YTHDF2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070925Biological processorganelle assembly
GO_1903679Biological processpositive regulation of cap-independent translational initiation
GO_0045948Biological processpositive regulation of translational initiation
GO_0034063Biological processstress granule assembly
GO_0043488Biological processregulation of mRNA stability
GO_0006402Biological processmRNA catabolic process
GO_0045087Biological processinnate immune response
GO_0007276Biological processgamete generation
GO_0061157Biological processmRNA destabilization
GO_2000232Biological processregulation of rRNA processing
GO_0071425Biological processhematopoietic stem cell proliferation
GO_0006959Biological processhumoral immune response
GO_0001556Biological processoocyte maturation
GO_0048598Biological processembryonic morphogenesis
GO_1902036Biological processregulation of hematopoietic stem cell differentiation
GO_0007284Biological processspermatogonial cell division
GO_2000737Biological processnegative regulation of stem cell differentiation
GO_0098508Biological processendothelial to hematopoietic transition
GO_0050767Biological processregulation of neurogenesis
GO_0060339Biological processnegative regulation of type I interferon-mediated signaling pathway
GO_0045746Biological processnegative regulation of Notch signaling pathway
GO_0030155Biological processregulation of cell adhesion
GO_1903538Biological processregulation of meiotic cell cycle process involved in oocyte maturation
GO_0034451Cellular componentcentriolar satellite
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0000932Cellular componentP-body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0062153Molecular functionC5-methylcytidine-containing RNA reader activity
GO_0003729Molecular functionmRNA binding
GO_1990247Molecular functionN6-methyladenosine-containing RNA reader activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameYTHDF2
Protein nameYTH N6-methyladenosine RNA binding protein 2
YTH domain-containing family protein 2 (DF2) (CLL-associated antigen KW-14) (High-glucose-regulated protein 8) (Renal carcinoma antigen NY-REN-2)
YTH domain-containing family protein
SynonymsHGRG8
DescriptionFUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates their stability . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing . Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT and ribonuclease P/MRP complexes, depending on the context . The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) share m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation . M6A-containing mRNAs containing a binding site for RIDA/HRSP12 (5'-GGUUC-3') are preferentially degraded by endoribonucleolytic cleavage: cooperative binding of RIDA/HRSP12 and YTHDF2 to transcripts leads to recruitment of the ribonuclease P/MRP complex . Other m6A-containing mRNAs undergo deadenylation via direct interaction between YTHDF2 and CNOT1, leading to recruitment of the CCR4-NOT and subsequent deadenylation of m6A-containing mRNAs . Required maternally to regulate oocyte maturation: probably acts by binding to m6A-containing mRNAs, thereby regulating maternal transcript dosage during oocyte maturation, which is essential for the competence of oocytes to sustain early zygotic development (By similarity). Also required during spermatogenesis: regulates spermagonial adhesion by promoting degradation of m6A-containing transcripts coding for matrix metallopeptidases (By similarity). Also involved in hematopoietic stem cells specification by binding to m6A-containing mRNAs, leading to promote their degradation . Also acts as a regulator of neural development by promoting m6A-dependent degradation of neural development-related mRNA targets (By similarity). Inhibits neural specification of induced pluripotent stem cells by binding to methylated neural-specific mRNAs and promoting their degradation, thereby restraining neural differentiation . Regulates circadian regulation of hepatic lipid metabolism: acts by promoting m6A-dependent degradation of PPARA transcripts . Regulates the innate immune response to infection by inhibiting the type I interferon response: acts by binding to m6A-containing IFNB transcripts and promoting their degradation . May also act as a promoter of cap-independent mRNA translation following heat shock stress: upon stress, relocalizes to the nucleus and specifically binds mRNAs with some m6A methylation mark at their 5'-UTR, protecting demethylation of mRNAs by FTO, thereby promoting cap-independent mRNA translation . Regulates mitotic entry by promoting the phase-specific m6A-dependent degradation of WEE1 transcripts . Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation . The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules . May also recognize and bind RNAs modified by C5-methylcytosine (m5C) and act as a regulator of rRNA processing . .; FUNCTION: (Microbial infection) Promotes viral gene expression and replication of polyomavirus SV40: acts by binding to N6-methyladenosine (m6A)-containing viral RNAs . .; FUNCTION: (Microbial infection) Promotes viral gene expression and virion production of kaposis sarcoma-associated herpesvirus (KSHV) at some stage of the KSHV life cycle (in iSLK.219 and iSLK.BAC16 cells) . Acts by binding to N6-methyladenosine (m6A)-containing viral RNAs . .

FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. .

AccessionsS4R3V3
ENST00000496288.5
B5BU99
ENST00000373812.8 [Q9Y5A9-1]
ENST00000542507.5 [Q9Y5A9-1]
ENST00000541996.5 [Q9Y5A9-2]
S4R3J8
ENST00000474884.5
Q9Y5A9