CCT8 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	32 studies	32% ± 11%	Explore
natural killer cell	30 studies	28% ± 12%	Explore
endothelial cell	27 studies	29% ± 12%	Explore
conventional dendritic cell	27 studies	36% ± 16%	Explore
CD4-positive, alpha-beta T cell	26 studies	35% ± 17%	Explore
CD8-positive, alpha-beta T cell	26 studies	32% ± 16%	Explore
fibroblast	25 studies	30% ± 12%	Explore
T cell	24 studies	30% ± 13%	Explore
smooth muscle cell	24 studies	29% ± 12%	Explore
macrophage	22 studies	25% ± 9%	Explore
classical monocyte	21 studies	26% ± 11%	Explore
regulatory T cell	21 studies	35% ± 13%	Explore
non-classical monocyte	20 studies	30% ± 12%	Explore
basal cell	20 studies	30% ± 17%	Explore
pericyte	20 studies	32% ± 12%	Explore
memory B cell	18 studies	28% ± 10%	Explore
naive B cell	18 studies	25% ± 7%	Explore
plasmacytoid dendritic cell	17 studies	36% ± 11%	Explore
epithelial cell	17 studies	38% ± 21%	Explore
mast cell	15 studies	32% ± 14%	Explore
plasma cell	15 studies	39% ± 17%	Explore
gamma-delta T cell	15 studies	30% ± 16%	Explore
monocyte	14 studies	29% ± 9%	Explore
ciliated cell	14 studies	37% ± 16%	Explore
connective tissue cell	14 studies	36% ± 14%	Explore
endothelial cell of lymphatic vessel	13 studies	29% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	24% ± 7%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	28% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	31% ± 10%	Explore
mature NK T cell	13 studies	26% ± 8%	Explore
dendritic cell	12 studies	41% ± 25%	Explore
myofibroblast cell	11 studies	37% ± 15%	Explore
endothelial cell of vascular tree	11 studies	26% ± 6%	Explore
plasmablast	10 studies	52% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	32% ± 13%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	30% ± 13%	Explore
abnormal cell	10 studies	34% ± 11%	Explore
vein endothelial cell	10 studies	23% ± 9%	Explore
mucosal invariant T cell	10 studies	26% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	30% ± 7%	Explore
progenitor cell	9 studies	46% ± 19%	Explore
secretory cell	8 studies	30% ± 16%	Explore
capillary endothelial cell	8 studies	26% ± 11%	Explore
neuron	8 studies	44% ± 22%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	28% ± 7%	Explore
epithelial cell of proximal tubule	7 studies	26% ± 12%	Explore
endothelial cell of artery	7 studies	22% ± 4%	Explore
hematopoietic stem cell	7 studies	52% ± 12%	Explore
precursor B cell	7 studies	44% ± 14%	Explore
myeloid cell	7 studies	32% ± 11%	Explore
T follicular helper cell	7 studies	25% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	38% ± 18%	Explore
leukocyte	6 studies	33% ± 9%	Explore
goblet cell	6 studies	28% ± 10%	Explore
mesothelial cell	6 studies	52% ± 17%	Explore
innate lymphoid cell	6 studies	27% ± 3%	Explore
erythrocyte	6 studies	38% ± 25%	Explore
hematopoietic precursor cell	5 studies	60% ± 23%	Explore
mononuclear phagocyte	5 studies	32% ± 15%	Explore
intestinal crypt stem cell	5 studies	32% ± 10%	Explore
transit amplifying cell	5 studies	24% ± 4%	Explore
erythroblast	5 studies	52% ± 24%	Explore
pro-B cell	5 studies	49% ± 9%	Explore
immature B cell	5 studies	42% ± 19%	Explore
microglial cell	5 studies	23% ± 6%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	38% ± 14%	Explore
granulocyte	5 studies	30% ± 13%	Explore
type I pneumocyte	4 studies	30% ± 9%	Explore
deuterosomal cell	4 studies	20% ± 2%	Explore
exhausted T cell	4 studies	38% ± 10%	Explore
kidney loop of Henle epithelial cell	4 studies	24% ± 3%	Explore
enterocyte	4 studies	26% ± 12%	Explore
enteroendocrine cell	4 studies	46% ± 14%	Explore
retinal ganglion cell	4 studies	62% ± 27%	Explore
club cell	4 studies	31% ± 4%	Explore
astrocyte	4 studies	20% ± 7%	Explore
retina horizontal cell	4 studies	31% ± 14%	Explore
alveolar macrophage	4 studies	25% ± 3%	Explore
muscle cell	4 studies	27% ± 17%	Explore
germinal center B cell	4 studies	39% ± 12%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	50% ± 10%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	24% ± 4%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	65% ± 17%	Explore
glutamatergic neuron	4 studies	36% ± 15%	Explore
interneuron	4 studies	31% ± 12%	Explore
oligodendrocyte	4 studies	18% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 7%	Explore
oligodendrocyte precursor cell	4 studies	32% ± 16%	Explore
precursor cell	3 studies	58% ± 16%	Explore
pancreatic A cell	3 studies	37% ± 10%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	55% ± 24%	Explore
renal alpha-intercalated cell	3 studies	40% ± 20%	Explore
neural crest cell	3 studies	55% ± 11%	Explore
retinal bipolar neuron	3 studies	30% ± 11%	Explore
extravillous trophoblast	3 studies	37% ± 4%	Explore
placental villous trophoblast	3 studies	56% ± 7%	Explore
common myeloid progenitor	3 studies	38% ± 26%	Explore
lymphocyte	3 studies	35% ± 6%	Explore
type II pneumocyte	3 studies	37% ± 12%	Explore
amacrine cell	3 studies	31% ± 15%	Explore
retinal cone cell	3 studies	32% ± 13%	Explore
retinal rod cell	3 studies	24% ± 9%	Explore
