XRN2 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	41 studies	29% ± 12%	Explore
macrophage	33 studies	25% ± 9%	Explore
fibroblast	30 studies	25% ± 8%	Explore
natural killer cell	27 studies	26% ± 7%	Explore
CD4-positive, alpha-beta T cell	26 studies	26% ± 8%	Explore
B cell	25 studies	22% ± 6%	Explore
conventional dendritic cell	25 studies	29% ± 15%	Explore
classical monocyte	25 studies	35% ± 11%	Explore
regulatory T cell	22 studies	27% ± 6%	Explore
monocyte	21 studies	29% ± 9%	Explore
pericyte	21 studies	26% ± 8%	Explore
smooth muscle cell	21 studies	22% ± 4%	Explore
non-classical monocyte	21 studies	31% ± 11%	Explore
CD8-positive, alpha-beta T cell	21 studies	27% ± 8%	Explore
T cell	20 studies	24% ± 6%	Explore
ciliated cell	18 studies	32% ± 15%	Explore
naive B cell	15 studies	21% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	26% ± 8%	Explore
dendritic cell	14 studies	36% ± 21%	Explore
endothelial cell of lymphatic vessel	14 studies	28% ± 9%	Explore
capillary endothelial cell	14 studies	21% ± 7%	Explore
gamma-delta T cell	14 studies	28% ± 13%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	25% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	26% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	26% ± 6%	Explore
memory B cell	13 studies	22% ± 5%	Explore
endothelial cell of vascular tree	13 studies	26% ± 11%	Explore
basal cell	12 studies	29% ± 15%	Explore
mature NK T cell	12 studies	25% ± 6%	Explore
epithelial cell	12 studies	34% ± 20%	Explore
mucosal invariant T cell	12 studies	25% ± 5%	Explore
plasmacytoid dendritic cell	12 studies	26% ± 8%	Explore
mast cell	11 studies	23% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	25% ± 8%	Explore
connective tissue cell	11 studies	26% ± 9%	Explore
vein endothelial cell	11 studies	27% ± 13%	Explore
myeloid cell	11 studies	28% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	26% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	25% ± 7%	Explore
myofibroblast cell	10 studies	27% ± 6%	Explore
endothelial cell of artery	10 studies	23% ± 5%	Explore
microglial cell	10 studies	30% ± 12%	Explore
mesothelial cell	8 studies	26% ± 11%	Explore
neuron	8 studies	42% ± 18%	Explore
oligodendrocyte precursor cell	8 studies	29% ± 11%	Explore
oligodendrocyte	8 studies	29% ± 9%	Explore
plasmablast	7 studies	36% ± 21%	Explore
progenitor cell	7 studies	24% ± 7%	Explore
abnormal cell	7 studies	31% ± 12%	Explore
GABAergic neuron	7 studies	36% ± 18%	Explore
type II pneumocyte	6 studies	25% ± 10%	Explore
hematopoietic precursor cell	6 studies	39% ± 11%	Explore
secretory cell	6 studies	26% ± 17%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	29% ± 8%	Explore
interneuron	6 studies	37% ± 20%	Explore
hematopoietic stem cell	6 studies	32% ± 8%	Explore
lymphocyte	6 studies	30% ± 9%	Explore
precursor B cell	6 studies	31% ± 8%	Explore
T follicular helper cell	6 studies	24% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	29% ± 8%	Explore
astrocyte	6 studies	30% ± 11%	Explore
alveolar macrophage	5 studies	24% ± 8%	Explore
type I pneumocyte	5 studies	20% ± 5%	Explore
plasma cell	5 studies	30% ± 15%	Explore
leukocyte	5 studies	28% ± 5%	Explore
mononuclear phagocyte	5 studies	32% ± 9%	Explore
pro-B cell	5 studies	27% ± 3%	Explore
retina horizontal cell	5 studies	25% ± 9%	Explore
innate lymphoid cell	5 studies	23% ± 5%	Explore
exhausted T cell	4 studies	31% ± 10%	Explore
club cell	4 studies	25% ± 4%	Explore
immature B cell	4 studies	24% ± 4%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	34% ± 6%	Explore
intermediate monocyte	4 studies	41% ± 21%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	26% ± 8%	Explore
glutamatergic neuron	4 studies	56% ± 15%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	43% ± 21%	Explore
neutrophil	4 studies	19% ± 4%	Explore
goblet cell	4 studies	32% ± 20%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 5%	Explore
precursor cell	3 studies	25% ± 6%	Explore
neural crest cell	3 studies	34% ± 5%	Explore
glial cell	3 studies	31% ± 15%	Explore
common myeloid progenitor	3 studies	34% ± 20%	Explore
erythroblast	3 studies	37% ± 12%	Explore
megakaryocyte	3 studies	20% ± 0%	Explore
retinal cone cell	3 studies	21% ± 4%	Explore
adipocyte	3 studies	22% ± 1%	Explore
CD4-positive helper T cell	3 studies	23% ± 5%	Explore
