TTC3 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	43 studies	40% ± 16%	Explore
endothelial cell	37 studies	32% ± 17%	Explore
B cell	34 studies	28% ± 8%	Explore
macrophage	31 studies	29% ± 14%	Explore
natural killer cell	27 studies	21% ± 5%	Explore
smooth muscle cell	27 studies	37% ± 19%	Explore
pericyte	27 studies	32% ± 15%	Explore
CD4-positive, alpha-beta T cell	26 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	26 studies	24% ± 8%	Explore
T cell	21 studies	25% ± 8%	Explore
astrocyte	21 studies	43% ± 15%	Explore
regulatory T cell	20 studies	23% ± 6%	Explore
conventional dendritic cell	19 studies	26% ± 13%	Explore
ciliated cell	19 studies	42% ± 14%	Explore
epithelial cell	19 studies	43% ± 23%	Explore
naive B cell	19 studies	29% ± 7%	Explore
plasmacytoid dendritic cell	17 studies	40% ± 11%	Explore
basal cell	17 studies	33% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	17 studies	31% ± 9%	Explore
memory B cell	17 studies	28% ± 6%	Explore
plasma cell	16 studies	31% ± 12%	Explore
connective tissue cell	16 studies	47% ± 22%	Explore
oligodendrocyte precursor cell	16 studies	61% ± 15%	Explore
mature NK T cell	16 studies	23% ± 7%	Explore
gamma-delta T cell	16 studies	28% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	15 studies	30% ± 12%	Explore
oligodendrocyte	15 studies	46% ± 14%	Explore
myofibroblast cell	15 studies	43% ± 19%	Explore
microglial cell	15 studies	41% ± 17%	Explore
endothelial cell of lymphatic vessel	14 studies	27% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	24% ± 6%	Explore
mucosal invariant T cell	13 studies	25% ± 5%	Explore
dendritic cell	12 studies	32% ± 18%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	26% ± 9%	Explore
glutamatergic neuron	12 studies	79% ± 15%	Explore
type II pneumocyte	11 studies	32% ± 12%	Explore
club cell	11 studies	39% ± 15%	Explore
classical monocyte	11 studies	22% ± 8%	Explore
GABAergic neuron	11 studies	73% ± 18%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	11 studies	29% ± 9%	Explore
monocyte	10 studies	24% ± 7%	Explore
type I pneumocyte	10 studies	32% ± 12%	Explore
secretory cell	10 studies	33% ± 12%	Explore
neuron	10 studies	73% ± 15%	Explore
mesothelial cell	10 studies	46% ± 13%	Explore
adipocyte	10 studies	45% ± 7%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	28% ± 10%	Explore
progenitor cell	9 studies	44% ± 16%	Explore
abnormal cell	9 studies	44% ± 17%	Explore
endothelial cell of artery	9 studies	22% ± 8%	Explore
goblet cell	9 studies	38% ± 22%	Explore
myeloid cell	9 studies	33% ± 11%	Explore
respiratory goblet cell	8 studies	41% ± 17%	Explore
vein endothelial cell	8 studies	28% ± 11%	Explore
amacrine cell	8 studies	67% ± 14%	Explore
retinal rod cell	8 studies	42% ± 14%	Explore
retinal cone cell	8 studies	69% ± 20%	Explore
leukocyte	7 studies	31% ± 8%	Explore
kidney loop of Henle epithelial cell	7 studies	34% ± 6%	Explore
capillary endothelial cell	7 studies	23% ± 5%	Explore
interneuron	7 studies	81% ± 12%	Explore
retinal ganglion cell	7 studies	75% ± 18%	Explore
hematopoietic stem cell	7 studies	40% ± 17%	Explore
T follicular helper cell	7 studies	26% ± 9%	Explore
hematopoietic precursor cell	6 studies	44% ± 16%	Explore
mononuclear phagocyte	6 studies	26% ± 13%	Explore
renal alpha-intercalated cell	6 studies	36% ± 9%	Explore
glial cell	6 studies	37% ± 19%	Explore
retina horizontal cell	6 studies	80% ± 9%	Explore
Mueller cell	6 studies	47% ± 12%	Explore
endothelial cell of vascular tree	6 studies	24% ± 10%	Explore
non-classical monocyte	5 studies	27% ± 9%	Explore
plasmablast	5 studies	36% ± 18%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	37% ± 10%	Explore
