BRK1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	40 studies	42% ± 18%	Explore
natural killer cell	38 studies	42% ± 13%	Explore
fibroblast	37 studies	48% ± 19%	Explore
CD8-positive, alpha-beta T cell	35 studies	42% ± 19%	Explore
macrophage	34 studies	47% ± 16%	Explore
endothelial cell	33 studies	49% ± 20%	Explore
pericyte	31 studies	50% ± 20%	Explore
T cell	30 studies	41% ± 17%	Explore
CD4-positive, alpha-beta T cell	30 studies	42% ± 16%	Explore
conventional dendritic cell	29 studies	65% ± 16%	Explore
regulatory T cell	27 studies	45% ± 17%	Explore
smooth muscle cell	25 studies	51% ± 18%	Explore
classical monocyte	25 studies	51% ± 15%	Explore
dendritic cell	23 studies	54% ± 24%	Explore
non-classical monocyte	23 studies	57% ± 15%	Explore
plasmacytoid dendritic cell	23 studies	60% ± 18%	Explore
epithelial cell	22 studies	51% ± 23%	Explore
memory B cell	20 studies	41% ± 12%	Explore
naive B cell	20 studies	34% ± 12%	Explore
mast cell	19 studies	40% ± 16%	Explore
monocyte	19 studies	50% ± 16%	Explore
endothelial cell of lymphatic vessel	19 studies	57% ± 16%	Explore
basal cell	19 studies	51% ± 20%	Explore
mature NK T cell	18 studies	41% ± 11%	Explore
connective tissue cell	18 studies	56% ± 21%	Explore
gamma-delta T cell	17 studies	42% ± 15%	Explore
ciliated cell	16 studies	49% ± 19%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	45% ± 13%	Explore
myeloid cell	15 studies	48% ± 20%	Explore
mucosal invariant T cell	14 studies	32% ± 11%	Explore
plasma cell	14 studies	43% ± 15%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	14 studies	33% ± 10%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	37% ± 13%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	38% ± 16%	Explore
myofibroblast cell	13 studies	59% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	40% ± 19%	Explore
secretory cell	12 studies	49% ± 15%	Explore
capillary endothelial cell	12 studies	46% ± 15%	Explore
endothelial cell of artery	12 studies	49% ± 19%	Explore
endothelial cell of vascular tree	12 studies	49% ± 14%	Explore
vein endothelial cell	11 studies	53% ± 17%	Explore
plasmablast	10 studies	42% ± 22%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	43% ± 20%	Explore
innate lymphoid cell	10 studies	39% ± 13%	Explore
abnormal cell	10 studies	45% ± 17%	Explore
platelet	9 studies	38% ± 10%	Explore
leukocyte	9 studies	40% ± 21%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	37% ± 11%	Explore
progenitor cell	9 studies	55% ± 15%	Explore
goblet cell	9 studies	34% ± 17%	Explore
type I pneumocyte	8 studies	34% ± 16%	Explore
neuron	8 studies	53% ± 28%	Explore
T follicular helper cell	8 studies	48% ± 14%	Explore
hematopoietic stem cell	8 studies	45% ± 16%	Explore
type II pneumocyte	7 studies	47% ± 20%	Explore
club cell	7 studies	51% ± 10%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	51% ± 21%	Explore
epithelial cell of proximal tubule	7 studies	43% ± 14%	Explore
neutrophil	7 studies	34% ± 13%	Explore
mesothelial cell	7 studies	57% ± 28%	Explore
CD4-positive helper T cell	6 studies	25% ± 6%	Explore
hematopoietic precursor cell	6 studies	51% ± 27%	Explore
respiratory goblet cell	6 studies	42% ± 22%	Explore
mononuclear phagocyte	6 studies	54% ± 24%	Explore
kidney loop of Henle epithelial cell	6 studies	35% ± 7%	Explore
renal alpha-intercalated cell	6 studies	49% ± 15%	Explore
megakaryocyte	6 studies	60% ± 24%	Explore
enterocyte	6 studies	32% ± 10%	Explore
precursor B cell	6 studies	47% ± 19%	Explore
