UQCR11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006122Biological processmitochondrial electron transport, ubiquinol to cytochrome c
GO_0006091Biological processgeneration of precursor metabolites and energy
GO_0045333Biological processcellular respiration
GO_0005750Cellular componentmitochondrial respiratory chain complex III
GO_0005743Cellular componentmitochondrial inner membrane
GO_0009055Molecular functionelectron transfer activity

IV. Literature review

[source]
Gene nameUQCR11
Protein nameCytochrome b-c1 complex subunit 10 (Complex III subunit 10) (Complex III subunit XI) (Ubiquinol-cytochrome c reductase complex 6.4 kDa protein)
SynonymsUQCR
DescriptionFUNCTION: Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. QCR10 has a role in CIII assembly and RIP1 stability. .

AccessionsENST00000585671.2
ENST00000591899.8
ENST00000589880.1
O14957