epithelial cell of proximal tubule	5 studies	23% ± 6%	Explore
enteroendocrine cell	5 studies	40% ± 15%	Explore
retinal bipolar neuron	5 studies	69% ± 11%	Explore
OFF-bipolar cell	5 studies	59% ± 17%	Explore
ON-bipolar cell	5 studies	62% ± 17%	Explore
precursor B cell	5 studies	25% ± 8%	Explore
pro-B cell	5 studies	37% ± 13%	Explore
brush cell	5 studies	32% ± 23%	Explore
retinal pigment epithelial cell	5 studies	66% ± 15%	Explore
adventitial cell	5 studies	26% ± 10%	Explore
mucus secreting cell	5 studies	55% ± 15%	Explore
cardiac muscle cell	5 studies	39% ± 6%	Explore
lymphocyte	5 studies	34% ± 12%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	31% ± 10%	Explore
innate lymphoid cell	5 studies	24% ± 4%	Explore
mast cell	5 studies	27% ± 8%	Explore
alveolar macrophage	5 studies	31% ± 13%	Explore
deuterosomal cell	4 studies	34% ± 8%	Explore
duct epithelial cell	4 studies	43% ± 23%	Explore
ionocyte	4 studies	35% ± 14%	Explore
IgG plasma cell	4 studies	24% ± 6%	Explore
transit amplifying cell	4 studies	32% ± 21%	Explore
granule cell	4 studies	73% ± 11%	Explore
GABAergic amacrine cell	4 studies	68% ± 20%	Explore
glycinergic amacrine cell	4 studies	57% ± 18%	Explore
immature B cell	4 studies	24% ± 4%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	42% ± 14%	Explore
hepatocyte	4 studies	55% ± 17%	Explore
luminal cell of prostate epithelium	4 studies	35% ± 8%	Explore
megakaryocyte-erythroid progenitor cell	4 studies	50% ± 21%	Explore
melanocyte	4 studies	43% ± 18%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	22% ± 2%	Explore
renal principal cell	4 studies	33% ± 6%	Explore
pancreatic A cell	3 studies	63% ± 8%	Explore
type B pancreatic cell	3 studies	70% ± 11%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	23% ± 6%	Explore
effector CD8-positive, alpha-beta T cell	3 studies	21% ± 4%	Explore
podocyte	3 studies	36% ± 10%	Explore
differentiation-committed oligodendrocyte precursor	3 studies	67% ± 2%	Explore
enterocyte	3 studies	16% ± 1%	Explore
intestinal crypt stem cell	3 studies	25% ± 4%	Explore
neural crest cell	3 studies	59% ± 3%	Explore
IgA plasma cell	3 studies	30% ± 11%	Explore
GABAergic interneuron	3 studies	78% ± 5%	Explore
common myeloid progenitor	3 studies	34% ± 22%	Explore
Schwann cell	3 studies	40% ± 17%	Explore
serous secreting cell	3 studies	38% ± 9%	Explore
rod bipolar cell	3 studies	76% ± 4%	Explore
erythroblast	3 studies	40% ± 18%	Explore
CD4-positive helper T cell	3 studies	24% ± 5%	Explore
myoepithelial cell	3 studies	47% ± 11%	Explore
muscle cell	3 studies	40% ± 18%	Explore
ependymal cell	3 studies	49% ± 14%	Explore
granulocyte monocyte progenitor cell	3 studies	38% ± 5%	Explore
chondrocyte	3 studies	59% ± 9%	Explore
group 3 innate lymphoid cell	3 studies	33% ± 9%	Explore
T-helper 17 cell	3 studies	22% ± 2%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	29% ± 7%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	27% ± 8%	Explore
double negative thymocyte	3 studies	36% ± 18%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	19 studies	58% ± 21%	Explore
lung	17 studies	34% ± 15%	Explore
peripheral blood	16 studies	26% ± 9%	Explore
eye	11 studies	49% ± 15%	Explore
intestine	9 studies	33% ± 19%	Explore
kidney	9 studies	27% ± 9%	Explore
heart	5 studies	31% ± 6%	Explore
lymph node	5 studies	31% ± 15%	Explore
breast	5 studies	26% ± 5%	Explore
liver	5 studies	35% ± 15%	Explore
bone marrow	4 studies	35% ± 16%	Explore
uterus	4 studies	43% ± 21%	Explore
adipose	4 studies	41% ± 17%	Explore
pancreas	3 studies	53% ± 18%	Explore
placenta	3 studies	29% ± 7%	Explore
skin	3 studies	18% ± 1%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	100%	16697.36	245 / 245	100%	70.89	502 / 502