serous secreting cell	3 studies	27% ± 7%	Explore
Mueller cell	3 studies	18% ± 1%	Explore
CD4-positive helper T cell	3 studies	20% ± 4%	Explore
myoepithelial cell	3 studies	31% ± 9%	Explore
granulocyte monocyte progenitor cell	3 studies	48% ± 28%	Explore
group 3 innate lymphoid cell	3 studies	40% ± 18%	Explore
keratinocyte	3 studies	23% ± 1%	Explore
T-helper 17 cell	3 studies	42% ± 26%	Explore
GABAergic neuron	3 studies	34% ± 10%	Explore
T-helper 1 cell	3 studies	40% ± 17%	Explore
double negative thymocyte	3 studies	48% ± 25%	Explore
progenitor cell of mammary luminal epithelium	3 studies	26% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	15 studies	32% ± 15%	Explore
peripheral blood	15 studies	32% ± 10%	Explore
intestine	9 studies	29% ± 14%	Explore
kidney	8 studies	29% ± 11%	Explore
brain	8 studies	23% ± 6%	Explore
eye	7 studies	23% ± 9%	Explore
bone marrow	5 studies	27% ± 6%	Explore
liver	5 studies	35% ± 21%	Explore
lymph node	5 studies	35% ± 11%	Explore
uterus	4 studies	34% ± 16%	Explore
breast	4 studies	23% ± 4%	Explore
pancreas	3 studies	37% ± 13%	Explore
placenta	3 studies	40% ± 10%	Explore
adrenal gland	3 studies	29% ± 12%	Explore
prostate	3 studies	24% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	6676.49	1445 / 1445	100%	118.82	183 / 183
lung	100%	6973.32	578 / 578	100%	151.63	1155 / 1155
ovary	100%	7037.37	180 / 180	100%	138.23	430 / 430
pancreas	100%	5554.29	328 / 328	100%	121.62	178 / 178
prostate	100%	5699.05	245 / 245	100%	163.05	502 / 502
uterus	100%	6383.81	170 / 170	100%	189.31	459 / 459
breast	100%	6870.35	459 / 459	100%	200.54	1117 / 1118
intestine	100%	6318.22	966 / 966	100%	180.15	526 / 527
skin	100%	9449.32	1809 / 1809	100%	204.22	471 / 472
thymus	100%	5557.86	653 / 653	100%	142.70	603 / 605
stomach	100%	5741.20	359 / 359	100%	154.40	285 / 286
bladder	100%	7117.33	21 / 21	100%	187.72	502 / 504
adrenal gland	100%	10958.22	258 / 258	100%	153.82	229 / 230
kidney	100%	5791.70	89 / 89	99%	121.41	895 / 901
liver	100%	3850.69	225 / 226	100%	90.19	404 / 406
brain	98%	5062.69	2596 / 2642	100%	113.29	705 / 705
adipose	100%	7077.99	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8368.35	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	174.44	80 / 80
lymph node	0%	0	0 / 0	100%	300.25	29 / 29
muscle	100%	7228.54	803 / 803	0%	0	0 / 0
spleen	100%	7426.07	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	166.15	45 / 45
ureter	0%	0	0 / 0	100%	118.75	1 / 1
heart	96%	5830.98	826 / 861	0%	0	0 / 0
peripheral blood	92%	8418.71	859 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007339	Biological process	binding of sperm to zona pellucida
GO_1904871	Biological process	positive regulation of protein localization to Cajal body
GO_0061077	Biological process	chaperone-mediated protein folding
GO_1904874	Biological process	positive regulation of telomerase RNA localization to Cajal body
GO_1904851	Biological process	positive regulation of establishment of protein localization to telomere
GO_0006457	Biological process	protein folding
GO_0050821	Biological process	protein stabilization
GO_0032212	Biological process	positive regulation of telomere maintenance via telomerase
GO_0035578	Cellular component	azurophil granule lumen
GO_0005576	Cellular component	extracellular region
GO_0005874	Cellular component	microtubule
GO_0005832	Cellular component	chaperonin-containing T-complex
GO_0002199	Cellular component	zona pellucida receptor complex
GO_0005813	Cellular component	centrosome
GO_0070062	Cellular component	extracellular exosome
GO_0005654	Cellular component	nucleoplasm
GO_0034774	Cellular component	secretory granule lumen
GO_0045111	Cellular component	intermediate filament cytoskeleton
GO_1904813	Cellular component	ficolin-1-rich granule lumen
GO_0005929	Cellular component	cilium
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0044297	Cellular component	cell body
GO_0044183	Molecular function	protein folding chaperone
GO_0045296	Molecular function	cadherin binding
GO_0051082	Molecular function	unfolded protein binding
GO_0140662	Molecular function	ATP-dependent protein folding chaperone
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0016887	Molecular function	ATP hydrolysis activity

IV. Literature review

[source]

Gene name	CCT8
Protein name	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15) T-complex protein 1 subunit theta (CCT-theta) Chaperonin containing TCP1 subunit 8
Synonyms	KIAA0002 CCTQ hCG_1810843 C21orf112
Description	FUNCTION: Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis . The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance . As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia . The TRiC complex plays a role in the folding of actin and tubulin (Probable). .
Accessions	ENST00000286788.9 [P50990-1] ENST00000707892.1 [P50990-3] ENST00000626972.2 [P50990-2] H7C4C8 ENST00000707884.1 [P50990-1] ENST00000432178.5 ENST00000540844.5 [P50990-3] ENST00000707885.1 [P50990-2] ENST00000431234.1 P50990 H7C2U0 Q7Z759

CCT8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review