TMCO1 report

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I. Expression across cell types

Cell ontologyData table

Name	Number of supported studies	Average coverage
natural killer cell	32 studies	25% ± 6%	Explore
fibroblast	32 studies	28% ± 12%	Explore
endothelial cell	30 studies	28% ± 11%	Explore
CD8-positive, alpha-beta T cell	25 studies	25% ± 6%	Explore
CD4-positive, alpha-beta T cell	23 studies	23% ± 6%	Explore
pericyte	21 studies	26% ± 8%	Explore
T cell	19 studies	24% ± 8%	Explore
macrophage	19 studies	22% ± 10%	Explore
regulatory T cell	19 studies	26% ± 6%	Explore
smooth muscle cell	18 studies	24% ± 6%	Explore
B cell	17 studies	20% ± 7%	Explore
epithelial cell	17 studies	35% ± 21%	Explore
gamma-delta T cell	17 studies	24% ± 12%	Explore
ciliated cell	16 studies	41% ± 16%	Explore
basal cell	15 studies	31% ± 17%	Explore
mature NK T cell	15 studies	24% ± 5%	Explore
non-classical monocyte	14 studies	25% ± 11%	Explore
plasmacytoid dendritic cell	14 studies	31% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	13 studies	23% ± 6%	Explore
classical monocyte	13 studies	23% ± 9%	Explore
connective tissue cell	13 studies	31% ± 9%	Explore
capillary endothelial cell	12 studies	22% ± 5%	Explore
myofibroblast cell	12 studies	27% ± 8%	Explore
plasma cell	11 studies	36% ± 11%	Explore
conventional dendritic cell	11 studies	26% ± 13%	Explore
endothelial cell of lymphatic vessel	10 studies	28% ± 8%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	26% ± 8%	Explore
endothelial cell of artery	10 studies	21% ± 5%	Explore
mucosal invariant T cell	10 studies	20% ± 4%	Explore
astrocyte	10 studies	32% ± 15%	Explore
plasmablast	9 studies	34% ± 21%	Explore
secretory cell	9 studies	29% ± 12%	Explore
monocyte	9 studies	22% ± 5%	Explore
vein endothelial cell	9 studies	20% ± 4%	Explore
mast cell	8 studies	20% ± 4%	Explore
type I pneumocyte	8 studies	29% ± 11%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	8 studies	21% ± 4%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	24% ± 5%	Explore
effector memory CD8-positive, alpha-beta T cell	8 studies	23% ± 6%	Explore
endothelial cell of vascular tree	8 studies	23% ± 4%	Explore
CD4-positive, alpha-beta memory T cell	7 studies	27% ± 8%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	7 studies	26% ± 5%	Explore
epithelial cell of proximal tubule	7 studies	26% ± 11%	Explore
progenitor cell	7 studies	25% ± 7%	Explore
abnormal cell	7 studies	39% ± 14%	Explore
memory B cell	7 studies	19% ± 4%	Explore
T follicular helper cell	7 studies	24% ± 5%	Explore
club cell	6 studies	33% ± 13%	Explore
effector CD8-positive, alpha-beta T cell	6 studies	30% ± 6%	Explore
naive B cell	6 studies	21% ± 6%	Explore
enterocyte	6 studies	31% ± 7%	Explore
innate lymphoid cell	6 studies	22% ± 3%	Explore
type II pneumocyte	6 studies	26% ± 17%	Explore
ionocyte	5 studies	26% ± 12%	Explore
leukocyte	5 studies	25% ± 8%	Explore
kidney loop of Henle epithelial cell	5 studies	31% ± 11%	Explore
renal alpha-intercalated cell	5 studies	39% ± 5%	Explore
goblet cell	5 studies	30% ± 13%	Explore
myeloid cell	5 studies	28% ± 16%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	25% ± 7%	Explore
neuron	5 studies	36% ± 13%	Explore
oligodendrocyte precursor cell	5 studies	31% ± 8%	Explore
dendritic cell	5 studies	32% ± 18%	Explore
deuterosomal cell	4 studies	21% ± 6%	Explore
respiratory goblet cell	4 studies	35% ± 18%	Explore
pancreatic A cell	4 studies	49% ± 9%	Explore
type B pancreatic cell	4 studies	51% ± 17%	Explore
exhausted T cell	4 studies	33% ± 4%	Explore
hematopoietic precursor cell	4 studies	31% ± 11%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	46% ± 8%	Explore
mesothelial cell	4 studies	30% ± 21%	Explore
retinal cone cell	4 studies	50% ± 24%	Explore
brush cell	4 studies	31% ± 15%	Explore
precursor B cell	4 studies	31% ± 11%	Explore
pro-B cell	4 studies	24% ± 3%	Explore
retinal rod cell	4 studies	30% ± 14%	Explore
microglial cell	4 studies	25% ± 7%	Explore
adventitial cell	4 studies	23% ± 12%	Explore
Mueller cell	4 studies	45% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	31% ± 1%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	40% ± 1%	Explore
GABAergic neuron	4 studies	38% ± 8%	Explore
glutamatergic neuron	4 studies	45% ± 8%	Explore
enteroendocrine cell	4 studies	34% ± 19%	Explore
T-helper 17 cell	4 studies	28% ± 5%	Explore
oligodendrocyte	4 studies	29% ± 7%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	23% ± 6%	Explore
duct epithelial cell	3 studies	26% ± 3%	Explore
pancreatic D cell	3 studies	51% ± 13%	Explore
glomerular endothelial cell	3 studies	24% ± 4%	Explore
intestinal crypt stem cell	3 studies	24% ± 10%	Explore
neural crest cell	3 studies	24% ± 3%	Explore
IgA plasma cell	3 studies	21% ± 3%	Explore
transit amplifying cell	3 studies	20% ± 2%	Explore
retinal bipolar neuron	3 studies	37% ± 14%	Explore
retinal ganglion cell	3 studies	49% ± 23%	Explore
lymphocyte	3 studies	32% ± 16%	Explore
amacrine cell	3 studies	38% ± 10%	Explore
retina horizontal cell	3 studies	33% ± 14%	Explore
alveolar macrophage	3 studies	16% ± 1%	Explore
serous secreting cell	3 studies	29% ± 10%	Explore
intraepithelial lymphocyte	3 studies	34% ± 14%	Explore
rod bipolar cell	3 studies	29% ± 10%	Explore
CD4-positive helper T cell	3 studies	21% ± 4%	Explore
myoepithelial cell	3 studies	24% ± 6%	Explore
pancreatic ductal cell	3 studies	54% ± 7%	Explore
glial cell	3 studies	31% ± 20%	Explore
group 3 innate lymphoid cell	3 studies	28% ± 12%	Explore
mononuclear phagocyte	3 studies	29% ± 15%	Explore
interneuron	3 studies	44% ± 14%	Explore
double negative thymocyte	3 studies	36% ± 19%	Explore
hepatocyte	3 studies	49% ± 25%	Explore