breast	100%	10866.07	459 / 459	100%	79.58	1117 / 1118
brain	100%	20310.89	2641 / 2642	100%	89.18	703 / 705
thymus	100%	12692.70	653 / 653	100%	63.39	602 / 605
esophagus	100%	8057.42	1442 / 1445	98%	35.90	179 / 183
lung	100%	8528.12	576 / 578	98%	33.48	1131 / 1155
pancreas	100%	8492.55	327 / 328	98%	36.09	174 / 178
bladder	100%	11216.48	21 / 21	97%	32.52	491 / 504
stomach	100%	8769.47	359 / 359	97%	33.81	278 / 286
intestine	100%	12042.50	966 / 966	96%	29.98	507 / 527
uterus	100%	12083.64	170 / 170	96%	36.57	441 / 459
ovary	100%	16419.93	180 / 180	96%	26.65	413 / 430
kidney	100%	9928.94	89 / 89	95%	31.67	859 / 901
skin	100%	11905.59	1807 / 1809	95%	50.81	450 / 472
adrenal gland	100%	12541.42	258 / 258	93%	45.71	214 / 230
liver	100%	5713.51	226 / 226	76%	16.32	310 / 406
adipose	100%	10590.59	1204 / 1204	0%	0	0 / 0
spleen	100%	8422.76	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	23.66	1 / 1
blood vessel	100%	10524.06	1332 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	96%	26.04	43 / 45
heart	94%	6465.84	811 / 861	0%	0	0 / 0
muscle	94%	4648.89	753 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	17.91	26 / 29
eye	0%	0	0 / 0	84%	28.32	67 / 80
peripheral blood	36%	3463.73	337 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	TTC3
Protein name	RING-type E3 ubiquitin transferase (EC 2.3.2.27) Tetratricopeptide repeat domain 3 Hypothetical rhabdomyosarcoma antigen MU-RMS-40.11C E3 ubiquitin-protein ligase TTC3 E3 ubiquitin-protein ligase TTC3 (EC 2.3.2.27) (Protein DCRR1) (RING finger protein 105) (RING-type E3 ubiquitin transferase TTC3) (TPR repeat protein D) (Tetratricopeptide repeat protein 3) (TPR repeat protein 3)
Synonyms	RNF105 DCRR1 TPRD
Description	FUNCTION: E3 ubiquitin-protein ligase which catalyzes the formation of 'Lys-48'-polyubiquitin chains . Mediates the ubiquitination and subsequent degradation of phosphorylated Akt (AKT1, AKT2 and AKT3) in the nucleus . Acts as a terminal regulator of Akt signaling after activation; its phosphorylation by Akt, which is a prerequisite for ubiquitin ligase activity, suggests the existence of a regulation mechanism required to control Akt levels after activation . Positively regulates TGFB1-induced epithelial-mesenchymal transition and myofibroblast differentiation by mediating the ubiquitination and subsequent degradation of SMURF2 . Regulates neuronal differentiation by regulating actin remodeling and Golgi organization via a signaling cascade involving RHOA, CIT and ROCK . Inhibits cell proliferation . .
Accessions	A8MT23 ENST00000492275.6 [P53804-3] A0A8Q3WLK8 B4DSZ9 E9PMS7 ENST00000411496.2 E9PMP8 ENST00000481605.6 A0A8Q3SJJ4 A0A8Q3WMF6 ENST00000450533 A0A8Q3WLL9 ENST00000428693.1 ENST00000399017.6 [P53804-1] ENST00000479930.5 P53804 H7C3Z1 A0A8Q3WLN3 Q5GIT6 ENST00000399010 ENST00000438055.5 H7C097 ENST00000450533.6 [P53804-1] H7BZ57 ENST00000696812.1 ENST00000418766 ENST00000696811.1 ENST00000540756.5 ENST00000485402.5 E9PCE7 ENST00000418766.6 [P53804-1] ENST00000463216.6 [P53804-3] ENST00000354749.6 [P53804-1] ENST00000414818.1

GO_0006511	Biological process	ubiquitin-dependent protein catabolic process
GO_0070936	Biological process	protein K48-linked ubiquitination
GO_0005730	Cellular component	nucleolus
GO_0005654	Cellular component	nucleoplasm
GO_0005829	Cellular component	cytosol
GO_0005794	Cellular component	Golgi apparatus
GO_0005634	Cellular component	nucleus
GO_0004842	Molecular function	ubiquitin-protein transferase activity
GO_0005515	Molecular function	protein binding
GO_0046872	Molecular function	metal ion binding

TTC3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review