YTHDC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0009048Biological processdosage compensation by inactivation of X chromosome
GO_0006376Biological processmRNA splice site recognition
GO_0007283Biological processspermatogenesis
GO_0001701Biological processin utero embryonic development
GO_0010608Biological processpost-transcriptional regulation of gene expression
GO_0000381Biological processregulation of alternative mRNA splicing, via spliceosome
GO_0048160Biological processprimary follicle stage
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0006406Biological processmRNA export from nucleus
GO_0110104Biological processmRNA alternative polyadenylation
GO_0048024Biological processregulation of mRNA splicing, via spliceosome
GO_0005886Cellular componentplasma membrane
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0003729Molecular functionmRNA binding
GO_1990247Molecular functionN6-methyladenosine-containing RNA reader activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameYTHDC1
Protein nameAlternative protein YTHDC1
YTH domain-containing family protein
YTH domain containing 1 (YTH domain-containing protein 1)
YTH domain-containing protein 1 (Splicing factor YT521) (YT521-B)
SynonymsYT521
KIAA1966
DescriptionFUNCTION: Regulator of alternative splicing that specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability . Acts as a key regulator of exon-inclusion or exon-skipping during alternative splicing via interaction with mRNA splicing factors SRSF3 and SRSF10 . Specifically binds m6A-containing mRNAs and promotes recruitment of SRSF3 to its mRNA-binding elements adjacent to m6A sites, leading to exon-inclusion during alternative splicing . In contrast, interaction with SRSF3 prevents interaction with SRSF10, a splicing factor that promotes exon skipping: this prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing . May also regulate alternative splice site selection . Also involved in nuclear export of m6A-containing mRNAs via interaction with SRSF3: interaction with SRSF3 facilitates m6A-containing mRNA-binding to both SRSF3 and NXF1, promoting mRNA nuclear export . Involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts, probably by binding m6A-containing MAT2A mRNAs (By similarity). Also recognizes and binds m6A on other RNA molecules . Involved in random X inactivation mediated by Xist RNA: recognizes and binds m6A-containing Xist and promotes transcription repression activity of Xist . Also recognizes and binds m6A-containing single-stranded DNA . Involved in germline development: required for spermatogonial development in males and oocyte growth and maturation in females, probably via its role in alternative splicing (By similarity). .

FUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, and regulates mRNA stability. M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing. .

AccessionsENST00000615500.4 [Q96MU7-1]
ENST00000627168.2
J3QR07
ENST00000505251.1
L0R8L2
ENST00000625493.1
J3KS01
ENST00000355665.7 [Q96MU7-2]
ENST00000579690.5
ENST00000628264.1
Q96MU7
ENST00000510746.1
J3KRG5
ENST00000629100.1
ENST00000344157.9 [Q96MU7-1]
ENST00000507529.1
ENST00000613637.3 [Q96MU7-2]
J3KRW0