TAPBP | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	40 studies	43% ± 14%	Explore
B cell	39 studies	39% ± 15%	Explore
endothelial cell	35 studies	29% ± 10%	Explore
CD8-positive, alpha-beta T cell	35 studies	38% ± 13%	Explore
macrophage	32 studies	30% ± 10%	Explore
T cell	31 studies	33% ± 11%	Explore
CD4-positive, alpha-beta T cell	30 studies	34% ± 11%	Explore
conventional dendritic cell	27 studies	40% ± 15%	Explore
classical monocyte	24 studies	37% ± 15%	Explore
regulatory T cell	23 studies	38% ± 9%	Explore
dendritic cell	21 studies	44% ± 22%	Explore
mature NK T cell	21 studies	40% ± 13%	Explore
non-classical monocyte	21 studies	38% ± 15%	Explore
fibroblast	21 studies	23% ± 7%	Explore
monocyte	20 studies	34% ± 12%	Explore
memory B cell	20 studies	48% ± 10%	Explore
naive B cell	20 studies	42% ± 11%	Explore
plasmacytoid dendritic cell	20 studies	51% ± 11%	Explore
plasma cell	19 studies	43% ± 17%	Explore
gamma-delta T cell	18 studies	42% ± 12%	Explore
basal cell	16 studies	27% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	49% ± 16%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	54% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	34% ± 11%	Explore
mucosal invariant T cell	14 studies	39% ± 15%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	14 studies	41% ± 13%	Explore
capillary endothelial cell	14 studies	26% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	13 studies	43% ± 13%	Explore
endothelial cell of lymphatic vessel	12 studies	23% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	12 studies	43% ± 18%	Explore
ciliated cell	12 studies	33% ± 12%	Explore
epithelial cell	12 studies	36% ± 18%	Explore
vein endothelial cell	12 studies	27% ± 8%	Explore
plasmablast	11 studies	49% ± 25%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	38% ± 9%	Explore
pericyte	11 studies	22% ± 5%	Explore
myeloid cell	11 studies	41% ± 16%	Explore
mast cell	10 studies	24% ± 7%	Explore
type I pneumocyte	10 studies	31% ± 10%	Explore
secretory cell	10 studies	29% ± 11%	Explore
endothelial cell of artery	10 studies	24% ± 6%	Explore
endothelial cell of vascular tree	10 studies	25% ± 6%	Explore
alveolar macrophage	8 studies	32% ± 7%	Explore
innate lymphoid cell	8 studies	38% ± 11%	Explore
club cell	8 studies	28% ± 8%	Explore
leukocyte	8 studies	30% ± 10%	Explore
goblet cell	8 studies	35% ± 7%	Explore
abnormal cell	8 studies	35% ± 18%	Explore
neutrophil	7 studies	22% ± 4%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	38% ± 12%	Explore
T follicular helper cell	7 studies	33% ± 7%	Explore
hematopoietic precursor cell	6 studies	39% ± 20%	Explore
effector CD4-positive, alpha-beta T cell	6 studies	37% ± 12%	Explore
mononuclear phagocyte	6 studies	32% ± 15%	Explore
enterocyte	6 studies	26% ± 8%	Explore
precursor B cell	6 studies	41% ± 10%	Explore
immature B cell	6 studies	49% ± 8%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	40% ± 14%	Explore
type II pneumocyte	5 studies	26% ± 14%	Explore
CD4-positive helper T cell	5 studies	26% ± 10%	Explore
central memory CD8-positive, alpha-beta T cell	5 studies	36% ± 13%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	39% ± 13%	Explore
exhausted T cell	5 studies	54% ± 13%	Explore
respiratory goblet cell	5 studies	31% ± 10%	Explore
IgA plasma cell	5 studies	28% ± 12%	Explore
IgG plasma cell	5 studies	27% ± 11%	Explore
hematopoietic stem cell	5 studies	31% ± 5%	Explore
lymphocyte	5 studies	35% ± 11%	Explore
pro-B cell	5 studies	30% ± 6%	Explore
astrocyte	5 studies	21% ± 7%	Explore
connective tissue cell	5 studies	25% ± 7%	Explore
