CHD2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	35 studies	31% ± 10%	Explore
natural killer cell	31 studies	27% ± 8%	Explore
T cell	28 studies	30% ± 15%	Explore
endothelial cell	28 studies	37% ± 16%	Explore
fibroblast	26 studies	30% ± 14%	Explore
CD8-positive, alpha-beta T cell	26 studies	28% ± 7%	Explore
macrophage	25 studies	31% ± 14%	Explore
CD4-positive, alpha-beta T cell	24 studies	29% ± 8%	Explore
memory B cell	20 studies	29% ± 9%	Explore
regulatory T cell	20 studies	31% ± 9%	Explore
naive B cell	19 studies	31% ± 9%	Explore
astrocyte	19 studies	47% ± 21%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	16 studies	31% ± 10%	Explore
mature NK T cell	16 studies	26% ± 8%	Explore
pericyte	16 studies	29% ± 13%	Explore
gamma-delta T cell	16 studies	31% ± 12%	Explore
smooth muscle cell	16 studies	25% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	30% ± 8%	Explore
ciliated cell	15 studies	29% ± 13%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	32% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	31% ± 10%	Explore
oligodendrocyte	14 studies	37% ± 14%	Explore
oligodendrocyte precursor cell	14 studies	40% ± 20%	Explore
basal cell	14 studies	30% ± 16%	Explore
mast cell	13 studies	29% ± 11%	Explore
plasmacytoid dendritic cell	13 studies	31% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	13 studies	30% ± 12%	Explore
mucosal invariant T cell	13 studies	31% ± 9%	Explore
dendritic cell	12 studies	36% ± 12%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	32% ± 10%	Explore
classical monocyte	12 studies	27% ± 10%	Explore
glutamatergic neuron	12 studies	46% ± 25%	Explore
conventional dendritic cell	12 studies	27% ± 15%	Explore
epithelial cell	12 studies	40% ± 21%	Explore
microglial cell	12 studies	48% ± 16%	Explore
monocyte	10 studies	32% ± 14%	Explore
type I pneumocyte	10 studies	36% ± 16%	Explore
GABAergic neuron	10 studies	46% ± 24%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	30% ± 8%	Explore
endothelial cell of lymphatic vessel	9 studies	30% ± 15%	Explore
type II pneumocyte	9 studies	43% ± 20%	Explore
plasma cell	9 studies	30% ± 11%	Explore
non-classical monocyte	9 studies	28% ± 10%	Explore
myeloid cell	9 studies	36% ± 12%	Explore
adipocyte	9 studies	33% ± 13%	Explore
secretory cell	8 studies	23% ± 6%	Explore
leukocyte	8 studies	34% ± 8%	Explore
neuron	7 studies	40% ± 16%	Explore
interneuron	7 studies	51% ± 23%	Explore
club cell	7 studies	42% ± 15%	Explore
endothelial cell of vascular tree	7 studies	26% ± 11%	Explore
respiratory goblet cell	6 studies	40% ± 16%	Explore
mononuclear phagocyte	6 studies	28% ± 11%	Explore
retinal ganglion cell	6 studies	32% ± 18%	Explore
precursor B cell	6 studies	32% ± 6%	Explore
myofibroblast cell	6 studies	25% ± 10%	Explore
retina horizontal cell	6 studies	34% ± 13%	Explore
retinal cone cell	6 studies	37% ± 13%	Explore
vein endothelial cell	6 studies	28% ± 13%	Explore
T follicular helper cell	6 studies	32% ± 11%	Explore
abnormal cell	6 studies	32% ± 13%	Explore
connective tissue cell	6 studies	26% ± 6%	Explore
goblet cell	6 studies	35% ± 24%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	29% ± 7%	Explore
retinal bipolar neuron	5 studies	29% ± 10%	Explore
