SRSF4 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	45 studies	37% ± 14%	Explore
B cell	34 studies	25% ± 8%	Explore
natural killer cell	31 studies	27% ± 8%	Explore
fibroblast	31 studies	30% ± 10%	Explore
pericyte	31 studies	28% ± 10%	Explore
T cell	27 studies	25% ± 6%	Explore
smooth muscle cell	27 studies	28% ± 7%	Explore
CD4-positive, alpha-beta T cell	27 studies	25% ± 8%	Explore
CD8-positive, alpha-beta T cell	26 studies	27% ± 9%	Explore
macrophage	23 studies	25% ± 9%	Explore
regulatory T cell	21 studies	27% ± 6%	Explore
classical monocyte	18 studies	25% ± 12%	Explore
naive B cell	18 studies	23% ± 6%	Explore
memory B cell	18 studies	23% ± 5%	Explore
endothelial cell of lymphatic vessel	16 studies	33% ± 10%	Explore
non-classical monocyte	16 studies	25% ± 13%	Explore
conventional dendritic cell	16 studies	24% ± 15%	Explore
epithelial cell	16 studies	37% ± 20%	Explore
gamma-delta T cell	16 studies	27% ± 12%	Explore
mast cell	15 studies	24% ± 8%	Explore
monocyte	15 studies	26% ± 9%	Explore
basal cell	15 studies	33% ± 15%	Explore
ciliated cell	15 studies	33% ± 12%	Explore
CD16-negative, CD56-bright natural killer cell, human	15 studies	23% ± 6%	Explore
capillary endothelial cell	15 studies	28% ± 9%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	28% ± 7%	Explore
mature NK T cell	14 studies	24% ± 5%	Explore
connective tissue cell	14 studies	27% ± 9%	Explore
endothelial cell of vascular tree	14 studies	33% ± 12%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	23% ± 6%	Explore
vein endothelial cell	13 studies	35% ± 14%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	26% ± 6%	Explore
endothelial cell of artery	12 studies	29% ± 6%	Explore
mucosal invariant T cell	12 studies	23% ± 4%	Explore
plasmacytoid dendritic cell	12 studies	28% ± 8%	Explore
astrocyte	12 studies	28% ± 13%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	24% ± 6%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	25% ± 6%	Explore
myofibroblast cell	11 studies	31% ± 8%	Explore
type I pneumocyte	10 studies	30% ± 6%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	27% ± 9%	Explore
microglial cell	10 studies	25% ± 10%	Explore
dendritic cell	10 studies	33% ± 20%	Explore
type II pneumocyte	9 studies	32% ± 11%	Explore
plasma cell	9 studies	30% ± 10%	Explore
neuron	9 studies	35% ± 15%	Explore
oligodendrocyte precursor cell	9 studies	26% ± 13%	Explore
myeloid cell	9 studies	28% ± 10%	Explore
adipocyte	9 studies	52% ± 16%	Explore
plasmablast	8 studies	38% ± 22%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	26% ± 7%	Explore
progenitor cell	7 studies	23% ± 5%	Explore
abnormal cell	7 studies	27% ± 10%	Explore
goblet cell	7 studies	32% ± 23%	Explore
mesothelial cell	7 studies	24% ± 4%	Explore
glutamatergic neuron	7 studies	38% ± 20%	Explore
club cell	7 studies	30% ± 9%	Explore
amacrine cell	7 studies	27% ± 11%	Explore
T follicular helper cell	7 studies	22% ± 3%	Explore
GABAergic neuron	7 studies	35% ± 16%	Explore
oligodendrocyte	7 studies	26% ± 9%	Explore
respiratory goblet cell	6 studies	29% ± 13%	Explore
secretory cell	6 studies	29% ± 9%	Explore
leukocyte	6 studies	25% ± 5%	Explore
interneuron	6 studies	34% ± 22%	Explore
lymphocyte	6 studies	33% ± 9%	Explore
precursor B cell	6 studies	36% ± 8%	Explore
retina horizontal cell	6 studies	25% ± 7%	Explore
retinal rod cell	6 studies	26% ± 6%	Explore
Mueller cell	6 studies	26% ± 7%	Explore
hematopoietic precursor cell	5 studies	37% ± 14%	Explore
retinal bipolar neuron	5 studies	22% ± 6%	Explore
pro-B cell	5 studies	37% ± 5%	Explore
cardiac muscle cell	5 studies	28% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	34% ± 9%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	5 studies	22% ± 5%	Explore
exhausted T cell	4 studies	34% ± 10%	Explore
glial cell	4 studies	28% ± 14%	Explore
brush cell	4 studies	29% ± 7%	Explore
immature B cell	4 studies	28% ± 5%	Explore
retinal cone cell	4 studies	28% ± 7%	Explore
retinal pigment epithelial cell	4 studies	32% ± 17%	Explore
mononuclear phagocyte	4 studies	27% ± 10%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	28% ± 4%	Explore
innate lymphoid cell	4 studies	25% ± 3%	Explore
hepatocyte	4 studies	60% ± 18%	Explore
muscle cell	4 studies	39% ± 15%	Explore
enteroendocrine cell	4 studies	26% ± 7%	Explore