ionocyte	4 studies	34% ± 5%	Explore
squamous epithelial cell	4 studies	36% ± 24%	Explore
smooth muscle cell	4 studies	24% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	23% ± 3%	Explore
luminal cell of prostate epithelium	4 studies	25% ± 5%	Explore
brush cell	4 studies	26% ± 2%	Explore
T-helper 17 cell	4 studies	33% ± 6%	Explore
double negative thymocyte	4 studies	46% ± 12%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	33% ± 10%	Explore
duct epithelial cell	3 studies	27% ± 15%	Explore
platelet	3 studies	20% ± 4%	Explore
pancreatic A cell	3 studies	41% ± 2%	Explore
type B pancreatic cell	3 studies	28% ± 5%	Explore
glomerular endothelial cell	3 studies	27% ± 2%	Explore
mucus secreting cell	3 studies	22% ± 0%	Explore
serous secreting cell	3 studies	20% ± 2%	Explore
mesothelial cell	3 studies	19% ± 1%	Explore
tissue-resident macrophage	3 studies	33% ± 12%	Explore
intraepithelial lymphocyte	3 studies	36% ± 14%	Explore
germinal center B cell	3 studies	33% ± 6%	Explore
intermediate monocyte	3 studies	52% ± 28%	Explore
myofibroblast cell	3 studies	23% ± 7%	Explore
inflammatory macrophage	3 studies	23% ± 9%	Explore
pancreatic ductal cell	3 studies	64% ± 18%	Explore
granulocyte	3 studies	24% ± 4%	Explore
enteroendocrine cell	3 studies	27% ± 7%	Explore
group 3 innate lymphoid cell	3 studies	48% ± 10%	Explore
T-helper 1 cell	3 studies	41% ± 8%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	40% ± 12%	Explore
hepatocyte	3 studies	32% ± 11%	Explore
microglial cell	3 studies	20% ± 2%	Explore
erythrocyte	3 studies	28% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	18 studies	30% ± 11%	Explore
peripheral blood	18 studies	44% ± 13%	Explore
intestine	9 studies	23% ± 8%	Explore
kidney	5 studies	30% ± 11%	Explore
liver	5 studies	27% ± 6%	Explore
uterus	4 studies	29% ± 11%	Explore
lymph node	4 studies	36% ± 3%	Explore
breast	4 studies	23% ± 3%	Explore
brain	4 studies	24% ± 9%	Explore
pancreas	3 studies	39% ± 7%	Explore
bone marrow	3 studies	36% ± 14%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	8518.40	1445 / 1445	100%	285.92	183 / 183
liver	100%	10247.81	226 / 226	100%	190.51	406 / 406
ovary	100%	5930.77	180 / 180	100%	241.72	430 / 430
thymus	100%	11851.10	653 / 653	100%	170.00	605 / 605
intestine	100%	11699.62	966 / 966	100%	216.16	526 / 527
prostate	100%	12464.72	245 / 245	100%	171.67	501 / 502
lung	100%	15610.99	578 / 578	100%	232.05	1152 / 1155
breast	100%	8574.72	459 / 459	100%	209.80	1113 / 1118
stomach	100%	7634.76	359 / 359	99%	231.11	284 / 286
bladder	100%	8329.43	21 / 21	99%	216.41	500 / 504
kidney	100%	11278.85	89 / 89	99%	260.30	892 / 901
skin	100%	8254.18	1808 / 1809	99%	256.78	467 / 472
brain	99%	5174.87	2611 / 2642	100%	102.70	705 / 705
adrenal gland	100%	12953.68	258 / 258	99%	114.27	227 / 230
uterus	100%	7704.75	170 / 170	98%	215.06	451 / 459
pancreas	99%	5250.77	324 / 328	99%	201.31	176 / 178
adipose	100%	8509.20	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	136.27	80 / 80
lymph node	0%	0	0 / 0	100%	330.80	29 / 29
spleen	100%	23775.95	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	319.30	45 / 45
heart	100%	6654.42	860 / 861	0%	0	0 / 0
blood vessel	100%	6736.60	1333 / 1335	0%	0	0 / 0
peripheral blood	99%	20017.29	922 / 929	0%	0	0 / 0
muscle	93%	2753.65	744 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0010468	Biological process	regulation of gene expression
GO_0006890	Biological process	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO_0019885	Biological process	antigen processing and presentation of endogenous peptide antigen via MHC class I