erythrocyte	6 studies	40% ± 22%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	44% ± 22%	Explore
glutamatergic neuron	6 studies	36% ± 16%	Explore
alveolar macrophage	5 studies	49% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	36% ± 13%	Explore
exhausted T cell	5 studies	61% ± 12%	Explore
ionocyte	5 studies	37% ± 11%	Explore
enteroendocrine cell	5 studies	60% ± 22%	Explore
erythroblast	5 studies	42% ± 24%	Explore
intestinal crypt stem cell	5 studies	38% ± 13%	Explore
transit amplifying cell	5 studies	31% ± 12%	Explore
pro-B cell	5 studies	42% ± 15%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	63% ± 24%	Explore
intermediate monocyte	5 studies	65% ± 20%	Explore
duct epithelial cell	4 studies	46% ± 11%	Explore
pancreatic A cell	4 studies	77% ± 13%	Explore
type B pancreatic cell	4 studies	67% ± 18%	Explore
glomerular endothelial cell	4 studies	45% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	58% ± 17%	Explore
retinal ganglion cell	4 studies	56% ± 30%	Explore
brush cell	4 studies	37% ± 21%	Explore
immature B cell	4 studies	60% ± 19%	Explore
microglial cell	4 studies	41% ± 18%	Explore
adventitial cell	4 studies	40% ± 8%	Explore
keratinocyte	4 studies	38% ± 10%	Explore
acinar cell	4 studies	35% ± 19%	Explore
germinal center B cell	4 studies	60% ± 18%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	67% ± 11%	Explore
granulocyte	4 studies	48% ± 18%	Explore
GABAergic neuron	4 studies	26% ± 7%	Explore
oligodendrocyte precursor cell	4 studies	45% ± 18%	Explore
hepatocyte	4 studies	41% ± 30%	Explore
group 3 innate lymphoid cell	4 studies	50% ± 15%	Explore
T-helper 17 cell	4 studies	50% ± 17%	Explore
interneuron	4 studies	39% ± 21%	Explore
T-helper 1 cell	4 studies	53% ± 16%	Explore
double negative thymocyte	4 studies	48% ± 20%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	56% ± 26%	Explore
deuterosomal cell	3 studies	40% ± 5%	Explore
precursor cell	3 studies	67% ± 17%	Explore
squamous epithelial cell	3 studies	43% ± 22%	Explore
pancreatic D cell	3 studies	74% ± 20%	Explore
monocyte-derived dendritic cell	3 studies	57% ± 30%	Explore
podocyte	3 studies	54% ± 11%	Explore
neural crest cell	3 studies	64% ± 18%	Explore
IgG plasma cell	3 studies	21% ± 3%	Explore
lymphocyte	3 studies	54% ± 7%	Explore
neuroendocrine cell	3 studies	62% ± 26%	Explore
Schwann cell	3 studies	48% ± 24%	Explore
amacrine cell	3 studies	43% ± 14%	Explore
astrocyte	3 studies	37% ± 20%	Explore
mucus secreting cell	3 studies	45% ± 10%	Explore
serous secreting cell	3 studies	51% ± 5%	Explore
intraepithelial lymphocyte	3 studies	51% ± 13%	Explore
Mueller cell	3 studies	32% ± 10%	Explore
chondrocyte	3 studies	36% ± 25%	Explore
melanocyte	3 studies	32% ± 6%	Explore
endothelial cell of sinusoid	3 studies	27% ± 7%	Explore
muscle cell	3 studies	42% ± 27%	Explore
myoepithelial cell	3 studies	48% ± 9%	Explore
inflammatory macrophage	3 studies	36% ± 10%	Explore
luminal cell of prostate epithelium	3 studies	50% ± 11%	Explore
pancreatic ductal cell	3 studies	72% ± 6%	Explore
glial cell	3 studies	52% ± 25%	Explore
oligodendrocyte	3 studies	21% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	34% ± 11%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	32% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	54% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	19 studies	43% ± 14%	Explore
lung	18 studies	49% ± 18%	Explore
intestine	11 studies	41% ± 20%	Explore