II. Expression across tissues

sc-RNAseq dataData table

Name	Number of supported studies	Average coverage
lung	15 studies	30% ± 12%	Explore
peripheral blood	12 studies	24% ± 6%	Explore
intestine	10 studies	26% ± 10%	Explore
kidney	9 studies	25% ± 5%	Explore
brain	8 studies	31% ± 8%	Explore
eye	7 studies	29% ± 15%	Explore
liver	6 studies	32% ± 16%	Explore
lymph node	5 studies	23% ± 6%	Explore
pancreas	4 studies	47% ± 15%	Explore
uterus	4 studies	38% ± 17%	Explore
breast	4 studies	24% ± 2%	Explore
bone marrow	3 studies	18% ± 1%	Explore
adrenal gland	3 studies	21% ± 4%	Explore

Bulk RNAseq dataData table

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	3346.20	459 / 459	100%	116.08	1118 / 1118
liver	100%	3217.00	226 / 226	100%	92.66	406 / 406
pancreas	100%	2075.08	328 / 328	100%	67.31	178 / 178
brain	100%	2305.53	2639 / 2642	100%	69.86	705 / 705
prostate	100%	3018.47	245 / 245	100%	73.50	501 / 502
ovary	100%	2796.55	180 / 180	100%	59.30	429 / 430
stomach	100%	2688.93	359 / 359	100%	61.44	285 / 286
bladder	100%	2883.90	21 / 21	100%	72.39	502 / 504
adrenal gland	100%	4986.35	258 / 258	100%	67.00	229 / 230
thymus	100%	3860.92	653 / 653	100%	60.03	602 / 605
lung	100%	2794.51	578 / 578	99%	75.74	1149 / 1155
esophagus	100%	2761.64	1445 / 1445	99%	59.22	182 / 183
kidney	100%	3325.84	89 / 89	99%	59.08	895 / 901
skin	100%	3219.18	1809 / 1809	99%	76.80	468 / 472
intestine	100%	3457.57	966 / 966	99%	63.54	521 / 527
uterus	100%	2923.34	170 / 170	98%	70.71	451 / 459
adipose	100%	3120.85	1204 / 1204	0%	0	0 / 0
spleen	100%	2468.83	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	48.95	45 / 45
ureter	0%	0	0 / 0	100%	33.12	1 / 1
blood vessel	100%	3023.25	1334 / 1335	0%	0	0 / 0
muscle	99%	1463.57	797 / 803	0%	0	0 / 0
heart	98%	1878.90	842 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	97%	48.99	28 / 29
eye	0%	0	0 / 0	94%	35.09	75 / 80
peripheral blood	78%	1560.17	726 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0