GO_0061635	Biological process	regulation of protein complex stability
GO_0002398	Biological process	MHC class Ib protein complex assembly
GO_0065003	Biological process	protein-containing complex assembly
GO_0006457	Biological process	protein folding
GO_0002502	Biological process	peptide antigen assembly with MHC class I protein complex
GO_0050823	Biological process	peptide antigen stabilization
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0033116	Cellular component	endoplasmic reticulum-Golgi intermediate compartment membrane
GO_0000139	Cellular component	Golgi membrane
GO_0042824	Cellular component	MHC class I peptide loading complex
GO_0061779	Cellular component	Tapasin-ERp57 complex
GO_0005783	Cellular component	endoplasmic reticulum
GO_0098553	Cellular component	lumenal side of endoplasmic reticulum membrane
GO_0030670	Cellular component	phagocytic vesicle membrane
GO_0060090	Molecular function	molecular adaptor activity
GO_0044183	Molecular function	protein folding chaperone
GO_0062061	Molecular function	TAP complex binding
GO_0023024	Molecular function	MHC class I protein complex binding
GO_0051082	Molecular function	unfolded protein binding
GO_0042288	Molecular function	MHC class I protein binding
GO_0046979	Molecular function	TAP2 binding
GO_0005515	Molecular function	protein binding
GO_0046978	Molecular function	TAP1 binding
GO_0042605	Molecular function	peptide antigen binding

IV. Literature review

[source]

Gene name	TAPBP
Protein name	Tapasin (TAP-binding protein) Tapasin Tapasin (TPN) (TPSN) (NGS-17) (TAP-associated protein) (TAP-binding protein) TAPBP protein (Tapasin) TAP binding protein
Synonyms	NGS17 TAPA
Description	FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). . FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). . FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). . FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). . FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). . FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). . FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). . FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). . FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). . FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). . FUNCTION: Involved in the association of MHC class I with transporter associated with antigen processing (TAP) and in the assembly of MHC class I with peptide (peptide loading). .
Accessions	ENST00000432848.5 ENST00000551943.3 [O15533-4] ENST00000489157 ENST00000444432.5 ENST00000383065 ENST00000383067.8 ENST00000699651.1 A2AB90 ENST00000374568.8 A0A8V8TNS3 A0A8V8TQC5 ENST00000412144.6 A0A0G2JJI5 ENST00000426633.6 [O15533-3] ENST00000426633 ENST00000437315.6 ENST00000451696.5 ENST00000699650.1 A0A8V8TP19 ENST00000699657.1 A0A140T9B2 ENST00000551943 ENST00000383066.8 [O15533-1] A0A0G2JH37 A0A0A0MSV9 ENST00000699654.1 ENST00000383198.6 ENST00000456807.6 A0A8V8TQC1 ENST00000456051.5 A0A0A0MT98 ENST00000548408.3 ENST00000550794.3 ENST00000550330.3 ENST00000699659.1 [O15533-3] ENST00000417059.5 ENST00000383065.8 [O15533-3] A0A8V8TP24 ENST00000699652.1 ENST00000475304.5 ENST00000699648.1 A0A0G2JKZ1 O15533 C9JA35 Q6P1N7 ENST00000699656.1 ENST00000489157.6 [O15533-4] ENST00000549142.4 A0A8V8TPY1 ENST00000383197.8 ENST00000699649.1 ENST00000467025.2 ENST00000553235.3 ENST00000395114.7 ENST00000434618.7 [O15533-1] ENST00000374572.7 A0A8V8TPY6

TAPBP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review