brain	11 studies	30% ± 13%	Explore
kidney	9 studies	44% ± 15%	Explore
eye	7 studies	29% ± 13%	Explore
liver	6 studies	40% ± 24%	Explore
pancreas	5 studies	59% ± 26%	Explore
placenta	5 studies	33% ± 17%	Explore
bone marrow	5 studies	34% ± 14%	Explore
uterus	5 studies	48% ± 22%	Explore
lymph node	5 studies	50% ± 12%	Explore
skin	4 studies	32% ± 15%	Explore
prostate	4 studies	36% ± 13%	Explore
breast	4 studies	50% ± 9%	Explore
adrenal gland	3 studies	32% ± 7%	Explore
esophagus	3 studies	53% ± 30%	Explore
thymus	3 studies	59% ± 27%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	8946.31	1445 / 1445	100%	195.66	183 / 183
lung	100%	7417.96	578 / 578	100%	332.73	1155 / 1155
ovary	100%	7527.84	180 / 180	100%	457.38	430 / 430
prostate	100%	7722.53	245 / 245	100%	513.70	502 / 502
stomach	100%	6476.81	359 / 359	100%	286.16	286 / 286
thymus	100%	7595.48	653 / 653	100%	532.68	604 / 605
breast	100%	8820.62	459 / 459	100%	537.45	1116 / 1118
brain	100%	5957.63	2637 / 2642	100%	464.42	705 / 705
bladder	100%	9415.76	21 / 21	100%	487.71	503 / 504
skin	100%	8082.67	1809 / 1809	100%	419.37	471 / 472
uterus	100%	8146.55	170 / 170	100%	444.23	458 / 459
pancreas	100%	3461.60	327 / 328	100%	409.47	178 / 178
kidney	100%	8226.58	89 / 89	100%	300.59	898 / 901
intestine	100%	8237.42	966 / 966	100%	323.78	525 / 527
liver	100%	3194.34	225 / 226	100%	245.68	406 / 406
adrenal gland	100%	6118.34	258 / 258	99%	314.07	227 / 230
adipose	100%	8550.63	1204 / 1204	0%	0	0 / 0
blood vessel	100%	10233.08	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	338.18	80 / 80
lymph node	0%	0	0 / 0	100%	634.17	29 / 29
spleen	100%	6905.52	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	391.75	45 / 45
ureter	0%	0	0 / 0	100%	432.17	1 / 1
muscle	100%	5418.90	799 / 803	0%	0	0 / 0
heart	99%	5108.46	855 / 861	0%	0	0 / 0
peripheral blood	99%	5807.36	921 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0048870	Biological process	cell motility
GO_0048146	Biological process	positive regulation of fibroblast proliferation
GO_0001701	Biological process	in utero embryonic development
GO_0008064	Biological process	regulation of actin polymerization or depolymerization
GO_0010592	Biological process	positive regulation of lamellipodium assembly
GO_0031334	Biological process	positive regulation of protein-containing complex assembly
GO_0048144	Biological process	fibroblast proliferation
GO_0016601	Biological process	Rac protein signal transduction
GO_0007015	Biological process	actin filament organization
GO_2000601	Biological process	positive regulation of Arp2/3 complex-mediated actin nucleation
GO_0005856	Cellular component	cytoskeleton
GO_0070062	Cellular component	extracellular exosome
GO_0005829	Cellular component	cytosol
GO_0030027	Cellular component	lamellipodium
GO_0031209	Cellular component	SCAR complex
GO_0044877	Molecular function	protein-containing complex binding
GO_0042802	Molecular function	identical protein binding
GO_0031267	Molecular function	small GTPase binding
GO_0005515	Molecular function	protein binding

Gene name	BRK1
Protein name	Protein BRICK1 (BRK1)
Synonyms	HSPC300 C3orf10 MDS027
Description	FUNCTION: Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2/3 complex. As component of the WAVE1 complex, required for BDNF-NTRK2 endocytic trafficking and signaling from early endosomes (By similarity). .
Accessions	ENST00000530758.2 [Q8WUW1-1] Q8WUW1

BRK1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review