alveolar macrophage	4 studies	29% ± 12%	Explore
transit amplifying cell	4 studies	37% ± 29%	Explore
T-helper 17 cell	4 studies	25% ± 7%	Explore
kidney distal convoluted tubule epithelial cell	3 studies	23% ± 3%	Explore
neural crest cell	3 studies	32% ± 4%	Explore
retinal ganglion cell	3 studies	32% ± 10%	Explore
placental villous trophoblast	3 studies	28% ± 9%	Explore
erythroblast	3 studies	41% ± 17%	Explore
squamous epithelial cell	3 studies	37% ± 25%	Explore
ON-bipolar cell	3 studies	20% ± 4%	Explore
glycinergic amacrine cell	3 studies	23% ± 7%	Explore
rod bipolar cell	3 studies	28% ± 2%	Explore
germinal center B cell	3 studies	22% ± 2%	Explore
luminal hormone-sensing cell of mammary gland	3 studies	22% ± 8%	Explore
cholangiocyte	3 studies	51% ± 16%	Explore
pancreatic A cell	3 studies	20% ± 4%	Explore
ependymal cell	3 studies	35% ± 12%	Explore
granulocyte	3 studies	23% ± 8%	Explore
adventitial cell	3 studies	22% ± 1%	Explore
group 3 innate lymphoid cell	3 studies	35% ± 12%	Explore
T-helper 1 cell	3 studies	27% ± 1%	Explore
double negative thymocyte	3 studies	39% ± 16%	Explore
myoepithelial cell	3 studies	24% ± 2%	Explore
mucus secreting cell	3 studies	27% ± 8%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	17 studies	28% ± 9%	Explore
peripheral blood	15 studies	27% ± 11%	Explore
brain	14 studies	28% ± 13%	Explore
eye	9 studies	28% ± 13%	Explore
kidney	6 studies	23% ± 4%	Explore
intestine	6 studies	27% ± 10%	Explore
heart	5 studies	25% ± 4%	Explore
lymph node	5 studies	23% ± 2%	Explore
breast	5 studies	22% ± 7%	Explore
bone marrow	4 studies	26% ± 8%	Explore
liver	4 studies	45% ± 15%	Explore
adipose	4 studies	41% ± 22%	Explore
placenta	3 studies	26% ± 8%	Explore
uterus	3 studies	31% ± 17%	Explore
prostate	3 studies	26% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	8477.15	1445 / 1445	100%	35.92	183 / 183
intestine	100%	9619.87	966 / 966	100%	35.14	527 / 527
lung	100%	10054.75	578 / 578	100%	37.34	1155 / 1155
ovary	100%	10101.07	180 / 180	100%	27.69	430 / 430
prostate	100%	9218.08	245 / 245	100%	33.37	502 / 502
skin	100%	8418.82	1809 / 1809	100%	41.38	472 / 472
breast	100%	9964.02	459 / 459	100%	37.38	1116 / 1118
bladder	100%	9454.48	21 / 21	100%	45.20	503 / 504
thymus	100%	9877.26	653 / 653	100%	43.73	603 / 605
stomach	100%	6396.47	359 / 359	100%	31.74	285 / 286
uterus	100%	10638.51	170 / 170	100%	57.66	457 / 459
brain	100%	4865.00	2630 / 2642	100%	38.40	705 / 705
kidney	100%	6756.17	89 / 89	99%	31.33	896 / 901
pancreas	100%	4227.53	328 / 328	99%	38.20	176 / 178
adrenal gland	100%	6944.38	258 / 258	99%	20.82	227 / 230
liver	100%	6023.23	226 / 226	98%	19.79	398 / 406
adipose	100%	9931.79	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7851.79	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	42.19	29 / 29
muscle	100%	6444.79	803 / 803	0%	0	0 / 0
spleen	100%	9722.50	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	45.75	45 / 45
ureter	0%	0	0 / 0	100%	31.37	1 / 1
heart	99%	4704.89	851 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	99%	32.68	79 / 80
peripheral blood	99%	6524.01	916 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0000398	Biological process	mRNA splicing, via spliceosome
GO_0032868	Biological process	response to insulin
GO_0048025	Biological process	negative regulation of mRNA splicing, via spliceosome
GO_0008380	Biological process	RNA splicing
GO_0000375	Biological process	RNA splicing, via transesterification reactions
GO_0006397	Biological process	mRNA processing
GO_0016607	Cellular component	nuclear speck
GO_0005654	Cellular component	nucleoplasm
GO_0005634	Cellular component	nucleus
GO_1990825	Molecular function	sequence-specific mRNA binding
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

Gene name	SRSF4
Protein name	Serine and arginine rich splicing factor 4 Serine/arginine-rich splicing factor 4 (Pre-mRNA-splicing factor SRP75) (SRP001LB) (Splicing factor, arginine/serine-rich 4)
Synonyms	SRP75 SFRS4
Description	FUNCTION: Plays a role in alternative splice site selection during pre-mRNA splicing. Represses the splicing of MAPT/Tau exon 10. .
Accessions	ENST00000691479.1 A0A0D9SEM4 S4R2X6 ENST00000373795.7 ENST00000466448.4 ENST00000605204.1 Q08170

SRSF4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review