 23%	Explore
serous secreting cell	3 studies	50% ± 6%	Explore
tissue-resident macrophage	3 studies	42% ± 8%	Explore
intraepithelial lymphocyte	3 studies	30% ± 12%	Explore
Mueller cell	3 studies	47% ± 5%	Explore
rod bipolar cell	3 studies	35% ± 14%	Explore
germinal center B cell	3 studies	46% ± 7%	Explore
myoepithelial cell	3 studies	51% ± 9%	Explore
endothelial cell of sinusoid	3 studies	41% ± 19%	Explore
inflammatory macrophage	3 studies	41% ± 12%	Explore
acinar cell	3 studies	33% ± 13%	Explore
pancreatic ductal cell	3 studies	69% ± 2%	Explore
granulocyte monocyte progenitor cell	3 studies	52% ± 25%	Explore
megakaryocyte-erythroid progenitor cell	3 studies	61% ± 31%	Explore
neutrophil	3 studies	28% ± 5%	Explore
group 3 innate lymphoid cell	3 studies	34% ± 18%	Explore
melanocyte	3 studies	35% ± 14%	Explore
keratinocyte	3 studies	39% ± 6%	Explore
T-helper 1 cell	3 studies	36% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	3 studies	17% ± 1%	Explore
progenitor cell of mammary luminal epithelium	3 studies	59% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	48% ± 16%	Explore
peripheral blood	17 studies	30% ± 10%	Explore
brain	14 studies	31% ± 13%	Explore
intestine	10 studies	43% ± 20%	Explore
kidney	8 studies	45% ± 13%	Explore
eye	8 studies	38% ± 12%	Explore
liver	6 studies	38% ± 20%	Explore
adipose	5 studies	21% ± 5%	Explore
lymph node	5 studies	41% ± 20%	Explore
pancreas	4 studies	58% ± 15%	Explore
bone marrow	4 studies	33% ± 19%	Explore
uterus	4 studies	56% ± 15%	Explore
breast	4 studies	46% ± 4%	Explore
prostate	4 studies	30% ± 12%	Explore
placenta	3 studies	78% ± 10%	Explore
adrenal gland	3 studies	30% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6397.34	1445 / 1445	100%	164.94	183 / 183
kidney	100%	8464.04	89 / 89	100%	155.32	901 / 901
lung	100%	6893.60	578 / 578	100%	178.62	1155 / 1155
ovary	100%	8647.82	180 / 180	100%	238.33	430 / 430
prostate	100%	6808.42	245 / 245	100%	207.94	502 / 502
stomach	100%	5581.99	359 / 359	100%	214.67	286 / 286
thymus	100%	7757.64	653 / 653	100%	298.25	605 / 605
uterus	100%	7527.74	170 / 170	100%	217.19	459 / 459
brain	100%	7333.75	2638 / 2642	100%	170.29	705 / 705
intestine	100%	6683.37	966 / 966	100%	246.80	526 / 527
skin	100%	8022.30	1809 / 1809	100%	177.55	471 / 472
pancreas	100%	4126.03	327 / 328	100%	176.86	178 / 178
liver	100%	3556.35	225 / 226	100%	137.41	406 / 406
breast	100%	7617.82	459 / 459	99%	165.63	1112 / 1118
bladder	100%	6771.62	21 / 21	99%	211.19	500 / 504
adrenal gland	100%	7472.07	258 / 258	99%	167.56	228 / 230
adipose	100%	7653.30	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	230.46	80 / 80
lymph node	0%	0	0 / 0	100%	269.16	29 / 29
spleen	100%	6781.16	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	178.28	45 / 45
ureter	0%	0	0 / 0	100%	179.57	1 / 1
blood vessel	100%	7286.46	1334 / 1335	0%	0	0 / 0
heart	98%	2832.67	841 / 861	0%	0	0 / 0
muscle	95%	2290.25	763 / 803	0%	0	0 / 0
peripheral blood	88%	3746.02	820 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006886	Biological process	intracellular protein transport
GO_0051301	Biological process	cell division
GO_0048268	Biological process	clathrin coat assembly
GO_0072583	Biological process	clathrin-dependent endocytosis
GO_0030125	Cellular component	clathrin vesicle coat
GO_0099631	Cellular component	postsynaptic endocytic zone cytoplasmic component
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0016020	Cellular component	membrane
GO_0030118	Cellular component	clathrin coat
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0071439	Cellular component	clathrin complex
GO_0032588	Cellular component	trans-Golgi network membrane
GO_0036020	Cellular component	endolysosome membrane
GO_0030130	Cellular component	clathrin coat of trans-Golgi network vesicle
GO_0098835	Cellular component	presynaptic endocytic zone membrane
GO_0005829	Cellular component	cytosol
GO_0030132	Cellular component	clathrin coat of coated pit
GO_0045334	Cellular component	clathrin-coated endocytic vesicle
GO_0005819	Cellular component	spindle
GO_0044877	Molecular function	protein-containing complex binding
GO_0042277	Molecular function	peptide binding
GO_0032050	Molecular function	clathrin heavy chain binding
GO_0051020	Molecular function	GTPase binding
GO_0005198	Molecular function	structural molecule activity
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	CLTA
Protein name	Clathrin light chain A (Lca) Clathrin light chain A Clathrin light chain
Synonyms
Description	FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. Acts as a component of the TACC3/ch-TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter-microtubule bridge . . FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. . FUNCTION: Clathrin is the major protein of the polyhedral coat of coated pits and vesicles. .
Accessions	P09496 ENST00000396603.6 [P09496-3] F8WF69 ENST00000464497.5 ENST00000470744.5 [P09496-4] ENST00000242285.11 [P09496-1] ENST00000345519.10 [P09496-2] S4R3F6 ENST00000493185.2 ENST00000466396.6 C9J8P9 ENST00000540080.5 [P09496-5]

CLTA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review