pro-B cell	5 studies	24% ± 3%	Explore
capillary endothelial cell	5 studies	20% ± 3%	Explore
immature B cell	5 studies	37% ± 5%	Explore
amacrine cell	5 studies	35% ± 8%	Explore
mesothelial cell	5 studies	36% ± 11%	Explore
Mueller cell	5 studies	42% ± 17%	Explore
retinal rod cell	5 studies	37% ± 13%	Explore
endothelial cell of artery	5 studies	22% ± 5%	Explore
innate lymphoid cell	5 studies	29% ± 4%	Explore
erythrocyte	5 studies	36% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	25% ± 4%	Explore
neutrophil	4 studies	19% ± 3%	Explore
squamous epithelial cell	4 studies	37% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	34% ± 12%	Explore
exhausted T cell	4 studies	28% ± 9%	Explore
plasmablast	4 studies	45% ± 15%	Explore
glial cell	4 studies	29% ± 13%	Explore
granule cell	4 studies	27% ± 5%	Explore
progenitor cell	4 studies	33% ± 8%	Explore
cardiac muscle cell	4 studies	27% ± 10%	Explore
lymphocyte	4 studies	46% ± 7%	Explore
OFF-bipolar cell	4 studies	31% ± 14%	Explore
ON-bipolar cell	4 studies	32% ± 14%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	35% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	25% ± 8%	Explore
hepatocyte	4 studies	57% ± 20%	Explore
granulocyte	4 studies	27% ± 6%	Explore
luminal cell of prostate epithelium	4 studies	28% ± 5%	Explore
muscle cell	4 studies	27% ± 12%	Explore
brush cell	4 studies	27% ± 6%	Explore
hematopoietic precursor cell	3 studies	40% ± 16%	Explore
ionocyte	3 studies	27% ± 5%	Explore
GABAergic interneuron	3 studies	45% ± 3%	Explore
GABAergic amacrine cell	3 studies	39% ± 10%	Explore
glycinergic amacrine cell	3 studies	37% ± 5%	Explore
rod bipolar cell	3 studies	40% ± 15%	Explore
CD4-positive helper T cell	3 studies	37% ± 12%	Explore
retinal pigment epithelial cell	3 studies	45% ± 16%	Explore
pancreatic A cell	3 studies	40% ± 17%	Explore
neural progenitor cell	3 studies	42% ± 11%	Explore
ependymal cell	3 studies	62% ± 14%	Explore
enteroendocrine cell	3 studies	26% ± 6%	Explore
intestinal crypt stem cell	3 studies	19% ± 3%	Explore
adventitial cell	3 studies	26% ± 10%	Explore
alveolar macrophage	3 studies	46% ± 15%	Explore
chondrocyte	3 studies	38% ± 15%	Explore
group 3 innate lymphoid cell	3 studies	43% ± 9%	Explore
transit amplifying cell	3 studies	36% ± 28%	Explore
double negative thymocyte	3 studies	38% ± 12%	Explore
double-positive, alpha-beta thymocyte	3 studies	42% ± 18%	Explore
mural cell	3 studies	44% ± 19%	Explore
mucus secreting cell	3 studies	38% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	40% ± 22%	Explore
lung	14 studies	29% ± 12%	Explore
peripheral blood	14 studies	29% ± 11%	Explore
eye	9 studies	35% ± 15%	Explore
intestine	6 studies	20% ± 6%	Explore
liver	5 studies	31% ± 11%	Explore
bone marrow	4 studies	24% ± 5%	Explore
heart	4 studies	25% ± 11%	Explore
kidney	4 studies	27% ± 6%	Explore
breast	4 studies	20% ± 2%	Explore
adipose	4 studies	29% ± 4%	Explore
uterus	3 studies	29% ± 7%	Explore
prostate	3 studies	25% ± 3%	Explore
lymph node	3 studies	26% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9010.05	1445 / 1445	100%	21.49	183 / 183
prostate	100%	10836.02	245 / 245	100%	21.97	502 / 502
breast	100%	10484.87	459 / 459	100%	22.44	1116 / 1118