hepatocyte	3 studies	41% ± 30%	Explore
muscle cell	3 studies	29% ± 4%	Explore
pancreatic ductal cell	3 studies	46% ± 17%	Explore
granulocyte	3 studies	22% ± 6%	Explore
granulocyte monocyte progenitor cell	3 studies	30% ± 8%	Explore
intestinal crypt stem cell	3 studies	21% ± 2%	Explore
adventitial cell	3 studies	21% ± 2%	Explore
group 3 innate lymphoid cell	3 studies	30% ± 13%	Explore
transit amplifying cell	3 studies	34% ± 24%	Explore
T-helper 17 cell	3 studies	27% ± 6%	Explore
T-helper 1 cell	3 studies	26% ± 4%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	29% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	25% ± 6%	Explore
double negative thymocyte	3 studies	40% ± 13%	Explore
myoepithelial cell	3 studies	24% ± 2%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	17 studies	32% ± 9%	Explore
lung	14 studies	28% ± 12%	Explore
brain	12 studies	31% ± 16%	Explore
kidney	5 studies	22% ± 5%	Explore
intestine	5 studies	25% ± 10%	Explore
eye	5 studies	23% ± 9%	Explore
liver	5 studies	32% ± 16%	Explore
bone marrow	4 studies	25% ± 6%	Explore
uterus	4 studies	29% ± 16%	Explore
lymph node	4 studies	28% ± 13%	Explore
adipose	4 studies	22% ± 3%	Explore
heart	3 studies	17% ± 0%	Explore
breast	3 studies	22% ± 5%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	3988.95	1445 / 1445	100%	124.76	183 / 183
ovary	100%	4828.39	180 / 180	100%	99.45	430 / 430
stomach	100%	3481.60	359 / 359	100%	115.13	286 / 286
lung	100%	5237.09	578 / 578	100%	111.10	1153 / 1155
breast	100%	5731.18	459 / 459	100%	137.83	1115 / 1118
intestine	100%	4398.80	966 / 966	99%	113.23	524 / 527
bladder	100%	5210.71	21 / 21	99%	104.80	501 / 504
prostate	100%	3927.70	245 / 245	99%	85.62	498 / 502
thymus	100%	4773.31	653 / 653	99%	89.04	599 / 605
pancreas	99%	3222.06	325 / 328	99%	84.21	177 / 178
kidney	100%	3318.69	89 / 89	98%	82.66	883 / 901
uterus	100%	5376.65	170 / 170	98%	95.46	449 / 459
skin	100%	5400.14	1809 / 1809	97%	128.35	460 / 472
brain	97%	1910.15	2569 / 2642	100%	81.20	704 / 705
liver	100%	2395.87	225 / 226	93%	52.79	378 / 406
adrenal gland	100%	5896.79	258 / 258	90%	57.82	207 / 230
adipose	100%	5653.78	1204 / 1204	0%	0	0 / 0
blood vessel	100%	4673.63	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	86.20	29 / 29
spleen	100%	5371.45	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	106.02	45 / 45
ureter	0%	0	0 / 0	100%	24.05	1 / 1
muscle	100%	3845.73	802 / 803	0%	0	0 / 0
peripheral blood	97%	6098.45	898 / 929	0%	0	0 / 0
heart	97%	2505.92	831 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	95%	76.97	76 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0007283	Biological process	spermatogenesis
GO_0021766	Biological process	hippocampus development
GO_0006397	Biological process	mRNA processing
GO_0006396	Biological process	RNA processing
GO_0060041	Biological process	retina development in camera-type eye
GO_0006369	Biological process	termination of RNA polymerase II transcription
GO_0006401	Biological process	RNA catabolic process
GO_0030182	Biological process	neuron differentiation
GO_0016070	Biological process	RNA metabolic process
GO_0000956	Biological process	nuclear-transcribed mRNA catabolic process
GO_0006364	Biological process	rRNA processing
GO_0005730	Cellular component	nucleolus
GO_0016020	Cellular component	membrane
GO_0005654	Cellular component	nucleoplasm
GO_0016235	Cellular component	aggresome
GO_0005634	Cellular component	nucleus
GO_0008409	Molecular function	5'-3' exonuclease activity
GO_0042802	Molecular function	identical protein binding
GO_0004518	Molecular function	nuclease activity
GO_0046872	Molecular function	metal ion binding
GO_0003723	Molecular function	RNA binding
GO_0000175	Molecular function	3'-5'-RNA exonuclease activity
GO_0004534	Molecular function	5'-3' RNA exonuclease activity
GO_0005515	Molecular function	protein binding
GO_0001147	Molecular function	transcription termination site sequence-specific DNA binding

IV. Literature review

[source]

Gene name	XRN2
Protein name	5'-3' exoribonuclease 2 (EC 3.1.13.-) (DHM1-like protein) (DHP protein) XRN2 protein
Synonyms
Description	FUNCTION: Possesses 5'->3' exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites . .
Accessions	Q9H0D6 ENST00000377191.5 [Q9H0D6-1] A2RRQ1

XRN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review