ALKBH7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_1902445Biological processregulation of mitochondrial membrane permeability involved in programmed necrotic cell death
GO_0010883Biological processregulation of lipid storage
GO_0006631Biological processfatty acid metabolic process
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0051213Molecular functiondioxygenase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameALKBH7
Protein nameAlkB homolog 7
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 7, mitochondrial (EC 1.14.11.-) (Alkylated DNA repair protein alkB homolog 7) (Spermatogenesis cell proliferation-related protein) (Spermatogenesis-associated protein 11)
SynonymsSPATA11
UNQ6002/PRO34564
ABH7
DescriptionFUNCTION: May function as protein hydroxylase; can catalyze auto-hydroxylation at Leu-110 (in vitro), but this activity may be due to the absence of the true substrate . Required to induce programmed necrosis in response to DNA damage caused by cytotoxic alkylating agents. Acts by triggering the collapse of mitochondrial membrane potential and loss of mitochondrial function that leads to energy depletion and cell death . ALKBH7-mediated necrosis is probably required to prevent the accumulation of cells with DNA damage . Does not display DNA demethylase activity . Involved in fatty acid metabolism (By similarity). .

AccessionsM0QZI0
ENST00000245812.8
ENST00000599849.1
ENST00000596657.1
Q9BT30
M0QZH2