thymus	100%	13454.13	653 / 653	100%	26.40	602 / 605
pancreas	100%	4994.57	328 / 328	99%	20.10	176 / 178
lung	100%	14475.54	578 / 578	99%	19.62	1140 / 1155
uterus	100%	10333.68	170 / 170	99%	18.02	453 / 459
bladder	100%	8969.19	21 / 21	99%	15.55	497 / 504
skin	100%	11555.23	1809 / 1809	99%	16.49	465 / 472
brain	100%	7141.42	2638 / 2642	99%	26.19	695 / 705
intestine	100%	10311.14	966 / 966	98%	15.41	518 / 527
stomach	100%	8191.21	359 / 359	98%	15.10	281 / 286
kidney	100%	7008.92	89 / 89	98%	16.33	882 / 901
adrenal gland	100%	7459.89	258 / 258	96%	13.51	220 / 230
ovary	100%	11887.26	180 / 180	95%	11.36	410 / 430
liver	100%	4620.62	226 / 226	83%	7.87	336 / 406
adipose	100%	9707.38	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8807.20	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	15.58	29 / 29
muscle	100%	7057.80	803 / 803	0%	0	0 / 0
spleen	100%	12503.45	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	16.69	45 / 45
ureter	0%	0	0 / 0	100%	9.23	1 / 1
peripheral blood	96%	8161.24	896 / 929	0%	0	0 / 0
heart	96%	4406.97	827 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	94%	12.60	75 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0060218	Biological process	hematopoietic stem cell differentiation
GO_0006974	Biological process	DNA damage response
GO_0010467	Biological process	gene expression
GO_0034728	Biological process	nucleosome organization
GO_0007517	Biological process	muscle organ development
GO_0000785	Cellular component	chromatin
GO_0005634	Cellular component	nucleus
GO_0003677	Molecular function	DNA binding
GO_0140658	Molecular function	ATP-dependent chromatin remodeler activity
GO_0000978	Molecular function	RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0004386	Molecular function	helicase activity
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity
GO_0042393	Molecular function	histone binding
GO_0003682	Molecular function	chromatin binding
GO_0005524	Molecular function	ATP binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	CHD2
Protein name	Chromodomain helicase DNA binding protein 2 (cDNA FLJ53879, highly similar to Chromodomain-helicase-DNA-binding protein 2) DNA helicase (EC 3.6.4.12) Chromodomain helicase DNA binding protein 2 Chromodomain-helicase-DNA-binding protein 2 (CHD-2) (EC 3.6.4.12) (ATP-dependent helicase CHD2)
Synonyms
Description	FUNCTION: DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression (By similarity). .
Accessions	ENST00000420239.7 [O14647-3] ENST00000636881.1 ENST00000637613.1 A0A8V8TQD9 ENST00000394196.9 [O14647-1] A0A0D9SEU0 A0A1B0GTU9 A0A8V8TR03 Q8N677 A0A0D9SGK0 ENST00000627460.1 ENST00000700551.1 A0A0D9SFA3 A0A8V8TQC6 ENST00000628118.2 ENST00000625662.3 A0A0D9SEP7 ENST00000625990.3 ENST00000627622.1 ENST00000625243.1 A0A0D9SF92 ENST00000626782.2 ENST00000625463.1 ENST00000700549.1 O14647 ENST00000629346.2 A0A0D9SEH6 ENST00000700552.1 A0A8V8TPT9 ENST00000630016.1 ENST00000628375.2 ENST00000629104.1 A0A0D9SET4 A0A8V8TRB2 ENST00000637789.1 ENST00000700550.1 A0A0D9SFV4 B7Z3I4 A0A0D9SFV8 A0A1B0GTM9 A0A1B0GU59 ENST00000626874.2 [O14647-2] A0A0D9SGA6

CHD2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review