ATP5F1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001525Biological processangiogenesis
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0098761Biological processcellular response to interleukin-7
GO_0043536Biological processpositive regulation of blood vessel endothelial cell migration
GO_0015986Biological processproton motive force-driven ATP synthesis
GO_0001649Biological processosteoblast differentiation
GO_0006754Biological processATP biosynthetic process
GO_0006933Biological processnegative regulation of cell adhesion involved in substrate-bound cell migration
GO_0042776Biological processproton motive force-driven mitochondrial ATP synthesis
GO_0051453Biological processregulation of intracellular pH
GO_0006629Biological processlipid metabolic process
GO_1902600Biological processproton transmembrane transport
GO_0045261Cellular componentproton-transporting ATP synthase complex, catalytic core F(1)
GO_0005754Cellular componentmitochondrial proton-transporting ATP synthase, catalytic core
GO_0005886Cellular componentplasma membrane
GO_0042645Cellular componentmitochondrial nucleoid
GO_0016020Cellular componentmembrane
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0070062Cellular componentextracellular exosome
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005753Cellular componentmitochondrial proton-transporting ATP synthase complex
GO_0009986Cellular componentcell surface
GO_0005759Cellular componentmitochondrial matrix
GO_0045259Cellular componentproton-transporting ATP synthase complex
GO_0005634Cellular componentnucleus
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0046933Molecular functionproton-transporting ATP synthase activity, rotational mechanism
GO_0042288Molecular functionMHC class I protein binding
GO_0005524Molecular functionATP binding
GO_0043532Molecular functionangiostatin binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP5F1B
Protein nameATP synthase subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta)
ATP synthase subunit beta (EC 7.1.2.2)
ATP synthase subunit beta, mitochondrial
SynonymsATP5B
ATPMB
ATPSB
DescriptionFUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. .

FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. .; FUNCTION: Produces ATP from ADP in the presence of a proton gradient across the membrane. .

FUNCTION: Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. .; FUNCTION: Produces ATP from ADP in the presence of a proton gradient across the membrane. .

AccessionsENST00000262030.8
Q0QEN7
F8W0P7
F8W079
ENST00000551570.5
ENST00000551020.5
H0YH81
H0YI37
ENST00000553007.2
P06576
ENST00000552959.5